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Found 2578 hits Enz. Inhib. hit(s) with Target = 'Rho kinase 2 (ROCKII)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho kinase 2 (ROCKII)


(Homo sapiens (Human))
BDBM97666
PNG
(US8476295, 1.1.04)
Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO
Show InChI InChI=1S/C24H30N4O2/c1-16-2-3-17(10-24(16)30-9-8-29)15-28-21-5-6-22(28)13-20(12-21)26-19-4-7-23-18(11-19)14-25-27-23/h2-4,7,10-11,14,20-22,26,29H,5-6,8-9,12-13,15H2,1H3,(H,25,27)
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10n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)


BindingDB Entry DOI: 10.7270/Q2H993TS
More data for this
Ligand-Target Pair
Rho kinase 2 (ROCKII)


(Homo sapiens (Human))
BDBM97664
PNG
(US8476295, 1.1.02)
Show SMILES Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1
Show InChI InChI=1S/C22H26N4/c1-15-2-4-16(5-3-15)14-26-20-7-8-21(26)12-19(11-20)24-18-6-9-22-17(10-18)13-23-25-22/h2-6,9-10,13,19-21,24H,7-8,11-12,14H2,1H3,(H,23,25)
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20n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)


BindingDB Entry DOI: 10.7270/Q2H993TS
More data for this
Ligand-Target Pair
Rho kinase 2 (ROCKII)


(Homo sapiens (Human))
BDBM97665
PNG
(US8476295, 1.1.03)
Show SMILES OCCOc1cccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)c1
Show InChI InChI=1S/C23H28N4O2/c28-8-9-29-22-3-1-2-16(10-22)15-27-20-5-6-21(27)13-19(12-20)25-18-4-7-23-17(11-18)14-24-26-23/h1-4,7,10-11,14,19-21,25,28H,5-6,8-9,12-13,15H2,(H,24,26)
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21n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)


BindingDB Entry DOI: 10.7270/Q2H993TS
More data for this
Ligand-Target Pair
Rho kinase 2 (ROCKII)


(Homo sapiens (Human))
BDBM97663
PNG
(US8476295, 1.1.01)
Show SMILES C(N1C2CCC1CC(C2)Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C21H24N4/c1-2-4-15(5-3-1)14-25-19-7-8-20(25)12-18(11-19)23-17-6-9-21-16(10-17)13-22-24-21/h1-6,9-10,13,18-20,23H,7-8,11-12,14H2,(H,22,24)
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29n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)


BindingDB Entry DOI: 10.7270/Q2H993TS
More data for this
Ligand-Target Pair
Rho kinase 2 (ROCKII)


(Homo sapiens (Human))
BDBM97667
PNG
(US8476295, 2.1.01)
Show SMILES C(N1C2CCC1CC(C2)Nc1cccc2[nH]ncc12)c1ccccc1
Show InChI InChI=1S/C23H25N3/c1-2-5-17(6-3-1)16-26-20-9-10-21(26)14-19(13-20)25-23-8-4-7-18-15-24-12-11-22(18)23/h1-8,11-12,15,19-21,25H,9-10,13-14,16H2
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220n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)


BindingDB Entry DOI: 10.7270/Q2H993TS
More data for this
Ligand-Target Pair
Rho kinase 2 (ROCKII)


(Homo sapiens (Human))
BDBM97668
PNG
(US8476295, 3.1.01)
Show SMILES C(N1CC2CCC1C2Nc1ccc2[nH]ncc2c1)c1ccccc1
Show InChI InChI=1S/C20H22N4/c1-2-4-14(5-3-1)12-24-13-15-6-9-19(24)20(15)22-17-7-8-18-16(10-17)11-21-23-18/h1-5,7-8,10-11,15,19-20,22H,6,9,12-13H2,(H,21,23)
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464n/an/an/an/an/an/a7.2n/a



Inspire

US Patent


Assay Description
Inhibition of Rho kinase 2 and Rho kinase I activity was determined using the IMAP Screening Express Kit (Molecular Devices product number #8073).


