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Compile Data Set for Download or QSAR

Found 105 hits Enz. Inhib. hit(s) with Target = 'Plasminogen (aa101-181)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290260
PNG
(4-(Piperidin-4-yl)pyrimido[1,2-b]indazol-2(1H)-one...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ccccc3c2[nH]1
Show InChI InChI=1S/C15H16N4O/c20-14-9-13(10-5-7-16-8-6-10)19-15(17-14)11-3-1-2-4-12(11)18-19/h1-4,9-10,16H,5-8H2,(H,17,20)
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n/an/a 51n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290261
PNG
(4-(Piperidin-4-yl)-9-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-1-2-12-11(7-10)15-21-14(24)8-13(23(15)22-12)9-3-5-20-6-4-9/h1-2,7-9,20H,3-6H2,(H,21,24)
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n/an/a 30n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290262
PNG
(10-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Clc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290263
PNG
(10-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Fc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290264
PNG
(9-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 37n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290265
PNG
(7,9-Dichloro-4-(piperidin-4-yl)pyrimido[1,2-b]inda...)
Show SMILES Clc1cc(Cl)c2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H14Cl2N4O/c16-9-5-10-14(11(17)6-9)20-21-12(7-13(22)19-15(10)21)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
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n/an/a 94n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290266
PNG
(9-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 95n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290267
PNG
(10-Methoxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazo...)
Show SMILES COc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H18N4O2/c1-22-13-4-2-3-11-15(13)16-18-14(21)9-12(20(16)19-11)10-5-7-17-8-6-10/h2-4,9-10,17H,5-8H2,1H3,(H,18,21)
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n/an/a 46n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290268
PNG
(7-(Piperidin-4-yl)pyrido[3′,2′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccnc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-12-8-11(9-3-6-15-7-4-9)19-14(17-12)13-10(18-19)2-1-5-16-13/h1-2,5,8-9,15H,3-4,6-7H2,(H,17,20)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290269
PNG
(10-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Brc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 34n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290270
PNG
(4-(Piperidin-4-yl)-8-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-1-2-11-12(7-10)22-23-13(8-14(24)21-15(11)23)9-3-5-20-6-4-9/h1-2,7-9,20H,3-6H2,(H,21,24)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290271
PNG
(4-(Piperidin-4-yl)-10-(trifluoromethyl)pyrimido[1,...)
Show SMILES FC(F)(F)c1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)10-2-1-3-11-14(10)15-21-13(24)8-12(23(15)22-11)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 32n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290272
PNG
(8-tert-Butyl-4-(piperidin-4-yl)pyrido[2′,3&#...)
Show SMILES CC(C)(C)c1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C18H23N5O/c1-18(2,3)14-5-4-12-16(20-14)22-23-13(10-15(24)21-17(12)23)11-6-8-19-9-7-11/h4-5,10-11,19H,6-9H2,1-3H3,(H,21,24)
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n/an/a 31n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290273
PNG
(10-Methyl-4-(piperidin-4-yl)-8-(trifluoromethyl)py...)
Show SMILES Cc1cc(cc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C17H17F3N4O/c1-9-6-11(17(18,19)20)7-12-15(9)16-22-14(25)8-13(24(16)23-12)10-2-4-21-5-3-10/h6-8,10,21H,2-5H2,1H3,(H,22,25)
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n/an/a 50n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290274
PNG
(9-Methyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Cc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C16H18N4O/c1-10-2-3-13-12(8-10)16-18-15(21)9-14(20(16)19-13)11-4-6-17-7-5-11/h2-3,8-9,11,17H,4-7H2,1H3,(H,18,21)
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n/an/a 48n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290275
PNG
(8-Amino-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Nc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6,16H2,(H,18,21)
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n/an/a 34n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290276
PNG
(3,4-Dimethyl-8-(piperidin-4-yl)pyrimido[1′,2...)
