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Compile Data Set for Download or QSAR

Found 809 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase ATR'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103465
PNG
(US8552004, 1.01)
Show SMILES C[C@@H]1COCCN1c1cc(C=S(C)(N)=O)nc(n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O2S/c1-12-10-26-8-7-24(12)16-9-13(11-27(2,19)25)22-18(23-16)15-4-6-21-17-14(15)3-5-20-17/h3-6,9,11-12H,7-8,10H2,1-2H3,(H2,19,25)(H,20,21)/t12-,27?/m1/s1
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n/an/a 34.0n/an/an/an/a7.437



AstraZeneca AB

US Patent


Assay Description
ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM60432
PNG
(US8552004, 2.02)
Show SMILES C[C@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@@](C)(=N)=O
Show InChI InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29-/m0/s1
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n/an/a 3.75n/an/an/an/a7.437



AstraZeneca AB

US Patent


Assay Description
ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103467
PNG
(US8552004, 2.03)
Show SMILES CNc1nc2ccccc2n1-c1nc(cc(n1)C1(CC1)[S@](C)(=N)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H27N7O2S/c1-14-13-30-11-10-27(14)18-12-17(21(8-9-21)31(3,22)29)25-20(26-18)28-16-7-5-4-6-15(16)24-19(28)23-2/h4-7,12,14H,3,8-11,13H2,1-2H3,(H2,22,29)(H,23,24)/t14-,31?/m1/s1
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n/an/a 5.61n/an/an/an/a7.437



AstraZeneca AB

US Patent


Assay Description
ATR for use in the in vitro enzyme assay was obtained from HeLa nuclear extract (CIL Biotech, Mons, Belgium) by immunoprecipitation with rabbit polyc...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM97372
PNG
(US20130089624, 1)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1cc(no1)-c1ccc(cc1)[C@@H]1COCCN1
Show InChI InChI=1S/C26H27N5O4S/c1-16(2)36(32,33)20-9-7-18(8-10-20)22-14-29-26(27)25(30-22)24-13-21(31-35-24)17-3-5-19(6-4-17)23-15-34-12-11-28-23/h3-10,13-14,16,23,28H,11-12,15H2,1-2H3,(H2,27,29)/t23-/m0/s1
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0.503 -53.1 200n/an/an/an/a7.525



Vertex Pharmaceuticals

US Patent


Assay Description
Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay.


US Patent US20130089624 (2013)


BindingDB Entry DOI: 10.7270/Q2PZ57DN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM132734
PNG
(US8846917, I-1)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)-c1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C21H20N6O2S/c1-14(2)30(28,29)17-10-8-15(9-11-17)18-12-23-21(22)20(24-18)19-13-27(26-25-19)16-6-4-3-5-7-16/h3-14H,1-2H3,(H2,22,23)
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6n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Incorporated

US Patent


Assay Description
Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...


US Patent US8846917 (2014)


BindingDB Entry DOI: 10.7270/Q2CC0ZCB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM50341751
PNG
(3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfon...)
Show SMILES CC(CN(C)C)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C22H25N5O3S/c1-15(14-27(2)3)31(29,30)18-11-9-16(10-12-18)19-13-24-21(23)20(26-19)22(28)25-17-7-5-4-6-8-17/h4-13,15H,14H2,1-3H3,(H2,23,24)(H,25,28)
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6n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Competitive inhibition of full length recombinant ATR Morrison equation analysis


J Med Chem 54: 2320-30 (2011)


Article DOI: 10.1021/jm101488z
BindingDB Entry DOI: 10.7270/Q2WS8TK6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM50437437
PNG
(CHEMBL2409217 | US8841450, I-2)
Show SMILES CNCc1ccc(cc1)C1=NOC(C1)c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H27N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-11,14-15,22,26H,12-13H2,1-3H3,(H2,25,27)
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16n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of ATR (unknown origin)


Citation and Details

Article DOI: 10.1021/ml4002198
BindingDB Entry DOI: 10.7270/Q2W097CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM50437436
PNG
(CHEMBL2409216 | US8841450, I-1)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C1CC(=NO1)c1ccccc1
Show InChI InChI=1S/C22H22N4O3S/c1-14(2)30(27,28)17-10-8-16(9-11-17)19-13-24-22(23)21(25-19)20-12-18(26-29-20)15-6-4-3-5-7-15/h3-11,13-14,20H,12H2,1-2H3,(H2,23,24)
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16n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Incorporated

US Patent


Assay Description
Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...


