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Found 3925 hits Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119990
PNG
(US8697911, 176)
Show SMILES O=C(NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](Cc2s1)N1CCOCC1)c1cc2ccc(cc2[nH]1)C#N
Show InChI InChI=1S/C29H28N6O3S/c30-16-18-4-5-20-14-25(32-24(20)13-18)28(37)31-17-19-2-1-3-21(12-19)27(36)34-29-33-23-7-6-22(15-26(23)39-29)35-8-10-38-11-9-35/h1-5,12-14,22,32H,6-11,15,17H2,(H,31,37)(H,33,34,36)/t22-/m0/s1
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n/an/a 0.870n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119992
PNG
(US8697911, 178)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4cncn4)c3)cc2C1
Show InChI InChI=1S/C27H26N6O2/c1-32-12-11-20-5-8-24(14-23(20)16-32)31-27(35)22-4-2-3-19(13-22)15-29-26(34)21-6-9-25(10-7-21)33-18-28-17-30-33/h2-10,13-14,17-18H,11-12,15-16H2,1H3,(H,29,34)(H,31,35)
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n/an/a 48n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119981
PNG
(US8697911, 155 | US8697911, 179)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4cc[nH]n4)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-33-14-12-20-9-10-25(16-24(20)18-33)31-28(35)23-4-2-3-19(15-23)17-29-27(34)22-7-5-21(6-8-22)26-11-13-30-32-26/h2-11,13,15-16H,12,14,17-18H2,1H3,(H,29,34)(H,30,32)(H,31,35)
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n/an/a 34n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119998
PNG
(US8697911, 190)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cnco4)c3)cc2C1
Show InChI InChI=1S/C28H26N4O3/c1-32-11-10-20-8-9-25(14-24(20)17-32)31-28(34)22-6-2-4-19(12-22)15-30-27(33)23-7-3-5-21(13-23)26-16-29-18-35-26/h2-9,12-14,16,18H,10-11,15,17H2,1H3,(H,30,33)(H,31,34)
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n/an/a 56n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119999
PNG
(US8697911, 194)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cnc(s4)-c4cccnc4)c3)cc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-11-9-19-7-8-23(13-22(19)17-32)31-25(33)20-5-2-4-18(12-20)14-29-26(34)24-16-30-27(35-24)21-6-3-10-28-15-21/h2-8,10,12-13,15-16H,9,11,14,17H2,1H3,(H,29,34)(H,31,33)
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n/an/a 30n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120001
PNG
(US8697911, 200)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4ccnc4C)c3)cc2C1
Show InChI InChI=1S/C29H29N5O2/c1-20-30-13-15-34(20)27-10-7-23(8-11-27)28(35)31-18-21-4-3-5-24(16-21)29(36)32-26-9-6-22-12-14-33(2)19-25(22)17-26/h3-11,13,15-17H,12,14,18-19H2,1-2H3,(H,31,35)(H,32,36)
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n/an/a 1.60n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120002
PNG
(US8697911, 201)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)N4CCc5c4cccc5C#N)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-32-12-10-20-8-9-24(15-23(20)18-32)31-27(34)21-5-2-4-19(14-21)17-30-28(35)33-13-11-25-22(16-29)6-3-7-26(25)33/h2-9,14-15H,10-13,17-18H2,1H3,(H,30,35)(H,31,34)
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n/an/a 34n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120003
PNG
(US8697911, 202)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4nc(cs4)-c4cccnc4)c3)cc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-11-9-19-7-8-23(13-22(19)16-32)30-25(33)20-5-2-4-18(12-20)14-29-26(34)27-31-24(17-35-27)21-6-3-10-28-15-21/h2-8,10,12-13,15,17H,9,11,14,16H2,1H3,(H,29,34)(H,30,33)
