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Compile Data Set for Download or QSAR

Found 204 hits Enz. Inhib. hit(s) with Target = 'Phosphodiesterase Type 3 (PDE3B)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 280n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15337
PNG
((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1
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Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Biochemistry 43: 6091-100 (2004)


Article DOI: 10.1021/bi049868i
BindingDB Entry DOI: 10.7270/Q2DR2SQM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15298
PNG
(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C13H15N3O2/c1-8-7-12(18)15-16-13(8)10-3-5-11(6-4-10)14-9(2)17/h3-6,8H,7H2,1-2H3,(H,14,17)(H,15,18)/t8-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15299
PNG
(N-{4-[(4R)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC(=O)c2ccccc2C(F)(F)F)cc1
Show InChI InChI=1S/C19H16F3N3O2/c1-11-10-16(26)24-25-17(11)12-6-8-13(9-7-12)23-18(27)14-4-2-3-5-15(14)19(20,21)22/h2-9,11H,10H2,1H3,(H,23,27)(H,24,26)/t11-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15300
PNG
(dihydropyridazinone 6c | ethyl N-{4-[(4R)-4-methyl...)
Show SMILES CCOC(=O)Nc1ccc(cc1)C1=NNC(=O)C[C@H]1C
Show InChI InChI=1S/C14H17N3O3/c1-3-20-14(19)15-11-6-4-10(5-7-11)13-9(2)8-12(18)16-17-13/h4-7,9H,3,8H2,1-2H3,(H,15,19)(H,16,18)/t9-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15301
PNG
(benzyl N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyri...)
Show SMILES CC1CC(=O)NN=C1c1ccc(NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C19H19N3O3/c1-13-11-17(23)21-22-18(13)15-7-9-16(10-8-15)20-19(24)25-12-14-5-3-2-4-6-14/h2-10,13H,11-12H2,1H3,(H,20,24)(H,21,23)
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15302
PNG
((5R)-6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H25N3O2/c1-16-14-23(29)26-27-24(16)18-10-12-19(13-11-18)25-21-8-5-9-22(28)20(21)15-17-6-3-2-4-7-17/h2-4,6-7,10-13,16,25H,5,8-9,14-15H2,1H3,(H,26,29)/t16-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15303
PNG
((5R)-5-methyl-6-{4-[(2-methyl-3-oxocyclohex-1-en-1...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(C)C(=O)CCC2)cc1
Show InChI InChI=1S/C18H21N3O2/c1-11-10-17(23)20-21-18(11)13-6-8-14(9-7-13)19-15-4-3-5-16(22)12(15)2/h6-9,11,19H,3-5,10H2,1-2H3,(H,20,23)/t11-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15304
PNG
((5R)-6-[4-({2-[(2-methoxyphenyl)methyl]-3-oxocyclo...)
Show SMILES COc1ccccc1CC1=C(CCCC1=O)Nc1ccc(cc1)C1=NNC(=O)C[C@H]1C
Show InChI InChI=1S/C25H27N3O3/c1-16-14-24(30)27-28-25(16)17-10-12-19(13-11-17)26-21-7-5-8-22(29)20(21)15-18-6-3-4-9-23(18)31-2/h3-4,6,9-13,16,26H,5,7-8,14-15H2,1-2H3,(H,27,30)/t16-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15305
PNG
((5R)-5-methyl-6-{4-[(3-oxo-2-{[2-(trifluoromethyl)...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3C(F)(F)F)C(=O)CCC2)cc1
Show InChI InChI=1S/C25H24F3N3O2/c1-15-13-23(33)30-31-24(15)16-9-11-18(12-10-16)29-21-7-4-8-22(32)19(21)14-17-5-2-3-6-20(17)25(26,27)28/h2-3,5-6,9-12,15,29H,4,7-8,13-14H2,1H3,(H,30,33)/t15-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15306
PNG
((5R)-6-[4-({2-[(3-fluorophenyl)methyl]-3-oxocycloh...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H24FN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15307
PNG
((5R)-6-[4-({2-[(3-bromophenyl)methyl]-3-oxocyclohe...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(Br)c3)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H24BrN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15337
PNG
((5R)-6-(4-{[2-(3-iodobenzyl)-3-oxocyclohex-1-en-1-...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H24IN3O2/c1-15-12-23(30)27-28-24(15)17-8-10-19(11-9-17)26-21-6-3-7-22(29)20(21)14-16-4-2-5-18(25)13-16/h2,4-5,8-11,13,15,26H,3,6-7,12,14H2,1H3,(H,27,30)/t15-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15309