US Patent US8841450 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SKK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM50437436
PNG
(CHEMBL2409216 | US8841450, I-1)
Show SMILES CC(C)S(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C1CC(=NO1)c1ccccc1
Show InChI InChI=1S/C22H22N4O3S/c1-14(2)30(27,28)17-10-8-16(9-11-17)19-13-24-22(23)21(25-19)20-12-18(26-29-20)15-6-4-3-5-7-15/h3-11,13-14,20H,12H2,1-2H3,(H2,23,24)
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90n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of ATR (unknown origin)


Citation and Details

Article DOI: 10.1021/ml4002198
BindingDB Entry DOI: 10.7270/Q2W097CX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM50437437
PNG
(CHEMBL2409217 | US8841450, I-2)
Show SMILES CNCc1ccc(cc1)C1=NOC(C1)c1nc(cnc1N)-c1ccc(cc1)S(=O)(=O)C(C)C
Show InChI InChI=1S/C24H27N5O3S/c1-15(2)33(30,31)19-10-8-18(9-11-19)21-14-27-24(25)23(28-21)22-12-20(29-32-22)17-6-4-16(5-7-17)13-26-3/h4-11,14-15,22,26H,12-13H2,1-3H3,(H2,25,27)
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90n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Incorporated

US Patent


Assay Description
Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...


US Patent US8841450 (2014)


