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Compile Data Set for Download or QSAR

Found 533 hits Enz. Inhib. hit(s) with Target = 'Protein kinase C (PKC)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36604
PNG
(5'-Deoxybalanol, 7)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccccc1
Show InChI InChI=1S/C28H26N2O9/c31-19-9-4-8-17(27(36)37)23(19)25(34)24-20(32)12-16(13-21(24)33)28(38)39-22-10-5-11-29-14-18(22)30-26(35)15-6-2-1-3-7-15/h1-4,6-9,12-13,18,22,29,31-33H,5,10-11,14H2,(H,30,35)(H,36,37)/t18-,22-/m1/s1
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PubMed
69 -41.6 95n/an/an/an/a7.530



University of California, San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1124/jpet.103.062794
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36603
PNG
(4'',6''-Dideoxybalanol, 6)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1ccc(cc1)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O8/c31-19-12-10-17(11-13-19)26(34)30-21-15-29-14-2-5-23(21)38-28(37)18-8-6-16(7-9-18)25(33)24-20(27(35)36)3-1-4-22(24)32/h1,3-4,6-13,21,23,29,31-32H,2,5,14-15H2,(H,30,34)(H,35,36)/t21-,23-/m1/s1
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PubMed
80 -41.2 111n/an/an/an/a7.530



University of California, San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1124/jpet.103.062794
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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640 -35.9 834n/an/an/an/a7.530



University of California, San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1124/jpet.103.062794
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM36600
PNG
(Benzophenone fragment, 2)
Show SMILES COC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1
Show InChI InChI=1S/C16H12O8/c1-24-16(23)7-5-10(18)13(11(19)6-7)14(20)12-8(15(21)22)3-2-4-9(12)17/h2-6,17-19H,1H3,(H,21,22)
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PubMed
>1.00E+6>-17.4n/an/an/an/an/a7.530



University of California, San Diego



Assay Description
Protein kinase C (PKC) enzyme inhibition assay using purified rat brain protein kinase C from Calbiochem #539494.


Chem Biol 2: 601-8 (1995)