PNG
((5R)-5-methyl-6-[4-({2-[(3-nitrophenyl)methyl]-3-o...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)[N+]([O-])=O)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H24N4O4/c1-15-12-23(30)26-27-24(15)17-8-10-18(11-9-17)25-21-6-3-7-22(29)20(21)14-16-4-2-5-19(13-16)28(31)32/h2,4-5,8-11,13,15,25H,3,6-7,12,14H2,1H3,(H,26,30)/t15-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15310
PNG
((5R)-5-methyl-6-{4-[(3-oxo-2-{[3-(thiophen-3-yl)ph...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)-c3ccsc3)C(=O)CCC2)cc1
Show InChI InChI=1S/C28H27N3O2S/c1-18-14-27(33)30-31-28(18)20-8-10-23(11-9-20)29-25-6-3-7-26(32)24(25)16-19-4-2-5-21(15-19)22-12-13-34-17-22/h2,4-5,8-13,15,17-18,29H,3,6-7,14,16H2,1H3,(H,30,33)/t18-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15311
PNG
((5R)-5-methyl-6-{4-[(2-{[3-(3-nitrophenyl)phenyl]m...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(c3)-c3cccc(c3)[N+]([O-])=O)C(=O)CCC2)cc1
Show InChI InChI=1S/C30H28N4O4/c1-19-15-29(36)32-33-30(19)21-11-13-24(14-12-21)31-27-9-4-10-28(35)26(27)17-20-5-2-6-22(16-20)23-7-3-8-25(18-23)34(37)38/h2-3,5-8,11-14,16,18-19,31H,4,9-10,15,17H2,1H3,(H,32,36)/t19-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15312
PNG
((5R)-6-[4-({2-[(4-methoxyphenyl)methyl]-3-oxocyclo...)
Show SMILES COc1ccc(CC2=C(CCCC2=O)Nc2ccc(cc2)C2=NNC(=O)C[C@H]2C)cc1
Show InChI InChI=1S/C25H27N3O3/c1-16-14-24(30)27-28-25(16)18-8-10-19(11-9-18)26-22-4-3-5-23(29)21(22)15-17-6-12-20(31-2)13-7-17/h6-13,16,26H,3-5,14-15H2,1-2H3,(H,27,30)/t16-/m1/s1
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Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15313
PNG
((5R)-5-methyl-6-[4-({2-[(4-nitrophenyl)methyl]-3-o...)
Show SMILES C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccc(cc3)[N+]([O-])=O)C(=O)CCC2)cc1
Show InChI InChI=1S/C24H24N4O4/c1-15-13-23(30)26-27-24(15)17-7-9-18(10-8-17)25-21-3-2-4-22(29)20(21)14-16-5-11-19(12-6-16)28(31)32/h5-12,15,25H,2-4,13-14H2,1H3,(H,26,30)/t15-/m1/s1
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n/an/a 5.5n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15314
PNG
(6-{4-[(2-benzyl-3-oxocyclohex-1-en-1-yl)amino]-2-m...)
Show SMILES CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1C
Show InChI InChI=1S/C25H27N3O2/c1-16-13-19(11-12-20(16)25-17(2)14-24(30)27-28-25)26-22-9-6-10-23(29)21(22)15-18-7-4-3-5-8-18/h3-5,7-8,11-13,17,26H,6,9-10,14-15H2,1-2H3,(H,27,30)
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n/an/a 2.60n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15315
PNG
(N-{4-[(4S)-4-methyl-6-oxo-1,4,5,6-tetrahydropyrida...)
Show SMILES C[C@H]1CC(=O)NN=C1c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C18H17N3O2/c1-12-11-16(22)20-21-17(12)13-7-9-15(10-8-13)19-18(23)14-5-3-2-4-6-14/h2-10,12H,11H2,1H3,(H,19,23)(H,20,22)/t12-/m0/s1
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n/an/a 5.10n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15336
PNG
(1-methyl-3-(2-methylpropyl)-2,3,6,7-tetrahydro-1H-...)
Show SMILES CC(C)Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
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n/an/a 242n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Biochemistry 43: 6091-100 (2004)


Article DOI: 10.1021/bi049868i
BindingDB Entry DOI: 10.7270/Q2DR2SQM
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Phosphodiesterase Type 3 (PDE3B)


(Homo sapiens (human))
BDBM15297
PNG
(CHEMBL34431 | Cilostamide | N-Cyclohexyl-N-methyl-...)
Show SMILES CN(C1CCCCC1)C(=O)CCCOc1ccc2[nH]c(=O)ccc2c1
Show InChI InChI=1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
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n/an/a 18n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using scintillation proximity assay (SPA). [3H]-AMP was captured by t...