US Patent US8476295 (2013)


BindingDB Entry DOI: 10.7270/Q2H993TS
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119972
PNG
(US8697911, 140)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C26H26N6O2S2/c1-32(2)19-6-7-20-22(13-19)36-26(30-20)31-23(33)18-5-3-4-16(12-18)14-28-24(34)21-15-35-25(29-21)17-8-10-27-11-9-17/h3-5,8-12,15,19H,6-7,13-14H2,1-2H3,(H,28,34)(H,30,31,33)/t19-/m0/s1
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n/an/a 0.870n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119973
PNG
(US8697911, 142)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4nnn(c4C)-c4nonc4N)c3)sc2C1
Show InChI InChI=1S/C23H26N10O3S/c1-12-18(28-31-33(12)20-19(24)29-36-30-20)22(35)25-11-13-5-4-6-14(9-13)21(34)27-23-26-16-8-7-15(32(2)3)10-17(16)37-23/h4-6,9,15H,7-8,10-11H2,1-3H3,(H2,24,29)(H,25,35)(H,26,27,34)/t15-/m0/s1
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n/an/a 0.330n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119974
PNG
(US8697911, 144)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4ccnc(C)c4)c3)sc2C1
Show InChI InChI=1S/C28H27N5O2S/c1-18-14-22(10-12-29-18)20-6-8-21(9-7-20)26(34)30-16-19-4-3-5-23(15-19)27(35)32-28-31-24-11-13-33(2)17-25(24)36-28/h3-10,12,14-15H,11,13,16-17H2,1-2H3,(H,30,34)(H,31,32,35)
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n/an/a 4.35n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119976
PNG
(US8697911, 146)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1csc(n1)-c1cccnc1
Show InChI InChI=1S/C28H28N6O3S2/c35-25(33-28-32-22-7-6-21(14-24(22)39-28)34-9-11-37-12-10-34)19-4-1-3-18(13-19)15-30-26(36)23-17-38-27(31-23)20-5-2-8-29-16-20/h1-5,8,13,16-17,21H,6-7,9-12,14-15H2,(H,30,36)(H,32,33,35)/t21-/m0/s1
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n/an/a 0.730n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119977
PNG
(US8697911, 148)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1cn2ccc(cc2n1)C#N
Show InChI InChI=1S/C28H27N7O3S/c29-15-18-6-7-35-17-23(31-25(35)13-18)27(37)30-16-19-2-1-3-20(12-19)26(36)33-28-32-22-5-4-21(14-24(22)39-28)34-8-10-38-11-9-34/h1-3,6-7,12-13,17,21H,4-5,8-11,14,16H2,(H,30,37)(H,32,33,36)/t21-/m0/s1
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n/an/a 0.520n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119978
PNG
(US8697911, 150)
Show SMILES Nc1nonc1-n1nnc(C(=O)NCc2cccc(c2)C(=O)Nc2nc3CC[C@@H](Cc3s2)N2CCOCC2)c1-c1ccccc1
Show InChI InChI=1S/C30H30N10O4S/c31-26-27(37-44-36-26)40-25(19-6-2-1-3-7-19)24(35-38-40)29(42)32-17-18-5-4-8-20(15-18)28(41)34-30-33-22-10-9-21(16-23(22)45-30)39-11-13-43-14-12-39/h1-8,15,21H,9-14,16-17H2,(H2,31,36)(H,32,42)(H,33,34,41)/t21-/m0/s1
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n/an/a 2.65n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119979
PNG
(US8697911, 152)
Show SMILES Cc1c(nnn1-c1nonc1N)C(=O)NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1
Show InChI InChI=1S/C25H28N10O4S/c1-14-20(30-33-35(14)22-21(26)31-39-32-22)24(37)27-13-15-3-2-4-16(11-15)23(36)29-25-28-18-6-5-17(12-19(18)40-25)34-7-9-38-10-8-34/h2-4,11,17H,5-10,12-13H2,1H3,(H2,26,31)(H,27,37)(H,28,29,36)/t17-/m0/s1
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n/an/a 0.570n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119980
PNG
(US8697911, 154)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cnc(s4)-c4ccnc(C)c4)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S2/c1-15-10-18(6-8-26-15)24-28-13-20(34-24)23(33)27-12-16-4-3-5-17(11-16)22(32)30-25-29-19-7-9-31(2)14-21(19)35-25/h3-6,8,10-11,13H,7,9,12,14H2,1-2H3,(H,27,33)(H,29,30,32)
