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Compile Data Set for Download or QSAR

Found 2122 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 10A (PDE10A2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244119
PNG
(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8O/c1-11-25-16(8-17(26-11)32-20(27-12(2)29-32)18(33)21(22,23)24)31-9-13(10-31)19-28-14-6-4-5-7-15(14)30(19)3/h4-8,13,18,33H,9-10H2,1-3H3
PDB

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US Patent
0.0600 -58.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236019
PNG
(US9365562, 57)
Show SMILES Cc1nc(Cc2cc(F)ccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H24F2N8/c1-15-29-23(35-13-18(14-35)26-32-21-6-4-5-7-22(21)34(26)3)12-25(30-15)36-24(31-16(2)33-36)11-17-10-19(27)8-9-20(17)28/h4-10,12,18H,11,13-14H2,1-3H3
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US Patent
0.0650 -58.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244145
PNG
(US9428492, 15)
Show SMILES Cc1nc([C@H](O)c2ccccc2)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C26H25N7O/c1-15-27-21(18-13-19(18)25-30-20-11-7-8-12-22(20)32(25)3)14-23(28-15)33-26(29-16(2)31-33)24(34)17-9-5-4-6-10-17/h4-12,14,18-19,24,34H,13H2,1-3H3/t18?,19-,24-/m1/s1
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US Patent
0.0900 -57.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244119
PNG
(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8O/c1-11-25-16(8-17(26-11)32-20(27-12(2)29-32)18(33)21(22,23)24)31-9-13(10-31)19-28-14-6-4-5-7-15(14)30(19)3/h4-8,13,18,33H,9-10H2,1-3H3
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US Patent
0.110 -56.8n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236020
PNG
(US9365562, 58)
Show SMILES Cc1nc(Cc2ccc(F)cc2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C26H25FN8/c1-16-28-23(34-14-19(15-34)26-31-21-6-4-5-7-22(21)33(26)3)13-25(29-16)35-24(30-17(2)32-35)12-18-8-10-20(27)11-9-18/h4-11,13,19H,12,14-15H2,1-3H3
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US Patent
0.120 -56.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236035
PNG
(US9365562, 73)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccnn2C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H26N10O/c1-15-26-16(2)34(30-15)22-11-21(28-24(29-22)35-14-18-9-10-25-32(18)4)33-12-17(13-33)23-27-19-7-5-6-8-20(19)31(23)3/h5-11,17H,12-14H2,1-4H3
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0.130 -56.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244137
PNG
(US9428492, 10 | US9428492, 10a | US9428492, 10b)
Show SMILES CC(O)c1nc(C)nn1-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O/c1-13(32)22-24-14(2)28-31(22)20-10-19(26-21(27-20)15-8-9-15)30-11-16(12-30)23-25-17-6-4-5-7-18(17)29(23)3/h4-7,10,13,15-16,32H,8-9,11-12H2,1-3H3
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0.130 -56.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244127
PNG
(US9428492, 6 | US9428492, 6a | US9428492, 6b)
Show SMILES Cc1nc(C(O)C2CC2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O/c1-13-24-19(10-20(25-13)31-23(26-14(2)28-31)21(32)15-8-9-15)30-11-16(12-30)22-27-17-6-4-5-7-18(17)29(22)3/h4-7,10,15-16,21,32H,8-9,11-12H2,1-3H3
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US Patent
0.170 -55.8n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235985
PNG
(US9365562, 23)
Show SMILES CSc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H22N8S/c1-12-21-13(2)28(25-12)18-9-17(23-20(24-18)29-4)27-10-14(11-27)19-22-15-7-5-6-8-16(15)26(19)3/h5-9,14H,10-11H2,1-4H3
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US Patent
0.200 -55.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244137
PNG
(US9428492, 10 | US9428492, 10a | US9428492, 10b)
Show SMILES CC(O)c1nc(C)nn1-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O/c1-13(32)22-24-14(2)28-31(22)20-10-19(26-21(27-20)15-8-9-15)30-11-16(12-30)23-25-17-6-4-5-7-18(17)29(23)3/h4-7,10,13,15-16,32H,8-9,11-12H2,1-3H3
PDB

