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Compile Data Set for Download or QSAR

Found 9878 hits Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase PIM'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108377
PNG
(US8604217, 128)
Show SMILES Brc1c(Br)c(Br)c2[nH]c(NCCc3ccccn3)nc2c1Br
Show InChI InChI=1S/C14H10Br4N4/c15-8-9(16)11(18)13-12(10(8)17)21-14(22-13)20-6-4-7-3-1-2-5-19-7/h1-3,5H,4,6H2,(H2,20,21,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
n/an/a 71.3n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108378
PNG
(US8604217, 158)
Show SMILES CN(C)CCN(Cc1ccccc1)c1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1
Show InChI InChI=1S/C18H18Br4N4/c1-25(2)8-9-26(10-11-6-4-3-5-7-11)18-23-16-14(21)12(19)13(20)15(22)17(16)24-18/h3-7H,8-10H2,1-2H3,(H,23,24)
PDB
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KEGG

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UniChem

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n/an/a 62.7n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108379
PNG
(US8604217, 166)
Show SMILES CN(C)CCN1CCC(CNc2nc3c(Br)c(Br)c(Br)c(Br)c3[nH]2)C1
Show InChI InChI=1S/C16H21Br4N5/c1-24(2)5-6-25-4-3-9(8-25)7-21-16-22-14-12(19)10(17)11(18)13(20)15(14)23-16/h9H,3-8H2,1-2H3,(H2,21,22,23)
PDB
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n/an/a 51.0n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108380
PNG
(US8604217, 192)
Show SMILES Brc1c(Br)c(Br)c2[nH]c(NCCCN3CCOCC3)nc2c1Br
Show InChI InChI=1S/C14H16Br4N4O/c15-8-9(16)11(18)13-12(10(8)17)20-14(21-13)19-2-1-3-22-4-6-23-7-5-22/h1-7H2,(H2,19,20,21)
PDB
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n/an/a 45.4n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108383
PNG
(US8604217, 247)
Show SMILES Brc1c(Br)c(Br)c2[nH]c(NCCN3CCN(CC3)c3ncccn3)nc2c1Br
Show InChI InChI=1S/C17H17Br4N7/c18-10-11(19)13(21)15-14(12(10)20)25-16(26-15)22-4-5-27-6-8-28(9-7-27)17-23-2-1-3-24-17/h1-3H,4-9H2,(H2,22,25,26)
PDB
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n/an/a 109n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108384
PNG
(US8604217, 248)
Show SMILES Cc1c(Nc2nc3c(Br)c(Br)c(Br)c(Br)c3[nH]2)cccc1-c1nncn1C
Show InChI InChI=1S/C17H12Br4N6/c1-7-8(16-26-22-6-27(16)2)4-3-5-9(7)23-17-24-14-12(20)10(18)11(19)13(21)15(14)25-17/h3-6H,1-2H3,(H2,23,24,25)
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UniChem
n/an/a 48.9n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108386