Show SMILES Cc1nnc2nn3c(cc(=O)[nH]c3c2c1C)C1CCNCC1
Show InChI InChI=1S/C15H18N6O/c1-8-9(2)18-19-14-13(8)15-17-12(22)7-11(21(15)20-14)10-3-5-16-6-4-10/h7,10,16H,3-6H2,1-2H3,(H,17,22)
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n/an/a 22n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290277
PNG
(8-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 38n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290278
PNG
(9-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Brc1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 26n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290279
PNG
(10-Iodo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Ic1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H15IN4O/c16-10-2-1-3-11-14(10)15-18-13(21)8-12(20(15)19-11)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 22n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290280
PNG
(8-Bromo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2...)
Show SMILES Brc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15BrN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290281
PNG
(7-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-11-3-1-2-10-14(11)19-20-12(8-13(21)18-15(10)20)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290282
PNG
(8,10-Difluoro-4-(piperidin-4-yl)pyrimido[1,2-b]ind...)
Show SMILES Fc1cc(F)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H14F2N4O/c16-9-5-10(17)14-11(6-9)20-21-12(7-13(22)19-15(14)21)8-1-3-18-4-2-8/h5-8,18H,1-4H2,(H,19,22)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290283
PNG
(8-Methyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES Cc1ccc2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C15H17N5O/c1-9-2-3-11-14(17-9)19-20-12(8-13(21)18-15(11)20)10-4-6-16-7-5-10/h2-3,8,10,16H,4-7H2,1H3,(H,18,21)
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BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290284
PNG
(3-Fluoro-7-(piperidin-4-yl)pyrido[3′,2′...)
Show SMILES Fc1cnc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C14H14FN5O/c15-9-5-10-13(17-7-9)14-18-12(21)6-11(20(14)19-10)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 21n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290285
PNG
(10-Ethoxy-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES CCOc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C17H20N4O2/c1-2-23-14-5-3-4-12-16(14)17-19-15(22)10-13(21(17)20-12)11-6-8-18-9-7-11/h3-5,10-11,18H,2,6-9H2,1H3,(H,19,22)
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n/an/a 29n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290286
PNG
(7-Bromo-4-(piperidin-4-yl)pyrido[4′,3′...)
Show SMILES Brc1cncc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C14H14BrN5O/c15-10-7-17-6-9-13(10)19-20-11(5-12(21)18-14(9)20)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 13n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290287
PNG
(7-Fluoro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Fc1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15FN4O/c16-11-3-1-2-10-14(11)19-20-12(8-13(21)18-15(10)20)9-4-6-17-7-5-9/h1-3,8-9,17H,4-7H2,(H,18,21)
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n/an/a 33n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290288
PNG
(4-(Piperidin-4-yl)pyrido[3′,4′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cnccc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-13-7-12(9-1-4-15-5-2-9)19-14(17-13)10-3-6-16-8-11(10)18-19/h3,6-9,15H,1-2,4-5H2,(H,17,20)
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n/an/a 28n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290289
PNG
(4-(Piperidin-4-yl)-7-(trifluoromethyl)pyrimido[1,2...)
Show SMILES FC(F)(F)c1cccc2c1nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)11-3-1-2-10-14(11)22-23-12(8-13(24)21-15(10)23)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 46n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290290
PNG
(10-Nitro-4-(piperidin-4-yl)-8-(trifluoromethyl)pyr...)
Show SMILES [O-][N+](=O)c1cc(cc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1)C(F)(F)F
Show InChI InChI=1S/C16H14F3N5O3/c17-16(18,19)9-5-10-14(12(6-9)24(26)27)15-21-13(25)7-11(23(15)22-10)8-1-3-20-4-2-8/h5-8,20H,1-4H2,(H,21,25)
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n/an/a 97n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290291
PNG
(8,10-Dimethyl-4-(piperidin-4-yl)pyrido[2′,3&...)
Show SMILES Cc1cc(C)c2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1
Show InChI InChI=1S/C16H19N5O/c1-9-7-10(2)18-15-14(9)16-19-13(22)8-12(21(16)20-15)11-3-5-17-6-4-11/h7-8,11,17H,3-6H2,1-2H3,(H,19,22)
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n/an/a 210n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290292
PNG
(2-Oxo-4-(piperidin-4-yl)-1,2-dihydropyrimido[1,2-b...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3cccc(C#N)c3c2[nH]1
Show InChI InChI=1S/C16H15N5O/c17-9-11-2-1-3-12-15(11)16-19-14(22)8-13(21(16)20-12)10-4-6-18-7-5-10/h1-3,8,10,18H,4-7H2,(H,19,22)
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n/an/a 21n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290293
PNG
(10-Methyl-4-(piperidin-4-yl)pyrimido[1,2-b]indazol...)
