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Compile Data Set for Download or QSAR

Found 219 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235735
PNG
(US9359371, 3)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C25H26ClN5O2/c1-33-22-8-7-17(9-21(22)26)12-27-23-20(24(32)28-11-16-5-3-2-4-6-16)13-29-25(30-23)31-14-18-10-19(18)15-31/h2-9,13,18-19H,10-12,14-15H2,1H3,(H,28,32)(H,27,29,30)
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n/an/a 8.89n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235742
PNG
(US9359371, 11)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1Cl
Show InChI InChI=1S/C24H30ClN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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n/an/a 61n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235755
PNG
(US9359371, 38)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C25H32ClN5O3/c1-34-21-7-2-16(12-20(21)26)13-27-22-19(23(33)29-17-3-5-18(32)6-4-17)14-28-24(30-22)31-11-10-25(15-31)8-9-25/h2,7,12,14,17-18,32H,3-6,8-11,13,15H2,1H3,(H,29,33)(H,27,28,30)/t17-,18-
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n/an/a 58n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235762
PNG
(US9359371, 46)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
Show InChI InChI=1S/C26H36ClN7O2/c1-32-11-13-33(14-12-32)10-8-28-24(35)20-17-30-25(34-9-7-26(18-34)5-6-26)31-23(20)29-16-19-3-4-22(36-2)21(27)15-19/h3-4,15,17H,5-14,16,18H2,1-2H3,(H,28,35)(H,29,30,31)
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n/an/a 310n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235764
PNG
(US9359371, 48)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1F
Show InChI InChI=1S/C24H30FN5O3/c1-33-21-7-2-14(8-20(21)25)10-26-22-19(23(32)28-17-3-5-18(31)6-4-17)11-27-24(29-22)30-12-15-9-16(15)13-30/h2,7-8,11,15-18,31H,3-6,9-10,12-13H2,1H3,(H,28,32)(H,26,27,29)/t15?,16?,17-,18-
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n/an/a 1.11E+3n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM253042
PNG
(US9493447, 1001)
Show SMILES CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1
Show InChI InChI=1S/C25H23ClN2O5S/c1-5-32-24(15-6-8-16(9-7-15)25-28-27-14(2)34-25)23(29)19-11-10-18(33-19)17-12-20(30-3)22(26)21(13-17)31-4/h6-13,24H,5H2,1-4H3
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n/an/a>3.00E+3n/an/an/an/a7.530



Omeros Corporation

US Patent


Assay Description
The PDE assay medium consisted of (final concentrations); 50 mM Tris-HCL, pH 7.5; 8.3 mM MgCl2; 1.7 mM EGTA; 0.5 mg/mL bovine serum albumin; and subs...


US Patent US9493447 (2016)


BindingDB Entry DOI: 10.7270/Q2SB44PB
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus (Bovine))
BDBM235765
PNG
(US9359371, 50)
Show SMILES COc1ccc(CNc2nc(ncc2C(=O)N[C@H]2CC[C@H](O)CC2)N2CC3CC3C2)cc1C
Show InChI InChI=1S/C25H33N5O3/c1-15-9-16(3-8-22(15)33-2)11-26-23-21(24(32)28-19-4-6-20(31)7-5-19)12-27-25(29-23)30-13-17-10-18(17)14-30/h3,8-9,12,17-20,31H,4-7,10-11,13-14H2,1-2H3,(H,28,32)(H,26,27,29)/t17?,18?,19-,20-
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n/an/a 660n/an/an/an/a7.5n/a



XUANZHU PHARMA CO., LTD.

US Patent


Assay Description
Method: The test compound or solvent was incubated at 25 C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...


US Patent US9359371 (2016)


BindingDB Entry DOI: 10.7270/Q2BR8R2B
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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50n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 6


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM23620
PNG
(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)
Show SMILES OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO
Show InChI InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
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125n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 6


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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400n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 6