BindingDB Entry DOI: 10.7270/Q2NS0SKK
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103465
PNG
(US8552004, 1.01)
Show SMILES C[C@@H]1COCCN1c1cc(C=S(C)(N)=O)nc(n1)-c1ccnc2[nH]ccc12
Show InChI InChI=1S/C18H22N6O2S/c1-12-10-26-8-7-24(12)16-9-13(11-27(2,19)25)22-18(23-16)15-4-6-21-17-14(15)3-5-20-17/h3-6,9,11-12H,7-8,10H2,1-2H3,(H2,19,25)(H,20,21)/t12-,27?/m1/s1
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n/an/a 581n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM60432
PNG
(BDBM103466 | US8552004, 2.04)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@@](C)(=N)=O
Show InChI InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29+/m1/s1
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n/an/a 236n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM60432
PNG
(US8552004, 2.02)
Show SMILES C[C@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@@](C)(=N)=O
Show InChI InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29-/m0/s1
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n/an/a 58.3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103467
PNG
(US8552004, 2.03)
Show SMILES CNc1nc2ccccc2n1-c1nc(cc(n1)C1(CC1)[S@](C)(=N)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H27N7O2S/c1-14-13-30-11-10-27(14)18-12-17(21(8-9-21)31(3,22)29)25-20(26-18)28-16-7-5-4-6-15(16)24-19(28)23-2/h4-7,12,14H,3,8-11,13H2,1-2H3,(H2,22,29)(H,23,24)/t14-,31?/m1/s1
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n/an/a 7.05n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM60433
PNG
(BDBM103466 | US8552004, 2.04)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1ccnc2[nH]ccc12)C1(CC1)[S@@](C)(=N)=O
Show InChI InChI=1S/C20H24N6O2S/c1-13-12-28-10-9-26(13)17-11-16(20(5-6-20)29(2,21)27)24-19(25-17)15-4-8-23-18-14(15)3-7-22-18/h3-4,7-8,11,13,21H,5-6,9-10,12H2,1-2H3,(H,22,23)/t13-,29+/m1/s1
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n/an/a 21.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103468
PNG
(US8552004, 2.05 | US8552004, 2.06)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(N)(=C)=O
Show InChI InChI=1S/C21H25N5O2S/c1-14-13-28-11-10-26(14)19-12-18(21(7-8-21)29(2,22)27)24-20(25-19)16-4-3-5-17-15(16)6-9-23-17/h3-6,9,12,14,23H,2,7-8,10-11,13H2,1H3,(H2,22,27)/t14-,29?/m1/s1
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n/an/a 75.8n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103468
PNG
(US8552004, 2.05 | US8552004, 2.06)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CC1)S(N)(=C)=O
Show InChI InChI=1S/C21H25N5O2S/c1-14-13-28-11-10-26(14)19-12-18(21(7-8-21)29(2,22)27)24-20(25-19)16-4-3-5-17-15(16)6-9-23-17/h3-6,9,12,14,23H,2,7-8,10-11,13H2,1H3,(H2,22,27)/t14-,29?/m1/s1
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n/an/a 12.9n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103469
PNG
(US8552004, 2.07 | US8552004, 2.08)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-n1c(N)nc2ccccc12)C1(CC1)S(N)(=C)=O
Show InChI InChI=1S/C20H25N7O2S/c1-13-12-29-10-9-26(13)17-11-16(20(7-8-20)30(2,22)28)24-19(25-17)27-15-6-4-3-5-14(15)23-18(27)21/h3-6,11,13H,2,7-10,12H2,1H3,(H2,21,23)(H2,22,28)/t13-,30?/m1/s1
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n/an/a 2.58n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103469
PNG
(US8552004, 2.07 | US8552004, 2.08)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-n1c(N)nc2ccccc12)C1(CC1)S(N)(=C)=O
Show InChI InChI=1S/C20H25N7O2S/c1-13-12-29-10-9-26(13)17-11-16(20(7-8-20)30(2,22)28)24-19(25-17)27-15-6-4-3-5-14(15)23-18(27)21/h3-6,11,13H,2,7-10,12H2,1H3,(H2,21,23)(H2,22,28)/t13-,30?/m1/s1
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n/an/a 2.76n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103470
PNG
(US8552004, 2.09 | US8552004, 2.10)
Show SMILES CNc1nc2c(F)cccc2n1-c1nc(cc(n1)C1(CC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H26FN7O2S/c1-13-12-31-10-9-28(13)17-11-16(21(7-8-21)32(3,23)30)25-20(26-17)29-15-6-4-5-14(22)18(15)27-19(29)24-2/h4-6,11,13H,3,7-10,12H2,1-2H3,(H2,23,30)(H,24,27)/t13-,32?/m1/s1
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n/an/a 159n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103470
PNG
(US8552004, 2.09 | US8552004, 2.10)
Show SMILES CNc1nc2c(F)cccc2n1-c1nc(cc(n1)C1(CC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H26FN7O2S/c1-13-12-31-10-9-28(13)17-11-16(21(7-8-21)32(3,23)30)25-20(26-17)29-15-6-4-5-14(22)18(15)27-19(29)24-2/h4-6,11,13H,3,7-10,12H2,1-2H3,(H2,23,30)(H,24,27)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103471
PNG
(US8552004, 2.11)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cncc2[nH]ccc12)C1(CC1)S(N)(=C)=O
Show InChI InChI=1S/C20H24N6O2S/c1-13-12-28-8-7-26(13)18-9-17(20(4-5-20)29(2,21)27)24-19(25-18)15-10-22-11-16-14(15)3-6-23-16/h3,6,9-11,13,23H,2,4-5,7-8,12H2,1H3,(H2,21,27)/t13-,29?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103472
PNG
(US8552004, 3.01 | US8552004, 3.02)
Show SMILES CNc1nc2ccccc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H29N7O2S/c1-14-13-30-11-10-27(14)18-12-17(21(2,3)31(5,22)29)25-20(26-18)28-16-9-7-6-8-15(16)24-19(28)23-4/h6-9,12,14H,5,10-11,13H2,1-4H3,(H2,22,29)(H,23,24)/t14-,31?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103472