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n/an/a 39n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119981
PNG
(US8697911, 155 | US8697911, 179)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4cc[nH]n4)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-33-14-12-20-9-10-25(16-24(20)18-33)31-28(35)23-4-2-3-19(15-23)17-29-27(34)22-7-5-21(6-8-22)26-11-13-30-32-26/h2-11,13,15-16H,12,14,17-18H2,1H3,(H,29,34)(H,30,32)(H,31,35)
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n/an/a 47n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119982
PNG
(US8697911, 162)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1ccc(cc1)-c1cnco1
Show InChI InChI=1S/C29H29N5O4S/c35-27(21-6-4-20(5-7-21)25-17-30-18-38-25)31-16-19-2-1-3-22(14-19)28(36)33-29-32-24-9-8-23(15-26(24)39-29)34-10-12-37-13-11-34/h1-7,14,17-18,23H,8-13,15-16H2,(H,31,35)(H,32,33,36)/t23-/m0/s1
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n/an/a 0.430n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119983
PNG
(US8697911, 164)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C28H28N6O3S2/c35-25(33-28-32-22-5-4-21(15-24(22)39-28)34-10-12-37-13-11-34)20-3-1-2-18(14-20)16-30-26(36)23-17-38-27(31-23)19-6-8-29-9-7-19/h1-3,6-9,14,17,21H,4-5,10-13,15-16H2,(H,30,36)(H,32,33,35)/t21-/m0/s1
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n/an/a 0.930n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119984
PNG
(US8697911, 166)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1cc(n[nH]1)-c1ccncc1
Show InChI InChI=1S/C28H29N7O3S/c36-26(32-28-31-22-5-4-21(15-25(22)39-28)35-10-12-38-13-11-35)20-3-1-2-18(14-20)17-30-27(37)24-16-23(33-34-24)19-6-8-29-9-7-19/h1-3,6-9,14,16,21H,4-5,10-13,15,17H2,(H,30,37)(H,33,34)(H,31,32,36)/t21-/m0/s1
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n/an/a 0.340n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119985
PNG
(US8697911, 168)
Show SMILES Cc1nc(sc1C(=O)NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)-c1ccncc1
Show InChI InChI=1S/C29H30N6O3S2/c1-18-25(40-28(32-18)20-7-9-30-10-8-20)27(37)31-17-19-3-2-4-21(15-19)26(36)34-29-33-23-6-5-22(16-24(23)39-29)35-11-13-38-14-12-35/h2-4,7-10,15,22H,5-6,11-14,16-17H2,1H3,(H,31,37)(H,33,34,36)/t22-/m0/s1
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n/an/a 0.370n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119986
PNG
(US8697911, 170)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1cccc(c1)-c1cn[nH]c1
Show InChI InChI=1S/C29H30N6O3S/c36-27(22-6-2-4-20(14-22)23-17-31-32-18-23)30-16-19-3-1-5-21(13-19)28(37)34-29-33-25-8-7-24(15-26(25)39-29)35-9-11-38-12-10-35/h1-6,13-14,17-18,24H,7-12,15-16H2,(H,30,36)(H,31,32)(H,33,34,37)/t24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119987
PNG
(US8697911, 172)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C29H30N6O3S/c36-27(21-4-6-23(7-5-21)35-11-10-30-19-35)31-18-20-2-1-3-22(16-20)28(37)33-29-32-25-9-8-24(17-26(25)39-29)34-12-14-38-15-13-34/h1-7,10-11,16,19,24H,8-9,12-15,17-18H2,(H,31,36)(H,32,33,37)/t24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119988
PNG
(US8697911, 174)
Show SMILES Cc1nnnn1-c1ccc(cc1)C(=O)NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1
Show InChI InChI=1S/C28H30N8O3S/c1-18-32-33-34-36(18)22-7-5-20(6-8-22)26(37)29-17-19-3-2-4-21(15-19)27(38)31-28-30-24-10-9-23(16-25(24)40-28)35-11-13-39-14-12-35/h2-8,15,23H,9-14,16-17H2,1H3,(H,29,37)(H,30,31,38)/t23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119990
PNG
(US8697911, 176)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C29H28N6O3S/c30-16-18-4-5-20-14-25(32-24(20)13-18)28(37)31-17-19-2-1-3-21(12-19)27(36)34-29-33-23-7-6-22(15-26(23)39-29)35-8-10-38-11-9-35/h1-5,12-14,22,32H,6-11,15,17H2,(H,31,37)(H,33,34,36)/t22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119992
