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Compile Data Set for Download or QSAR

Found 705 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase 7'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140133
PNG
(US8901315, 262)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CC[C@@H](O)C1
Show InChI InChI=1S/C23H28N4O2S/c1-15-20-13-21(30-23(20)27(25-15)18-5-3-2-4-6-18)22(29)24-16-7-9-17(10-8-16)26-12-11-19(28)14-26/h7-10,13,18-19,28H,2-6,11-12,14H2,1H3,(H,24,29)/t19-/m1/s1
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n/an/a 28n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140134
PNG
(US8901315, 263)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CC[C@@H](O)C2)c(F)c1
Show InChI InChI=1S/C23H27FN4O2S/c1-14-18-12-21(31-23(18)28(26-14)16-5-3-2-4-6-16)22(30)25-15-7-8-20(19(24)11-15)27-10-9-17(29)13-27/h7-8,11-12,16-17,29H,2-6,9-10,13H2,1H3,(H,25,30)/t17-/m1/s1
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n/an/a 54n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140135
PNG
(US8901315, 264)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1cccc(c1)S(=O)(=O)N1CCC(O)CC1
Show InChI InChI=1S/C24H30N4O4S2/c1-16-21-15-22(33-24(21)28(26-16)18-7-3-2-4-8-18)23(30)25-17-6-5-9-20(14-17)34(31,32)27-12-10-19(29)11-13-27/h5-6,9,14-15,18-19,29H,2-4,7-8,10-13H2,1H3,(H,25,30)
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n/an/a 81n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140136
PNG
(US8901315, 266)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCC(O)CC1
Show InChI InChI=1S/C24H30N4O4S2/c1-16-21-15-22(33-24(21)28(26-16)18-5-3-2-4-6-18)23(30)25-17-7-9-20(10-8-17)34(31,32)27-13-11-19(29)12-14-27/h7-10,15,18-19,29H,2-6,11-14H2,1H3,(H,25,30)
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n/an/a 70n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140137
PNG
(US8901315, 268)
Show SMILES Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(F)c1
Show InChI InChI=1S/C23H27FN4O3S/c1-14-18-13-21(32-23(18)28(26-14)16-6-10-31-11-7-16)22(30)25-15-2-3-20(19(24)12-15)27-8-4-17(29)5-9-27/h2-3,12-13,16-17,29H,4-11H2,1H3,(H,25,30)
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n/an/a 88n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140138
PNG
(US8901315, 270)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCOC1=O
Show InChI InChI=1S/C22H30N4O3S/c1-14-18-13-19(30-21(18)26(24-14)17-5-3-2-4-6-17)20(27)23-15-7-9-16(10-8-15)25-11-12-29-22(25)28/h13,15-17H,2-12H2,1H3,(H,23,27)/t15-,16-
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n/an/a 15n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140139
PNG
(US8901315, 271)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCNC1=O
Show InChI InChI=1S/C22H31N5O2S/c1-14-18-13-19(30-21(18)27(25-14)17-5-3-2-4-6-17)20(28)24-15-7-9-16(10-8-15)26-12-11-23-22(26)29/h13,15-17H,2-12H2,1H3,(H,23,29)(H,24,28)/t15-,16-
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n/an/a 8.90n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140140
PNG
(US8901315, 273)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1C(=O)CCC1=O
Show InChI InChI=1S/C23H30N4O3S/c1-14-18-13-19(31-23(18)27(25-14)17-5-3-2-4-6-17)22(30)24-15-7-9-16(10-8-15)26-20(28)11-12-21(26)29/h13,15-17H,2-12H2,1H3,(H,24,30)/t15-,16-
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n/an/a 14n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140141
PNG
(US8901315, 274)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCCS1(=O)=O
