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Compile Data Set for Download or QSAR

Found 1601 hits Enz. Inhib. hit(s) with Target = 'Polo-Like Kinase 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM41575
PNG
(CHEMBL1094408 | US8614220, A85B1C1Z)
Show SMILES COc1ccc(cc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H19F3N4O4/c1-12-16(13(2)33-28-12)10-29-17-5-4-15(7-18(17)32-11-20(29)30)21(31)27-9-14-3-6-19(26-8-14)22(23,24)25/h3-8H,9-11H2,1-2H3,(H,27,31)
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US Patent
n/an/a 10n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8614220 (2013)


BindingDB Entry DOI: 10.7270/Q23J3BNV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM41576
PNG
(US8614220, A45B2C1Z)
Show SMILES NC(=O)c1nn(CCF)c-2c1CCc1cnc(Nc3ccccc3OC(F)(F)F)nc-21
Show InChI InChI=1S/C29H32F3N3O5/c1-34(18-19-14-23(38-2)26(40-4)24(15-19)39-3)27(36)20-8-9-25(33-17-20)35-12-10-28(37,11-13-35)21-6-5-7-22(16-21)29(30,31)32/h5-9,14-17,37H,10-13,18H2,1-4H3
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n/an/a 26n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8614220 (2013)


BindingDB Entry DOI: 10.7270/Q23J3BNV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM41579
PNG
(US8614220, A47B1C1Z)
Show SMILES COc1ccc(CO)cc1Nc1ncc2CCc3c(nn(C)c3-c2n1)C(N)=O
Show InChI InChI=1S/C20H20IN3O4/c1-26-17-8-14(9-18(27-2)19(17)28-3)20(25)23-16-10-22-24(12-16)11-13-5-4-6-15(21)7-13/h4-10,12H,11H2,1-3H3,(H,23,25)
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n/an/a 7n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8614220 (2013)


BindingDB Entry DOI: 10.7270/Q23J3BNV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM41578
PNG
(US8614220, A101B1C1Z)
Show SMILES CN(C)CCCN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1
Show InChI InChI=1S/C26H29N3O4/c1-28(16-18-13-22(31-2)25(33-4)23(14-18)32-3)26(30)20-9-10-24(27-15-20)29-12-11-19-7-5-6-8-21(19)17-29/h5-10,13-15H,11-12,16-17H2,1-4H3
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n/an/a 46n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8614220 (2013)


BindingDB Entry DOI: 10.7270/Q23J3BNV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM41577
PNG
(US8614220, A98B1C3Z)
Show SMILES CN1CCN(CC1)c1ccc(C)c(Nc2ncc3CCc4c(nn(C)c4-c3n2)C([O-])=O)c1
Show InChI InChI=1S/C29H35N3O5/c1-31(20-22-16-24(35-2)27(37-4)25(17-22)36-3)28(33)23-10-11-26(30-19-23)32-14-12-29(34,13-15-32)18-21-8-6-5-7-9-21/h5-11,16-17,19,34H,12-15,18,20H2,1-4H3
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n/an/a 5n/an/an/an/a3.0n/a



Nerviano Medical Sciences S.r.l.

US Patent


Assay Description
The inhibitory activity of putative kinase inhibitors and the potency of selected compounds were determined using a trans-phosphorylation assay.Speci...


US Patent US8614220 (2013)