Show SMILES Cc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H18N4O/c1-10-3-2-4-12-15(10)16-18-14(21)9-13(20(16)19-12)11-5-7-17-8-6-11/h2-4,9,11,17H,5-8H2,1H3,(H,18,21)
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n/an/a 18n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290294
PNG
(4-(Piperidin-4-yl)-10-(trifluoromethoxy)pyrimido[1...)
Show SMILES FC(F)(F)Oc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H15F3N4O2/c17-16(18,19)25-12-3-1-2-10-14(12)15-21-13(24)8-11(23(15)22-10)9-4-6-20-7-5-9/h1-3,8-9,20H,4-7H2,(H,21,24)
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n/an/a 44n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290295
PNG
(7-(Piperidin-4-yl)pyrazino[2′,3′:3,4]p...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nccnc3c2[nH]1
Show InChI InChI=1S/C13H14N6O/c20-10-7-9(8-1-3-14-4-2-8)19-13(17-10)11-12(18-19)16-6-5-15-11/h5-8,14H,1-4H2,(H,17,20)
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n/an/a 60n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290296
PNG
(8-Chloro-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-...)
Show SMILES Clc1ccc2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C15H15ClN4O/c16-10-1-2-11-12(7-10)19-20-13(8-14(21)18-15(11)20)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 24n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290297
PNG
(10-(Dimethylamino)-4-(piperidin-4-yl)pyrido[2̸...)
Show SMILES CN(C)c1ccnc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C16H20N6O/c1-21(2)11-5-8-18-15-14(11)16-19-13(23)9-12(22(16)20-15)10-3-6-17-7-4-10/h5,8-10,17H,3-4,6-7H2,1-2H3,(H,19,23)
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n/an/a 38n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290298
PNG
(10-Chloro-4-(piperidin-4-yl)-8-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1cc(Cl)c2c(c1)nn1c(cc(=O)[nH]c21)C1CCNCC1
Show InChI InChI=1S/C16H14ClF3N4O/c17-10-5-9(16(18,19)20)6-11-14(10)15-22-13(25)7-12(24(15)23-11)8-1-3-21-4-2-8/h5-8,21H,1-4H2,(H,22,25)
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n/an/a 23n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290299
PNG
(8-(4-Fluorophenyl)-4-(piperidin-4-yl)-10-(trifluor...)
Show SMILES Fc1ccc(cc1)-c1cc(c2c(nn3c(cc(=O)[nH]c23)C2CCNCC2)n1)C(F)(F)F
Show InChI InChI=1S/C21H17F4N5O/c22-13-3-1-11(2-4-13)15-9-14(21(23,24)25)18-19(27-15)29-30-16(10-17(31)28-20(18)30)12-5-7-26-8-6-12/h1-4,9-10,12,26H,5-8H2,(H,28,31)
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n/an/a 110n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290300
PNG
(10-Bromo-4-(piperidin-4-yl)pyrido[3′,4′...)