Show InChI InChI=1S/C22H32N4O3S2/c1-15-19-14-20(30-22(19)26(24-15)18-6-3-2-4-7-18)21(27)23-16-8-10-17(11-9-16)25-12-5-13-31(25,28)29/h14,16-18H,2-13H2,1H3,(H,23,27)/t16-,17-
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n/an/a 9.90n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140142
PNG
(US8901315, 275)
Show SMILES CN1CC(=O)N([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O
Show InChI InChI=1S/C23H31N5O3S/c1-14-18-12-19(32-22(18)28(25-14)17-6-4-3-5-7-17)21(30)24-15-8-10-16(11-9-15)27-20(29)13-26(2)23(27)31/h12,15-17H,3-11,13H2,1-2H3,(H,24,30)/t15-,16-
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n/an/a 4n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140143
PNG
(US8901315, 277)
Show SMILES CN1CC(=O)N(CCNC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O
Show InChI InChI=1S/C19H25N5O3S/c1-12-14-10-15(28-18(14)24(21-12)13-6-4-3-5-7-13)17(26)20-8-9-23-16(25)11-22(2)19(23)27/h10,13H,3-9,11H2,1-2H3,(H,20,26)
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n/an/a 32n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140144
PNG
(US8901315, 280)
Show SMILES CN1CCN([C@H]2CC[C@@H](CC2)NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O
Show InChI InChI=1S/C23H33N5O2S/c1-15-19-14-20(31-22(19)28(25-15)18-6-4-3-5-7-18)21(29)24-16-8-10-17(11-9-16)27-13-12-26(2)23(27)30/h14,16-18H,3-13H2,1-2H3,(H,24,29)/t16-,17-
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n/an/a 17n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140145
PNG
(US8901315, 302)
Show SMILES CN1CCN(CCNC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O
Show InChI InChI=1S/C19H27N5O2S/c1-13-15-12-16(17(25)20-8-9-23-11-10-22(2)19(23)26)27-18(15)24(21-13)14-6-4-3-5-7-14/h12,14H,3-11H2,1-2H3,(H,20,25)
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n/an/a 60n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140146
PNG
(US8901315, 305)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)NCCN1C(=O)CNC1=O
Show InChI InChI=1S/C18H23N5O3S/c1-11-13-9-14(16(25)19-7-8-22-15(24)10-20-18(22)26)27-17(13)23(21-11)12-5-3-2-4-6-12/h9,12H,2-8,10H2,1H3,(H,19,25)(H,20,26)
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n/an/a 66n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140147
PNG
(US8901315, 313)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)NCCN1CC(=O)NC1=O
Show InChI InChI=1S/C18H23N5O3S/c1-11-13-9-14(16(25)19-7-8-22-10-15(24)20-18(22)26)27-17(13)23(21-11)12-5-3-2-4-6-12/h9,12H,2-8,10H2,1H3,(H,19,25)(H,20,24,26)
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n/an/a 90n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140148
PNG
(US8901315, 316)
Show SMILES CCN1C(=O)CN(CCNC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O
Show InChI InChI=1S/C20H27N5O3S/c1-3-24-17(26)12-23(20(24)28)10-9-21-18(27)16-11-15-13(2)22-25(19(15)29-16)14-7-5-4-6-8-14/h11,14H,3-10,12H2,1-2H3,(H,21,27)
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n/an/a 97n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140149
PNG
(US8901315, 317)
Show SMILES CN1C(=O)CN(CCNC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)C1=O
Show InChI InChI=1S/C19H25N5O3S/c1-12-14-10-15(28-18(14)24(21-12)13-6-4-3-5-7-13)17(26)20-8-9-23-11-16(25)22(2)19(23)27/h10,13H,3-9,11H2,1-2H3,(H,20,26)
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n/an/a 67n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140150
PNG
(US8901315, 323)
