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Found 2 hits Enz. Inhib. hit(s) with Target = 'Phosphoglycerate dehydrogenase N-terminal fragment (PHGDH fragment)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphoglycerate dehydrogenase N-terminal fragment (PHGDH fragment)


(Homo sapiens (Human))
BDBM209925
PNG
(PKUMDL-WQ-2201)
Show SMILES CCNC(=S)N\N=C/c1ccc(o1)-c1ccc(C(O)=O)c(Cl)c1
Show InChI InChI=1S/C15H14ClN3O3S/c1-2-17-15(23)19-18-8-10-4-6-13(22-10)9-3-5-11(14(20)21)12(16)7-9/h3-8H,2H2,1H3,(H,20,21)(H2,17,19,23)/b18-8-
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.50E+4n/an/an/an/a7.1n/a



Peking University



Assay Description
To evaluate the effects of compounds on PHGDH activity, compounds were first pre-incubated with enzyme samples in the assay buffer (25 mM HEPES, pH 7...


Cell Chem Biol 24: 55-65 (2017)


Article DOI: 10.1016/j.chembiol.2016.11.013
BindingDB Entry DOI: 10.7270/Q2X63KR3
More data for this
Ligand-Target Pair
Phosphoglycerate dehydrogenase N-terminal fragment (PHGDH fragment)


(Homo sapiens (Human))
BDBM209924
PNG
(PKUMDL-WQ-2101)
Show SMILES Oc1ccc(C(=O)N\N=C\c2cc(ccc2O)[N+]([O-])=O)c(O)c1
Show InChI InChI=1S/C14H11N3O6/c18-10-2-3-11(13(20)6-10)14(21)16-15-7-8-5-9(17(22)23)1-4-12(8)19/h1-7,18-20H,(H,16,21)/b15-7+
PDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.01E+4n/an/an/an/a7.1n/a



Peking University



Assay Description
To evaluate the effects of compounds on PHGDH activity, compounds were first pre-incubated with enzyme samples in the assay buffer (25 mM HEPES, pH 7...


Cell Chem Biol 24: 55-65 (2017)


Article DOI: 10.1016/j.chembiol.2016.11.013
BindingDB Entry DOI: 10.7270/Q2X63KR3
More data for this
Ligand-Target Pair