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US Patent
0.210 -55.2n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244117
PNG
(US9428492, 1 | US9428492, 2)
Show SMILES C[C@@H](O)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H24N8O/c1-12(30)20-24-14(3)26-29(20)19-9-18(22-13(2)23-19)28-10-15(11-28)21-25-16-7-5-6-8-17(16)27(21)4/h5-9,12,15,30H,10-11H2,1-4H3/t12-/m1/s1
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US Patent
0.230 -55.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236018
PNG
(US9365562, 56)
Show SMILES Cc1nc(-c2c(F)cccc2F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H22F2N8/c1-14-28-21(34-12-16(13-34)24-31-19-9-4-5-10-20(19)33(24)3)11-22(29-14)35-25(30-15(2)32-35)23-17(26)7-6-8-18(23)27/h4-11,16H,12-13H2,1-3H3
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0.240 -54.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236039
PNG
(US9365562, 77)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1ccnc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H24N10/c1-14-25-16(3)33(29-14)21-11-20(27-23(28-21)32-10-9-24-15(32)2)31-12-17(13-31)22-26-18-7-5-6-8-19(18)30(22)4/h5-11,17H,12-13H2,1-4H3
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0.260 -54.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236010
PNG
(US9365562, 48)
Show SMILES Cc1nc(CN2CCCC2=O)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C24H27N9O/c1-15-25-20(32-12-17(13-32)24-28-18-7-4-5-8-19(18)30(24)3)11-21(26-15)33-22(27-16(2)29-33)14-31-10-6-9-23(31)34/h4-5,7-8,11,17H,6,9-10,12-14H2,1-3H3
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0.260 -54.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236029
PNG
(US9365562, 67)
Show SMILES CCc1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8/c1-4-16-25-12(2)29-32(16)18-9-17(27-20(28-18)21(22,23)24)31-10-13(11-31)19-26-14-7-5-6-8-15(14)30(19)3/h5-9,13H,4,10-11H2,1-3H3
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US Patent
0.280 -54.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236041
PNG
(US9365562, 79)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C#N)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H19N9/c1-12-22-13(2)29(26-12)19-8-18(24-17(9-21)25-19)28-10-14(11-28)20-23-15-6-4-5-7-16(15)27(20)3/h4-8,14H,10-11H2,1-3H3
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0.280 -54.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236034
PNG
(US9365562, 72)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2nccs2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9OS/c1-14-25-15(2)32(29-14)20-10-19(27-23(28-20)33-13-21-24-8-9-34-21)31-11-16(12-31)22-26-17-6-4-5-7-18(17)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.280 -54.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236040
PNG
(US9365562, 78)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)N1CCCC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H27N9/c1-15-24-16(2)32(28-15)21-12-20(26-23(27-21)30-10-6-7-11-30)31-13-17(14-31)22-25-18-8-4-5-9-19(18)29(22)3/h4-5,8-9,12,17H,6-7,10-11,13-14H2,1-3H3
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0.290 -54.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244142
PNG
(US9428492, 12)
Show SMILES Cc1nc(C(O)CF)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23FN8O/c1-12-23-18(8-19(24-12)30-21(17(31)9-22)25-13(2)27-30)29-10-14(11-29)20-26-15-6-4-5-7-16(15)28(20)3/h4-8,14,17,31H,9-11H2,1-3H3
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0.340 -54.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244124
PNG
(US9428492, 5 | US9428492, 5a | US9428492, 5b)
Show SMILES CC(C)C(O)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H28N8O/c1-13(2)21(32)23-26-15(4)28-31(23)20-10-19(24-14(3)25-20)30-11-16(12-30)22-27-17-8-6-7-9-18(17)29(22)5/h6-10,13,16,21,32H,11-12H2,1-5H3
PDB