Article DOI: 10.1124/jpet.103.062794
BindingDB Entry DOI: 10.7270/Q2HQ3X8D
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2583
PNG
(3,4-Bis(3-indolyl)-1H-pyrrole-2,5-dione | 3,4-bis(...)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H13N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H,(H,23,24,25)
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n/an/a 550n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2584
PNG
((3R,4R)-3,4-bis(1H-indol-3-yl)pyrrolidine-2,5-dion...)
Show SMILES O=C1NC(=O)[C@H]([C@@H]1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,17-18,21-22H,(H,23,24,25)/t17-,18-/m0/s1
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2585
PNG
((3R,4S)-3,4-bis(1H-indol-3-yl)pyrrolidine-2,5-dion...)
Show SMILES O=C1NC(=O)[C@@H]([C@@H]1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,17-18,21-22H,(H,23,24,25)/t17-,18+
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2586
PNG
(3,4-Bis(3-indolyl)-3-pyrrolin-2-one | 3,4-bis(1H-i...)
Show SMILES O=C1NCC(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O/c24-20-19(15-10-22-18-8-4-2-6-13(15)18)16(11-23-20)14-9-21-17-7-3-1-5-12(14)17/h1-10,21-22H,11H2,(H,23,24)
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n/an/a 1.03E+4n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2587
PNG
(5-Hydroxy-3,4-Bis(3-indolyl)-3-pyrrolin-2-one | 5-...)
Show SMILES OC1NC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H15N3O2/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,19,21-22,24H,(H,23,25)
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n/an/a 5.10E+4n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2588
PNG
(3,4-bis(1H-indol-3-yl)-2,5-dihydrofuran-2,5-dione ...)
Show SMILES O=C1OC(=O)C(=C1c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H12N2O3/c23-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(24)25-19)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22H
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Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2589
PNG
(1-Hydroxy-3,4-bis(3-indolyl)-2,5-pyrroledione | 1-...)
Show SMILES ON1C(=O)C(=C(C1=O)c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C20H13N3O3/c24-19-17(13-9-21-15-7-3-1-5-11(13)15)18(20(25)23(19)26)14-10-22-16-8-4-2-6-12(14)16/h1-10,21-22,26H
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n/an/a 2.89E+4n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2590
PNG
((Arylindolyl)maleimide deriv. 12 | 3-(1H-indol-3-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H15N3O2/c1-24-11-15(13-7-3-5-9-17(13)24)19-18(20(25)23-21(19)26)14-10-22-16-8-4-2-6-12(14)16/h2-11,22H,1H3,(H,23,25,26)
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n/an/a 220n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2591
PNG
((Arylindolyl)maleimide deriv. 13 | 3,4-bis(1-methy...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H17N3O2/c1-24-11-15(13-7-3-5-9-17(13)24)19-20(22(27)23-21(19)26)16-12-25(2)18-10-6-4-8-14(16)18/h3-12H,1-2H3,(H,23,26,27)
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n/an/a 300n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2592
PNG
((Arylindolyl)maleimide deriv. 14 | 3-(1-benzyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(Cc3ccccc3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C28H21N3O2/c1-30-16-21(19-11-5-7-13-23(19)30)25-26(28(33)29-27(25)32)22-17-31(15-18-9-3-2-4-10-18)24-14-8-6-12-20(22)24/h2-14,16-17H,15H2,1H3,(H,29,32,33)
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n/an/a 1.20E+3n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2593
PNG
((Arylindolyl)maleimide deriv. 15 | 3-(1-methyl-1H-...)
Show SMILES CCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H21N3O2/c1-3-12-27-14-18(16-9-5-7-11-20(16)27)22-21(23(28)25-24(22)29)17-13-26(2)19-10-6-4-8-15(17)19/h4-11,13-14H,3,12H2,1-2H3,(H,25,28,29)
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n/an/a 480n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2594
PNG
((Arylindolyl)maleimide deriv. 16 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(-c3ccccc3)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H19N3O2/c1-29-15-20(18-11-5-7-13-22(18)29)24-25(27(32)28-26(24)31)21-16-30(17-9-3-2-4-10-17)23-14-8-6-12-19(21)23/h2-16H,1H3,(H,28,31,32)
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n/an/a 360n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2595
PNG
((Arylindolyl)maleimide deriv. 17 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cc3ccccc3n2C)c2ccccc12
Show InChI InChI=1S/C22H17N3O2/c1-24-12-15(14-8-4-6-10-17(14)24)19-20(22(27)23-21(19)26)18-11-13-7-3-5-9-16(13)25(18)2/h3-12H,1-2H3,(H,23,26,27)
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n/an/a>1.00E+5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2596
PNG
((Arylindolyl)maleimide deriv. 18 | 3-(1H-indol-1-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)n2ccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C21H15N3O2/c1-23-12-15(14-7-3-5-9-17(14)23)18-19(21(26)22-20(18)25)24-11-10-13-6-2-4-8-16(13)24/h2-12H,1H3,(H,22,25,26)
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n/an/a 3.00E+3n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2597
PNG
((Arylindolyl)maleimide deriv. 19 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(16-10-4-5-12-19(16)25)21-20(22(26)24-23(21)27)17-11-6-8-14-7-2-3-9-15(14)17/h2-13H,1H3,(H,24,26,27)
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n/an/a 810n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2598
PNG
((Arylindolyl)maleimide deriv. 20 | 3-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc3ccccc3c2)c2ccccc12
Show InChI InChI=1S/C23H16N2O2/c1-25-13-18(17-8-4-5-9-19(17)25)21-20(22(26)24-23(21)27)16-11-10-14-6-2-3-7-15(14)12-16/h2-13H,1H3,(H,24,26,27)
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n/an/a 2.80E+3n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 177-84 (1992)


Article DOI: 10.1021/jm00079a024
BindingDB Entry DOI: 10.7270/Q2K64G8V
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 9n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
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n/an/a 75n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2696
PNG
(3-{1H,2H,3H-benzo[b]pyrrolizin-9-yl}-4-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H19N3O2/c1-26-13-16(14-7-2-4-9-17(14)26)21-22(24(29)25-23(21)28)20-15-8-3-5-10-18(15)27-12-6-11-19(20)27/h2-5,7-10,13H,6,11-12H2,1H3,(H,25,28,29)
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n/an/a 210n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2697
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{1H,2H,3H,4H-pyrido[1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H21N3O2/c1-27-14-17(15-8-2-4-10-18(15)27)22-23(25(30)26-24(22)29)21-16-9-3-5-11-19(16)28-13-7-6-12-20(21)28/h2-5,8-11,14H,6-7,12-13H2,1H3,(H,26,29,30)
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n/an/a 155n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2698
PNG
(3-{6H,7H,8H,9H,10H-azepino[1,2-a]indol-11-yl}-4-(1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCCCCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H23N3O2/c1-28-15-18(16-9-4-6-11-19(16)28)23-24(26(31)27-25(23)30)22-17-10-5-7-12-20(17)29-14-8-2-3-13-21(22)29/h4-7,9-12,15H,2-3,8,13-14H2,1H3,(H,27,30,31)
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n/an/a 450n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2699
PNG
(3-[2-(aminomethyl)-1H,2H,3H-benzo[b]pyrrolizin-9-y...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H22N4O2/c1-28-13-17(15-6-2-4-8-18(15)28)22-23(25(31)27-24(22)30)21-16-7-3-5-9-19(16)29-12-14(11-26)10-20(21)29/h2-9,13-14H,10-12,26H2,1H3,(H,27,30,31)
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n/an/a 14n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2700
PNG
(3-[2-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 7.60n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2701
PNG
(3-[2-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CC(CCN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-11-16(10-12-28)14-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 47n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2702
PNG
(3-[3-(aminomethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H24N4O2/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-13-15(12-27)10-11-21(22)30/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32)
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n/an/a 15n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2703
PNG
(3-[3-(2-aminoethyl)-1H,2H,3H,4H-pyrido[1,2-a]indol...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CCN)Cn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-14-16(12-13-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 23n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2704
PNG
(3-[8-(aminomethyl)-6H,7H,8H,9H,10H-azepino[1,2-a]i...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2c3CCC(CN)CCn3c3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H26N4O2/c1-30-15-19(17-6-2-4-8-20(17)30)24-25(27(33)29-26(24)32)23-18-7-3-5-9-21(18)31-13-12-16(14-28)10-11-22(23)31/h2-9,15-16H,10-14,28H2,1H3,(H,29,32,33)
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n/an/a 16.5n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 36: 21-9 (1993)