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86639
PNG
(BC11-15 | US9173884, BC11-15)
Show SMILES CCN(CC)C(=O)c1cc(nc2n(nc(C)c12)-c1ccccc1C)-c1cccs1
Show InChI InChI=1S/C23H24N4OS/c1-5-26(6-2)23(28)17-14-18(20-12-9-13-29-20)24-22-21(17)16(4)25-27(22)19-11-8-7-10-15(19)3/h7-14H,5-6H2,1-4H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM60808
PNG
(BDBM86640 | US9173884, BC11-19)
Show SMILES O=c1nc2sc3ccccc3n2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C15H9N3O2S/c19-13-16-14-18(11-8-4-5-9-12(11)21-14)15(20)17(13)10-6-2-1-3-7-10/h1-9H
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Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM60812
PNG
(BDBM86641 | US9173884, BC11-28)
Show SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29)
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Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86642
PNG
(BC11-38 | US9173884, BC11-38)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
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Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86643
PNG
(BC11-38-1 | US9173884, BC11-38-1)
Show SMILES CCCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C16H18N2OS2/c1-2-3-10-21-16-17-13-9-11-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8H,2-3,9-11H2,1H3
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Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86644
PNG
(BC11-38-2 | US9173884, BC11-38-2)
Show SMILES CCC(C)Sc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C16H18N2OS2/c1-3-11(2)21-16-17-13-9-10-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8,11H,3,9-10H2,1-2H3
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n/an/a 5.12E+4n/an/an/an/an/an/a



Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86645
PNG
(BC11-38-3 | US9173884, BC11-38-3)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccc(C)cc1
Show InChI InChI=1S/C16H18N2OS2/c1-3-9-21-16-17-13-8-10-20-14(13)15(19)18(16)12-6-4-11(2)5-7-12/h4-7H,3,8-10H2,1-2H3
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Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86646
PNG
(BC11-38-4 | US9173884, BC11-38-4)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccccc1OC
Show InChI InChI=1S/C16H18N2O2S2/c1-3-9-22-16-17-11-8-10-21-14(11)15(19)18(16)12-6-4-5-7-13(12)20-2/h4-7H,3,8-10H2,1-2H3
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Boston College



Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipiation method using recombinant human PDE1C, PDE3B, PDE5A1, PDE6C, PDE8A, PDE9A2, PDE10A1...


Chem Biol 19: 155-63 (2012)


Article DOI: 10.1016/j.chembiol.2011.12.010
BindingDB Entry DOI: 10.7270/Q2FB51JK
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86642
PNG
(BC11-38 | US9173884, BC11-38)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C15H16N2OS2/c1-2-9-20-15-16-12-8-10-19-13(12)14(18)17(15)11-6-4-3-5-7-11/h3-7H,2,8-10H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM60812
PNG
(BDBM86641 | US9173884, BC11-28)
Show SMILES Cc1ccccc1Nc1ncnc2n(cc(-c3ccccc3)c12)-c1ccc(F)cc1
Show InChI InChI=1S/C25H19FN4/c1-17-7-5-6-10-22(17)29-24-23-21(18-8-3-2-4-9-18)15-30(25(23)28-16-27-24)20-13-11-19(26)12-14-20/h2-16H,1H3,(H,27,28,29)
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Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM60808
PNG
(BDBM86640 | US9173884, BC11-19)
Show SMILES O=c1nc2sc3ccccc3n2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C15H9N3O2S/c19-13-16-14-18(11-8-4-5-9-12(11)21-14)15(20)17(13)10-6-2-1-3-7-10/h1-9H
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n/an/a>1.00E+5n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86639
PNG
(BC11-15 | US9173884, BC11-15)
Show SMILES CCN(CC)C(=O)c1cc(nc2n(nc(C)c12)-c1ccccc1C)-c1cccs1
Show InChI InChI=1S/C23H24N4OS/c1-5-26(6-2)23(28)17-14-18(20-12-9-13-29-20)24-22-21(17)16(4)25-27(22)19-11-8-7-10-15(19)3/h7-14H,5-6H2,1-4H3
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US Patent
n/an/a 2.50E+4n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86643
PNG
(BC11-38-1 | US9173884, BC11-38-1)
Show SMILES CCCCSc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C16H18N2OS2/c1-2-3-10-21-16-17-13-9-11-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8H,2-3,9-11H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86644
PNG
(BC11-38-2 | US9173884, BC11-38-2)
Show SMILES CCC(C)Sc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C16H18N2OS2/c1-3-11(2)21-16-17-13-9-10-20-14(13)15(19)18(16)12-7-5-4-6-8-12/h4-8,11H,3,9-10H2,1-2H3
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n/an/a 5.12E+4n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86645
PNG
(BC11-38-3 | US9173884, BC11-38-3)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccc(C)cc1
Show InChI InChI=1S/C16H18N2OS2/c1-3-9-21-16-17-13-8-10-20-14(13)15(19)18(16)12-6-4-11(2)5-7-12/h4-7H,3,8-10H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6C (PDE6C)