PNG
(US8697911, 178)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4cncn4)c3)cc2C1
Show InChI InChI=1S/C27H26N6O2/c1-32-12-11-20-5-8-24(14-23(20)16-32)31-27(35)22-4-2-3-19(13-22)15-29-26(34)21-6-9-25(10-7-21)33-18-28-17-30-33/h2-10,13-14,17-18H,11-12,15-16H2,1H3,(H,29,34)(H,31,35)
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n/an/a 48n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119981
PNG
(US8697911, 155 | US8697911, 179)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4cc[nH]n4)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-33-14-12-20-9-10-25(16-24(20)18-33)31-28(35)23-4-2-3-19(15-23)17-29-27(34)22-7-5-21(6-8-22)26-11-13-30-32-26/h2-11,13,15-16H,12,14,17-18H2,1H3,(H,29,34)(H,30,32)(H,31,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119998
PNG
(US8697911, 190)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cnco4)c3)cc2C1
Show InChI InChI=1S/C28H26N4O3/c1-32-11-10-20-8-9-25(14-24(20)17-32)31-28(34)22-6-2-4-19(12-22)15-30-27(33)23-7-3-5-21(13-23)26-16-29-18-35-26/h2-9,12-14,16,18H,10-11,15,17H2,1H3,(H,30,33)(H,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119999
PNG
(US8697911, 194)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cnc(s4)-c4cccnc4)c3)cc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-11-9-19-7-8-23(13-22(19)17-32)31-25(33)20-5-2-4-18(12-20)14-29-26(34)24-16-30-27(35-24)21-6-3-10-28-15-21/h2-8,10,12-13,15-16H,9,11,14,17H2,1H3,(H,29,34)(H,31,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120001
PNG
(US8697911, 200)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4ccnc4C)c3)cc2C1
Show InChI InChI=1S/C29H29N5O2/c1-20-30-13-15-34(20)27-10-7-23(8-11-27)28(35)31-18-21-4-3-5-24(16-21)29(36)32-26-9-6-22-12-14-33(2)19-25(22)17-26/h3-11,13,15-17H,12,14,18-19H2,1-2H3,(H,31,35)(H,32,36)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120002
PNG
(US8697911, 201)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)N4CCc5c4cccc5C#N)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-32-12-10-20-8-9-24(15-23(20)18-32)31-27(34)21-5-2-4-19(14-21)17-30-28(35)33-13-11-25-22(16-29)6-3-7-26(25)33/h2-9,14-15H,10-13,17-18H2,1H3,(H,30,35)(H,31,34)
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n/an/a 34n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120003
PNG
(US8697911, 202)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4nc(cs4)-c4cccnc4)c3)cc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-11-9-19-7-8-23(13-22(19)16-32)30-25(33)20-5-2-4-18(12-20)14-29-26(34)27-31-24(17-35-27)21-6-3-10-28-15-21/h2-8,10,12-13,15,17H,9,11,14,16H2,1H3,(H,29,34)(H,30,33)
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n/an/a 72n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120004
PNG
(US8697911, 205)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4sc(nc4C)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C27H28N6O2S2/c1-16-23(37-26(30-16)18-9-11-28-12-10-18)25(35)29-15-17-5-4-6-19(13-17)24(34)32-27-31-21-8-7-20(33(2)3)14-22(21)36-27/h4-6,9-13,20H,7-8,14-15H2,1-3H3,(H,29,35)(H,31,32,34)/t20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120005
PNG
(US8697911, 207)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc(n[nH]4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C26H27N7O2S/c1-33(2)19-6-7-20-23(13-19)36-26(29-20)30-24(34)18-5-3-4-16(12-18)15-28-25(35)22-14-21(31-32-22)17-8-10-27-11-9-17/h3-5,8-12,14,19H,6-7,13,15H2,1-2H3,(H,28,35)(H,31,32)(H,29,30,34)/t19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120006