PNG
(US8604217, 261)
Show SMILES Brc1c(Br)c(Br)c2[nH]c(NC3CCCCCCC3)nc2c1Br
Show InChI InChI=1S/C15H17Br4N3/c16-9-10(17)12(19)14-13(11(9)18)21-15(22-14)20-8-6-4-2-1-3-5-7-8/h8H,1-7H2,(H2,20,21,22)
PDB
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n/an/a 138n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108387
PNG
(US8604217, 265a)
Show SMILES CCN1CCCC1CNc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1
Show InChI InChI=1S/C14H16Br4N4/c1-2-22-5-3-4-7(22)6-19-14-20-12-10(17)8(15)9(16)11(18)13(12)21-14/h7H,2-6H2,1H3,(H2,19,20,21)
PDB
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n/an/a 67.4n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108389
PNG
(US8604217, 272)
Show SMILES CN(C)CC(CNc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1)C(O)c1ccccc1
Show InChI InChI=1S/C19H20Br4N4O/c1-27(2)9-11(18(28)10-6-4-3-5-7-10)8-24-19-25-16-14(22)12(20)13(21)15(23)17(16)26-19/h3-7,11,18,28H,8-9H2,1-2H3,(H2,24,25,26)
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UniChem
n/an/a 43.3n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108390
PNG
(US8604217, 296)
Show SMILES Fc1ccc(CNc2nc3c(Br)c(Br)c(Br)c(Br)c3[nH]2)cc1F
Show InChI InChI=1S/C14H7Br4F2N3/c15-8-9(16)11(18)13-12(10(8)17)22-14(23-13)21-4-5-1-2-6(19)7(20)3-5/h1-3H,4H2,(H2,21,22,23)
PDB
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n/an/a 170n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108391
PNG
(US8604217, 303)
Show SMILES Brc1c(Br)c(Br)c2[nH]c(Nc3c[nH]c(=O)[nH]c3=O)nc2c1Br
Show InChI InChI=1S/C11H5Br4N5O2/c12-3-4(13)6(15)8-7(5(3)14)18-10(19-8)17-2-1-16-11(22)20-9(2)21/h1H,(H2,17,18,19)(H2,16,20,21,22)
PDB
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n/an/a 128n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108392
PNG
(US8604217, 304cis)
Show SMILES NC1CCCCC1Nc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1
Show InChI InChI=1S/C13H14Br4N4/c14-7-8(15)10(17)12-11(9(7)16)20-13(21-12)19-6-4-2-1-3-5(6)18/h5-6H,1-4,18H2,(H2,19,20,21)
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n/an/a 6.90n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM108393
PNG
(US8604217, 304RR)
Show SMILES N[C@@H]1CCCC[C@H]1Nc1nc2c(Br)c(Br)c(Br)c(Br)c2[nH]1
Show InChI InChI=1S/C13H14Br4N4/c14-7-8(15)10(17)12-11(9(7)16)20-13(21-12)19-6-4-2-1-3-5(6)18/h5-6H,1-4,18H2,(H2,19,20,21)/t5-,6-/m1/s1
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n/an/a 5.26n/an/an/an/a7.0n/a



