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Compile Data Set for Download or QSAR

Found 2578 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 5A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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Article
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n/an/a 3.5n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14392
PNG
(3-ethyl-5-{5-[(4-ethylpiperazine-1-)sulfonyl]-2-(2...)
Show SMILES CCN1CCN(CC1)S(=O)(=O)c1cnc(OCCOC)c(c1)-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1
Show InChI InChI=1S/C27H34N8O5S/c1-4-22-23-24(32-35(22)18-19-8-6-7-9-28-19)26(36)31-25(30-23)21-16-20(17-29-27(21)40-15-14-39-3)41(37,38)34-12-10-33(5-2)11-13-34/h6-9,16-17H,4-5,10-15,18H2,1-3H3,(H,30,31,36)
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n/an/a 1.30n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14393
PNG
(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(1-eth...)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)=O
Show InChI InChI=1S/C23H30N6O3/c1-5-8-9-32-23-17(10-15(11-24-23)14(4)30)21-25-19-18(6-2)29(16-12-28(7-3)13-16)27-20(19)22(31)26-21/h10-11,16H,5-9,12-13H2,1-4H3,(H,25,26,31)
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n/an/a 5.5n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14394
PNG
(5-(2-butoxy-5-acetylpyridin-3-yl)-3-ethyl-2-(pyrid...)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(Cc3ccccn3)nc2c(=O)[nH]1)C(C)=O
Show InChI InChI=1S/C24H26N6O3/c1-4-6-11-33-24-18(12-16(13-26-24)15(3)31)22-27-20-19(5-2)30(29-21(20)23(32)28-22)14-17-9-7-8-10-25-17/h7-10,12-13H,4-6,11,14H2,1-3H3,(H,27,28,32)
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n/an/a 3.10n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14400
PNG
(5-(5-acetyl-2-propoxypyridin-3-yl)-3-ethyl-2-(1-me...)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(C)C1)C(C)=O
Show InChI InChI=1S/C21H26N6O3/c1-5-7-30-21-15(8-13(9-22-21)12(3)28)19-23-17-16(6-2)27(14-10-26(4)11-14)25-18(17)20(29)24-19/h8-9,14H,5-7,10-11H2,1-4H3,(H,23,24,29)
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n/an/a 9.5n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14396
PNG
(5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1
Show InChI InChI=1S/C23H29N5O4/c1-4-6-17-20-21(27(3)26-17)23(30)25-22(24-20)16-13-15(7-8-19(16)32-5-2)18(29)14-28-9-11-31-12-10-28/h7-8,13H,4-6,9-12,14H2,1-3H3,(H,24,25,30)
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n/an/a 1.70n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14397
PNG
(5-(5-acetyl-2-ethoxyphenyl)-1-methyl-3-propyl-1H,6...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(C)=O
Show InChI InChI=1S/C19H22N4O3/c1-5-7-14-16-17(23(4)22-14)19(25)21-18(20-16)13-10-12(11(3)24)8-9-15(13)26-6-2/h8-10H,5-7H2,1-4H3,(H,20,21,25)
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n/an/a 17n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14398
PNG
(5-(5-Acetyl-2-propoxy-3-pyridinyl)-3-ethyl-2-[(1-m...)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(Cc3nccn3C)nc2c(=O)[nH]1)C(C)=O
Show InChI InChI=1S/C22H25N7O3/c1-5-9-32-22-15(10-14(11-24-22)13(3)30)20-25-18-16(6-2)29(27-19(18)21(31)26-20)12-17-23-7-8-28(17)4/h7-8,10-11H,5-6,9,12H2,1-4H3,(H,25,26,31)
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n/an/a 2.70n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14399
PNG
(2-(azetidin-3-yl)-5-(5-acetyl-2-propoxypyridin-3-y...)
