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Compile Data Set for Download or QSAR

Found 4130 hits Enz. Inhib. hit(s) with Target = 'Platelet-derived growth factor receptor beta'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
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Article
PubMed
n/an/a 2.80E+3n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
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PubMed
n/an/a 5.00E+3n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4168
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7a | 7-Amino-3-(...)
Show SMILES Cn1c2cc(N)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C15H11Cl2N3O/c1-20-12-6-13(18)19-7-8(12)5-9(15(20)21)14-10(16)3-2-4-11(14)17/h2-7H,1H3,(H2,18,19)
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PubMed
n/an/a 3.60E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4169
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7b | 3-(2,6-Dich...)
Show SMILES CNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H13Cl2N3O/c1-19-14-7-13-9(8-20-14)6-10(16(22)21(13)2)15-11(17)4-3-5-12(15)18/h3-8H,1-2H3,(H,19,20)
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PubMed
n/an/a 8.00E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4174
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7g | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C24H30Cl2N4O/c1-4-30(5-2)13-8-6-7-12-27-22-15-21-17(16-28-22)14-18(24(31)29(21)3)23-19(25)10-9-11-20(23)26/h9-11,14-16H,4-8,12-13H2,1-3H3,(H,27,28)
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n/an/a 740n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4171
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7d | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H24Cl2N4O/c1-4-27(5-2)10-9-24-19-12-18-14(13-25-19)11-15(21(28)26(18)3)20-16(22)7-6-8-17(20)23/h6-8,11-13H,4-5,9-10H2,1-3H3,(H,24,25)
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n/an/a>5.00E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4172
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7e | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H26Cl2N4O/c1-4-28(5-2)11-7-10-25-20-13-19-15(14-26-20)12-16(22(29)27(19)3)21-17(23)8-6-9-18(21)24/h6,8-9,12-14H,4-5,7,10-11H2,1-3H3,(H,25,26)
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n/an/a 4.60E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4173
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7f | 3-(2,6-Dich...)
Show SMILES CCN(CC)CCCCNc1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H28Cl2N4O/c1-4-29(5-2)12-7-6-11-26-21-14-20-16(15-27-21)13-17(23(30)28(20)3)22-18(24)9-8-10-19(22)25/h8-10,13-15H,4-7,11-12H2,1-3H3,(H,26,27)
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n/an/a 2.40E+3n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4170
PNG
(1,6-naphthyridin-2(1H)-one deriv. 7c | 3-(2,6-Dich...)
Show SMILES CN(C)c1cc2n(C)c(=O)c(cc2cn1)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H15Cl2N3O/c1-21(2)15-8-14-10(9-20-15)7-11(17(23)22(14)3)16-12(18)5-4-6-13(16)19/h4-9H,1-3H3
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n/an/a>5.00E+4n/an/an/an/a7.025



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 43: 3134-47 (2000)


Article DOI: 10.1021/jm000148t
BindingDB Entry DOI: 10.7270/Q2028PQ1
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM31094
PNG
(PKC-412 | cid_24202429)
Show SMILES CO[C@H]1[C@H](C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Show InChI InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m0/s1
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n/an/an/a 4.50E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4851
PNG
((4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
Show InChI InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
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n/an/an/a 9.60E+3n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM31095
PNG
(5-[(Z)-(5-fluoranyl-2-oxidanylidene-1H-indol-3-yli...)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
Show InChI InChI=1S/C23H27FN4O4/c1-13-20(10-18-17-9-15(24)3-4-19(17)27-22(18)30)26-14(2)21(13)23(31)25-11-16(29)12-28-5-7-32-8-6-28/h3-4,9-10,16,26,29H,5-8,11-12H2,1-2H3,(H,25,31)(H,27,30)/b18-10-/t16-/m0/s1
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n/an/an/a 4.70E+3n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM16673
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
Show InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)
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n/an/an/a 3.10E+4n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM31096
PNG
(CHEMBL290084 | Staurosporine | cid_451705)
Show SMILES CN[C@H]1C[C@@H]2O[C@](C)([C@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m0/s1
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n/an/an/a 1.50E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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n/an/an/a 1.80E+3n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM13534
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29)
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n/an/an/a 1.00E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM21
PNG
(6-[(4R,5S,6S,7R)-4,7-dibenzyl-3-(5-carboxypentyl)-...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/an/a 2.60E+5n/an/an/a7.425



Ambit Biosciences

Curated by PubChem BioAssay


Assay Description
Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...