(Homo sapiens (Human))
BDBM86646
PNG
(BC11-38-4 | US9173884, BC11-38-4)
Show SMILES CCCSc1nc2CCSc2c(=O)n1-c1ccccc1OC
Show InChI InChI=1S/C16H18N2O2S2/c1-3-9-22-16-17-11-8-10-21-14(11)15(19)18(16)12-6-4-5-7-13(12)20-2/h4-7H,3,8-10H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Trustees of Boston College

US Patent


Assay Description
In vitro enzyme assays were conducted via the Ba(OH)2 precipitation method of Wang et al. (32) using recombinant human PDE11A4, PDE10A1, PDE5A1, PDE6...


US Patent US9173884 (2015)


BindingDB Entry DOI: 10.7270/Q2PK0DZ6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126456
PNG
((6R,12aR)-2-[(R)-1-(3-Azetidin-1-yl-3-oxo-propyl)-...)
Show SMILES O=C(CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O)N1CCC1
Show InChI InChI=1S/C31H33N5O5/c37-27(34-10-3-11-34)9-13-33-12-8-20(16-33)35-17-28(38)36-24(31(35)39)15-22-21-4-1-2-5-23(21)32-29(22)30(36)19-6-7-25-26(14-19)41-18-40-25/h1-2,4-7,14,20,24,30,32H,3,8-13,15-18H2/t20-,24-,30-/m1/s1
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n/an/a 846n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126453
PNG
(3-[(R)-3-((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-1,4-di...)
Show SMILES CCNC(=O)CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H33N5O5/c1-2-31-26(36)10-12-33-11-9-19(15-33)34-16-27(37)35-23(30(34)38)14-21-20-5-3-4-6-22(20)32-28(21)29(35)18-7-8-24-25(13-18)40-17-39-24/h3-8,13,19,23,29,32H,2,9-12,14-17H2,1H3,(H,31,36)/t19-,23-,29-/m1/s1
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n/an/a 620n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126458
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-benzyl-...)
Show SMILES O=C1CN([C@@H]2CCN(Cc3ccccc3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H30N4O4/c37-29-18-35(22-12-13-34(17-22)16-20-6-2-1-3-7-20)32(38)26-15-24-23-8-4-5-9-25(23)33-30(24)31(36(26)29)21-10-11-27-28(14-21)40-19-39-27/h1-11,14,22,26,31,33H,12-13,15-19H2/t22-,26-,31-/m1/s1
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n/an/a 249n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126470
PNG
(3-[(R)-3-((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-1,4-di...)
Show SMILES NC(=O)CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C28H29N5O5/c29-24(34)8-10-31-9-7-17(13-31)32-14-25(35)33-21(28(32)36)12-19-18-3-1-2-4-20(18)30-26(19)27(33)16-5-6-22-23(11-16)38-15-37-22/h1-6,11,17,21,27,30H,7-10,12-15H2,(H2,29,34)/t17-,21-,27-/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126473
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-(1-benzyl-pipe...)
Show SMILES O=C1CN(C2CCN(Cc3ccccc3)CC2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C33H32N4O4/c38-30-19-36(23-12-14-35(15-13-23)18-21-6-2-1-3-7-21)33(39)27-17-25-24-8-4-5-9-26(24)34-31(25)32(37(27)30)22-10-11-28-29(16-22)41-20-40-28/h1-11,16,23,27,32,34H,12-15,17-20H2/t27-,32-/m1/s1
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n/an/a 1.62E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126460
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-(2-dimethylami...)
Show SMILES CN(C)CCN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C25H26N4O4/c1-27(2)9-10-28-13-22(30)29-19(25(28)31)12-17-16-5-3-4-6-18(16)26-23(17)24(29)15-7-8-20-21(11-15)33-14-32-20/h3-8,11,19,24,26H,9-10,12-14H2,1-2H3/t19-,24-/m1/s1
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n/an/a 8.22E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126457
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(3-meth...)
Show SMILES COCCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C29H32N4O5/c1-36-12-4-10-31-11-9-19(15-31)32-16-26(34)33-23(29(32)35)14-21-20-5-2-3-6-22(20)30-27(21)28(33)18-7-8-24-25(13-18)38-17-37-24/h2-3,5-8,13,19,23,28,30H,4,9-12,14-17H2,1H3/t19-,23-,28-/m1/s1
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n/an/a 1.34E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126465
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-(2-morpholin-4...)
Show SMILES O=C1CN(CCN2CCOCC2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C27H28N4O5/c32-24-15-30(8-7-29-9-11-34-12-10-29)27(33)21-14-19-18-3-1-2-4-20(18)28-25(19)26(31(21)24)17-5-6-22-23(13-17)36-16-35-22/h1-6,13,21,26,28H,7-12,14-16H2/t21-,26-/m1/s1
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n/an/a 2.97E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 1.26E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126469
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-propyl-...)
Show SMILES CCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C28H30N4O4/c1-2-10-30-11-9-18(14-30)31-15-25(33)32-22(28(31)34)13-20-19-5-3-4-6-21(19)29-26(20)27(32)17-7-8-23-24(12-17)36-16-35-23/h3-8,12,18,22,27,29H,2,9-11,13-16H2,1H3/t18-,22-,27-/m1/s1