Selvita S.A.

US Patent


Assay Description
Kinase assay was performed using luminescent Kinase-Glo (Promega) system. The Kinase-Glo Luminescent Kinase Assay Platform provides a homogeneous, hi...


US Patent US8604217 (2013)


BindingDB Entry DOI: 10.7270/Q2RJ4H31
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26623
PNG
((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C11H9NO2S/c1-7-2-4-8(5-3-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
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Article
PubMed
n/an/a 60n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26624
PNG
((5Z)-5-[(3-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1cccc(C=C2SC(O)=NC2=O)c1
Show InChI InChI=1S/C11H9NO2S/c1-7-3-2-4-8(5-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
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Article
PubMed
n/an/a 160n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26625
PNG
((5Z)-5-{[4-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-6(2-4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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Article
PubMed
n/an/a 330n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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Article
PubMed
n/an/a 24n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26627
PNG
((5Z)-3-{[4-(trifluoromethoxy)phenyl]methyl}-5-{[3-...)
Show SMILES FC(F)(F)Oc1ccc(CN2C(=O)S\C(=C/c3cccc(c3)C(F)(F)F)C2=O)cc1
Show InChI InChI=1S/C19H11F6NO3S/c20-18(21,22)13-3-1-2-12(8-13)9-15-16(27)26(17(28)30-15)10-11-4-6-14(7-5-11)29-19(23,24)25/h1-9H,10H2/b15-9-
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n/an/a 2.80E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26628
PNG
((5Z)-5-{[2-(methoxymethoxy)-3-(trifluoromethyl)phe...)
Show SMILES COCOc1c(C=C2SC(O)=NC2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C13H10F3NO4S/c1-20-6-21-10-7(3-2-4-8(10)13(14,15)16)5-9-11(18)17-12(19)22-9/h2-5H,6H2,1H3,(H,17,18,19)
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Article
PubMed
n/an/a 460n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26629
PNG
((5Z)-5-{[2-(2-methoxyethoxy)-3-(trifluoromethyl)ph...)
Show SMILES COCCOc1c(C=C2SC(O)=NC2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C14H12F3NO4S/c1-21-5-6-22-11-8(3-2-4-9(11)14(15,16)17)7-10-12(19)18-13(20)23-10/h2-4,7H,5-6H2,1H3,(H,18,19,20)
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Article
PubMed
n/an/a 280n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26630
PNG
((5Z)-5-[(4-ethylphenyl)methylidene]-1,3-thiazolidi...)
Show SMILES CCc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H11NO2S/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)
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Article
PubMed
n/an/a 600n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26631
PNG
((5Z)-5-{[4-(propan-2-yl)phenyl]methylidene}-1,3-th...)
Show SMILES CC(C)c1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C13H13NO2S/c1-8(2)10-5-3-9(4-6-10)7-11-12(15)14-13(16)17-11/h3-8H,1-2H3,(H,14,15,16)
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n/an/a 40n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26632
PNG
((5Z)-5-[(4-methoxyphenyl)methylidene]-1,3-thiazoli...)
Show SMILES COc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C11H9NO3S/c1-15-8-4-2-7(3-5-8)6-9-10(13)12-11(14)16-9/h2-6H,1H3,(H,12,13,14)
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n/an/a 5.10E+3n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26633
PNG
((5Z)-5-{[4-(trifluoromethoxy)phenyl]methylidene}-1...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C11H6F3NO3S/c12-11(13,14)18-7-3-1-6(2-4-7)5-8-9(16)15-10(17)19-8/h1-5H,(H,15,16,17)
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n/an/a 300n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26634
PNG
((5Z)-5-[(3-methoxyphenyl)methylidene]-1,3-thiazoli...)
Show SMILES COc1cccc(C=C2SC(O)=NC2=O)c1
Show InChI InChI=1S/C11H9NO3S/c1-15-8-4-2-3-7(5-8)6-9-10(13)12-11(14)16-9/h2-6H,1H3,(H,12,13,14)
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n/an/a 650n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26635
PNG
((5Z)-5-{[3-(trifluoromethoxy)phenyl]methylidene}-1...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C11H6F3NO3S/c12-11(13,14)18-7-3-1-2-6(4-7)5-8-9(16)15-10(17)19-8/h1-5H,(H,15,16,17)
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n/an/a 67n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26636
PNG
((5Z)-5-[(4-ethoxyphenyl)methylidene]-1,3-thiazolid...)
Show SMILES CCOc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H11NO3S/c1-2-16-9-5-3-8(4-6-9)7-10-11(14)13-12(15)17-10/h3-7H,2H2,1H3,(H,13,14,15)
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n/an/a 170n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26637
PNG
((5Z)-5-{[3-(1,1,2,2-tetrafluoroethoxy)phenyl]methy...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(OC(F)(F)C(F)F)c1
Show InChI InChI=1S/C12H7F4NO3S/c13-10(14)12(15,16)20-7-3-1-2-6(4-7)5-8-9(18)17-11(19)21-8/h1-5,10H,(H,17,18,19)
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n/an/a 73n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26638
PNG
((5Z)-5-[(4-propoxyphenyl)methylidene]-1,3-thiazoli...)
Show SMILES CCCOc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C13H13NO3S/c1-2-7-17-10-5-3-9(4-6-10)8-11-12(15)14-13(16)18-11/h3-6,8H,2,7H2,1H3,(H,14,15,16)