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n/an/a 72n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120004
PNG
(US8697911, 205)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4sc(nc4C)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C27H28N6O2S2/c1-16-23(37-26(30-16)18-9-11-28-12-10-18)25(35)29-15-17-5-4-6-19(13-17)24(34)32-27-31-21-8-7-20(33(2)3)14-22(21)36-27/h4-6,9-13,20H,7-8,14-15H2,1-3H3,(H,29,35)(H,31,32,34)/t20-/m0/s1
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n/an/a 0.25n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120005
PNG
(US8697911, 207)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc(n[nH]4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C26H27N7O2S/c1-33(2)19-6-7-20-23(13-19)36-26(29-20)30-24(34)18-5-3-4-16(12-18)15-28-25(35)22-14-21(31-32-22)17-8-10-27-11-9-17/h3-5,8-12,14,19H,6-7,13,15H2,1-2H3,(H,28,35)(H,31,32)(H,29,30,34)/t19-/m0/s1
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n/an/a 0.200n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM120006
PNG
(US8697911, 209)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5cc(ccc5n4)C(N)=O)c3)sc2C1
Show InChI InChI=1S/C24H23N7O3S/c1-30-8-7-17-19(13-30)35-24(28-17)29-22(33)15-4-2-3-14(9-15)10-26-23(34)18-12-31-11-16(21(25)32)5-6-20(31)27-18/h2-6,9,11-12H,7-8,10,13H2,1H3,(H2,25,32)(H,26,34)(H,28,29,33)
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n/an/a 3.70n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119911
PNG
(US8697911, 34)
Show SMILES N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C24H22N6O2S2/c25-17-4-5-18-20(11-17)34-24(29-18)30-21(31)16-3-1-2-14(10-16)12-27-22(32)19-13-33-23(28-19)15-6-8-26-9-7-15/h1-3,6-10,13,17H,4-5,11-12,25H2,(H,27,32)(H,29,30,31)/t17-/m0/s1
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n/an/a 1.10n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119912
PNG
(US8697911, 36)
Show SMILES Cc1nnnn1-c1ccc(cc1)C(=O)NCc1cccc(c1)C(=O)Nc1nc2CC[C@@H](N)Cc2s1
Show InChI InChI=1S/C24H24N8O2S/c1-14-29-30-31-32(14)19-8-5-16(6-9-19)22(33)26-13-15-3-2-4-17(11-15)23(34)28-24-27-20-10-7-18(25)12-21(20)35-24/h2-6,8-9,11,18H,7,10,12-13,25H2,1H3,(H,26,33)(H,27,28,34)/t18-/m1/s1
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n/an/a 3n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119914
PNG
(US8697911, 38)
Show SMILES Cc1nnnn1-c1ccc(cc1)C(=O)NCc1cccc(c1)C(=O)Nc1nc2CC[C@H](N)Cc2s1
Show InChI InChI=1S/C24H24N8O2S/c1-14-29-30-31-32(14)19-8-5-16(6-9-19)22(33)26-13-15-3-2-4-17(11-15)23(34)28-24-27-20-10-7-18(25)12-21(20)35-24/h2-6,8-9,11,18H,7,10,12-13,25H2,1H3,(H,26,33)(H,27,28,34)/t18-/m0/s1
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n/an/a 0.670n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119915
PNG
(US8697911, 39)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4ccnc4)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2/c1-32-13-11-21-5-8-25(16-24(21)18-32)31-28(35)23-4-2-3-20(15-23)17-30-27(34)22-6-9-26(10-7-22)33-14-12-29-19-33/h2-10,12,14-16,19H,11,13,17-18H2,1H3,(H,30,34)(H,31,35)
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n/an/a 9.90n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119916
PNG
(US8697911, 40)
Show SMILES N[C@@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cccnc4)c3)sc2C1