Show SMILES CCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CNC1)C(C)=O
Show InChI InChI=1S/C20H24N6O3/c1-4-6-29-20-14(7-12(8-22-20)11(3)27)18-23-16-15(5-2)26(13-9-21-10-13)25-17(16)19(28)24-18/h7-8,13,21H,4-6,9-10H2,1-3H3,(H,23,24,28)
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n/an/a 34n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM14395
PNG
(5-[2-Butoxy-5-(1-hydroxyethyl)-3-pyridinyl]-3-ethy...)
Show SMILES CCCCOc1ncc(cc1-c1nc2c(CC)n(nc2c(=O)[nH]1)C1CN(CC)C1)C(C)O
Show InChI InChI=1S/C23H32N6O3/c1-5-8-9-32-23-17(10-15(11-24-23)14(4)30)21-25-19-18(6-2)29(16-12-28(7-3)13-16)27-20(19)22(31)26-21/h10-11,14,16,30H,5-9,12-13H2,1-4H3,(H,25,26,31)
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n/an/a 825n/an/an/an/a7.430



Pfizer



Assay Description
PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-...


J Med Chem 49: 3581-94 (2006)


Article DOI: 10.1021/jm060113e
BindingDB Entry DOI: 10.7270/Q2C24TP4
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258375
PNG
(US9505786, 13)
Show SMILES CCOCCC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C23H21F2N7O2/c1-3-34-9-8-23(2)18-20(28-22(23)33)27-19(30-29-18)17-15-10-14(24)11-26-21(15)32(31-17)12-13-6-4-5-7-16(13)25/h4-7,10-11H,3,8-9,12H2,1-2H3,(H,27,28,30,33)
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n/an/a 660n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258376
PNG
(US9505786, 14)
Show SMILES CCOc1ccc(cn1)-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C28H24FN7O2/c1-4-38-20-12-11-16(14-31-20)22-21-24(34-27(37)28(21,2)3)33-25(32-22)23-18-9-7-13-30-26(18)36(35-23)15-17-8-5-6-10-19(17)29/h5-14H,4,15H2,1-3H3,(H,32,33,34,37)
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n/an/a 2.00E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258377
PNG
(US9505786, 15)
Show SMILES CC1(C)C(=O)Nc2nc(nc(-c3ccn[nH]3)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C24H19FN8O/c1-24(2)17-19(16-9-11-27-31-16)28-21(29-20(17)30-23(24)34)18-14-7-5-10-26-22(14)33(32-18)12-13-6-3-4-8-15(13)25/h3-11H,12H2,1-2H3,(H,27,31)(H,28,29,30,34)
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n/an/a 40n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258378
PNG
(US9505786, 16)
Show SMILES CC1(C)C(=O)Nc2nc(nc(C#CC3CC3)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H21FN6O/c1-26(2)20-19(12-11-15-9-10-15)29-23(30-22(20)31-25(26)34)21-17-7-5-13-28-24(17)33(32-21)14-16-6-3-4-8-18(16)27/h3-8,13,15H,9-10,14H2,1-2H3,(H,29,30,31,34)
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n/an/a 410n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258379
PNG
(US9505786, 17)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CCC3CC3)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H25FN6O/c1-26(2)20-19(12-11-15-9-10-15)29-23(30-22(20)31-25(26)34)21-17-7-5-13-28-24(17)33(32-21)14-16-6-3-4-8-18(16)27/h3-8,13,15H,9-12,14H2,1-2H3,(H,29,30,31,34)
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n/an/a 260n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258380
PNG
(US9505786, 18)
Show SMILES CC1(C)C(=O)Nc2nc(nc(\C=C/C3CC3)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H23FN6O/c1-26(2)20-19(12-11-15-9-10-15)29-23(30-22(20)31-25(26)34)21-17-7-5-13-28-24(17)33(32-21)14-16-6-3-4-8-18(16)27/h3-8,11-13,15H,9-10,14H2,1-2H3,(H,29,30,31,34)/b12-11-
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n/an/a 150n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258381