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n/an/a>10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126449
PNG
(3-[(R)-3-((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-1,4-di...)
Show SMILES CN(C)C(=O)CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H33N5O5/c1-32(2)26(36)10-12-33-11-9-19(15-33)34-16-27(37)35-23(30(34)38)14-21-20-5-3-4-6-22(20)31-28(21)29(35)18-7-8-24-25(13-18)40-17-39-24/h3-8,13,19,23,29,31H,9-12,14-17H2,1-2H3/t19-,23-,29-/m1/s1
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n/an/a 807n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126466
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-cycl...)
Show SMILES O=C1CN([C@@H]2CCN(CCC3CC3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C30H32N4O4/c35-27-16-33(20-10-12-32(15-20)11-9-18-5-6-18)30(36)24-14-22-21-3-1-2-4-23(21)31-28(22)29(34(24)27)19-7-8-25-26(13-19)38-17-37-25/h1-4,7-8,13,18,20,24,29,31H,5-6,9-12,14-17H2/t20-,24-,29-/m1/s1
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n/an/a 2.66E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126468
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-hexyl-p...)
Show SMILES CCCCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C30H34N4O4/c1-2-3-6-12-32-13-11-20(16-32)33-17-27(35)34-24(30(33)36)15-22-21-7-4-5-8-23(21)31-28(22)29(34)19-9-10-25-26(14-19)38-18-37-25/h4-5,7-10,14,20,24,29,31H,2-3,6,11-13,15-18H2,1H3/t20-,24-,29-/m1/s1
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n/an/a 1.77E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126452
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyri...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3ccccn3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H31N5O4/c38-29-18-36(22-11-14-35(17-22)13-10-21-5-3-4-12-33-21)32(39)26-16-24-23-6-1-2-7-25(23)34-30(24)31(37(26)29)20-8-9-27-28(15-20)41-19-40-27/h1-9,12,15,22,26,31,34H,10-11,13-14,16-19H2/t22-,26-,31-/m1/s1
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n/an/a 226n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126462
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1-m...)
Show SMILES Cn1ccnc1CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C31H32N6O4/c1-34-13-10-32-27(34)9-12-35-11-8-20(16-35)36-17-28(38)37-24(31(36)39)15-22-21-4-2-3-5-23(21)33-29(22)30(37)19-6-7-25-26(14-19)41-18-40-25/h2-7,10,13-14,20,24,30,33H,8-9,11-12,15-18H2,1H3/t20-,24-,30-/m1/s1
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n/an/a 125n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126462
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1-m...)
Show SMILES Cn1ccnc1CCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C31H32N6O4/c1-34-13-10-32-27(34)9-12-35-11-8-20(16-35)36-17-28(38)37-24(31(36)39)15-22-21-4-2-3-5-23(21)33-29(22)30(37)19-6-7-25-26(14-19)41-18-40-25/h2-7,10,13-14,20,24,30,33H,8-9,11-12,15-18H2,1H3/t20-,24-,30-/m1/s1
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n/an/a 494n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126467
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-{(R)-1-[2-(1H-...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3ncc[nH]3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C30H30N6O4/c37-27-16-35(19-7-11-34(15-19)12-8-26-31-9-10-32-26)30(38)23-14-21-20-3-1-2-4-22(20)33-28(21)29(36(23)27)18-5-6-24-25(13-18)40-17-39-24/h1-6,9-10,13,19,23,29,33H,7-8,11-12,14-17H2,(H,31,32)/t19-,23-,29-/m1/s1
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n/an/a 357n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126464
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyra...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3cnccn3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C31H30N6O4/c38-28-17-36(21-8-12-35(16-21)11-7-20-15-32-9-10-33-20)31(39)25-14-23-22-3-1-2-4-24(22)34-29(23)30(37(25)28)19-5-6-26-27(13-19)41-18-40-26/h1-6,9-10,13,15,21,25,30,34H,7-8,11-12,14,16-18H2/t21-,25-,30-/m1/s1
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n/an/a 358n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Homo sapiens-Homo sapiens (Human))
BDBM50126455
PNG
((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-[(R)-1-(2-pyri...)
Show SMILES O=C1CN([C@@H]2CCN(CCc3cccnc3)C2)C(=O)[C@H]2Cc3c([nH]c4ccccc34)[C@H](N12)c1ccc2OCOc2c1
Show InChI InChI=1S/C32H31N5O4/c38-29-18-36(22-10-13-35(17-22)12-9-20-4-3-11-33-16-20)32(39)26-15-24-23-5-1-2-6-25(23)34-30(24)31(37(26)29)21-7-8-27-28(14-21)41-19-40-27/h1-8,11,14,16,22,26,31,34H,9-10,12-13,15,17-19H2/t22-,26-,31-/m1/s1
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n/an/a 271n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina


Bioorg Med Chem Lett 13: 1425-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00159-8
BindingDB Entry DOI: 10.7270/Q2GM86N6
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50014718
PNG
(CHEMBL3262027)
Show SMILES COc1cc(cc(OC)c1OC)-c1cnc2c(nccn12)N1CCOCC1
Show InChI InChI=1S/C19H22N4O4/c1-24-15-10-13(11-16(25-2)17(15)26-3)14-12-21-19-18(20-4-5-23(14)19)22-6-8-27-9-7-22/h4-5,10-12H,6-9H2,1-3H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6A (unknown origin)


J Med Chem 57: 4196-212 (2014)


Article DOI: 10.1021/jm500073h
BindingDB Entry DOI: 10.7270/Q2X068K6
More data for this
Ligand-Target Pair
Phosphodiesterase 6A


(Homo sapiens)
BDBM50014817
PNG
(CHEMBL3262029)
Show SMILES COCCn1cc(cn1)-c1cnc2c(nccn12)N1CCOCC1
Show InChI InChI=1S/C16H20N6O2/c1-23-7-6-21-12-13(10-19-21)14-11-18-16-15(17-2-3-22(14)16)20-4-8-24-9-5-20/h2-3,10-12H,4-9H2,1H3
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n/an/a<1.00E+4n/an/an/an/an/an/a



Janssen Research& Development

Curated by ChEMBL


Assay Description
Inhibition of PDE6A (unknown origin)


J Med Chem 57: 4196-212 (2014)


Article DOI: 10.1021/jm500073h
BindingDB Entry DOI: 10.7270/Q2X068K6
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus-Bos taurus (Bovine))
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/a 74n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of bovine retina PDE6 (Phosphodiesterase 6)


J Med Chem 46: 4533-42 (2003)


Article DOI: 10.1021/jm0300577
BindingDB Entry DOI: 10.7270/Q2N015X2
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus-Bos taurus (Bovine))
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a 5.10E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of bovine retina PDE6 (Phosphodiesterase 6)


J Med Chem 46: 4533-42 (2003)


Article DOI: 10.1021/jm0300577
BindingDB Entry DOI: 10.7270/Q2N015X2
More data for this
Ligand-Target Pair
Phosphodiesterase 6


(Bos taurus-Bos taurus (Bovine))
BDBM50165816
PNG
(3-(7-Benzyl-9-methyl-6-oxo-2-phenyl-6,7-dihydro-3,...)
Show SMILES Cc1nn(Cc2ccccc2)c(=O)c2nc(CCC(O)=O)n3nc(cc3c12)-c1ccccc1
Show InChI InChI=1S/C25H21N5O3/c1-16-23-20-14-19(18-10-6-3-7-11-18)28-30(20)21(12-13-22(31)32)26-24(23)25(33)29(27-16)15-17-8-4-2-5-9-17/h2-11,14H,12-13,15H2,1H3,(H,31,32)
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n/an/a 590n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of bovine Phosphodiesterase 6 (n=2-3)


Bioorg Med Chem Lett 15: 2381-4 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.090
BindingDB Entry DOI: 10.7270/Q2K64HK9
More data for this
Ligand-Target Pair
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