BindingDB Entry DOI: 10.7270/Q23J3BNV
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24937
PNG
(2-amino-isoxazolopyridine, 19 | N-[(1S)-1-phenylet...)
Show SMILES C[C@H](Nc1cc2c(noc2cn1)-c1cccs1)c1ccccc1
Show InChI InChI=1S/C18H15N3OS/c1-12(13-6-3-2-4-7-13)20-17-10-14-15(11-19-17)22-21-18(14)16-8-5-9-23-16/h2-12H,1H3,(H,19,20)/t12-/m0/s1
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n/an/a 3.01E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24938
PNG
(2-amino-isoxazolopyridine, 20 | 3-(4-methylthiophe...)
Show SMILES C[C@H](Nc1cc2c(noc2cn1)-c1cscc1C)c1ccccc1
Show InChI InChI=1S/C19H17N3OS/c1-12-10-24-11-16(12)19-15-8-18(20-9-17(15)23-22-19)21-13(2)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,20,21)/t13-/m0/s1
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n/an/a 779n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24939
PNG
(2-amino-isoxazolopyridine, 21 | 3-(2-methylcyclohe...)
Show SMILES C[C@H](Nc1cc2c(noc2cn1)C1CCCCC1C)c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-14-8-6-7-11-17(14)21-18-12-20(22-13-19(18)25-24-21)23-15(2)16-9-4-3-5-10-16/h3-5,9-10,12-15,17H,6-8,11H2,1-2H3,(H,22,23)/t14?,15-,17?/m0/s1
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n/an/a 5.69E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24940
PNG
(2-amino-isoxazolopyridine, 23 | 3-[3-(5-{[(1S)-1-p...)
Show SMILES C[C@H](Nc1cc2c(noc2cn1)C1CCCN(CCC(N)=O)C1)c1ccccc1
Show InChI InChI=1S/C22H27N5O2/c1-15(16-6-3-2-4-7-16)25-21-12-18-19(13-24-21)29-26-22(18)17-8-5-10-27(14-17)11-9-20(23)28/h2-4,6-7,12-13,15,17H,5,8-11,14H2,1H3,(H2,23,28)(H,24,25)/t15-,17?/m0/s1
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n/an/a 7.48E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5186-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.091
BindingDB Entry DOI: 10.7270/Q22Z13T8
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24925
PNG
(3-methyl-1-phenyl-N-[(1S)-1-phenylethyl]-1H-pyrazo...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20N4/c1-15(17-9-5-3-6-10-17)23-21-13-20-19(14-22-21)16(2)24-25(20)18-11-7-4-8-12-18/h3-15H,1-2H3,(H,22,23)/t15-/m0/s1
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n/an/a 1.30E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25501
PNG
(2-amino-pyrazolopyridine, 6 | 3-methyl-1-(2-methyl...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1C)c1ccccc1
Show InChI InChI=1S/C22H22N4/c1-15-9-7-8-12-20(15)26-21-13-22(23-14-19(21)17(3)25-26)24-16(2)18-10-5-4-6-11-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1
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n/an/a 7.69E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25502
PNG
(2-amino-pyrazolopyridine, 7 | 3-methyl-1-(3-methyl...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(C)c1)c1ccccc1
Show InChI InChI=1S/C22H22N4/c1-15-8-7-11-19(12-15)26-21-13-22(23-14-20(21)17(3)25-26)24-16(2)18-9-5-4-6-10-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1
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n/an/a 474n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25503
PNG
(2-amino-pyrazolopyridine, 8 | 3-methyl-1-(4-methyl...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccc(C)cc1)c1ccccc1
Show InChI InChI=1S/C22H22N4/c1-15-9-11-19(12-10-15)26-21-13-22(23-14-20(21)17(3)25-26)24-16(2)18-7-5-4-6-8-18/h4-14,16H,1-3H3,(H,23,24)/t16-/m0/s1
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n/an/a 4.53E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25504
PNG
(1-(2-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl...)
Show SMILES COc1ccccc1-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C22H22N4O/c1-15(17-9-5-4-6-10-17)24-22-13-20-18(14-23-22)16(2)25-26(20)19-11-7-8-12-21(19)27-3/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 1.45E+4n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25505
PNG