PNG
(US9505786, 19)
Show SMILES CC1(C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2nc(ccc12)C(F)(F)F
Show InChI InChI=1S/C21H15F4N7O/c1-20(2)15-17(28-19(20)33)27-16(30-29-15)14-11-7-8-13(21(23,24)25)26-18(11)32(31-14)9-10-5-3-4-6-12(10)22/h3-8H,9H2,1-2H3,(H,27,28,30,33)
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n/an/a 38n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258382
PNG
(US9505786, 20)
Show SMILES Cc1nc2n(Cc3ccccc3F)nc(-c3ncc4c(NC(=O)C4(C)C)n3)c2cc1F
Show InChI InChI=1S/C22H18F2N6O/c1-11-16(24)8-13-17(19-25-9-14-18(27-19)28-21(31)22(14,2)3)29-30(20(13)26-11)10-12-6-4-5-7-15(12)23/h4-9H,10H2,1-3H3,(H,25,27,28,31)
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n/an/a 920n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258383
PNG
(US9505786, 21)
Show SMILES Cc1nc2n(Cc3ccccc3F)nc(-c3nnc4c(NC(=O)C4(C)C)n3)c2cc1F
Show InChI InChI=1S/C21H17F2N7O/c1-10-14(23)8-12-15(17-25-18-16(27-28-17)21(2,3)20(31)26-18)29-30(19(12)24-10)9-11-6-4-5-7-13(11)22/h4-8H,9H2,1-3H3,(H,25,26,28,31)
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n/an/a 22n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258384
PNG
(US9505786, 22)
Show SMILES Cc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C22H19FN6O/c1-12-16-18(27-21(30)22(16,2)3)26-19(25-12)17-14-8-6-10-24-20(14)29(28-17)11-13-7-4-5-9-15(13)23/h4-10H,11H2,1-3H3,(H,25,26,27,30)
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n/an/a 130n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258385
PNG
(US9505786, 23)
Show SMILES CC1(CCC=C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C23H20FN7O/c1-3-4-11-23(2)18-20(27-22(23)32)26-19(29-28-18)17-15-9-7-12-25-21(15)31(30-17)13-14-8-5-6-10-16(14)24/h3,5-10,12H,1,4,11,13H2,2H3,(H,26,27,29,32)
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n/an/a 140n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258386
PNG
(US9505786, 24)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CNS(C)(=O)=O)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C23H22FN7O3S/c1-23(2)17-16(11-26-35(3,33)34)27-20(28-19(17)29-22(23)32)18-14-8-6-10-25-21(14)31(30-18)12-13-7-4-5-9-15(13)24/h4-10,26H,11-12H2,1-3H3,(H,27,28,29,32)
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n/an/a 48n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258387
PNG
(US9505786, 25)
Show SMILES CCOC(=O)C1C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C21H16FN7O3/c1-2-32-21(31)14-16-17(25-20(14)30)24-18(27-26-16)15-12-7-5-9-23-19(12)29(28-15)10-11-6-3-4-8-13(11)22/h3-9,14H,2,10H2,1H3,(H,24,25,27,30)
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n/an/a 1.50E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258388
PNG
(US9505786, 26)
Show SMILES CC1(CC(O)=O)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C21H16FN7O3/c1-21(9-14(30)31)16-18(25-20(21)32)24-17(27-26-16)15-12-6-4-8-23-19(12)29(28-15)10-11-5-2-3-7-13(11)22/h2-8H,9-10H2,1H3,(H,30,31)(H,24,25,27,32)
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n/an/a 3.40E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258389
PNG
(US9505786, 27)
Show SMILES CCOC(=O)\C=C\c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H23FN6O3/c1-4-36-19(34)12-11-18-20-22(31-25(35)26(20,2)3)30-23(29-18)21-16-9-7-13-28-24(16)33(32-21)14-15-8-5-6-10-17(15)27/h5-13H,4,14H2,1-3H3,(H,29,30,31,35)/b12-11+