PubChem Bioassay (2008)


BindingDB Entry DOI: 10.7270/Q2NC5ZHH
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4619
PNG
(Anilinoquinazoline deriv. 2 | CHEMBL1204360 | CHEM...)
Show SMILES COc1cc2ncnc(Nc3ccccc3F)c2cc1OC
Show InChI InChI=1S/C16H14FN3O2/c1-21-14-7-10-13(8-15(14)22-2)18-9-19-16(10)20-12-6-4-3-5-11(12)17/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 2.60E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4620
PNG
(Anilinoquinazoline deriv. 3 | N-(4-chlorophenyl)-6...)
Show SMILES COc1cc2ncnc(Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-10(17)4-6-11/h3-9H,1-2H3,(H,18,19,20)
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n/an/a 1.10E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4621
PNG
(Anilinoquinazoline deriv. 4 | CHEMBL150315 | N-(4-...)
Show SMILES COc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 2.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4622
PNG
(3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol | An...)
Show SMILES COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
Show InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
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n/an/a 200n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4623
PNG
(Anilinoquinazoline deriv. 6 | N-(2-fluoro-4-iodoph...)
Show SMILES COc1cc2ncnc(Nc3ccc(I)cc3F)c2cc1OC
Show InChI InChI=1S/C16H13FIN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(18)5-11(12)17/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 800n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4624
PNG
(Anilinoquinazoline deriv. 7 | N-(2-chloro-4-iodoph...)
Show SMILES COc1cc2ncnc(Nc3ccc(I)cc3Cl)c2cc1OC
Show InChI InChI=1S/C16H13ClIN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(18)5-11(12)17/h3-8H,1-2H3,(H,19,20,21)
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n/an/a>3.30E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4625
PNG
(Anilinoquinazoline deriv. 8 | N-(2,4-difluoropheny...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)cc3F)c2cc1OC
Show InChI InChI=1S/C16H13F2N3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-12-4-3-9(17)5-11(12)18/h3-8H,1-2H3,(H,19,20,21)
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n/an/a 2.20E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4626
PNG
(Anilinoquinazoline deriv. 9 | CHEMBL301018 | N-(3-...)
Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C16H13ClFN3O2/c1-22-14-6-10-13(7-15(14)23-2)19-8-20-16(10)21-9-3-4-12(18)11(17)5-9/h3-8H,1-2H3,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4627
PNG
(5-[(6,7-dimethoxyquinazolin-4-yl)amino]-4-fluoro-2...)
Show SMILES COc1cc2ncnc(Nc3cc(O)c(C)cc3F)c2cc1OC
Show InChI InChI=1S/C17H16FN3O3/c1-9-4-11(18)13(6-14(9)22)21-17-10-5-15(23-2)16(24-3)7-12(10)19-8-20-17/h4-8,22H,1-3H3,(H,19,20,21)
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n/an/a 30n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4628
PNG
(Anilinoquinazoline deriv. 11 | CHEMBL286160 | KDR ...)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C18H17ClFN3O3/c1-24-5-6-26-17-9-15-12(8-16(17)25-2)18(22-10-21-15)23-14-4-3-11(19)7-13(14)20/h3-4,7-10H,5-6H2,1-2H3,(H,21,22,23)
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n/an/a 400n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4629
PNG
(3-{[6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]a...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC
Show InChI InChI=1S/C18H19N3O4/c1-23-6-7-25-17-10-15-14(9-16(17)24-2)18(20-11-19-15)21-12-4-3-5-13(22)8-12/h3-5,8-11,22H,6-7H2,1-2H3,(H,19,20,21)
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n/an/a 30n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4630
PNG
(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Show SMILES COCCOc1cc2ncnc(Nc3cc(O)c(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C18H17ClFN3O4/c1-25-3-4-27-17-8-13-10(5-16(17)26-2)18(22-9-21-13)23-14-7-15(24)11(19)6-12(14)20/h5-9,24H,3-4H2,1-2H3,(H,21,22,23)
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n/an/a<2n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4631
PNG
(Anilinoquinazoline deriv. 14 | N-(4-chloro-2-fluor...)
Show SMILES COCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OCCOC
Show InChI InChI=1S/C20H21ClFN3O4/c1-26-5-7-28-18-10-14-17(11-19(18)29-8-6-27-2)23-12-24-20(14)25-16-4-3-13(21)9-15(16)22/h3-4,9-12H,5-8H2,1-2H3,(H,23,24,25)
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n/an/a 900n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4632
PNG
(Anilinoquinazoline deriv. 15 | N-(4-Chloro-2-fluor...)
Show SMILES COCCOc1ccc2c(Nc3ccc(Cl)cc3F)ncnc2c1
Show InChI InChI=1S/C17H15ClFN3O2/c1-23-6-7-24-12-3-4-13-16(9-12)20-10-21-17(13)22-15-5-2-11(18)8-14(15)19/h2-5,8-10H,6-7H2,1H3,(H,20,21,22)
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n/an/a 1.50E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4633
PNG
(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Show SMILES COCCOc1cc2nccc(Nc3cc(O)c(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C19H18ClFN2O4/c1-25-5-6-27-19-10-15-11(7-18(19)26-2)14(3-4-22-15)23-16-9-17(24)12(20)8-13(16)21/h3-4,7-10,24H,5-6H2,1-2H3,(H,22,23)
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n/an/a 3n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4634
PNG
(Anilinoquinoline deriv. 17 | N-(4-chloro-2-fluorop...)
Show SMILES COCCOc1cc2nccc(Nc3ccc(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C19H18ClFN2O3/c1-24-7-8-26-19-11-17-13(10-18(19)25-2)15(5-6-22-17)23-16-4-3-12(20)9-14(16)21/h3-6,9-11H,7-8H2,1-2H3,(H,22,23)
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n/an/a 300n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4635
PNG
(2-chloro-4-fluoro-5-{[6-methoxy-7-(2-methoxyethoxy...)
Show SMILES COCCOc1cc2nncc(Nc3cc(O)c(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C18H17ClFN3O4/c1-25-3-4-27-18-8-13-10(5-17(18)26-2)15(9-21-23-13)22-14-7-16(24)11(19)6-12(14)20/h5-9,24H,3-4H2,1-2H3,(H,22,23)
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n/an/a 50n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4636
PNG
(4-anilinocinnoline deriv. 19 | CHEMBL150825 | N-(4...)
Show SMILES COCCOc1cc2nncc(Nc3ccc(Cl)cc3F)c2cc1OC
Show InChI InChI=1S/C18H17ClFN3O3/c1-24-5-6-26-18-9-15-12(8-17(18)25-2)16(10-21-23-15)22-14-4-3-11(19)7-13(14)20/h3-4,7-10H,5-6H2,1-2H3,(H,22,23)
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n/an/a 6.30E+4n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 42: 5369-89 (1999)