(1-(3-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl...)
Show SMILES COc1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C22H22N4O/c1-15(17-8-5-4-6-9-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-10-7-11-19(12-18)27-3/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 5.93E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25506
PNG
(1-(4-methoxyphenyl)-3-methyl-N-[(1S)-1-phenylethyl...)
Show SMILES COc1ccc(cc1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C22H22N4O/c1-15(17-7-5-4-6-8-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-9-11-19(27-3)12-10-18/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 703n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25507
PNG
(1-(2-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccccc1F)c1ccccc1
Show InChI InChI=1S/C21H19FN4/c1-14(16-8-4-3-5-9-16)24-21-12-20-17(13-23-21)15(2)25-26(20)19-11-7-6-10-18(19)22/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 4.52E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25508
PNG
(1-(3-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(F)c1)c1ccccc1
Show InChI InChI=1S/C21H19FN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 464n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25509
PNG
(1-(4-fluorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1ccc(F)cc1)c1ccccc1
Show InChI InChI=1S/C21H19FN4/c1-14(16-6-4-3-5-7-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-8-17(22)9-11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 3.24E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM24926
PNG
(1-(3-chlorophenyl)-3-methyl-N-[(1S)-1-phenylethyl]...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H19ClN4/c1-14(16-7-4-3-5-8-16)24-21-12-20-19(13-23-21)15(2)25-26(20)18-10-6-9-17(22)11-18/h3-14H,1-2H3,(H,23,24)/t14-/m0/s1
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n/an/a 121n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25510
PNG
(2-amino-pyrazolopyridine, 16 | 3-methyl-N-[(1S)-1-...)
Show SMILES CC(C)c1cccc(c1)-n1nc(C)c2cnc(N[C@@H](C)c3ccccc3)cc12
Show InChI InChI=1S/C24H26N4/c1-16(2)20-11-8-12-21(13-20)28-23-14-24(25-15-22(23)18(4)27-28)26-17(3)19-9-6-5-7-10-19/h5-17H,1-4H3,(H,25,26)/t17-/m0/s1
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n/an/a 1.48E+3n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25511
PNG
(2-amino-pyrazolopyridine, 17 | 3-(3-methyl-6-{[(1S...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)C#N)c1ccccc1
Show InChI InChI=1S/C22H19N5/c1-15(18-8-4-3-5-9-18)25-22-12-21-20(14-24-22)16(2)26-27(21)19-10-6-7-17(11-19)13-23/h3-12,14-15H,1-2H3,(H,24,25)/t15-/m0/s1
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n/an/a 412n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25512
PNG
(1-[3-(dimethylamino)phenyl]-3-methyl-N-[(1S)-1-phe...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)N(C)C)c1ccccc1
Show InChI InChI=1S/C23H25N5/c1-16(18-9-6-5-7-10-18)25-23-14-22-21(15-24-23)17(2)26-28(22)20-12-8-11-19(13-20)27(3)4/h5-16H,1-4H3,(H,24,25)/t16-/m0/s1
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n/an/a 977n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25513
PNG
(1-(3-methanesulfonylphenyl)-3-methyl-N-[(1S)-1-phe...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cccc(c1)S(C)(=O)=O)c1ccccc1
Show InChI InChI=1S/C22H22N4O2S/c1-15(17-8-5-4-6-9-17)24-22-13-21-20(14-23-22)16(2)25-26(21)18-10-7-11-19(12-18)29(3,27)28/h4-15H,1-3H3,(H,23,24)/t15-/m0/s1
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n/an/a 225n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25514
PNG
(1-(3,5-dimethylphenyl)-3-methyl-N-[(1S)-1-phenylet...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(C)cc(C)c1)c1ccccc1
Show InChI InChI=1S/C23H24N4/c1-15-10-16(2)12-20(11-15)27-22-13-23(24-14-21(22)18(4)26-27)25-17(3)19-8-6-5-7-9-19/h5-14,17H,1-4H3,(H,24,25)/t17-/m0/s1