Article DOI: 10.1021/jm00053a003
BindingDB Entry DOI: 10.7270/Q29P2ZTD
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3163
PNG
(3-[1-(2-hydroxyethyl)-1H-indol-3-yl]-4-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCO)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H19N3O3/c1-25-12-16(14-6-2-4-8-18(14)25)20-21(23(29)24-22(20)28)17-13-26(10-11-27)19-9-5-3-7-15(17)19/h2-9,12-13,27H,10-11H2,1H3,(H,24,28,29)
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n/an/a 340n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3164
PNG
(3-[1-(3-Hydroxypropyl)-3-indolyl]-4-(1-methyl-3-in...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCO)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H21N3O3/c1-26-13-17(15-7-2-4-9-19(15)26)21-22(24(30)25-23(21)29)18-14-27(11-6-12-28)20-10-5-3-8-16(18)20/h2-5,7-10,13-14,28H,6,11-12H2,1H3,(H,25,29,30)
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n/an/a 130n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3165
PNG
(3-[1-(4-hydroxybutyl)-1H-indol-3-yl]-4-(1-methyl-1...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCO)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H23N3O3/c1-27-14-18(16-8-2-4-10-20(16)27)22-23(25(31)26-24(22)30)19-15-28(12-6-7-13-29)21-11-5-3-9-17(19)21/h2-5,8-11,14-15,29H,6-7,12-13H2,1H3,(H,26,30,31)
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n/an/a 170n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3166
PNG
(3-[1-(5-hydroxypentyl)-1H-indol-3-yl]-4-(1-methyl-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCCO)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H25N3O3/c1-28-15-19(17-9-3-5-11-21(17)28)23-24(26(32)27-25(23)31)20-16-29(13-7-2-8-14-30)22-12-6-4-10-18(20)22/h3-6,9-12,15-16,30H,2,7-8,13-14H2,1H3,(H,27,31,32)
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n/an/a 280n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3167
PNG
(3-[1-(2-aminoethyl)-1H-indol-3-yl]-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20N4O2/c1-26-12-16(14-6-2-4-8-18(14)26)20-21(23(29)25-22(20)28)17-13-27(11-10-24)19-9-5-3-7-15(17)19/h2-9,12-13H,10-11,24H2,1H3,(H,25,28,29)
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n/an/a 64n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM2695
PNG
(3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H22N4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30)
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n/an/a 75n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3169
PNG
(3-[1-(4-aminobutyl)-1H-indol-3-yl]-4-(1-methyl-1H-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28-14-18(16-8-2-4-10-20(16)28)22-23(25(31)27-24(22)30)19-15-29(13-7-6-12-26)21-11-5-3-9-17(19)21/h2-5,8-11,14-15H,6-7,12-13,26H2,1H3,(H,27,30,31)
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n/an/a 55n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3170
PNG
(3-[1-(5-aminopentyl)-1H-indol-3-yl]-4-(1-methyl-1H...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCCCN)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C26H26N4O2/c1-29-15-19(17-9-3-5-11-21(17)29)23-24(26(32)28-25(23)31)20-16-30(14-8-2-7-13-27)22-12-6-4-10-18(20)22/h3-6,9-12,15-16H,2,7-8,13-14,27H2,1H3,(H,28,31,32)
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n/an/a 76n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM3171
PNG
(3-(1-methyl-1H-indol-3-yl)-4-{1-[3-(methylamino)pr...)
Show SMILES CNCCCn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-26-12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-28(2)20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
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n/an/a 35n/an/an/an/a7.530



Roche Products Limited



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


J Med Chem 35: 994-1001 (1992)


Article DOI: 10.1021/jm00084a004
BindingDB Entry DOI: 10.7270/Q2M043KK
More data for this
Ligand-Target Pair
Protein Kinase C