Show SMILES CN(C)C(=O)N1CC[C@H](C1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1
Show InChI InChI=1S/C20H29N5O2S/c1-13-16-11-17(28-19(16)25(22-13)15-7-5-4-6-8-15)18(26)21-14-9-10-24(12-14)20(27)23(2)3/h11,14-15H,4-10,12H2,1-3H3,(H,21,26)/t14-/m1/s1
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n/an/a 71n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140151
PNG
(US8901315, 325)
Show SMILES C[C@H](CN1C(=O)CNC1=O)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1
Show InChI InChI=1S/C19H25N5O3S/c1-11(10-23-16(25)9-20-19(23)27)21-17(26)15-8-14-12(2)22-24(18(14)28-15)13-6-4-3-5-7-13/h8,11,13H,3-7,9-10H2,1-2H3,(H,20,27)(H,21,26)/t11-/m1/s1
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n/an/a 34n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140152
PNG
(US8901315, 331)
Show SMILES CC[C@H](CN1C(=O)CNC1=O)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1
Show InChI InChI=1S/C20H27N5O3S/c1-3-13(11-24-17(26)10-21-20(24)28)22-18(27)16-9-15-12(2)23-25(19(15)29-16)14-7-5-4-6-8-14/h9,13-14H,3-8,10-11H2,1-2H3,(H,21,28)(H,22,27)/t13-/m1/s1
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n/an/a 29n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140153
PNG
(US8901315, 339)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)NCC(C)(C)CN1C(=O)CNC1=O
Show InChI InChI=1S/C21H29N5O3S/c1-13-15-9-16(30-19(15)26(24-13)14-7-5-4-6-8-14)18(28)23-11-21(2,3)12-25-17(27)10-22-20(25)29/h9,14H,4-8,10-12H2,1-3H3,(H,22,29)(H,23,28)
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n/an/a 20n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140154
PNG
(US8901315, 340)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)N[C@H]1C[C@@H]1CO
Show InChI InChI=1S/C17H23N3O2S/c1-10-13-8-15(16(22)18-14-7-11(14)9-21)23-17(13)20(19-10)12-5-3-2-4-6-12/h8,11-12,14,21H,2-7,9H2,1H3,(H,18,22)/t11-,14+/m1/s1
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n/an/a 54n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140155
PNG
(US8901315, 341)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCNC(=O)C1
Show InChI InChI=1S/C23H27N5O2S/c1-15-19-13-20(31-23(19)28(26-15)18-5-3-2-4-6-18)22(30)25-16-7-9-17(10-8-16)27-12-11-24-21(29)14-27/h7-10,13,18H,2-6,11-12,14H2,1H3,(H,24,29)(H,25,30)
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n/an/a 5n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140156
PNG
(US8901315, 342)
Show SMILES Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCNC(=O)C1
Show InChI InChI=1S/C22H25N5O3S/c1-14-18-12-19(31-22(18)27(25-14)17-6-10-30-11-7-17)21(29)24-15-2-4-16(5-3-15)26-9-8-23-20(28)13-26/h2-5,12,17H,6-11,13H2,1H3,(H,23,28)(H,24,29)
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n/an/a 28n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140157
PNG
(US8901315, 349)
Show SMILES CN(C)C(=O)[C@H]1CCC(CC1)NC(=O)c1cc2c(C)nn(C3CCOCC3)c2s1
Show InChI InChI=1S/C21H30N4O3S/c1-13-17-12-18(29-21(17)25(23-13)16-8-10-28-11-9-16)19(26)22-15-6-4-14(5-7-15)20(27)24(2)3/h12,14-16H,4-11H2,1-3H3,(H,22,26)/t14-,15?
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n/an/a 78n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140158
PNG
(US8901315, 358)
Show SMILES Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)NC1CC[C@H](CN2CCOCC2)CC1
Show InChI InChI=1S/C23H34N4O3S/c1-16-20-14-21(31-23(20)27(25-16)19-6-10-29-11-7-19)22(28)24-18-4-2-17(3-5-18)15-26-8-12-30-13-9-26/h14,17-19H,2-13,15H2,1H3,(H,24,28)/t17-,18?