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n/an/a 149n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25515
PNG
(1-(3,5-dichlorophenyl)-3-methyl-N-[(1S)-1-phenylet...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H18Cl2N4/c1-13(15-6-4-3-5-7-15)25-21-11-20-19(12-24-21)14(2)26-27(20)18-9-16(22)8-17(23)10-18/h3-13H,1-2H3,(H,24,25)/t13-/m0/s1
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n/an/a 641n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25516
PNG
(1-(3-bromo-5-chlorophenyl)-3-methyl-N-[(1S)-1-phen...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(Br)c1)c1ccccc1
Show InChI InChI=1S/C21H18BrClN4/c1-13(15-6-4-3-5-7-15)25-21-11-20-19(12-24-21)14(2)26-27(20)18-9-16(22)8-17(23)10-18/h3-13H,1-2H3,(H,24,25)/t13-/m0/s1
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n/an/a 274n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25517
PNG
(2-amino-pyrazolopyridine, 28 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(O)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H23ClN4O2/c1-15(18-6-4-3-5-7-18)27-23-13-22-21(14-26-23)16(2)28-29(22)20-11-17(8-9-24(30)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H,26,27)(H,30,31)/t15-/m0/s1
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n/an/a 21n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25518
PNG
(2-amino-pyrazolopyridine, 29 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(N)=O)c1)c1ccccc1
Show InChI InChI=1S/C24H24ClN5O/c1-15(18-6-4-3-5-7-18)28-24-13-22-21(14-27-24)16(2)29-30(22)20-11-17(8-9-23(26)31)10-19(25)12-20/h3-7,10-15H,8-9H2,1-2H3,(H2,26,31)(H,27,28)/t15-/m0/s1
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n/an/a 32n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25519
PNG
(2-amino-pyrazolopyridine, 30 | 3-[3-chloro-5-(3-me...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCC(=O)NCCO)c1)c1ccccc1
Show InChI InChI=1S/C26H28ClN5O2/c1-17(20-6-4-3-5-7-20)30-25-15-24-23(16-29-25)18(2)31-32(24)22-13-19(12-21(27)14-22)8-9-26(34)28-10-11-33/h3-7,12-17,33H,8-11H2,1-2H3,(H,28,34)(H,29,30)/t17-/m0/s1
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n/an/a 48n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25520
PNG
(1-[3-(3-aminopropyl)-5-chlorophenyl]-3-methyl-N-[(...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(CCCN)c1)c1ccccc1
Show InChI InChI=1S/C24H26ClN5/c1-16(19-8-4-3-5-9-19)28-24-14-23-22(15-27-24)17(2)29-30(23)21-12-18(7-6-10-26)11-20(25)13-21/h3-5,8-9,11-16H,6-7,10,26H2,1-2H3,(H,27,28)/t16-/m0/s1
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n/an/a 59n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25521
PNG
(2-amino-pyrazolopyridine, 37 | N-{2-[3-chloro-5-(3...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1NC(C)=O)c1ccccc1
Show InChI InChI=1S/C29H26ClN5O/c1-18(21-9-5-4-6-10-21)32-29-16-28-26(17-31-29)19(2)34-35(28)24-14-22(13-23(30)15-24)25-11-7-8-12-27(25)33-20(3)36/h4-18H,1-3H3,(H,31,32)(H,33,36)/t18-/m0/s1
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n/an/a 207n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25522
PNG
(2-[3-chloro-5-(3-methyl-6-{[(1S)-1-phenylethyl]ami...)
Show SMILES C[C@H](Nc1cc2n(nc(C)c2cn1)-c1cc(Cl)cc(c1)-c1ccccc1C(N)=O)c1ccccc1
Show InChI InChI=1S/C28H24ClN5O/c1-17(19-8-4-3-5-9-19)32-27-15-26-25(16-31-27)18(2)33-34(26)22-13-20(12-21(29)14-22)23-10-6-7-11-24(23)28(30)35/h3-17H,1-2H3,(H2,30,35)(H,31,32)/t17-/m0/s1
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n/an/a 42n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM25523
PNG
(2-[3-chloro-5-(6-{[(1S)-1-phenylethyl]amino}-1H-py...)
Show SMILES C[C@H](Nc1cc2n(ncc2cn1)-c1cc(Cl)cc(c1)-c1ccccc1C(N)=O)c1ccccc1
Show InChI InChI=1S/C27H22ClN5O/c1-17(18-7-3-2-4-8-18)32-26-14-25-20(15-30-26)16-31-33(25)22-12-19(11-21(28)13-22)23-9-5-6-10-24(23)27(29)34/h2-17H,1H3,(H2,29,34)(H,30,32)/t17-/m0/s1
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n/an/a 50n/an/an/an/a7.230