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n/an/a 215n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258390
PNG
(US9505786, 28)
Show SMILES CC1(CC=C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C22H18FN7O/c1-3-10-22(2)17-19(26-21(22)31)25-18(28-27-17)16-14-8-6-11-24-20(14)30(29-16)12-13-7-4-5-9-15(13)23/h3-9,11H,1,10,12H2,2H3,(H,25,26,28,31)
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n/an/a 310n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258391
PNG
(US9505786, 29)
Show SMILES CC(C)Cc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H25FN6O/c1-14(2)12-18-19-21(30-24(33)25(19,3)4)29-22(28-18)20-16-9-7-11-27-23(16)32(31-20)13-15-8-5-6-10-17(15)26/h5-11,14H,12-13H2,1-4H3,(H,28,29,30,33)
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n/an/a 420n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258392
PNG
(US9505786, 30)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CCCC(F)(F)F)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H22F4N6O/c1-24(2)18-17(10-5-11-25(27,28)29)31-21(32-20(18)33-23(24)36)19-15-8-6-12-30-22(15)35(34-19)13-14-7-3-4-9-16(14)26/h3-4,6-9,12H,5,10-11,13H2,1-2H3,(H,31,32,33,36)
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n/an/a 130n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258393
PNG
(US9505786, 31)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CCC(F)(F)F)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C24H20F4N6O/c1-23(2)17-16(9-10-24(26,27)28)30-20(31-19(17)32-22(23)35)18-14-7-5-11-29-21(14)34(33-18)12-13-6-3-4-8-15(13)25/h3-8,11H,9-10,12H2,1-2H3,(H,30,31,32,35)
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n/an/a 260n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258394
PNG
(US9505786, 32)
Show SMILES CCCc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C24H23FN6O/c1-4-8-17-18-20(29-23(32)24(18,2)3)28-21(27-17)19-15-10-7-12-26-22(15)31(30-19)13-14-9-5-6-11-16(14)25/h5-7,9-12H,4,8,13H2,1-3H3,(H,27,28,29,32)
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n/an/a 110n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258395
PNG
(US9505786, 33)
Show SMILES CCOC(=O)C1(C)C(=O)Nc2nc(ncc12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C23H19FN6O3/c1-3-33-22(32)23(2)15-11-26-19(27-18(15)28-21(23)31)17-14-8-6-10-25-20(14)30(29-17)12-13-7-4-5-9-16(13)24/h4-11H,3,12H2,1-2H3,(H,26,27,28,31)
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n/an/a 870n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258396
PNG
(US9505786, 34)
Show SMILES CC1(C(=O)Nc2nc(ncc12)-c1nn(Cc2ccccc2F)c2ncccc12)c1nncs1
Show InChI InChI=1S/C22H15FN8OS/c1-22(21-29-26-11-33-21)14-9-25-18(27-17(14)28-20(22)32)16-13-6-4-8-24-19(13)31(30-16)10-12-5-2-3-7-15(12)23/h2-9,11H,10H2,1H3,(H,25,27,28,32)
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n/an/a 1.20E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258397
PNG
(US9505786, 35)
Show SMILES Cc1ncc(s1)-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H20FN7OS/c1-13-28-11-17(35-13)20-18-21(31-24(34)25(18,2)3)30-22(29-20)19-15-8-6-10-27-23(15)33(32-19)12-14-7-4-5-9-16(14)26/h4-11H,12H2,1-3H3,(H,29,30,31,34)
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n/an/a 120n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258398
PNG
(US9505786, 36)
Show SMILES Cc1nc(C)c(s1)-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H22FN7OS/c1-13-21(36-14(2)29-13)20-18-22(32-25(35)26(18,3)4)31-23(30-20)19-16-9-7-11-28-24(16)34(33-19)12-15-8-5-6-10-17(15)27/h5-11H,12H2,1-4H3,(H,30,31,32,35)