PNG
(US8552004, 3.01 | US8552004, 3.02)
Show SMILES CNc1nc2ccccc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H29N7O2S/c1-14-13-30-11-10-27(14)18-12-17(21(2,3)31(5,22)29)25-20(26-18)28-16-9-7-6-8-15(16)24-19(28)23-4/h6-9,12,14H,5,10-11,13H2,1-4H3,(H2,22,29)(H,23,24)/t14-,31?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103473
PNG
(US8552004, 4.01 | US8552004, 4.02)
Show SMILES CNc1nc2ccccc2n1-c1nc(cc(n1)C1(CCOCC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C23H31N7O3S/c1-16-15-33-13-10-29(16)20-14-19(23(34(3,24)31)8-11-32-12-9-23)27-22(28-20)30-18-7-5-4-6-17(18)26-21(30)25-2/h4-7,14,16H,3,8-13,15H2,1-2H3,(H2,24,31)(H,25,26)/t16-,34?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103473
PNG
(US8552004, 4.01 | US8552004, 4.02)
Show SMILES CNc1nc2ccccc2n1-c1nc(cc(n1)C1(CCOCC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C23H31N7O3S/c1-16-15-33-13-10-29(16)20-14-19(23(34(3,24)31)8-11-32-12-9-23)27-22(28-20)30-18-7-5-4-6-17(18)26-21(30)25-2/h4-7,14,16H,3,8-13,15H2,1-2H3,(H2,24,31)(H,25,26)/t16-,34?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103474
PNG
(US8552004, 4.03)
Show SMILES C[C@@H]1COCCN1c1cc(nc(n1)-c1cccc2[nH]ccc12)C1(CCOCC1)S(N)(=C)=O
Show InChI InChI=1S/C23H29N5O3S/c1-16-15-31-13-10-28(16)21-14-20(23(32(2,24)29)7-11-30-12-8-23)26-22(27-21)18-4-3-5-19-17(18)6-9-25-19/h3-6,9,14,16,25H,2,7-8,10-13,15H2,1H3,(H2,24,29)/t16-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103475
PNG
(US8552004, 5.01 | US8552004, 5.02)
Show SMILES CNc1nc2c(F)cccc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H28FN7O2S/c1-13-12-31-10-9-28(13)17-11-16(21(2,3)32(5,23)30)25-20(26-17)29-15-8-6-7-14(22)18(15)27-19(29)24-4/h6-8,11,13H,5,9-10,12H2,1-4H3,(H2,23,30)(H,24,27)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103475
PNG
(US8552004, 5.01 | US8552004, 5.02)
Show SMILES CNc1nc2c(F)cccc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H28FN7O2S/c1-13-12-31-10-9-28(13)17-11-16(21(2,3)32(5,23)30)25-20(26-17)29-15-8-6-7-14(22)18(15)27-19(29)24-4/h6-8,11,13H,5,9-10,12H2,1-4H3,(H2,23,30)(H,24,27)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103476
PNG
(US8552004, 5.03 | US8552004, 5.06)
Show SMILES CNc1nc2ccc(F)cc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H28FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(2,3)32(5,23)30)26-20(27-18)29-16-10-14(22)6-7-15(16)25-19(29)24-4/h6-7,10-11,13H,5,8-9,12H2,1-4H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103487
PNG
(US8552004, 5.04 | US8552004, 5.05)
Show SMILES CNc1nc2cc(F)ccc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H28FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(2,3)32(5,23)30)26-20(27-18)29-16-7-6-14(22)10-15(16)25-19(29)24-4/h6-7,10-11,13H,5,8-9,12H2,1-4H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103487
PNG
(US8552004, 5.04 | US8552004, 5.05)
Show SMILES CNc1nc2cc(F)ccc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H28FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(2,3)32(5,23)30)26-20(27-18)29-16-7-6-14(22)10-15(16)25-19(29)24-4/h6-7,10-11,13H,5,8-9,12H2,1-4H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103476
PNG
(US8552004, 5.03 | US8552004, 5.06)
Show SMILES CNc1nc2ccc(F)cc2n1-c1nc(cc(n1)C(C)(C)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H28FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(2,3)32(5,23)30)26-20(27-18)29-16-10-14(22)6-7-15(16)25-19(29)24-4/h6-7,10-11,13H,5,8-9,12H2,1-4H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103477
PNG
(US8552004, 5.07 | US8552004, 5.10)
Show SMILES CNc1nc2ccc(F)cc2n1-c1nc(cc(n1)C1(CC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H26FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(6-7-21)32(3,23)30)26-20(27-18)29-16-10-14(22)4-5-15(16)25-19(29)24-2/h4-5,10-11,13H,3,6-9,12H2,1-2H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103490
PNG
(US8552004, 5.08 | US8552004, 5.09)
Show SMILES CNc1nc2cc(F)ccc2n1-c1nc(cc(n1)C1(CC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H26FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(6-7-21)32(3,23)30)26-20(27-18)29-16-5-4-14(22)10-15(16)25-19(29)24-2/h4-5,10-11,13H,3,6-9,12H2,1-2H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103490
PNG
(US8552004, 5.08 | US8552004, 5.09)
Show SMILES CNc1nc2cc(F)ccc2n1-c1nc(cc(n1)C1(CC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H26FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(6-7-21)32(3,23)30)26-20(27-18)29-16-5-4-14(22)10-15(16)25-19(29)24-2/h4-5,10-11,13H,3,6-9,12H2,1-2H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM103477
PNG
(US8552004, 5.07 | US8552004, 5.10)
Show SMILES CNc1nc2ccc(F)cc2n1-c1nc(cc(n1)C1(CC1)S(N)(=C)=O)N1CCOC[C@H]1C
Show InChI InChI=1S/C21H26FN7O2S/c1-13-12-31-9-8-28(13)18-11-17(21(6-7-21)32(3,23)30)26-20(27-18)29-16-10-14(22)4-5-15(16)25-19(29)24-2/h4-5,10-11,13H,3,6-9,12H2,1-2H3,(H2,23,30)(H,24,25)/t13-,32?/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATM and ATR have distinct and overlapping responses to DNA damage. They must participate together and responses must be co-ordinated. Both pathways...