PNG
(US8697911, 209)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5cc(ccc5n4)C(N)=O)c3)sc2C1
Show InChI InChI=1S/C24H23N7O3S/c1-30-8-7-17-19(13-30)35-24(28-17)29-22(33)15-4-2-3-14(9-15)10-26-23(34)18-12-31-11-16(21(25)32)5-6-20(31)27-18/h2-6,9,11-12H,7-8,10,13H2,1H3,(H2,25,32)(H,26,34)(H,28,29,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119892
PNG
(US8697911, 3)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cn[nH]c4)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-33-11-10-20-8-9-26(14-24(20)18-33)32-28(35)22-6-2-4-19(12-22)15-29-27(34)23-7-3-5-21(13-23)25-16-30-31-17-25/h2-9,12-14,16-17H,10-11,15,18H2,1H3,(H,29,34)(H,30,31)(H,32,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119893
PNG
(US8697911, 4)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cccnc4)c3)sc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-12-10-23-24(17-32)35-27(30-23)31-26(34)20-7-2-5-18(13-20)15-29-25(33)21-8-3-6-19(14-21)22-9-4-11-28-16-22/h2-9,11,13-14,16H,10,12,15,17H2,1H3,(H,29,33)(H,30,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119894
PNG
(US8697911, 6)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cn[nH]c4)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S/c1-31-9-8-21-22(15-31)34-25(29-21)30-24(33)18-6-2-4-16(10-18)12-26-23(32)19-7-3-5-17(11-19)20-13-27-28-14-20/h2-7,10-11,13-14H,8-9,12,15H2,1H3,(H,26,32)(H,27,28)(H,29,30,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119895
PNG
(US8697911, 8)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4nnnc4C)c3)sc2C1
Show InChI InChI=1S/C24H24N8O2S/c1-15-28-29-30-32(15)19-8-6-17(7-9-19)22(33)25-13-16-4-3-5-18(12-16)23(34)27-24-26-20-10-11-31(2)14-21(20)35-24/h3-9,12H,10-11,13-14H2,1-2H3,(H,25,33)(H,26,27,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119896
PNG
(US8697911, 12)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4cnco4)c3)sc2C1
Show InChI InChI=1S/C25H23N5O3S/c1-30-10-9-20-22(14-30)34-25(28-20)29-24(32)19-4-2-3-16(11-19)12-27-23(31)18-7-5-17(6-8-18)21-13-26-15-33-21/h2-8,11,13,15H,9-10,12,14H2,1H3,(H,27,31)(H,28,29,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119897
PNG
(US8697911, 14)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4cccnc4)c3)sc2C1
Show InChI InChI=1S/C24H22N6O2S2/c1-30-9-7-18-20(13-30)34-24(28-18)29-21(31)16-5-2-4-15(10-16)11-26-22(32)19-14-33-23(27-19)17-6-3-8-25-12-17/h2-6,8,10,12,14H,7,9,11,13H2,1H3,(H,26,32)(H,28,29,31)
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n/an/a 7.90n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119899
PNG
(US8697911, 20)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc5cc(O)ccc5c4)c3)sc2C1
Show InChI InChI=1S/C26H24N4O3S/c1-30-10-9-22-23(15-30)34-26(28-22)29-25(33)19-4-2-3-16(11-19)14-27-24(32)20-6-5-18-13-21(31)8-7-17(18)12-20/h2-8,11-13,31H,9-10,14-15H2,1H3,(H,27,32)(H,28,29,33)
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n/an/a 0.390n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119900
PNG
(US8697911, 21)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cn5cc(ccc5n4)C(N)=O)c3)cc2C1
Show InChI InChI=1S/C27H26N6O3/c1-32-10-9-18-5-7-22(12-21(18)14-32)30-26(35)19-4-2-3-17(11-19)13-29-27(36)23-16-33-15-20(25(28)34)6-8-24(33)31-23/h2-8,11-12,15-16H,9-10,13-14H2,1H3,(H2,28,34)(H,29,36)(H,30,35)
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n/an/a 25n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119901
PNG
(US8697911, 22)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C24H22N6O2S2/c1-30-10-7-18-20(13-30)34-24(28-18)29-21(31)17-4-2-3-15(11-17)12-26-22(32)19-14-33-23(27-19)16-5-8-25-9-6-16/h2-6,8-9,11,14H,7,10,12-13H2,1H3,(H,26,32)(H,28,29,31)