Sunesis Pharmaceuticals



Assay Description
An IMAP fluorescence polarization-based assay format (Molecular Devices) was used to determine the ability of compounds to inhibit the phosphorylatio...


Bioorg Med Chem Lett 18: 5648-52 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.095
BindingDB Entry DOI: 10.7270/Q29C6VRP
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27444
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C22H21N3O6S2/c1-29-17-8-15-16(9-18(17)30-2)25(12-24-15)20-10-19(21(32-20)22(23)26)31-11-13-4-6-14(7-5-13)33(3,27)28/h4-10,12H,11H2,1-3H3,(H2,23,26)
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n/an/a 126n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27445
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccc(cc4)S(C)(=O)=O)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C22H19N3O5S2/c1-28-18-8-16-17(9-19(18)29-2)25(13-24-16)22-10-20(21(11-23)31-22)30-12-14-4-6-15(7-5-14)32(3,26)27/h4-10,13H,12H2,1-3H3
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n/an/a 631n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27446
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)
Show SMILES COc1cc2ncn(-c3cc(OCC4CCCO4)c(s3)C(N)=O)c2cc1OC
Show InChI InChI=1S/C19H21N3O5S/c1-24-14-6-12-13(7-15(14)25-2)22(10-21-12)17-8-16(18(28-17)19(20)23)27-9-11-4-3-5-26-11/h6-8,10-11H,3-5,9H2,1-2H3,(H2,20,23)
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n/an/a 251n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27447
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)
Show SMILES COc1cc2ncn(-c3cc(OCC4CCCO4)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C19H19N3O4S/c1-23-15-6-13-14(7-16(15)24-2)22(11-21-13)19-8-17(18(9-20)27-19)26-10-12-4-3-5-25-12/h6-8,11-12H,3-5,10H2,1-2H3
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PubMed
n/an/a>1.00E+4n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27452
PNG
(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-me...)
Show SMILES COc1cc2ncn(-c3cc(OCc4ccccc4S(C)(=O)=O)c(s3)C#N)c2cc1OC
Show InChI InChI=1S/C22H19N3O5S2/c1-28-17-8-15-16(9-18(17)29-2)25(13-24-15)22-10-19(20(11-23)31-22)30-12-14-6-4-5-7-21(14)32(3,26)27/h4-10,13H,12H2,1-3H3
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Article
PubMed
n/an/a 794n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27443
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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Article
PubMed
n/an/a 126n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...


Bioorg Med Chem Lett 16: 6236-40 (2006)


Article DOI: 10.1016/j.bmcl.2006.09.018
BindingDB Entry DOI: 10.7270/Q2VQ311M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28156
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-(benzyloxy)thiophene...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H15N3O2S/c20-19(23)18-16(24-11-13-6-2-1-3-7-13)10-17(25-18)22-12-21-14-8-4-5-9-15(14)22/h1-10,12H,11H2,(H2,20,23)
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PubMed
n/an/a 61n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28157
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methylphenyl)met...)
Show SMILES Cc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-2-3-7-14(13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-8-4-5-9-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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PubMed
n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28158
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methylphenyl)met...)
Show SMILES Cc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1
Show InChI InChI=1S/C20H17N3O2S/c1-13-5-4-6-14(9-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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Article
PubMed
n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM27443
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)
Show SMILES Cc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O2S/c1-13-6-8-14(9-7-13)11-25-17-10-18(26-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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PubMed
n/an/a 70n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28159
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-methoxyphenyl)me...)
Show SMILES COc1ccccc1COc1cc(sc1C(N)=O)-n1cnc2ccccc12
Show InChI InChI=1S/C20H17N3O3S/c1-25-16-9-5-2-6-13(16)11-26-17-10-18(27-19(17)20(21)24)23-12-22-14-7-3-4-8-15(14)23/h2-10,12H,11H2,1H3,(H2,21,24)
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PubMed
n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28160
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-methoxyphenyl)me...)
Show SMILES COc1cccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)c1
Show InChI InChI=1S/C20H17N3O3S/c1-25-14-6-4-5-13(9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-7-2-3-8-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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PubMed
n/an/a 28n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28161
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methoxyphenyl)me...)
Show SMILES COc1ccc(COc2cc(sc2C(N)=O)-n2cnc3ccccc23)cc1
Show InChI InChI=1S/C20H17N3O3S/c1-25-14-8-6-13(7-9-14)11-26-17-10-18(27-19(17)20(21)24)23-12-22-15-4-2-3-5-16(15)23/h2-10,12H,11H2,1H3,(H2,21,24)
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PubMed
n/an/a 35n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28162
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Cl)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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PubMed
n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28163
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(3-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1cccc(Cl)c1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-5-3-4-12(8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-6-1-2-7-15(14)23/h1-9,11H,10H2,(H2,21,24)
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PubMed
n/an/a 22n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (human))
BDBM28164
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccc(Cl)cc1)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-7-5-12(6-8-13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-3-1-2-4-15(14)23/h1-9,11H,10H2,(H2,21,24)
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Article
PubMed
n/an/a 100n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
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