Bioorg Med Chem Lett 13: 3983-7 (2003)


Article DOI: 10.1016/j.bmcl.2003.08.056
BindingDB Entry DOI: 10.7270/Q2JD4V11
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14761
PNG
((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccc4ccccc34)c2cc1OC
Show InChI InChI=1S/C24H23N3O3/c1-28-22-12-19-20(13-23(22)29-2)25-15-26-24(19)27-11-10-17(14-27)30-21-9-5-7-16-6-3-4-8-18(16)21/h3-9,12-13,15,17H,10-11,14H2,1-2H3/t17-/m1/s1
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56n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14761
PNG
((R)-6,7-Dimethoxy-4-[3-(naphthalen-1-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cccc4ccccc34)c2cc1OC
Show InChI InChI=1S/C24H23N3O3/c1-28-22-12-19-20(13-23(22)29-2)25-15-26-24(19)27-11-10-17(14-27)30-21-9-5-7-16-6-3-4-8-18(16)21/h3-9,12-13,15,17H,10-11,14H2,1-2H3/t17-/m1/s1
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56n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14751
PNG
((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES CCOc1cccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C22H25N3O4/c1-4-28-15-6-5-7-16(10-15)29-17-8-9-25(13-17)22-18-11-20(26-2)21(27-3)12-19(18)23-14-24-22/h5-7,10-12,14,17H,4,8-9,13H2,1-3H3/t17-/m1/s1
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88n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14751
PNG
((R)-4-[3-(3-Ethoxy-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES CCOc1cccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C22H25N3O4/c1-4-28-15-6-5-7-16(10-15)29-17-8-9-25(13-17)22-18-11-20(26-2)21(27-3)12-19(18)23-14-24-22/h5-7,10-12,14,17H,4,8-9,13H2,1-3H3/t17-/m1/s1
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88n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14741
PNG
((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Show SMILES COc1ccccc1O[C@@H]1CCN(C1)c1ncnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C21H23N3O4/c1-25-17-6-4-5-7-18(17)28-14-8-9-24(12-14)21-15-10-19(26-2)20(27-3)11-16(15)22-13-23-21/h4-7,10-11,13-14H,8-9,12H2,1-3H3/t14-/m1/s1
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>100n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14744
PNG
((R)-2-[1-(6,7-Dimethoxy-quinazolin-4-yl)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C#N)c2cc1OC
Show InChI InChI=1S/C21H20N4O3/c1-26-19-9-16-17(10-20(19)27-2)23-13-24-21(16)25-8-7-15(12-25)28-18-6-4-3-5-14(18)11-22/h3-6,9-10,13,15H,7-8,12H2,1-2H3/t15-/m1/s1
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<100n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14743
PNG
((R)-4-[3-(2-Chloro-phenoxy)-pyrrolidin-1-yl]-6,7-d...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3Cl)c2cc1OC
Show InChI InChI=1S/C20H20ClN3O3/c1-25-18-9-14-16(10-19(18)26-2)22-12-23-20(14)24-8-7-13(11-24)27-17-6-4-3-5-15(17)21/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t13-/m1/s1
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<100n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14742
PNG
((S)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Show SMILES COc1ccccc1O[C@H]1CCN(C1)c1ncnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C21H23N3O4/c1-25-17-6-4-5-7-18(17)28-14-8-9-24(12-14)21-15-10-19(26-2)20(27-3)11-16(15)22-13-23-21/h4-7,10-11,13-14H,8-9,12H2,1-3H3/t14-/m0/s1
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>100n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14741
PNG
((R)-6,7-Dimethoxy-4-[3-(2-methoxy-phenoxy)-pyrroli...)
Show SMILES COc1ccccc1O[C@@H]1CCN(C1)c1ncnc2cc(OC)c(OC)cc12
Show InChI InChI=1S/C21H23N3O4/c1-25-17-6-4-5-7-18(17)28-14-8-9-24(12-14)21-15-10-19(26-2)20(27-3)11-16(15)22-13-23-21/h4-7,10-11,13-14H,8-9,12H2,1-3H3/t14-/m1/s1
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>100n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14739
PNG