Show InChI InChI=1S/C27H25N5O2S/c28-22-9-10-23-24(14-22)35-27(31-23)32-26(34)19-6-1-4-17(12-19)15-30-25(33)20-7-2-5-18(13-20)21-8-3-11-29-16-21/h1-8,11-13,16,22H,9-10,14-15,28H2,(H,30,33)(H,31,32,34)/t22-/m1/s1
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n/an/a 10n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119917
PNG
(US8697911, 42)
Show SMILES N[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cccc(c4)-c4cccnc4)c3)sc2C1
Show InChI InChI=1S/C27H25N5O2S/c28-22-9-10-23-24(14-22)35-27(31-23)32-26(34)19-6-1-4-17(12-19)15-30-25(33)20-7-2-5-18(13-20)21-8-3-11-29-16-21/h1-8,11-13,16,22H,9-10,14-15,28H2,(H,30,33)(H,31,32,34)/t22-/m0/s1
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n/an/a 2n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119918
PNG
(US8697911, 44)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4nnn(c4C)-c4nonc4N)c3)sc2C1
Show InChI InChI=1S/C21H22N10O3S/c1-11-16(26-29-31(11)18-17(22)27-34-28-18)20(33)23-9-12-4-3-5-13(8-12)19(32)25-21-24-14-6-7-30(2)10-15(14)35-21/h3-5,8H,6-7,9-10H2,1-2H3,(H2,22,27)(H,23,33)(H,24,25,32)
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n/an/a 9.30n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119919
PNG
(US8697911, 46)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)sc2C1
Show InChI InChI=1S/C26H24N10O3S/c1-35-11-10-18-19(14-35)40-26(29-18)30-24(37)17-9-5-6-15(12-17)13-28-25(38)20-21(16-7-3-2-4-8-16)36(34-31-20)23-22(27)32-39-33-23/h2-9,12H,10-11,13-14H2,1H3,(H2,27,32)(H,28,38)(H,29,30,37)
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n/an/a 4.90n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119921
PNG
(US8697911, 49)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4cnco4)c3)cc2C1
Show InChI InChI=1S/C28H26N4O3/c1-32-12-11-20-9-10-25(14-24(20)17-32)31-28(34)23-4-2-3-19(13-23)15-30-27(33)22-7-5-21(6-8-22)26-16-29-18-35-26/h2-10,13-14,16,18H,11-12,15,17H2,1H3,(H,30,33)(H,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119922
PNG
(US8697911, 50)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cn5ccc(cc5n4)C(N)=O)c3)cc2C1
Show InChI InChI=1S/C27H26N6O3/c1-32-9-7-18-5-6-22(12-21(18)15-32)30-26(35)20-4-2-3-17(11-20)14-29-27(36)23-16-33-10-8-19(25(28)34)13-24(33)31-23/h2-6,8,10-13,16H,7,9,14-15H2,1H3,(H2,28,34)(H,29,36)(H,30,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119923
PNG
(US8697911, 52)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(cc5[nH]4)C#N)c3)cc2C1
Show InChI InChI=1S/C28H25N5O2/c1-33-10-9-20-7-8-24(13-23(20)17-33)31-27(34)22-4-2-3-19(11-22)16-30-28(35)26-14-21-6-5-18(15-29)12-25(21)32-26/h2-8,11-14,32H,9-10,16-17H2,1H3,(H,30,35)(H,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119925
PNG
(US8697911, 54)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(cc5[nH]4)C(N)=O)c3)cc2C1
Show InChI InChI=1S/C28H27N5O3/c1-33-10-9-18-7-8-23(12-22(18)16-33)31-27(35)21-4-2-3-17(11-21)15-30-28(36)25-13-19-5-6-20(26(29)34)14-24(19)32-25/h2-8,11-14,32H,9-10,15-16H2,1H3,(H2,29,34)(H,30,36)(H,31,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119926
PNG
(US8697911, 56)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C27H25N5O2S/c1-32-14-11-23-24(17-32)35-27(30-23)31-26(34)22-4-2-3-18(15-22)16-29-25(33)21-7-5-19(6-8-21)20-9-12-28-13-10-20/h2-10,12-13,15H,11,14,16-17H2,1H3,(H,29,33)(H,30,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119927
PNG