Article DOI: 10.1021/jm990345w
BindingDB Entry DOI: 10.7270/Q2F47MBM
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM3085
PNG
(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Show SMILES Cn1c2nc(Nc3cccc(CO)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C21H16Cl2N4O2/c1-27-19-13(9-15(20(27)29)18-16(22)6-3-7-17(18)23)10-24-21(26-19)25-14-5-2-4-12(8-14)11-28/h2-10,28H,11H2,1H3,(H,24,25,26)
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n/an/a 139n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM4213
PNG
(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Show SMILES Cn1c2nc(Nc3ccc(cc3)N3CCOCC3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29)
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n/an/a 636n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6568
PNG
(6-(2,6-dichlorophenyl)-8-methyl-2-{[3-(methylsulfa...)
Show SMILES CSc1cccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)c1
Show InChI InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)
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n/an/a 1.66E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6569
PNG
(6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8...)
Show SMILES Cn1c2nc(Nc3ccc(F)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O
Show InChI InChI=1S/C20H13Cl2FN4O/c1-27-18-11(9-14(19(27)28)17-15(21)3-2-4-16(17)22)10-24-20(26-18)25-13-7-5-12(23)6-8-13/h2-10H,1H3,(H,24,25,26)
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n/an/a 1.25E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6570
PNG
(6-(2,6-dichlorophenyl)-2-[(4-ethoxyphenyl)amino]-8...)
Show SMILES CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
Show InChI InChI=1S/C22H18Cl2N4O2/c1-3-30-15-9-7-14(8-10-15)26-22-25-12-13-11-16(21(29)28(2)20(13)27-22)19-17(23)5-4-6-18(19)24/h4-12H,3H2,1-2H3,(H,25,26,27)
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n/an/a 2.34E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6571
PNG
(N-[2-(4-{[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7H...)
Show SMILES CCN(CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1)C(C)=O
Show InChI InChI=1S/C26H25Cl2N5O3/c1-4-33(16(2)34)12-13-36-19-10-8-18(9-11-19)30-26-29-15-17-14-20(25(35)32(3)24(17)31-26)23-21(27)6-5-7-22(23)28/h5-11,14-15H,4,12-13H2,1-3H3,(H,29,30,31)
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n/an/a 463n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6572
PNG
(6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl...)
Show SMILES Cc1cc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)ccc1F
Show InChI InChI=1S/C21H15Cl2FN4O/c1-11-8-13(6-7-17(11)24)26-21-25-10-12-9-14(20(29)28(2)19(12)27-21)18-15(22)4-3-5-16(18)23/h3-10H,1-2H3,(H,25,26,27)
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n/an/a 1.43E+3n/an/an/an/a7.425