((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C21H20F3N3O3/c1-28-18-9-14-16(10-19(18)29-2)25-12-26-20(14)27-8-7-13(11-27)30-17-6-4-3-5-15(17)21(22,23)24/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t13-/m1/s1
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>100n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14739
PNG
((R)-6,7-Dimethoxy-4-[3-(2-trifluoromethyl-phenoxy)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C(F)(F)F)c2cc1OC
Show InChI InChI=1S/C21H20F3N3O3/c1-28-18-9-14-16(10-19(18)29-2)25-12-26-20(14)27-8-7-13(11-27)30-17-6-4-3-5-15(17)21(22,23)24/h3-6,9-10,12-13H,7-8,11H2,1-2H3/t13-/m1/s1
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>100n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14767
PNG
((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cc4ccccc4cn3)c2cc1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-20-10-18-19(11-21(20)29-2)25-14-26-23(18)27-8-7-17(13-27)30-22-9-15-5-3-4-6-16(15)12-24-22/h3-6,9-12,14,17H,7-8,13H2,1-2H3/t17-/m1/s1
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196n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14767
PNG
((R)-4-[3-(Isoquinolin-3-yloxy)-pyrrolidin-1-yl]-6,...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cc4ccccc4cn3)c2cc1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-20-10-18-19(11-21(20)29-2)25-14-26-23(18)27-8-7-17(13-27)30-22-9-15-5-3-4-6-16(15)12-24-22/h3-6,9-12,14,17H,7-8,13H2,1-2H3/t17-/m1/s1
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196n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14764
PNG
((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4ncccc4c3)c2cc1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-21-11-18-20(12-22(21)29-2)25-14-26-23(18)27-9-7-17(13-27)30-16-5-6-19-15(10-16)4-3-8-24-19/h3-6,8,10-12,14,17H,7,9,13H2,1-2H3/t17-/m1/s1
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201n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14764
PNG
((R)-6,7-Dimethoxy-4-[3-(quinolin-6-yloxy)-pyrrolid...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4ncccc4c3)c2cc1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-21-11-18-20(12-22(21)29-2)25-14-26-23(18)27-9-7-17(13-27)30-16-5-6-19-15(10-16)4-3-8-24-19/h3-6,8,10-12,14,17H,7,9,13H2,1-2H3/t17-/m1/s1
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201n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14757
PNG
((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccn3)c2cc1OC
Show InChI InChI=1S/C19H20N4O3/c1-24-16-9-14-15(10-17(16)25-2)21-12-22-19(14)23-8-6-13(11-23)26-18-5-3-4-7-20-18/h3-5,7,9-10,12-13H,6,8,11H2,1-2H3/t13-/m1/s1
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207n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14757
PNG
((R)-6,7-Dimethoxy-4-[3-(pyridin-2-yloxy)-pyrrolidi...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccn3)c2cc1OC
Show InChI InChI=1S/C19H20N4O3/c1-24-16-9-14-15(10-17(16)25-2)21-12-22-19(14)23-8-6-13(11-23)26-18-5-3-4-7-20-18/h3-5,7,9-10,12-13H,6,8,11H2,1-2H3/t13-/m1/s1
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207n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14765
PNG
((R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4nc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C24H24N4O3/c1-15-4-5-16-10-17(6-7-20(16)27-15)31-18-8-9-28(13-18)24-19-11-22(29-2)23(30-3)12-21(19)25-14-26-24/h4-7,10-12,14,18H,8-9,13H2,1-3H3/t18-/m1/s1
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223n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14765
PNG
((R)-6,7-Dimethoxy-4-[3-(2-methyl-quinolin-6-yloxy)...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4nc(C)ccc4c3)c2cc1OC
Show InChI InChI=1S/C24H24N4O3/c1-15-4-5-16-10-17(6-7-20(16)27-15)31-18-8-9-28(13-18)24-19-11-22(29-2)23(30-3)12-21(19)25-14-26-24/h4-7,10-12,14,18H,8-9,13H2,1-3H3/t18-/m1/s1
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223n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14752
