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Found 3528 hits Enz. Inhib. hit(s) with Target = 'Phosphoinositide 3-Kinase (PI3K), gamma'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 1.80E+3 170n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 3.80E+3 280n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.40E+3 210n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 9.00E+3 290n/an/an/a7.220



MRC



Assay Description
Binding was detected as a change in the intrinsic tryptophan fluorescence of the PI3K upon the addition of inhibitor. The inhibitor was incubated wit...


Mol Cell 6: 909-19 (2000)


BindingDB Entry DOI: 10.7270/Q22F7KPC
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.60E+3n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25036
PNG
(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Show SMILES CN(\N=C\c1cnc2ccc(Br)cn12)S(=O)(=O)c1cc(ccc1C)[N+]([O-])=O
Show InChI InChI=1S/C16H14BrN5O4S/c1-11-3-5-13(22(23)24)7-15(11)27(25,26)20(2)19-9-14-8-18-16-6-4-12(17)10-21(14)16/h3-10H,1-2H3/b19-9+
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n/an/a 40n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25018
PNG
(3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phe...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2sccc2n1
Show InChI InChI=1S/C16H15N3O2S/c20-12-3-1-2-11(10-12)15-17-13-4-9-22-14(13)16(18-15)19-5-7-21-8-6-19/h1-4,9-10,20H,5-8H2
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n/an/a 660n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25045
PNG
(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
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n/an/a 250n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 5837-44 (2007)


Article DOI: 10.1016/j.bmc.2007.05.070
BindingDB Entry DOI: 10.7270/Q2X928M7
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.60E+3n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 403-12 (2007)


Article DOI: 10.1016/j.bmc.2006.09.047
BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25056
PNG
(4-{6-chloroimidazo[1,2-a]pyridin-3-yl}-2-[(2-methy...)
Show SMILES Cc1ccc(cc1S(=O)(=O)c1nc(cs1)-c1cnc2ccc(Cl)cn12)[N+]([O-])=O
Show InChI InChI=1S/C17H11ClN4O4S2/c1-10-2-4-12(22(23)24)6-15(10)28(25,26)17-20-13(9-27-17)14-7-19-16-5-3-11(18)8-21(14)16/h2-9H,1H3
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n/an/a 230n/an/an/an/a7.422



Astellas Pharma Inc.



Assay Description
The test compounds and enzyme were mixed in buffer, and the substrate and [gamma-33P] ATP/ATP were added to the mixture to initiate the reaction. Aft...


Bioorg Med Chem 15: 403-12 (2007)