(Rattus norvegicus (rat))
BDBM7781
PNG
(4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione ...)
Show SMILES Cn1sc(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
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n/an/a>1.00E+5n/an/an/an/a7.537



Instituto de Quimica Medica (CSIC)



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 37 °C in the presence of 10 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 45: 1292-9 (2002)


Article DOI: 10.1021/jm011020u
BindingDB Entry DOI: 10.7270/Q2P26WB1
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92968
PNG
(Amphiphile, III)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)NCC[NH+](C)C
Show InChI InChI=1S/C32H56N2O/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-25-21-24(30(35)33-19-20-34(6)7)15-17-31(25,4)29(26)16-18-32(27,28)5/h11,22-24,26-29H,8-10,12-21H2,1-7H3,(H,33,35)/p+1
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n/an/a 2.58E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92969
PNG
(Amphiphile, IV)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)NCC[N+](C)(C)C
Show InChI InChI=1S/C32H60N2O/c1-23(2)10-9-11-24(3)27-16-21-36-29-13-12-26-22-25(30(35)33-19-20-34(6,7)8)14-17-31(26,4)28(29)15-18-32(27,36)5/h12,23-25,27-29,34H,9-11,13-22H2,1-8H3,(H,33,35)/q+1
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n/an/a 1.20E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92970
PNG
(Amphiphile, V)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)OC(C[NH+](C)C)C[NH+](C)C
Show InChI InChI=1S/C35H62N2O2/c1-24(2)11-10-12-25(3)30-15-16-31-29-14-13-27-21-26(33(38)39-28(22-36(6)7)23-37(8)9)17-19-34(27,4)32(29)18-20-35(30,31)5/h13,24-26,28-32H,10-12,14-23H2,1-9H3/p+2
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n/an/a 6.43E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92971
PNG
(Amphiphile, VI)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)OC(C[NH+](C)C)C[N+](C)(C)C
Show InChI InChI=1S/C36H65N2O2/c1-25(2)12-11-13-26(3)31-16-17-32-30-15-14-28-22-27(18-20-35(28,4)33(30)19-21-36(31,32)5)34(39)40-29(23-37(6)7)24-38(8,9)10/h14,25-27,29-33H,11-13,15-24H2,1-10H3/q+1/p+1
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n/an/a 1.10E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92972
PNG
(Amphiphile, VII)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)NCC[NH3+]
Show InChI InChI=1S/C30H52N2O/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-23-19-22(28(33)32-18-17-31)13-15-29(23,4)27(24)14-16-30(25,26)5/h9,20-22,24-27H,6-8,10-19,31H2,1-5H3,(H,32,33)/p+1
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n/an/a 2.46E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92973
PNG
(Amphiphile, VIII)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)NCC[NH+](C)C
Show InChI InChI=1S/C32H56N4O4/c1-22(2)8-7-9-27(33)25-14-18-36-30-26(13-16-32(25,36)4)31(3)15-12-24(20-23(31)21-39-30)40-29(38)11-10-28(37)34-17-19-35(5)6/h21-22,24-27,30H,7-20,33H2,1-6H3,(H,34,37)/p+1
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n/an/a 1.91E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92974
PNG
(Amphiphile, IX)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)NCC[N+](C)(C)C
Show InChI InChI=1S/C33H58N4O4/c1-23(2)9-8-10-28(34)26-15-19-36-31-27(14-17-33(26,36)4)32(3)16-13-25(21-24(32)22-40-31)41-30(39)12-11-29(38)35-18-20-37(5,6)7/h22-23,25-28,31H,8-21,34H2,1-7H3/p+1
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n/an/a 5.90E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92975
PNG
(Amphiphile, X)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)OC(C[NH+](C)C)C[NH+](C)C
Show InChI InChI=1S/C35H62N4O5/c1-24(2)10-9-11-30(36)28-16-19-39-33-29(15-18-35(28,39)4)34(3)17-14-26(20-25(34)23-42-33)43-31(40)12-13-32(41)44-27(21-37(5)6)22-38(7)8/h23-24,26-30,33H,9-22,36H2,1-8H3/p+2
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n/an/a 4.08E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92976
PNG
(Amphiphile, XI)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)OC(C[NH+](C)C)C[N+](C)(C)C
Show InChI InChI=1S/C36H65N4O5/c1-25(2)11-10-12-31(37)29-17-20-39-34-30(16-19-36(29,39)4)35(3)18-15-27(21-26(35)24-43-34)44-32(41)13-14-33(42)45-28(22-38(5)6)23-40(7,8)9/h24-25,27-31,34H,10-23,37H2,1-9H3/q+1/p+1
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n/an/a 1.50E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)


Article DOI: 10.1021/bi00152a045
BindingDB Entry DOI: 10.7270/Q2W66JCK
More data for this
Ligand-Target Pair
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