(US8697911, 58)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4nc(sc4C)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S2/c1-15-21(29-24(34-15)17-6-9-26-10-7-17)23(33)27-13-16-4-3-5-18(12-16)22(32)30-25-28-19-8-11-31(2)14-20(19)35-25/h3-7,9-10,12H,8,11,13-14H2,1-2H3,(H,27,33)(H,28,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119929
PNG
(US8697911, 64)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(s4)-c4cnco4)c3)cc2C1
Show InChI InChI=1S/C26H24N4O3S/c1-30-10-9-18-5-6-21(12-20(18)15-30)29-25(31)19-4-2-3-17(11-19)13-28-26(32)24-8-7-23(34-24)22-14-27-16-33-22/h2-8,11-12,14,16H,9-10,13,15H2,1H3,(H,28,32)(H,29,31)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119930
PNG
(US8697911, 66)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5ccc(cc5n4)C#N)c3)sc2C1
Show InChI InChI=1S/C24H21N7O2S/c1-30-7-6-18-20(14-30)34-24(28-18)29-22(32)17-4-2-3-16(9-17)12-26-23(33)19-13-31-8-5-15(11-25)10-21(31)27-19/h2-5,8-10,13H,6-7,12,14H2,1H3,(H,26,33)(H,28,29,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119933
PNG
(US8697911, 70)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(s4)-c4ccncc4)c3)cc2C1
Show InChI InChI=1S/C28H26N4O2S/c1-32-14-11-20-5-6-24(16-23(20)18-32)31-27(33)22-4-2-3-19(15-22)17-30-28(34)26-8-7-25(35-26)21-9-12-29-13-10-21/h2-10,12-13,15-16H,11,14,17-18H2,1H3,(H,30,34)(H,31,33)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119934
PNG
(US8697911, 74)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc(n[nH]4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C24H23N7O2S/c1-31-10-7-18-21(14-31)34-24(27-18)28-22(32)17-4-2-3-15(11-17)13-26-23(33)20-12-19(29-30-20)16-5-8-25-9-6-16/h2-6,8-9,11-12H,7,10,13-14H2,1H3,(H,26,33)(H,29,30)(H,27,28,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119935
PNG
(US8697911, 76)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4sc(nc4C)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S2/c1-15-21(35-24(28-15)17-6-9-26-10-7-17)23(33)27-13-16-4-3-5-18(12-16)22(32)30-25-29-19-8-11-31(2)14-20(19)34-25/h3-7,9-10,12H,8,11,13-14H2,1-2H3,(H,27,33)(H,29,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119936
PNG
(US8697911, 78)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4ccc(s4)-c4cn[nH]c4)c3)cc2C1
Show InChI InChI=1S/C26H25N5O2S/c1-31-10-9-18-5-6-22(12-20(18)16-31)30-25(32)19-4-2-3-17(11-19)13-27-26(33)24-8-7-23(34-24)21-14-28-29-15-21/h2-8,11-12,14-15H,9-10,13,16H2,1H3,(H,27,33)(H,28,29)(H,30,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119937
PNG
(US8697911, 80)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(ccc5[nH]4)C#N)c3)cc2C1
Show InChI InChI=1S/C28H25N5O2/c1-33-10-9-20-6-7-24(13-23(20)17-33)31-27(34)21-4-2-3-19(12-21)16-30-28(35)26-14-22-11-18(15-29)5-8-25(22)32-26/h2-8,11-14,32H,9-10,16-17H2,1H3,(H,30,35)(H,31,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119938
PNG
(US8697911, 84)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(cc5n4C)C(N)=O)c3)cc2C1
Show InChI InChI=1S/C29H29N5O3/c1-33-11-10-19-8-9-24(13-23(19)17-33)32-28(36)22-5-3-4-18(12-22)16-31-29(37)26-14-20-6-7-21(27(30)35)15-25(20)34(26)2/h3-9,12-15H,10-11,16-17H2,1-2H3,(H2,30,35)(H,31,37)(H,32,36)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119939
PNG
(US8697911, 86)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(ccc5[nH]4)C(N)=O)c3)cc2C1
Show InChI InChI=1S/C28H27N5O3/c1-33-10-9-18-5-7-23(13-22(18)16-33)31-27(35)20-4-2-3-17(11-20)15-30-28(36)25-14-21-12-19(26(29)34)6-8-24(21)32-25/h2-8,11-14,32H,9-10,15-16H2,1H3,(H2,29,34)(H,30,36)(H,31,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119941