PNG
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1
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237n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14752
PNG
((R)-4-[3-(Indan-5-yloxy)-pyrrolidin-1-yl]-6,7-dime...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4CCCc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N3O3/c1-27-21-11-19-20(12-22(21)28-2)24-14-25-23(19)26-9-8-18(13-26)29-17-7-6-15-4-3-5-16(15)10-17/h6-7,10-12,14,18H,3-5,8-9,13H2,1-2H3/t18-/m1/s1
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237n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14766
PNG
((R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolid...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4cccnc4c3)c2cc1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-21-11-18-20(12-22(21)29-2)25-14-26-23(18)27-9-7-17(13-27)30-16-6-5-15-4-3-8-24-19(15)10-16/h3-6,8,10-12,14,17H,7,9,13H2,1-2H3/t17-/m1/s1
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240n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14766
PNG
((R)-6,7-Dimethoxy-4-[3-(quinolin-7-yloxy)-pyrrolid...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3ccc4cccnc4c3)c2cc1OC
Show InChI InChI=1S/C23H22N4O3/c1-28-21-11-18-20(12-22(21)29-2)25-14-26-23(18)27-9-7-17(13-27)30-16-6-5-15-4-3-8-24-19(15)10-16/h3-6,8,10-12,14,17H,7,9,13H2,1-2H3/t17-/m1/s1
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240n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14753
PNG
((R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-...)
Show SMILES COc1ccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C22H25N3O5/c1-26-18-6-5-14(9-19(18)27-2)30-15-7-8-25(12-15)22-16-10-20(28-3)21(29-4)11-17(16)23-13-24-22/h5-6,9-11,13,15H,7-8,12H2,1-4H3/t15-/m1/s1
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260n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14753
PNG
((R)-4-[3-(3,4-Dimethoxy-phenoxy)-pyrrolidin-1-yl]-...)
Show SMILES COc1ccc(O[C@@H]2CCN(C2)c2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C22H25N3O5/c1-26-18-6-5-14(9-19(18)27-2)30-15-7-8-25(12-15)22-16-10-20(28-3)21(29-4)11-17(16)23-13-24-22/h5-6,9-11,13,15H,7-8,12H2,1-4H3/t15-/m1/s1
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260n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14768
PNG
((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cnc4ccccc4n3)c2cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1
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273n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14768
PNG
((R)-6,7-Dimethoxy-4-[3-(quinoxalin-2-yloxy)-pyrrol...)
Show SMILES COc1cc2ncnc(N3CC[C@H](C3)Oc3cnc4ccccc4n3)c2cc1OC
Show InChI InChI=1S/C22H21N5O3/c1-28-19-9-15-18(10-20(19)29-2)24-13-25-22(15)27-8-7-14(12-27)30-21-11-23-16-5-3-4-6-17(16)26-21/h3-6,9-11,13-14H,7-8,12H2,1-2H3/t14-/m1/s1
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273n/an/an/an/an/an/an/an/a



Pfizer



Assay Description
PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by...


J Med Chem 50: 182-5 (2007)


Article DOI: 10.1021/jm060653b
BindingDB Entry DOI: 10.7270/Q2930RDX
More data for this
Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase B


(Homo sapiens (human))
BDBM14762
PNG
((R)-6,7-Dimethoxy-4-[3-(6-methoxy-naphthalen-2-ylo...)
Show SMILES COc1ccc2cc(O[C@@H]3CCN(C3)c3ncnc4cc(OC)c(OC)cc34)ccc2c1
Show InChI InChI=1S/C25H25N3O4/c1-29-18-6-4-17-11-19(7-5-16(17)10-18)32-20-8-9-28(14-20)25-21-12-23(30-2)24(31-3)13-22(21)26-15-27-25/h4-7,10-13,15,20H,8-9,14H2,1-3H3/t20-/m1/s1
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280n/an/an/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of PDE3B


Bioorg Med Chem 16: 3675-86 (2008)


Article DOI: 10.1016/j.bmc.2008.02.013
BindingDB Entry DOI: 10.7270/Q2V988ZC
More data for this
Ligand-Target Pair
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