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n/an/a 150n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26639
PNG
((5Z)-5-{[4-(dimethylamino)phenyl]methylidene}-1,3-...)
Show SMILES CN(C)c1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H12N2O2S/c1-14(2)9-5-3-8(4-6-9)7-10-11(15)13-12(16)17-10/h3-7H,1-2H3,(H,13,15,16)
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n/an/a 6.00E+3n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26640
PNG
((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 13n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26641
PNG
((5Z)-3-[(2-fluorophenyl)methyl]-5-[(4-fluorophenyl...)
Show SMILES Fc1ccc(\C=C2/SC(=O)N(Cc3ccccc3F)C2=O)cc1
Show InChI InChI=1S/C17H11F2NO2S/c18-13-7-5-11(6-8-13)9-15-16(21)20(17(22)23-15)10-12-3-1-2-4-14(12)19/h1-9H,10H2/b15-9-
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n/an/a 4.50E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26642
PNG
((5Z)-5-[(3-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(F)c1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 130n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26643
PNG
((5Z)-5-[(4-chlorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Cl)cc1
Show InChI InChI=1S/C10H6ClNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 40n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26644
PNG
((5Z)-5-[(3-chlorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Cl)c1
Show InChI InChI=1S/C10H6ClNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 600n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26645
PNG
((5Z)-5-[(4-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Br)cc1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 2.80E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26646
PNG
((5Z)-5-[(3-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 4.50E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26647
PNG
(3-[(2-fluorophenyl)methyl]-1,3-thiazolidine-2,4-di...)
Show SMILES Oc1csc(=O)n1Cc1ccccc1F
Show InChI InChI=1S/C10H8FNO2S/c11-8-4-2-1-3-7(8)5-12-9(13)6-15-10(12)14/h1-4,6,13H,5H2
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n/an/a 6.30E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM23408
PNG
(2-(3,4-dihydroxyphenyl)-3,5,6,7-tetrahydroxy-4H-ch...)
Show SMILES Oc1ccc(cc1O)-c1oc2cc(O)c(O)c(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
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n/an/a 340n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26655
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-ch...)
Show SMILES Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H
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n/an/a 430n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26656
PNG
(5,7,3,4,5-pentahydroxyflavone | 5,7-dihydroxy-2-(3...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C15H10O7/c16-7-3-8(17)14-9(18)5-12(22-13(14)4-7)6-1-10(19)15(21)11(20)2-6/h1-5,16-17,19-21H
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n/an/a 650n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM15236
PNG
(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1cc(O)c(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,16-20,22H
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n/an/a 780n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM7457
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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n/an/a 850n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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n/an/a 940n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26657
PNG
(3,7,4-trihydroxyflavone | 3,7-dihydroxy-2-(4-hydro...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)ccc2c(=O)c1O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)15-14(19)13(18)11-6-5-10(17)7-12(11)20-15/h1-7,16-17,19H
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n/an/a 980n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 1.10E+3n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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n/an/a 1.30E+3n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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PubMed
n/an/a 1.60E+3n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26658
PNG
(2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-1-benzopy...)
Show SMILES Oc1ccc(c(O)c1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O7/c16-6-1-2-8(9(18)3-6)15-14(21)13(20)12-10(19)4-7(17)5-11(12)22-15/h1-5,16-19,21H
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n/an/a 2.70E+3n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26659
PNG
(7,3-dihydroxyflavone | 7-hydroxy-2-(3-hydroxypheny...)
Show SMILES Oc1cccc(c1)-c1cc(=O)c2ccc(O)cc2o1
Show InChI InChI=1S/C15H10O4/c16-10-3-1-2-9(6-10)14-8-13(18)12-5-4-11(17)7-15(12)19-14/h1-8,16-17H
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n/an/a 4.52E+3n/an/an/an/a7.030



Loma Linda University



Assay Description
The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...


Mol Cancer Ther 6: 163-72 (2007)


Article DOI: 10.1158/1535-7163.MCT-06-0397
BindingDB Entry DOI: 10.7270/Q2N8783K
More data for this
Ligand-Target Pair
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