Parke-Davis Pharmaceutical Research



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


Biochem Pharmacol 60: 885-98 (2000)


Article DOI: 10.1016/s0006-2952(00)00405-6
BindingDB Entry DOI: 10.7270/Q2MC8X7B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6573
PNG
((5-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-6-7-15-12(8-13)10-17(20-15)18(21)16-9-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 300n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6574
PNG
((6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-7-6-12-9-17(20-15(12)10-13)18(21)16-8-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 300n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6575
PNG
((7-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1cccc2cc([nH]c12)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-16-8-4-6-12-10-15(20-17(12)16)18(21)14-9-11-5-2-3-7-13(11)19-14/h2-10,19-20H,1H3
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n/an/a>3.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6576
PNG
(5-methoxy-2-[(5-methoxy-1H-indol-2-yl)carbonyl]-1H...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C19H16N2O3/c1-23-13-3-5-15-11(7-13)9-17(20-15)19(22)18-10-12-8-14(24-2)4-6-16(12)21-18/h3-10,20-21H,1-2H3
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n/an/a 2.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6577
PNG
((1H-2-Indolyl)(5-methyl-1H-2-indolyl)methanone | 2...)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O/c1-11-6-7-15-13(8-11)10-17(20-15)18(21)16-9-12-4-2-3-5-14(12)19-16/h2-10,19-20H,1H3
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n/an/a 7.50E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6578
PNG
((Benzo[b]thiophen-2-yl)(5-methoxy-1H-2-indolyl)-1-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C18H13NO2S/c1-21-13-6-7-14-12(8-13)9-15(19-14)18(20)17-10-11-4-2-3-5-16(11)22-17/h2-10,19H,1H3
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n/an/a 1.00E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6579
PNG
((Benzo[b]furan-2-yl)(5-methoxy-1H-2-indolyl)methan...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C18H13NO3/c1-21-13-6-7-14-12(8-13)9-15(19-14)18(20)17-10-11-4-2-3-5-16(11)22-17/h2-10,19H,1H3
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n/an/a 4.00E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM6580
PNG
(Bis(1H-2-indolyl)methanone 18 | bis(1-benzothiophe...)
Show SMILES O=C(c1cc2ccccc2s1)c1cc2ccccc2s1
Show InChI InChI=1S/C17H10OS2/c18-17(15-9-11-5-1-3-7-13(11)19-15)16-10-12-6-2-4-8-14(12)20-16/h1-10H
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n/an/a>3.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm010988n
BindingDB Entry DOI: 10.7270/Q2GM85H0
More data for this
Ligand-Target Pair
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