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n/an/a 71n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140159
PNG
(US8901315, 360)
Show SMILES CC(=O)N1CCN(C[C@H]2CCC(CC2)NC(=O)c2cc3c(C)nn(C4CCOCC4)c3s2)CC1
Show InChI InChI=1S/C25H37N5O3S/c1-17-22-15-23(34-25(22)30(27-17)21-7-13-33-14-8-21)24(32)26-20-5-3-19(4-6-20)16-28-9-11-29(12-10-28)18(2)31/h15,19-21H,3-14,16H2,1-2H3,(H,26,32)/t19-,20?
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n/an/a 57n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140083
PNG
(US8901315, 159 | US8901315, 365 | US8901315, 366)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(F)c1
Show InChI InChI=1S/C24H29FN4O2S/c1-15-19-14-22(32-24(19)29(27-15)17-5-3-2-4-6-17)23(31)26-16-7-8-21(20(25)13-16)28-11-9-18(30)10-12-28/h7-8,13-14,17-18,30H,2-6,9-12H2,1H3,(H,26,31)
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n/an/a 41n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140083
PNG
(US8901315, 159 | US8901315, 365 | US8901315, 366)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(F)c1
Show InChI InChI=1S/C24H29FN4O2S/c1-15-19-14-22(32-24(19)29(27-15)17-5-3-2-4-6-17)23(31)26-16-7-8-21(20(25)13-16)28-11-9-18(30)10-12-28/h7-8,13-14,17-18,30H,2-6,9-12H2,1H3,(H,26,31)
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n/an/a 49n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140069
PNG
(US8901315, 114 | US8901315, 367 | US8901315, 368)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCC(O)CC1
Show InChI InChI=1S/C24H30N4O2S/c1-16-21-15-22(31-24(21)28(26-16)19-5-3-2-4-6-19)23(30)25-17-7-9-18(10-8-17)27-13-11-20(29)12-14-27/h7-10,15,19-20,29H,2-6,11-14H2,1H3,(H,25,30)
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n/an/a 20n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140069
PNG
(US8901315, 114 | US8901315, 367 | US8901315, 368)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(cc1)N1CCC(O)CC1
Show InChI InChI=1S/C24H30N4O2S/c1-16-21-15-22(31-24(21)28(26-16)19-5-3-2-4-6-19)23(30)25-17-7-9-18(10-8-17)27-13-11-20(29)12-14-27/h7-10,15,19-20,29H,2-6,11-14H2,1H3,(H,25,30)
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n/an/a 26n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140164
PNG
(US8901315, 369)
Show SMILES Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCOCC1
Show InChI InChI=1S/C22H32N4O3S/c1-15-19-14-20(30-22(19)26(24-15)18-6-10-28-11-7-18)21(27)23-16-2-4-17(5-3-16)25-8-12-29-13-9-25/h14,16-18H,2-13H2,1H3,(H,23,27)/t16-,17-
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n/an/a 24n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140165
PNG
(US8901315, 370)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(nc1)N1CCC(O)CC1
Show InChI InChI=1S/C23H29N5O2S/c1-15-19-13-20(31-23(19)28(26-15)17-5-3-2-4-6-17)22(30)25-16-7-8-21(24-14-16)27-11-9-18(29)10-12-27/h7-8,13-14,17-18,29H,2-6,9-12H2,1H3,(H,25,30)
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n/an/a 8.70n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140166
PNG
(US8901315, 371)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(F)c1F
Show InChI InChI=1S/C24H28F2N4O2S/c1-14-17-13-20(33-24(17)30(28-14)15-5-3-2-4-6-15)23(32)27-18-7-8-19(22(26)21(18)25)29-11-9-16(31)10-12-29/h7-8,13,15-16,31H,2-6,9-12H2,1H3,(H,27,32)
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n/an/a 17n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140167
PNG