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n/an/a 37n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119903
PNG
(US8697911, 26)
Show SMILES N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4csnn4)c3)sc2C1
Show InChI InChI=1S/C24H22N6O2S2/c25-18-8-9-19-21(11-18)34-24(27-19)28-23(32)17-3-1-2-14(10-17)12-26-22(31)16-6-4-15(5-7-16)20-13-33-30-29-20/h1-7,10,13,18H,8-9,11-12,25H2,(H,26,31)(H,27,28,32)/t18-/m0/s1
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n/an/a 40n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119904
PNG
(US8697911, 27)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4cccnc4)c3)cc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-11-9-19-7-8-23(13-22(19)16-32)30-25(33)20-5-2-4-18(12-20)14-29-26(34)24-17-35-27(31-24)21-6-3-10-28-15-21/h2-8,10,12-13,15,17H,9,11,14,16H2,1H3,(H,29,34)(H,30,33)
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n/an/a 45n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119905
PNG
(US8697911, 28)
Show SMILES N[C@@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cn[nH]c4)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S/c26-20-7-8-21-22(11-20)34-25(30-21)31-24(33)17-5-1-3-15(9-17)12-27-23(32)18-6-2-4-16(10-18)19-13-28-29-14-19/h1-6,9-10,13-14,20H,7-8,11-12,26H2,(H,27,32)(H,28,29)(H,30,31,33)/t20-/m1/s1
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n/an/a 0.450n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119906
PNG
(US8697911, 29)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc5cc(O)ccc5c4)c3)cc2C1
Show InChI InChI=1S/C29H27N3O3/c1-32-12-11-20-7-9-26(15-25(20)18-32)31-29(35)23-4-2-3-19(13-23)17-30-28(34)24-6-5-22-16-27(33)10-8-21(22)14-24/h2-10,13-16,33H,11-12,17-18H2,1H3,(H,30,34)(H,31,35)
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n/an/a 2n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119907
PNG
(US8697911, 30)
Show SMILES N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cn[nH]c4)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S/c26-20-7-8-21-22(11-20)34-25(30-21)31-24(33)17-5-1-3-15(9-17)12-27-23(32)18-6-2-4-16(10-18)19-13-28-29-14-19/h1-6,9-10,13-14,20H,7-8,11-12,26H2,(H,27,32)(H,28,29)(H,30,31,33)/t20-/m0/s1
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n/an/a 0.160n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119908
PNG
(US8697911, 31)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)C4CSN=N4)c3)cc2C1
Show InChI InChI=1S/C27H27N5O2S/c1-32-12-11-19-9-10-24(14-23(19)16-32)29-27(34)22-4-2-3-18(13-22)15-28-26(33)21-7-5-20(6-8-21)25-17-35-31-30-25/h2-10,13-14,25H,11-12,15-17H2,1H3,(H,28,33)(H,29,34)
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n/an/a 4.60n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119909
PNG
(US8697911, 32)
Show SMILES N[C@@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C24H22N6O2S2/c25-17-4-5-18-20(11-17)34-24(29-18)30-21(31)16-3-1-2-14(10-16)12-27-22(32)19-13-33-23(28-19)15-6-8-26-9-7-15/h1-3,6-10,13,17H,4-5,11-12,25H2,(H,27,32)(H,29,30,31)/t17-/m1/s1
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n/an/a 4.80n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119911
PNG
(US8697911, 34)
Show SMILES N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C24H22N6O2S2/c25-17-4-5-18-20(11-17)34-24(29-18)30-21(31)16-3-1-2-14(10-16)12-27-22(32)19-13-33-23(28-19)15-6-8-26-9-7-15/h1-3,6-10,13,17H,4-5,11-12,25H2,(H,27,32)(H,29,30,31)/t17-/m0/s1
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n/an/a 1.10n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
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