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0.340 -54.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236012
PNG
(US9365562, 50)
Show SMILES Cc1nc(-c2ccccc2Cl)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C25H23ClN8/c1-15-27-22(33-13-17(14-33)24-30-20-10-6-7-11-21(20)32(24)3)12-23(28-15)34-25(29-16(2)31-34)18-8-4-5-9-19(18)26/h4-12,17H,13-14H2,1-3H3
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0.350 -54.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244127
PNG
(US9428492, 6 | US9428492, 6a | US9428492, 6b)
Show SMILES Cc1nc(C(O)C2CC2)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O/c1-13-24-19(10-20(25-13)31-23(26-14(2)28-31)21(32)15-8-9-15)30-11-16(12-30)22-27-17-6-4-5-7-18(17)29(22)3/h4-7,10,15-16,21,32H,8-9,11-12H2,1-3H3
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0.360 -53.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244148
PNG
(US9428492, 18)
Show SMILES C[C@H](O)c1nc(C)nn1-c1cc(nc(n1)C1CC1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C23H25N7O/c1-12(31)22-24-13(2)28-30(22)20-11-18(25-21(27-20)14-8-9-14)15-10-16(15)23-26-17-6-4-5-7-19(17)29(23)3/h4-7,11-12,14-16,31H,8-10H2,1-3H3/t12-,15?,16+/m0/s1
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0.360 -53.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236032
PNG
(US9365562, 70)
Show SMILES CC(C)Oc1nc(cc(n1)-n1nc(C)nc1C)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-13(2)31-22-25-19(10-20(26-22)30-15(4)23-14(3)27-30)29-11-16(12-29)21-24-17-8-6-7-9-18(17)28(21)5/h6-10,13,16H,11-12H2,1-5H3
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0.380 -53.8n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244137
PNG
(US9428492, 10 | US9428492, 10a | US9428492, 10b)
Show SMILES CC(O)c1nc(C)nn1-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O/c1-13(32)22-24-14(2)28-31(22)20-10-19(26-21(27-20)15-8-9-15)30-11-16(12-30)23-25-17-6-4-5-7-18(17)29(23)3/h4-7,10,13,15-16,32H,8-9,11-12H2,1-3H3
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0.390 -53.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236033
PNG
(US9365562, 71)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccno2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9O2/c1-14-25-15(2)32(29-14)21-10-20(27-23(28-21)33-13-17-8-9-24-34-17)31-11-16(12-31)22-26-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.400 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236026
PNG
(US9365562, 64)
Show SMILES CCc1nc(C)nn1-c1cc(nc(OC)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H24N8O/c1-5-17-22-13(2)26-29(17)19-10-18(24-21(25-19)30-4)28-11-14(12-28)20-23-15-8-6-7-9-16(15)27(20)3/h6-10,14H,5,11-12H2,1-4H3
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0.400 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244124
PNG
(US9428492, 5 | US9428492, 5a | US9428492, 5b)
Show SMILES CC(C)C(O)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H28N8O/c1-13(2)21(32)23-26-15(4)28-31(23)20-10-19(24-14(3)25-20)30-11-16(12-30)22-27-17-8-6-7-9-18(17)29(22)5/h6-10,13,16,21,32H,11-12H2,1-5H3
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0.410 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244121
PNG
(US9428492, 4 | US9428492, 4a | US9428492, 4b)
Show SMILES CCC(O)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-5-18(31)22-25-14(3)27-30(22)20-10-19(23-13(2)24-20)29-11-15(12-29)21-26-16-8-6-7-9-17(16)28(21)4/h6-10,15,18,31H,5,11-12H2,1-4H3
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0.410 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236000
PNG
(US9365562, 38)
Show SMILES CCCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8/c1-5-8-19-25-15(3)27-30(19)21-11-20(23-14(2)24-21)29-12-16(13-29)22-26-17-9-6-7-10-18(17)28(22)4/h6-7,9-11,16H,5,8,12-13H2,1-4H3
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Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236023
PNG
(US9365562, 61)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H24N8/c1-13-23-14(2)30(27-13)20-10-19(25-21(26-20)15-8-9-15)29-11-16(12-29)22-24-17-6-4-5-7-18(17)28(22)3/h4-7,10,15-16H,8-9,11-12H2,1-3H3
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0.460 -53.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244154
PNG
(US9428492, 21)
Show SMILES CC(C)C(O)c1nc(C)nn1-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C23H27N7O/c1-12(2)21(31)23-26-14(4)28-30(23)20-11-18(24-13(3)25-20)15-10-16(15)22-27-17-8-6-7-9-19(17)29(22)5/h6-9,11-12,15-16,21,31H,10H2,1-5H3/t15?,16-,21?/m1/s1
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0.470 -53.2n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