Article DOI: 10.1016/j.bmc.2006.09.047
BindingDB Entry DOI: 10.7270/Q2SJ1HXZ
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM15234
PNG
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Show SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
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n/an/a 19n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 1.72E+3n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25058
PNG
((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...)
Show SMILES COc1cc(O)cc(\C=C2/SC(=S)NC2=O)c1
Show InChI InChI=1S/C11H9NO3S2/c1-15-8-3-6(2-7(13)5-8)4-9-10(14)12-11(16)17-9/h2-5,13H,1H3,(H,12,14,16)/b9-4-
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n/an/a 77.7n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25059
PNG
(4-benzyl-6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazo...)
Show SMILES O=C1NC(=S)S\C1=C/c1ccc2OCC(=O)N(Cc3ccccc3)c2c1
Show InChI InChI=1S/C19H14N2O3S2/c22-17-11-24-15-7-6-13(9-16-18(23)20-19(25)26-16)8-14(15)21(17)10-12-4-2-1-3-5-12/h1-9H,10-11H2,(H,20,23,25)/b16-9-
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n/an/a 23n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25060
PNG
(4-[(4-methylphenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Show SMILES Cc1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C20H16N2O3S2/c1-12-2-4-13(5-3-12)10-22-15-8-14(6-7-16(15)25-11-18(22)23)9-17-19(24)21-20(26)27-17/h2-9H,10-11H2,1H3,(H,21,24,26)/b17-9-
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n/an/a 29.5n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25061
PNG
(4-[(4-tert-butylphenyl)methyl]-6-{[(5Z)-4-oxo-2-su...)
Show SMILES CC(C)(C)c1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C23H22N2O3S2/c1-23(2,3)16-7-4-14(5-8-16)12-25-17-10-15(6-9-18(17)28-13-20(25)26)11-19-21(27)24-22(29)30-19/h4-11H,12-13H2,1-3H3,(H,24,27,29)/b19-11-
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n/an/a 2.42n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25062
PNG
(4-[(4-chlorophenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Show SMILES Clc1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C19H13ClN2O3S2/c20-13-4-1-11(2-5-13)9-22-14-7-12(3-6-15(14)25-10-17(22)23)8-16-18(24)21-19(26)27-16/h1-8H,9-10H2,(H,21,24,26)/b16-8-
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n/an/a 7.16n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25063
PNG
(4-[(3-oxo-6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiaz...)
Show SMILES O=C1NC(=S)S\C1=C/c1ccc2OCC(=O)N(Cc3ccc(cc3)C#N)c2c1
Show InChI InChI=1S/C20H13N3O3S2/c21-9-12-1-3-13(4-2-12)10-23-15-7-14(5-6-16(15)26-11-18(23)24)8-17-19(25)22-20(27)28-17/h1-8H,10-11H2,(H,22,25,27)/b17-8-
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n/an/a 36.1n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25064
PNG
(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)
Show SMILES FC(F)(F)c1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C20H13F3N2O3S2/c21-20(22,23)13-4-1-11(2-5-13)9-25-14-7-12(3-6-15(14)28-10-17(25)26)8-16-18(27)24-19(29)30-16/h1-8H,9-10H2,(H,24,27,29)/b16-8-
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n/an/a 27.5n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25065
PNG
(4-[(3-methylphenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Show SMILES Cc1cccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1
Show InChI InChI=1S/C20H16N2O3S2/c1-12-3-2-4-14(7-12)10-22-15-8-13(5-6-16(15)25-11-18(22)23)9-17-19(24)21-20(26)27-17/h2-9H,10-11H2,1H3,(H,21,24,26)/b17-9-
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n/an/a 43.7n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25066
PNG
(4-[(3,4-dimethylphenyl)methyl]-6-{[(5Z)-4-oxo-2-su...)
Show SMILES Cc1ccc(CN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1C
Show InChI InChI=1S/C21H18N2O3S2/c1-12-3-4-15(7-13(12)2)10-23-16-8-14(5-6-17(16)26-11-19(23)24)9-18-20(25)22-21(27)28-18/h3-9H,10-11H2,1-2H3,(H,22,25,27)/b18-9-
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n/an/a 2.59n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25067
PNG
(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)
Show SMILES O=C1NC(=S)S\C1=C/c1ccc2OCC(=O)N(CCc3ccccc3)c2c1
Show InChI InChI=1S/C20H16N2O3S2/c23-18-12-25-16-7-6-14(11-17-19(24)21-20(26)27-17)10-15(16)22(18)9-8-13-4-2-1-3-5-13/h1-7,10-11H,8-9,12H2,(H,21,24,26)/b17-11-
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n/an/a 24.5n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25068
PNG
(4-[2-(3,5-dimethylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Show SMILES Cc1cc(C)cc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1
Show InChI InChI=1S/C22H20N2O3S2/c1-13-7-14(2)9-16(8-13)5-6-24-17-10-15(3-4-18(17)27-12-20(24)25)11-19-21(26)23-22(28)29-19/h3-4,7-11H,5-6,12H2,1-2H3,(H,23,26,28)/b19-11-
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n/an/a 2.65n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25069
PNG
(4-[2-(3,5-dimethoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-...)