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n/an/a 1.10E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258399
PNG
(US9505786, 37)
Show SMILES CC(C)c1nc(C)c(s1)-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C28H26FN7OS/c1-14(2)26-31-15(3)22(38-26)21-19-23(34-27(37)28(19,4)5)33-24(32-21)20-17-10-8-12-30-25(17)36(35-20)13-16-9-6-7-11-18(16)29/h6-12,14H,13H2,1-5H3,(H,32,33,34,37)
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n/an/a 500n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258400
PNG
(US9505786, 38)
Show SMILES Cc1cc(-c2nc(nc3NC(=O)C(C)(C)c23)-c2nn(Cc3ccccc3F)c3ncccc23)n(C)n1
Show InChI InChI=1S/C26H23FN8O/c1-14-12-18(34(4)32-14)21-19-22(31-25(36)26(19,2)3)30-23(29-21)20-16-9-7-11-28-24(16)35(33-20)13-15-8-5-6-10-17(15)27/h5-12H,13H2,1-4H3,(H,29,30,31,36)
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n/an/a 690n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258401
PNG
(US9505786, 39)
Show SMILES CC(C)n1ccc(n1)-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C27H25FN8O/c1-15(2)35-13-11-19(33-35)22-20-23(32-26(37)27(20,3)4)31-24(30-22)21-17-9-7-12-29-25(17)36(34-21)14-16-8-5-6-10-18(16)28/h5-13,15H,14H2,1-4H3,(H,30,31,32,37)
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n/an/a 240n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258402
PNG
(US9505786, 40)
Show SMILES Cn1nccc1-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H21FN8O/c1-25(2)18-20(17-10-12-28-33(17)3)29-22(30-21(18)31-24(25)35)19-15-8-6-11-27-23(15)34(32-19)13-14-7-4-5-9-16(14)26/h4-12H,13H2,1-3H3,(H,29,30,31,35)
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n/an/a 250n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258403
PNG
(US9505786, 41)
Show SMILES Cn1nc(cc1-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C(F)(F)F
Show InChI InChI=1S/C26H20F4N8O/c1-25(2)18-20(16-11-17(26(28,29)30)35-37(16)3)32-22(33-21(18)34-24(25)39)19-14-8-6-10-31-23(14)38(36-19)12-13-7-4-5-9-15(13)27/h4-11H,12H2,1-3H3,(H,32,33,34,39)
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n/an/a 1.60E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258404
PNG
(US9505786, 42)
Show SMILES Cn1c(ccc1-c1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12)C#N
Show InChI InChI=1S/C27H21FN8O/c1-27(2)20-22(19-11-10-16(13-29)35(19)3)31-24(32-23(20)33-26(27)37)21-17-8-6-12-30-25(17)36(34-21)14-15-7-4-5-9-18(15)28/h4-12H,14H2,1-3H3,(H,31,32,33,37)
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n/an/a 1.30E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258405
PNG
(US9505786, 43)
Show SMILES CCOC(=O)C1(C)C(=O)Nc2nc(nc(I)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C23H18FIN6O3/c1-3-34-22(33)23(2)15-17(25)27-19(28-18(15)29-21(23)32)16-13-8-6-10-26-20(13)31(30-16)11-12-7-4-5-9-14(12)24/h4-10H,3,11H2,1-2H3,(H,27,28,29,32)
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n/an/a 1.75E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258406
PNG
(US9505786, 44)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CN)c12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C22H19F2N7O/c1-22(2)16-15(8-25)27-19(28-18(16)29-21(22)32)17-13-7-12(23)9-26-20(13)31(30-17)10-11-5-3-4-6-14(11)24/h3-7,9H,8,10,25H2,1-2H3,(H,27,28,29,32)
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n/an/a 870n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258407