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Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236036
PNG
(US9365562, 74)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(OCc2ccon2)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H23N9O2/c1-14-24-15(2)32(28-14)21-10-20(26-23(27-21)33-13-17-8-9-34-29-17)31-11-16(12-31)22-25-18-6-4-5-7-19(18)30(22)3/h4-10,16H,11-13H2,1-3H3
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0.490 -53.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244157
PNG
(US9428492, C)
Show SMILES COCc1nc(C)nn1-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23N7O/c1-12-22-17(10-19(23-12)28-20(11-29-4)24-13(2)26-28)14-9-15(14)21-25-16-7-5-6-8-18(16)27(21)3/h5-8,10,14-15H,9,11H2,1-4H3/t14?,15-/m1/s1
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0.490 -53.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236005
PNG
(US9365562, 43)
Show SMILES COC(=O)CCc1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C23H26N8O2/c1-14-24-20(11-21(25-14)31-19(26-15(2)28-31)9-10-22(32)33-4)30-12-16(13-30)23-27-17-7-5-6-8-18(17)29(23)3/h5-8,11,16H,9-10,12-13H2,1-4H3
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0.490 -53.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244121
PNG
(US9428492, 4 | US9428492, 4a | US9428492, 4b)
Show SMILES CCC(O)c1nc(C)nn1-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H26N8O/c1-5-18(31)22-25-14(3)27-30(22)20-10-19(23-13(2)24-20)29-11-15(12-29)21-26-16-8-6-7-9-17(16)28(21)4/h6-10,15,18,31H,5,11-12H2,1-4H3
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0.510 -53.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244133
PNG
(US9428492, 8 | US9428492, 8a | US9428492, 8b)
Show SMILES CC(O)c1nc(C)nn1-c1cc(nc(n1)C(F)(F)F)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H21F3N8O/c1-11(33)18-25-12(2)29-32(18)17-8-16(27-20(28-17)21(22,23)24)31-9-13(10-31)19-26-14-6-4-5-7-15(14)30(19)3/h4-8,11,13,33H,9-10H2,1-3H3
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0.530 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235968
PNG
(US9365562, 6)
Show SMILES Cc1cnn(c1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H23N7/c1-14-10-23-29(11-14)20-9-19(25-21(26-20)15-7-8-15)28-12-16(13-28)22-24-17-5-3-4-6-18(17)27(22)2/h3-6,9-11,15-16H,7-8,12-13H2,1-2H3
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0.530 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235995
PNG
(US9365562, 33)
Show SMILES Cc1cnn(n1)-c1cc(nc(n1)C1CC1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H22N8/c1-13-10-22-29(26-13)19-9-18(24-20(25-19)14-7-8-14)28-11-15(12-28)21-23-16-5-3-4-6-17(16)27(21)2/h3-6,9-10,14-15H,7-8,11-12H2,1-2H3
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0.540 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244149
PNG
(US9428492, 19 | US9428492, 19a)
Show SMILES CCC(O)c1nc(C)nn1-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C22H25N7O/c1-5-19(30)22-25-13(3)27-29(22)20-11-17(23-12(2)24-20)14-10-15(14)21-26-16-8-6-7-9-18(16)28(21)4/h6-9,11,14-15,19,30H,5,10H2,1-4H3/t14?,15-,19?/m1/s1
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0.550 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244151
PNG
(US9428492, 20 | US9428492, 20a | US9428492, 20b)
Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C21H20F3N7O/c1-10-25-15(12-8-13(12)19-28-14-6-4-5-7-16(14)30(19)3)9-17(26-10)31-20(27-11(2)29-31)18(32)21(22,23)24/h4-7,9,12-13,18,32H,8H2,1-3H3/t12?,13-,18?/m1/s1
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0.550 -52.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244151
PNG
(US9428492, 20 | US9428492, 20a | US9428492, 20b)
Show SMILES Cc1nc(C(O)C(F)(F)F)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C21H20F3N7O/c1-10-25-15(12-8-13(12)19-28-14-6-4-5-7-16(14)30(19)3)9-17(26-10)31-20(27-11(2)29-31)18(32)21(22,23)24/h4-7,9,12-13,18,32H,8H2,1-3H3/t12?,13-,18?/m1/s1
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0.580 -52.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244159
PNG
(US9428492, 19b)
Show SMILES CCC(O)c1nc(C)nn1-c1cc(nc(C)n1)[C@@H]1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C22H25N7O/c1-5-19(30)22-25-13(3)27-29(22)20-11-17(23-12(2)24-20)14-10-15(14)21-26-16-8-6-7-9-18(16)28(21)4/h6-9,11,14-15,19,30H,5,10H2,1-4H3/t14-,15-,19?/m1/s1
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0.590 -52.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236038
PNG
(US9365562, 76)
Show SMILES Cc1nc(C)n(n1)-c1cc(nc(n1)-n1cccn1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H22N10/c1-14-24-15(2)32(28-14)20-11-19(26-22(27-20)31-10-6-9-23-31)30-12-16(13-30)21-25-17-7-4-5-8-18(17)29(21)3/h4-11,16H,12-13H2,1-3H3
PDB