Show SMILES COc1cc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc(OC)c1
Show InChI InChI=1S/C22H20N2O5S2/c1-27-15-7-14(8-16(11-15)28-2)5-6-24-17-9-13(3-4-18(17)29-12-20(24)25)10-19-21(26)23-22(30)31-19/h3-4,7-11H,5-6,12H2,1-2H3,(H,23,26,30)/b19-10-
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n/an/a 2.79n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25070
PNG
(4-[2-(4-chlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Show SMILES Clc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C20H15ClN2O3S2/c21-14-4-1-12(2-5-14)7-8-23-15-9-13(3-6-16(15)26-11-18(23)24)10-17-19(25)22-20(27)28-17/h1-6,9-10H,7-8,11H2,(H,22,25,27)/b17-10-
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n/an/a 4.76n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25071
PNG
(4-[2-(4-methoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulf...)
Show SMILES COc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C21H18N2O4S2/c1-26-15-5-2-13(3-6-15)8-9-23-16-10-14(4-7-17(16)27-12-19(23)24)11-18-20(25)22-21(28)29-18/h2-7,10-11H,8-9,12H2,1H3,(H,22,25,28)/b18-11-
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n/an/a 6.57n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25072
PNG
(4-[2-(4-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Show SMILES Cc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C21H18N2O3S2/c1-13-2-4-14(5-3-13)8-9-23-16-10-15(6-7-17(16)26-12-19(23)24)11-18-20(25)22-21(27)28-18/h2-7,10-11H,8-9,12H2,1H3,(H,22,25,27)/b18-11-
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n/an/a 8.83n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25073
PNG
(4-[2-(4-bromophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Show SMILES Brc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C20H15BrN2O3S2/c21-14-4-1-12(2-5-14)7-8-23-15-9-13(3-6-16(15)26-11-18(23)24)10-17-19(25)22-20(27)28-17/h1-6,9-10H,7-8,11H2,(H,22,25,27)/b17-10-
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n/an/a 2.34n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25074
PNG
(4-[2-(3-chlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Show SMILES Clc1cccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1
Show InChI InChI=1S/C20H15ClN2O3S2/c21-14-3-1-2-12(8-14)6-7-23-15-9-13(4-5-16(15)26-11-18(23)24)10-17-19(25)22-20(27)28-17/h1-5,8-10H,6-7,11H2,(H,22,25,27)/b17-10-
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n/an/a 4.27n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25075
PNG
(4-[2-(3,4-dichlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Show SMILES Clc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1Cl
Show InChI InChI=1S/C20H14Cl2N2O3S2/c21-13-3-1-11(7-14(13)22)5-6-24-15-8-12(2-4-16(15)27-10-18(24)25)9-17-19(26)23-20(28)29-17/h1-4,7-9H,5-6,10H2,(H,23,26,28)/b17-9-
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n/an/a 4.36n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25076
PNG
(4-[2-(4-tert-butylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Show SMILES CC(C)(C)c1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C24H24N2O3S2/c1-24(2,3)17-7-4-15(5-8-17)10-11-26-18-12-16(6-9-19(18)29-14-21(26)27)13-20-22(28)25-23(30)31-20/h4-9,12-13H,10-11,14H2,1-3H3,(H,25,28,30)/b20-13-
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n/an/a 33.2n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25077
PNG
(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)
Show SMILES FC(F)(F)c1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1
Show InChI InChI=1S/C21H15F3N2O3S2/c22-21(23,24)14-4-1-12(2-5-14)7-8-26-15-9-13(3-6-16(15)29-11-18(26)27)10-17-19(28)25-20(30)31-17/h1-6,9-10H,7-8,11H2,(H,25,28,30)/b17-10-
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n/an/a 1.92n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25078
PNG
(4-[2-(2,4-dichlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Show SMILES Clc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c(Cl)c1
Show InChI InChI=1S/C20H14Cl2N2O3S2/c21-13-3-2-12(14(22)9-13)5-6-24-15-7-11(1-4-16(15)27-10-18(24)25)8-17-19(26)23-20(28)29-17/h1-4,7-9H,5-6,10H2,(H,23,26,28)/b17-8-
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n/an/a 4.28n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25079
PNG
(4-[2-(3-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Show SMILES Cc1cccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1
Show InChI InChI=1S/C21H18N2O3S2/c1-13-3-2-4-14(9-13)7-8-23-16-10-15(5-6-17(16)26-12-19(23)24)11-18-20(25)22-21(27)28-18/h2-6,9-11H,7-8,12H2,1H3,(H,22,25,27)/b18-11-
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n/an/a 4.96n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25080
PNG
(4-[2-(3-methoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulf...)
Show SMILES COc1cccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)c1
Show InChI InChI=1S/C21H18N2O4S2/c1-26-15-4-2-3-13(9-15)7-8-23-16-10-14(5-6-17(16)27-12-19(23)24)11-18-20(25)22-21(28)29-18/h2-6,9-11H,7-8,12H2,1H3,(H,22,25,28)/b18-11-
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n/an/a 2.66n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), gamma