Show SMILES Brc1cncc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C14H14BrN5O/c15-9-6-17-7-10-13(9)14-18-12(21)5-11(20(14)19-10)8-1-3-16-4-2-8/h5-8,16H,1-4H2,(H,18,21)
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n/an/a 100n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290301
PNG
(8-Phenyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nc(ccc3c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-18-12-17(14-8-10-21-11-9-14)25-20(23-18)15-6-7-16(22-19(15)24-25)13-4-2-1-3-5-13/h1-7,12,14,21H,8-11H2,(H,23,26)
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n/an/a 48n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290302
PNG
(9-Phenyl-4-(piperidin-4-yl)pyrido[2′,3′...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ncc(cc3c2[nH]1)-c1ccccc1
Show InChI InChI=1S/C20H19N5O/c26-18-11-17(14-6-8-21-9-7-14)25-20(23-18)16-10-15(12-22-19(16)24-25)13-4-2-1-3-5-13/h1-5,10-12,14,21H,6-9H2,(H,23,26)
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n/an/a 37n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290303
PNG
(10-Phenyl-4-(piperidin-4-yl)pyrido[2′,3̸...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3nccc(-c4ccccc4)c3c2[nH]1
Show InChI InChI=1S/C20H19N5O/c26-17-12-16(14-6-9-21-10-7-14)25-20(23-17)18-15(8-11-22-19(18)24-25)13-4-2-1-3-5-13/h1-5,8,11-12,14,21H,6-7,9-10H2,(H,23,26)
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n/an/a 17n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290304
PNG
(10-methyl-4-(piperidin-4-yl)pyrido[2′,3̸...)
Show SMILES Cc1ccnc2nn3c(cc(=O)[nH]c3c12)C1CCNCC1
Show InChI InChI=1S/C15H17N5O/c1-9-2-7-17-14-13(9)15-18-12(21)8-11(20(15)19-14)10-3-5-16-6-4-10/h2,7-8,10,16H,3-6H2,1H3,(H,18,21)
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n/an/a 24n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290305
PNG
(9-Iodo-4-(piperidin-4-yl)pyrimido[1,2-b]indazol-2(...)
Show SMILES Ic1ccc2nn3c(cc(=O)[nH]c3c2c1)C1CCNCC1
Show InChI InChI=1S/C15H15IN4O/c16-10-1-2-12-11(7-10)15-18-14(21)8-13(20(15)19-12)9-3-5-17-6-4-9/h1-2,7-9,17H,3-6H2,(H,18,21)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290306
PNG
(4-(Piperidin-4-yl)pyrido[4′,3′:3,4]pyr...)
Show SMILES O=c1cc(C2CCNCC2)n2nc3ccncc3c2[nH]1
Show InChI InChI=1S/C14H15N5O/c20-13-7-12(9-1-4-15-5-2-9)19-14(17-13)10-8-16-6-3-11(10)18-19/h3,6-9,15H,1-2,4-5H2,(H,17,20)
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n/an/a 36n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290307
PNG
((−)-trans-10-Bromo-4-(2-methylpiperidin-4-yl...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Br)cccc3nn12
Show InChI InChI=1S/C16H17BrN4O/c1-9-7-10(5-6-18-9)13-8-14(22)19-16-15-11(17)3-2-4-12(15)20-21(13)16/h2-4,8-10,18H,5-7H2,1H3,(H,19,22)
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n/an/a 14n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290308
PNG
((−)-trans-4-(2-Methylpiperidin-4-yl)-10-phen...)
Show SMILES CC1CC(CCN1)c1cc(=O)[nH]c2c3c(ccnc3nn12)-c1ccccc1
Show InChI InChI=1S/C21H21N5O/c1-13-11-15(7-9-22-13)17-12-18(27)24-21-19-16(14-5-3-2-4-6-14)8-10-23-20(19)25-26(17)21/h2-6,8,10,12-13,15,22H,7,9,11H2,1H3,(H,24,27)
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n/an/a 15n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
Plasminogen (aa101-181)


(Homo sapiens (human))
BDBM290309
PNG
((−)-trans-10-Ethoxy-4-(2-methylpiperidin-4-y...)
Show SMILES CCOc1cccc2nn3c(cc(=O)[nH]c3c12)C1CCNC(C)C1
Show InChI InChI=1S/C18H22N4O2/c1-3-24-15-6-4-5-13-17(15)18-20-16(23)10-14(22(18)21-13)12-7-8-19-11(2)9-12/h4-6,10-12,19H,3,7-9H2,1-2H3,(H,20,23)
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PC sid
UniChem
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n/an/a 13n/an/an/an/a7.0n/a



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
The test compounds were dissolved in 1% acetic acid and further complemented with an equal volume of DMSO. The resulting stock solutions were seriall...


US Patent US10098883 (2018)

More data for this
Ligand-Target Pair
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