PNG
(US8697911, 90)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)N4CCc5c4cccc5C#N)c3)sc2C1
Show InChI InChI=1S/C25H24N6O2S/c1-30-10-9-20-22(15-30)34-24(28-20)29-23(32)17-5-2-4-16(12-17)14-27-25(33)31-11-8-19-18(13-26)6-3-7-21(19)31/h2-7,12H,8-11,14-15H2,1H3,(H,27,33)(H,28,29,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119942
PNG
(US8697911, 92)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5ccc(cc5n4C)C#N)c3)cc2C1
Show InChI InChI=1S/C29H27N5O2/c1-33-11-10-21-8-9-25(14-24(21)18-33)32-28(35)23-5-3-4-20(12-23)17-31-29(36)27-15-22-7-6-19(16-30)13-26(22)34(27)2/h3-9,12-15H,10-11,17-18H2,1-2H3,(H,31,36)(H,32,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119943
PNG
(US8697911, 94)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(ccc5n4C)C#N)c3)cc2C1
Show InChI InChI=1S/C29H27N5O2/c1-33-11-10-21-7-8-25(14-24(21)18-33)32-28(35)22-5-3-4-20(13-22)17-31-29(36)27-15-23-12-19(16-30)6-9-26(23)34(27)2/h3-9,12-15H,10-11,17-18H2,1-2H3,(H,31,36)(H,32,35)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119944
PNG
(US8697911, 95)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4sc(nc4C)-c4ccncc4)c3)cc2C1
Show InChI InChI=1S/C28H27N5O2S/c1-18-25(36-28(31-18)21-8-11-29-12-9-21)27(35)30-16-19-4-3-5-22(14-19)26(34)32-24-7-6-20-10-13-33(2)17-23(20)15-24/h3-9,11-12,14-15H,10,13,16-17H2,1-2H3,(H,30,35)(H,32,34)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119945
PNG
(US8697911, 96)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc5cc(ccc5n4C)C(N)=O)c3)cc2C1
Show InChI InChI=1S/C29H29N5O3/c1-33-11-10-19-6-8-24(14-23(19)17-33)32-28(36)21-5-3-4-18(12-21)16-31-29(37)26-15-22-13-20(27(30)35)7-9-25(22)34(26)2/h3-9,12-15H,10-11,16-17H2,1-2H3,(H2,30,35)(H,31,37)(H,32,36)
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n/an/a 12.3n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119946
PNG
(US8697911, 98)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5ccc(cc5n4)C#N)c3)sc2C1
Show InChI InChI=1S/C26H25N7O2S/c1-32(2)19-6-7-20-22(12-19)36-26(30-20)31-24(34)18-5-3-4-17(10-18)14-28-25(35)21-15-33-9-8-16(13-27)11-23(33)29-21/h3-5,8-11,15,19H,6-7,12,14H2,1-2H3,(H,28,35)(H,30,31,34)/t19-/m0/s1
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n/an/a 0.270n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119947
PNG
(US8697911, 100)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cn5cc(ccc5n4)C#N)c3)sc2C1
Show InChI InChI=1S/C26H25N7O2S/c1-32(2)19-7-8-20-22(11-19)36-26(30-20)31-24(34)18-5-3-4-16(10-18)13-28-25(35)21-15-33-14-17(12-27)6-9-23(33)29-21/h3-6,9-10,14-15,19H,7-8,11,13H2,1-2H3,(H,28,35)(H,30,31,34)/t19-/m0/s1
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n/an/a 2.60n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119949
PNG
(US8697911, 104)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-n4nnnc4C)c3)sc2C1
Show InChI InChI=1S/C26H28N8O2S/c1-16-30-31-32-34(16)20-9-7-18(8-10-20)24(35)27-15-17-5-4-6-19(13-17)25(36)29-26-28-22-12-11-21(33(2)3)14-23(22)37-26/h4-10,13,21H,11-12,14-15H2,1-3H3,(H,27,35)(H,28,29,36)/t21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119950
PNG
(US8697911, 106)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(cc4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C29H29N5O2S/c1-34(2)24-10-11-25-26(17-24)37-29(32-25)33-28(36)23-5-3-4-19(16-23)18-31-27(35)22-8-6-20(7-9-22)21-12-14-30-15-13-21/h3-9,12-16,24H,10-11,17-18H2,1-2H3,(H,31,35)(H,32,33,36)/t24-/m0/s1