(Homo sapiens (human))
BDBM25081
PNG
(4-[2-(3,4-difluorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Show SMILES Fc1ccc(CCN2C(=O)COc3ccc(\C=C4/SC(=S)NC4=O)cc23)cc1F
Show InChI InChI=1S/C20H14F2N2O3S2/c21-13-3-1-11(7-14(13)22)5-6-24-15-8-12(2-4-16(15)27-10-18(24)25)9-17-19(26)23-20(28)29-17/h1-4,7-9H,5-6,10H2,(H,23,26,28)/b17-9-
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n/an/a 4.84n/an/an/an/a7.430



Pfizer



Assay Description
PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...


Bioorg Med Chem Lett 17: 756-60 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.080
BindingDB Entry DOI: 10.7270/Q2NS0S6N
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 50n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25083
PNG
(6-(1H-indol-4-yl)-pteridin-2,4-diamine | 6-(1H-ind...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc2[nH]ccc12
Show InChI InChI=1S/C14H11N7/c15-12-11-13(21-14(16)20-12)18-6-10(19-11)7-2-1-3-9-8(7)4-5-17-9/h1-6,17H,(H4,15,16,18,20,21)
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n/an/a 85n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 83n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM12915
PNG
(2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one |...)
Show SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
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n/an/a 7.30E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM15234
PNG
((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Show SMILES COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
Show InChI InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1
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n/an/a 55n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25085
PNG
(3-[7-amino-3-(3-hydroxyphenyl)quinoxalin-2-yl]phen...)
Show SMILES Nc1ccc2nc(-c3cccc(O)c3)c(nc2c1)-c1cccc(O)c1
Show InChI InChI=1S/C20H15N3O2/c21-14-7-8-17-18(11-14)23-20(13-4-2-6-16(25)10-13)19(22-17)12-3-1-5-15(24)9-12/h1-11,24-25H,21H2
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n/an/a 1.70E+4n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25086
PNG
(3,3 -Pteridine-6,7-diyldiphenol | 3-[7-(3-hydroxyp...)
Show SMILES Oc1cccc(c1)-c1nc2cncnc2nc1-c1cccc(O)c1
Show InChI InChI=1S/C18H12N4O2/c23-13-5-1-3-11(7-13)16-17(12-4-2-6-14(24)8-12)22-18-15(21-16)9-19-10-20-18/h1-10,23-24H
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n/an/a 9.00E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25087
PNG
(3-[8-amino-3-(3-hydroxyphenyl)pyrido[3,4-b]pyrazin...)
Show SMILES Nc1cncc2nc(-c3cccc(O)c3)c(nc12)-c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c20-15-9-21-10-16-19(15)23-18(12-4-2-6-14(25)8-12)17(22-16)11-3-1-5-13(24)7-11/h1-10,24-25H,20H2
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n/an/an/an/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25088
PNG
(3-[6-amino-2-(3-hydroxyphenyl)pyrido[2,3-b]pyrazin...)
Show SMILES Nc1ccc2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c20-16-8-7-15-19(22-16)23-18(12-4-2-6-14(25)10-12)17(21-15)11-3-1-5-13(24)9-11/h1-10,24-25H,(H2,20,22,23)
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n/an/an/an/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25089
PNG
(6,7-bis(3-hydroxyphenyl)pteridine-2,4-diol | pteri...)
Show SMILES Oc1cccc(c1)-c1nc2[nH]c(=O)[nH]c(=O)c2nc1-c1cccc(O)c1
Show InChI InChI=1S/C18H12N4O4/c23-11-5-1-3-9(7-11)13-14(10-4-2-6-12(24)8-10)20-16-15(19-13)17(25)22-18(26)21-16/h1-8,23-24H,(H2,20,21,22,25,26)
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n/an/a 4.60E+4n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25090
PNG
(2-amino-6,7-bis(3-hydroxyphenyl)pteridin-4-ol | am...)
Show SMILES Nc1nc2nc(-c3cccc(O)c3)c(nc2c(=O)[nH]1)-c1cccc(O)c1
Show InChI InChI=1S/C18H13N5O3/c19-18-22-16-15(17(26)23-18)20-13(9-3-1-5-11(24)7-9)14(21-16)10-4-2-6-12(25)8-10/h1-8,24-25H,(H3,19,21,22,23,26)
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n/an/a 4.80E+4n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25091
PNG
(3-[4-amino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol...)
Show SMILES Nc1ncnc2nc(-c3cccc(O)c3)c(nc12)-c1cccc(O)c1
Show InChI InChI=1S/C18H13N5O2/c19-17-16-18(21-9-20-17)23-15(11-4-2-6-13(25)8-11)14(22-16)10-3-1-5-12(24)7-10/h1-9,24-25H,(H2,19,20,21,23)
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n/an/a 4.00E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25084
PNG
(3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-4-2-6-12(26)8-10)13(21-15)9-3-1-5-11(25)7-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 83n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25092
PNG
(3-[2-amino-7-(3-hydroxyphenyl)-4-{[3-(morpholin-4-...)
Show SMILES Nc1nc(NCCCN2CCOCC2)c2nc(-c3cccc(O)c3)c(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C25H27N7O3/c26-25-30-23(27-8-3-9-32-10-12-35-13-11-32)22-24(31-25)29-21(17-5-2-7-19(34)15-17)20(28-22)16-4-1-6-18(33)14-16/h1-2,4-7,14-15,33-34H,3,8-13H2,(H3,26,27,29,30,31)
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n/an/a 5.10E+4n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
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