US Patent US8552004 (2013)


BindingDB Entry DOI: 10.7270/Q20P0XN6
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185361
PNG
(US9156831, 1)
Show SMILES Cn1nc(nc1-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C)C1CCN(CC1)C(=O)CCO
Show InChI InChI=1S/C21H29N9O3/c1-21(2,3)20-27-26-19(33-20)15-16(22)23-11-13(24-15)18-25-17(28-29(18)4)12-5-8-30(9-6-12)14(32)7-10-31/h11-12,31H,5-10H2,1-4H3,(H2,22,23)
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185362
PNG
(US9156831, 3)
Show SMILES CCn1nc(nc1-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C)C1CCN(CC1)C(=O)CCO
Show InChI InChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185353
PNG
(US9156831, 4)
Show SMILES C[C@@H](O)CC(=O)N1CCC(CC1)c1nc(-c2cnc(N)c(n2)-c2nnc(o2)C(C)(C)C)n(C)n1
Show InChI InChI=1S/C22H31N9O3/c1-12(32)10-15(33)31-8-6-13(7-9-31)18-26-19(30(5)29-18)14-11-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h11-13,32H,6-10H2,1-5H3,(H2,23,24)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185354
PNG
(US9156831, 5)
Show SMILES C[C@H](O)CC(=O)N1CCC(CC1)c1nc(-c2cnc(N)c(n2)-c2nnc(o2)C(C)(C)C)n(C)n1
Show InChI InChI=1S/C22H31N9O3/c1-12(32)10-15(33)31-8-6-13(7-9-31)18-26-19(30(5)29-18)14-11-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h11-13,32H,6-10H2,1-5H3,(H2,23,24)/t12-/m0/s1
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185355
PNG
(US9156831, 6)
Show SMILES C[C@H](CO)C(=O)N1CCC(CC1)c1nc(-c2cnc(N)c(n2)-c2nnc(o2)C(C)(C)C)n(C)n1
Show InChI InChI=1S/C22H31N9O3/c1-12(11-32)20(33)31-8-6-13(7-9-31)17-26-18(30(5)29-17)14-10-24-16(23)15(25-14)19-27-28-21(34-19)22(2,3)4/h10,12-13,32H,6-9,11H2,1-5H3,(H2,23,24)/t12-/m1/s1
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185356
PNG
(US9156831, 7)
Show SMILES Cn1nc(nc1-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C)C1CCN(CC1)C(=O)C(C)(C)O
Show InChI InChI=1S/C22H31N9O3/c1-21(2,3)19-28-27-18(34-19)14-15(23)24-11-13(25-14)17-26-16(29-30(17)6)12-7-9-31(10-8-12)20(32)22(4,5)33/h11-12,33H,7-10H2,1-6H3,(H2,23,24)
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM185357
PNG
(US9156831, 8)
Show SMILES Cn1nc(nc1-c1cnc(N)c(n1)-c1nnc(o1)C(C)(C)C)C1CCN(CC1)C(=O)CC(O)=O
Show InChI InChI=1S/C21H27N9O4/c1-21(2,3)20-27-26-19(34-20)15-16(22)23-10-12(24-15)18-25-17(28-29(18)4)11-5-7-30(8-6-11)13(31)9-14(32)33/h10-11H,5-9H2,1-4H3,(H2,22,23)(H,32,33)
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AstraZeneca AB

US Patent


Assay Description
ATR (Ataxia Telangiectasia+Rad3-related kinase) is a PI3-kinase-related kinase which phosphorylates multiple substrates on serine or threonine residu...