(US8901315, 372)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(C)c1
Show InChI InChI=1S/C25H32N4O2S/c1-16-14-18(8-9-22(16)28-12-10-20(30)11-13-28)26-24(31)23-15-21-17(2)27-29(25(21)32-23)19-6-4-3-5-7-19/h8-9,14-15,19-20,30H,3-7,10-13H2,1-2H3,(H,26,31)
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n/an/a 11n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140168
PNG
(US8901315, 373)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(c1)C#N
Show InChI InChI=1S/C25H29N5O2S/c1-16-21-14-23(33-25(21)30(28-16)19-5-3-2-4-6-19)24(32)27-18-7-8-22(17(13-18)15-26)29-11-9-20(31)10-12-29/h7-8,13-14,19-20,31H,2-6,9-12H2,1H3,(H,27,32)
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n/an/a 4.5n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140169
PNG
(US8901315, 375)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(N2CCC(O)CC2)c(c1)C(O)=O
Show InChI InChI=1S/C25H30N4O4S/c1-15-19-14-22(34-24(19)29(27-15)17-5-3-2-4-6-17)23(31)26-16-7-8-21(20(13-16)25(32)33)28-11-9-18(30)10-12-28/h7-8,13-14,17-18,30H,2-6,9-12H2,1H3,(H,26,31)(H,32,33)
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n/an/a 7.20n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140170
PNG
(US8901315, 378)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(nc1)C(=O)N1CCC(O)CC1
Show InChI InChI=1S/C24H29N5O3S/c1-15-19-13-21(33-24(19)29(27-15)17-5-3-2-4-6-17)22(31)26-16-7-8-20(25-14-16)23(32)28-11-9-18(30)10-12-28/h7-8,13-14,17-18,30H,2-6,9-12H2,1H3,(H,26,31)
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n/an/a 44n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140171
PNG
(US8901315, 379)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(nc1)C(=O)NCCO
Show InChI InChI=1S/C21H25N5O3S/c1-13-16-11-18(30-21(16)26(25-13)15-5-3-2-4-6-15)20(29)24-14-7-8-17(23-12-14)19(28)22-9-10-27/h7-8,11-12,15,27H,2-6,9-10H2,1H3,(H,22,28)(H,24,29)
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n/an/a 13n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140172
PNG
(US8901315, 380)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cn1
Show InChI InChI=1S/C24H30N6O2S/c1-16-19-14-21(33-24(19)30(27-16)18-6-4-3-5-7-18)22(31)26-17-8-9-20(25-15-17)23(32)29-12-10-28(2)11-13-29/h8-9,14-15,18H,3-7,10-13H2,1-2H3,(H,26,31)
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n/an/a 56n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140173
PNG
(US8901315, 381)
Show SMILES CN(C)CCNC(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cn1
Show InChI InChI=1S/C23H30N6O2S/c1-15-18-13-20(32-23(18)29(27-15)17-7-5-4-6-8-17)22(31)26-16-9-10-19(25-14-16)21(30)24-11-12-28(2)3/h9-10,13-14,17H,4-8,11-12H2,1-3H3,(H,24,30)(H,26,31)
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n/an/a 22n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140174
PNG
(US8901315, 382)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(nc1)C(=O)N[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C25H31N5O3S/c1-15-20-13-22(34-25(20)30(29-15)18-5-3-2-4-6-18)24(33)28-17-9-12-21(26-14-17)23(32)27-16-7-10-19(31)11-8-16/h9,12-14,16,18-19,31H,2-8,10-11H2,1H3,(H,27,32)(H,28,33)/t16-,19-
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n/an/a 25n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140175
PNG
(US8901315, 383)
Show SMILES CN1CCCN(CC1)C(=O)c1ccc(NC(=O)c2cc3c(C)nn(C4CCCCC4)c3s2)cn1
Show InChI InChI=1S/C25H32N6O2S/c1-17-20-15-22(34-25(20)31(28-17)19-7-4-3-5-8-19)23(32)27-18-9-10-21(26-16-18)24(33)30-12-6-11-29(2)13-14-30/h9-10,15-16,19H,3-8,11-14H2,1-2H3,(H,27,32)