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UniChem
US Patent
0.610 -52.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235964
PNG
(US9365562, 2)
Show SMILES Cc1cnn(c1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C20H21N7/c1-13-9-21-27(10-13)19-8-18(22-14(2)23-19)26-11-15(12-26)20-24-16-6-4-5-7-17(16)25(20)3/h4-10,15H,11-12H2,1-3H3
PDB

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UniChem
US Patent
0.610 -52.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244146
PNG
(US9428492, 16)
Show SMILES Cc1nc([C@@H](O)c2ccccc2)n(n1)-c1cc(nc(C)n1)C1C[C@H]1c1nc2ccccc2n1C
Show InChI InChI=1S/C26H25N7O/c1-15-27-21(18-13-19(18)25-30-20-11-7-8-12-22(20)32(25)3)14-23(28-15)33-26(29-16(2)31-33)24(34)17-9-5-4-6-10-17/h4-12,14,18-19,24,34H,13H2,1-3H3/t18?,19-,24+/m1/s1
PDB

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US Patent
0.620 -52.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235970
PNG
(US9365562, 8)
Show SMILES Cc1cn(nc1C)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H23N7/c1-13-10-28(25-14(13)2)20-9-19(22-15(3)23-20)27-11-16(12-27)21-24-17-7-5-6-8-18(17)26(21)4/h5-10,16H,11-12H2,1-4H3
PDB

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UniChem
US Patent
0.630 -52.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM244140
PNG
(US9428492, 11a | US9428492, 11b)
Show SMILES Cc1nc(C(O)C(F)F)n(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C21H22F2N8O/c1-11-24-16(8-17(25-11)31-21(18(32)19(22)23)26-12(2)28-31)30-9-13(10-30)20-27-14-6-4-5-7-15(14)29(20)3/h4-8,13,18-19,32H,9-10H2,1-3H3
PDB

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US Patent
0.650 -52.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9428492 (2016)


BindingDB Entry DOI: 10.7270/Q2HD7TKM
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM235976
PNG
(US9365562, 14)
Show SMILES CC(C)c1ccn(n1)-c1cc(nc(C)n1)N1CC(C1)c1nc2ccccc2n1C
Show InChI InChI=1S/C22H25N7/c1-14(2)17-9-10-29(26-17)21-11-20(23-15(3)24-21)28-12-16(13-28)22-25-18-7-5-6-8-19(18)27(22)4/h5-11,14,16H,12-13H2,1-4H3
PDB

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UniChem
US Patent
0.650 -52.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
Phosphodiesterase 10A (PDE10A2)


(Homo sapiens (Human))
BDBM236037
PNG
(US9365562, 75)
Show SMILES Cc1noc(COc2nc(cc(n2)-n2nc(C)nc2C)N2CC(C2)c2nc3ccccc3n2C)n1
Show InChI InChI=1S/C23H24N10O2/c1-13-24-15(3)33(29-13)20-9-19(27-23(28-20)34-12-21-25-14(2)30-35-21)32-10-16(11-32)22-26-17-7-5-6-8-18(17)31(22)4/h5-9,16H,10-12H2,1-4H3
PDB

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UniChem
US Patent
0.700 -52.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...


US Patent US9365562 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NQZ
More data for this
Ligand-Target Pair
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