PNG
(US9505786, 46)
Show SMILES COCCCc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C25H25FN6O2/c1-25(2)19-18(11-7-13-34-3)28-22(29-21(19)30-24(25)33)20-16-9-6-12-27-23(16)32(31-20)14-15-8-4-5-10-17(15)26/h4-6,8-10,12H,7,11,13-14H2,1-3H3,(H,28,29,30,33)
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n/an/a 120n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258408
PNG
(US9505786, 49)
Show SMILES CC1(C(=O)NC2CC2)C(=O)Nc2nc(ncc12)-c1nn(CCC(F)(F)F)c2ncccc12
Show InChI InChI=1S/C20H18F3N7O2/c1-19(17(31)26-10-4-5-10)12-9-25-15(27-14(12)28-18(19)32)13-11-3-2-7-24-16(11)30(29-13)8-6-20(21,22)23/h2-3,7,9-10H,4-6,8H2,1H3,(H,26,31)(H,25,27,28,32)
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n/an/a 4.00E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258409
PNG
(US9505786, 51)
Show SMILES CC1(CC=C)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C22H17F2N7O/c1-3-8-22(2)17-19(27-21(22)32)26-18(29-28-17)16-14-9-13(23)10-25-20(14)31(30-16)11-12-6-4-5-7-15(12)24/h3-7,9-10H,1,8,11H2,2H3,(H,26,27,29,32)
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n/an/a 140n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258410
PNG
(US9505786, 52)
Show SMILES CC1(CC(O)=O)C(=O)Nc2nc(nnc12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C21H15F2N7O3/c1-21(7-14(31)32)16-18(26-20(21)33)25-17(28-27-16)15-12-6-11(22)8-24-19(12)30(29-15)9-10-4-2-3-5-13(10)23/h2-6,8H,7,9H2,1H3,(H,31,32)(H,25,26,28,33)
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n/an/a 3.90E+3n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258411
PNG
(US9505786, 53)
Show SMILES CCOC(=O)C#Cc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C26H21FN6O3/c1-4-36-19(34)12-11-18-20-22(31-25(35)26(20,2)3)30-23(29-18)21-16-9-7-13-28-24(16)33(32-21)14-15-8-5-6-10-17(15)27/h5-10,13H,4,14H2,1-3H3,(H,29,30,31,35)
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n/an/a 41n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258412
PNG
(US9505786, 54)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CN3CCCC3=O)c12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C26H23F2N7O2/c1-26(2)20-18(13-34-9-5-8-19(34)36)30-23(31-22(20)32-25(26)37)21-16-10-15(27)11-29-24(16)35(33-21)12-14-6-3-4-7-17(14)28/h3-4,6-7,10-11H,5,8-9,12-13H2,1-2H3,(H,30,31,32,37)
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n/an/a 145n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258413
PNG
(US9505786, 55)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CNS(=O)(=O)C3CC3)c12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C25H23F2N7O3S/c1-25(2)19-18(11-29-38(36,37)15-7-8-15)30-22(31-21(19)32-24(25)35)20-16-9-14(26)10-28-23(16)34(33-20)12-13-5-3-4-6-17(13)27/h3-6,9-10,15,29H,7-8,11-12H2,1-2H3,(H,30,31,32,35)
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n/an/a 190n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (human))
BDBM258414
PNG
(US9505786, 56)
Show SMILES CC1(C)C(=O)Nc2nc(nc(CNC(=O)C3CC3)c12)-c1nn(Cc2ccccc2F)c2ncc(F)cc12
Show InChI InChI=1S/C26H23F2N7O2/c1-26(2)19-18(11-30-24(36)13-7-8-13)31-22(32-21(19)33-25(26)37)20-16-9-15(27)10-29-23(16)35(34-20)12-14-5-3-4-6-17(14)28/h3-6,9-10,13H,7-8,11-12H2,1-2H3,(H,30,36)(H,31,32,33,37)
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n/an/a 570n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair
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