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n/an/a 0.220n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119951
PNG
(US8697911, 108)
Show SMILES CN(C)[C@H]1CCc2nc(NC(=O)c3cccc(CNC(=O)c4csc(n4)-c4cccnc4)c3)sc2C1
Show InChI InChI=1S/C26H26N6O2S2/c1-32(2)19-8-9-20-22(12-19)36-26(30-20)31-23(33)17-6-3-5-16(11-17)13-28-24(34)21-15-35-25(29-21)18-7-4-10-27-14-18/h3-7,10-11,14-15,19H,8-9,12-13H2,1-2H3,(H,28,34)(H,30,31,33)/t19-/m0/s1
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n/an/a 0.320n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119953
PNG
(US8697911, 112)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(s4)-c4ccncc4)c3)sc2C1
Show InChI InChI=1S/C25H23N5O2S2/c1-30-12-9-19-22(15-30)34-25(28-19)29-23(31)18-4-2-3-16(13-18)14-27-24(32)21-6-5-20(33-21)17-7-10-26-11-8-17/h2-8,10-11,13H,9,12,14-15H2,1H3,(H,27,32)(H,28,29,31)
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n/an/a 0.180n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119954
PNG
(US8697911, 114)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(s4)-c4cnco4)c3)sc2C1
Show InChI InChI=1S/C23H21N5O3S2/c1-28-8-7-16-20(12-28)33-23(26-16)27-21(29)15-4-2-3-14(9-15)10-25-22(30)19-6-5-18(32-19)17-11-24-13-31-17/h2-6,9,11,13H,7-8,10,12H2,1H3,(H,25,30)(H,26,27,29)
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n/an/a 0.450n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119957
PNG
(US8697911, 119)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4cc(n[nH]4)-c4ccncc4)c3)cc2C1
Show InChI InChI=1S/C27H26N6O2/c1-33-12-9-19-5-6-23(14-22(19)17-33)30-26(34)21-4-2-3-18(13-21)16-29-27(35)25-15-24(31-32-25)20-7-10-28-11-8-20/h2-8,10-11,13-15H,9,12,16-17H2,1H3,(H,29,35)(H,30,34)(H,31,32)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119958
PNG
(US8697911, 120)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4ccc(s4)-c4cn[nH]c4)c3)sc2C1
Show InChI InChI=1S/C23H22N6O2S2/c1-29-8-7-17-20(13-29)33-23(27-17)28-21(30)15-4-2-3-14(9-15)10-24-22(31)19-6-5-18(32-19)16-11-25-26-12-16/h2-6,9,11-12H,7-8,10,13H2,1H3,(H,24,31)(H,25,26)(H,27,28,30)
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n/an/a 0.770n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119960
PNG
(US8697911, 123)
Show SMILES CN1CCc2ccc(NC(=O)c3cccc(CNC(=O)c4nnn(-c5nonc5N)c4-c4ccccc4)c3)cc2C1
Show InChI InChI=1S/C29H27N9O3/c1-37-13-12-19-10-11-23(15-22(19)17-37)32-28(39)21-9-5-6-18(14-21)16-31-29(40)24-25(20-7-3-2-4-8-20)38(36-33-24)27-26(30)34-41-35-27/h2-11,14-15H,12-13,16-17H2,1H3,(H2,30,34)(H,31,40)(H,32,39)
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n/an/a 3.90n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
Rho-associated protein kinase


(Homo sapiens (Human))
BDBM119961
PNG
(US8697911, 124)
Show SMILES CN1CCc2nc(NC(=O)c3cccc(CNC(=O)c4cc5cc(ccc5n4C)C#N)c3)sc2C1
Show InChI InChI=1S/C26H24N6O2S/c1-31-9-8-20-23(15-31)35-26(29-20)30-24(33)18-5-3-4-17(11-18)14-28-25(34)22-12-19-10-16(13-27)6-7-21(19)32(22)2/h3-7,10-12H,8-9,14-15H2,1-2H3,(H,28,34)(H,29,30,33)
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n/an/a 11n/an/an/an/a7.2n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...


US Patent US8697911 (2014)


BindingDB Entry DOI: 10.7270/Q25X27KR
More data for this
Ligand-Target Pair
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