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n/an/a 74n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140176
PNG
(US8901315, 395)
Show SMILES CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCOCC3)c2s1
Show InChI InChI=1S/C24H35N5O3S/c1-16-21-15-22(33-24(21)29(26-16)20-7-13-32-14-8-20)23(31)25-18-3-5-19(6-4-18)28-11-9-27(10-12-28)17(2)30/h15,18-20H,3-14H2,1-2H3,(H,25,31)/t18-,19-
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n/an/a 19n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140177
PNG
(US8901315, 396)
Show SMILES Cc1nn(C2CCOCC2)c2sc(cc12)C(=O)N[C@H]1CC[C@@H](CC1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C23H35N5O4S2/c1-16-20-15-21(33-23(20)28(25-16)19-7-13-32-14-8-19)22(29)24-17-3-5-18(6-4-17)26-9-11-27(12-10-26)34(2,30)31/h15,17-19H,3-14H2,1-2H3,(H,24,29)/t17-,18-
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n/an/a 22n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140178
PNG
(US8901315, 402)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCOCC3)c2s1
Show InChI InChI=1S/C24H36N4O3S/c1-15-13-27(14-16(2)31-15)19-6-4-18(5-7-19)25-23(29)22-12-21-17(3)26-28(24(21)32-22)20-8-10-30-11-9-20/h12,15-16,18-20H,4-11,13-14H2,1-3H3,(H,25,29)/t15-,16+,18-,19-
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n/an/a 19n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140179
PNG
(US8901315, 404)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(CO)nc1
Show InChI InChI=1S/C19H22N4O2S/c1-12-16-9-17(18(25)21-13-7-8-14(11-24)20-10-13)26-19(16)23(22-12)15-5-3-2-4-6-15/h7-10,15,24H,2-6,11H2,1H3,(H,21,25)
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n/an/a 32n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140180
PNG
(US8901315, 412)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(CN2CCOCC2)nc1
Show InChI InChI=1S/C23H29N5O2S/c1-16-20-13-21(31-23(20)28(26-16)19-5-3-2-4-6-19)22(29)25-17-7-8-18(24-14-17)15-27-9-11-30-12-10-27/h7-8,13-14,19H,2-6,9-12,15H2,1H3,(H,25,29)
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n/an/a 43n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140181
PNG
(US8901315, 413)
Show SMILES Cc1nn(C2CCCCC2)c2sc(cc12)C(=O)Nc1ccc(CN2CCC(O)CC2)nc1
Show InChI InChI=1S/C24H31N5O2S/c1-16-21-13-22(32-24(21)29(27-16)19-5-3-2-4-6-19)23(31)26-17-7-8-18(25-14-17)15-28-11-9-20(30)10-12-28/h7-8,13-14,19-20,30H,2-6,9-12,15H2,1H3,(H,26,31)
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n/an/a 30n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
Phosphodiesterase 7


(Homo sapiens (Human))
BDBM140182
PNG
(US8901315, 414)
Show SMILES CC(=O)N1CCN(Cc2ccc(NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)cn2)CC1
Show InChI InChI=1S/C25H32N6O2S/c1-17-22-14-23(34-25(22)31(28-17)21-6-4-3-5-7-21)24(33)27-19-8-9-20(26-15-19)16-29-10-12-30(13-11-29)18(2)32/h8-9,14-15,21H,3-7,10-13,16H2,1-2H3,(H,27,33)
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n/an/a 35n/an/an/an/a7.54



Daiichi Sankyo Company, Limited

US Patent


Assay Description
The PDE 7 (phosphodiesterase VII) inhibiting effect of the compounds of the present invention was performed by the following method, which was modifi...


US Patent US8901315 (2014)


BindingDB Entry DOI: 10.7270/Q2GM860P
More data for this
Ligand-Target Pair
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