US Patent US9156831 (2015)


BindingDB Entry DOI: 10.7270/Q2NV9H2N
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM245474
PNG
(US9428503, 1)
Show SMILES CN(C)CCCOc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4CCOCC4)c3c2c1
Show InChI InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3
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n/an/a 6.16E+3n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...


US Patent US9428503 (2016)


BindingDB Entry DOI: 10.7270/Q2GH9GVJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM245475
PNG
(US9428503, 2)
Show SMILES CO[C@H]1C[C@H](C1)n1c2c(cnc3ccc(cc23)-c2ccc(OCCCN(C)C)nc2)n(C)c1=O
Show InChI InChI=1S/C26H31N5O3/c1-29(2)10-5-11-34-24-9-7-18(15-28-24)17-6-8-22-21(12-17)25-23(16-27-22)30(3)26(32)31(25)19-13-20(14-19)33-4/h6-9,12,15-16,19-20H,5,10-11,13-14H2,1-4H3/t19-,20+
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AstraZeneca AB

US Patent


Assay Description
Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...


US Patent US9428503 (2016)


BindingDB Entry DOI: 10.7270/Q2GH9GVJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM245476
PNG
(US9428503, 3)
Show SMILES CN(C)CCCOc1ccc(cn1)-c1cc2c3n(c(=O)n(C)c3cnc2cc1F)C1(C)CCOCC1
Show InChI InChI=1S/C27H32FN5O3/c1-27(8-12-35-13-9-27)33-25-20-14-19(18-6-7-24(30-16-18)36-11-5-10-31(2)3)21(28)15-22(20)29-17-23(25)32(4)26(33)34/h6-7,14-17H,5,8-13H2,1-4H3
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AstraZeneca AB

US Patent


Assay Description
Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...


US Patent US9428503 (2016)


BindingDB Entry DOI: 10.7270/Q2GH9GVJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM245477
PNG
(US9428503, 4)
Show SMILES CN(C)CCCOc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n(C4COC4)c3c2c1
Show InChI InChI=1S/C24H27N5O3/c1-27(2)9-4-10-32-22-8-6-17(12-26-22)16-5-7-20-19(11-16)23-21(13-25-20)28(3)24(30)29(23)18-14-31-15-18/h5-8,11-13,18H,4,9-10,14-15H2,1-3H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



AstraZeneca AB

US Patent


Assay Description
Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...


US Patent US9428503 (2016)


BindingDB Entry DOI: 10.7270/Q2GH9GVJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM245478
PNG
(US9428503, 5)
Show SMILES CN(C)CCCOc1ccc(cn1)-c1ccc2ncc3n(C)c(=O)n([C@@H]4C[C@H](O)C4)c3c2c1
Show InChI InChI=1S/C25H29N5O3/c1-28(2)9-4-10-33-23-8-6-17(14-27-23)16-5-7-21-20(11-16)24-22(15-26-21)29(3)25(32)30(24)18-12-19(31)13-18/h5-8,11,14-15,18-19,31H,4,9-10,12-13H2,1-3H3/t18-,19+
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AstraZeneca AB

US Patent


Assay Description
Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...


US Patent US9428503 (2016)


BindingDB Entry DOI: 10.7270/Q2GH9GVJ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase ATR


(Homo sapiens (Human))
BDBM245479
PNG
(US9428503, 6)
Show SMILES CO[C@H]1C[C@H](C1)n1c2c(cnc3cc(F)c(cc23)-c2ccc(OCCCN(C)C)nc2)n(C)c1=O
Show InChI InChI=1S/C26H30FN5O3/c1-30(2)8-5-9-35-24-7-6-16(14-29-24)19-12-20-22(13-21(19)27)28-15-23-25(20)32(26(33)31(23)3)17-10-18(11-17)34-4/h6-7,12-15,17-18H,5,8-11H2,1-4H3/t17-,18+
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AstraZeneca AB

US Patent


Assay Description
Assay b) HT29 cells (ECACC #85061109) were seeded into 384 well assay plates (Costar #3712) at a density of 6000 cells/well in 40 μl EMEM medium c...


US Patent US9428503 (2016)


BindingDB Entry DOI: 10.7270/Q2GH9GVJ
More data for this
Ligand-Target Pair
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