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Compile Data Set for Download or QSAR

Found 6945 hits Enz. Inhib. hit(s) with Target = 'Transient receptor potential cation channel subfamily V member 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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n/an/an/an/a 32n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20488
PNG
((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Show SMILES COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
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n/an/an/an/a 20n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20490
PNG
(1-(2-bromophenyl)-3-[2-(2,3-dihydro-1H-indol-1-yl)...)
Show SMILES Brc1ccccc1NC(=O)NCCN1CCc2ccccc12
Show InChI InChI=1S/C17H18BrN3O/c18-14-6-2-3-7-15(14)20-17(22)19-10-12-21-11-9-13-5-1-4-8-16(13)21/h1-8H,9-12H2,(H2,19,20,22)
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n/an/an/an/a 158n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20491
PNG
(1-(2-bromophenyl)-3-[2-(4-methyl-2,3-dihydro-1H-in...)
Show SMILES Cc1cccc2N(CCNC(=O)Nc3ccccc3Br)CCc12
Show InChI InChI=1S/C18H20BrN3O/c1-13-5-4-8-17-14(13)9-11-22(17)12-10-20-18(23)21-16-7-3-2-6-15(16)19/h2-8H,9-12H2,1H3,(H2,20,21,23)
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n/an/an/an/a 40n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20492
PNG
(1-(2-bromophenyl)-3-[2-(5-methyl-2,3-dihydro-1H-in...)
Show SMILES Cc1ccc2N(CCNC(=O)Nc3ccccc3Br)CCc2c1
Show InChI InChI=1S/C18H20BrN3O/c1-13-6-7-17-14(12-13)8-10-22(17)11-9-20-18(23)21-16-5-3-2-4-15(16)19/h2-7,12H,8-11H2,1H3,(H2,20,21,23)
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n/an/an/an/a 50n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20493
PNG
(1-(2-bromophenyl)-3-[2-(4-fluoro-2,3-dihydro-1H-in...)
Show SMILES Fc1cccc2N(CCNC(=O)Nc3ccccc3Br)CCc12
Show InChI InChI=1S/C17H17BrFN3O/c18-13-4-1-2-6-15(13)21-17(23)20-9-11-22-10-8-12-14(19)5-3-7-16(12)22/h1-7H,8-11H2,(H2,20,21,23)
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n/an/an/an/a 40n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20494
PNG
(1-(2-bromophenyl)-3-[2-(5-fluoro-2,3-dihydro-1H-in...)
Show SMILES Fc1ccc2N(CCNC(=O)Nc3ccccc3Br)CCc2c1
Show InChI InChI=1S/C17H17BrFN3O/c18-14-3-1-2-4-15(14)21-17(23)20-8-10-22-9-7-12-11-13(19)5-6-16(12)22/h1-6,11H,7-10H2,(H2,20,21,23)
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n/an/an/an/a 79n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20495
PNG
(3-(2-bromophenyl)-1-[2-(6-methyl-1,2,3,4-tetrahydr...)
Show SMILES Cc1ccc2N(CCNC(=O)Nc3ccccc3Br)CCCc2c1
Show InChI InChI=1S/C19H22BrN3O/c1-14-8-9-18-15(13-14)5-4-11-23(18)12-10-21-19(24)22-17-7-3-2-6-16(17)20/h2-3,6-9,13H,4-5,10-12H2,1H3,(H2,21,22,24)
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n/an/an/an/a 40n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20468
PNG
(3-(2-bromophenyl)-1-{2-[ethyl(3-methylphenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1
Show InChI InChI=1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 16n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20496
PNG
(1-(2-bromophenyl)-3-[(3S)-1-(3-methylphenyl)pyrrol...)
Show SMILES Cc1cccc(c1)N1CC[C@@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C18H20BrN3O/c1-13-5-4-6-15(11-13)22-10-9-14(12-22)20-18(23)21-17-8-3-2-7-16(17)19/h2-8,11,14H,9-10,12H2,1H3,(H2,20,21,23)/t14-/m0/s1
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n/an/an/an/a>158n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20497
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(3-methylphenyl)pyrrol...)
Show SMILES Cc1cccc(c1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C18H20BrN3O/c1-13-5-4-6-15(11-13)22-10-9-14(12-22)20-18(23)21-17-8-3-2-7-16(17)19/h2-8,11,14H,9-10,12H2,1H3,(H2,20,21,23)/t14-/m1/s1
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n/an/an/an/a 20n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20498
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(3-fluorophenyl)pyrrol...)
Show SMILES Fc1cccc(c1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H17BrFN3O/c18-15-6-1-2-7-16(15)21-17(23)20-13-8-9-22(11-13)14-5-3-4-12(19)10-14/h1-7,10,13H,8-9,11H2,(H2,20,21,23)/t13-/m1/s1
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n/an/an/an/a 16n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20499
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(3,4-difluorophenyl)py...)
Show SMILES Fc1ccc(cc1F)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H16BrF2N3O/c18-13-3-1-2-4-16(13)22-17(24)21-11-7-8-23(10-11)12-5-6-14(19)15(20)9-12/h1-6,9,11H,7-8,10H2,(H2,21,22,24)/t11-/m1/s1
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n/an/an/an/a 8n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20500
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(3-fluoro-4-methylphen...)
Show SMILES Cc1ccc(cc1F)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C18H19BrFN3O/c1-12-6-7-14(10-16(12)20)23-9-8-13(11-23)21-18(24)22-17-5-3-2-4-15(17)19/h2-7,10,13H,8-9,11H2,1H3,(H2,21,22,24)/t13-/m1/s1
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n/an/an/an/a 5n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20501
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(pyridin-2-yl)pyrrolid...)
Show SMILES Brc1ccccc1NC(=O)N[C@@H]1CCN(C1)c1ccccn1
Show InChI InChI=1S/C16H17BrN4O/c17-13-5-1-2-6-14(13)20-16(22)19-12-8-10-21(11-12)15-7-3-4-9-18-15/h1-7,9,12H,8,10-11H2,(H2,19,20,22)/t12-/m1/s1
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n/an/an/an/a>251n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20502
PNG
(1-(2-bromophenyl)-3-[(3R)-1-[3-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1cccnc1N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H16BrF3N4O/c18-13-5-1-2-6-14(13)24-16(26)23-11-7-9-25(10-11)15-12(17(19,20)21)4-3-8-22-15/h1-6,8,11H,7,9-10H2,(H2,23,24,26)/t11-/m1/s1
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n/an/an/an/a 79n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20503
PNG
(1-(2-bromophenyl)-3-[(3R)-1-[4-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1ccnc(c1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-6-8-25(10-12)15-9-11(5-7-22-15)17(19,20)21/h1-5,7,9,12H,6,8,10H2,(H2,23,24,26)/t12-/m1/s1
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n/an/an/an/a 126n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20504
PNG
(1-(2-bromophenyl)-3-[(3R)-1-[5-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H16BrF3N4O/c18-13-3-1-2-4-14(13)24-16(26)23-12-7-8-25(10-12)15-6-5-11(9-22-15)17(19,20)21/h1-6,9,12H,7-8,10H2,(H2,23,24,26)/t12-/m1/s1
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n/an/an/an/a 32n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20505
PNG
(1-(2-bromophenyl)-3-[(3R)-1-[6-(trifluoromethyl)py...)
Show SMILES FC(F)(F)c1cccc(n1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H16BrF3N4O/c18-12-4-1-2-5-13(12)23-16(26)22-11-8-9-25(10-11)15-7-3-6-14(24-15)17(19,20)21/h1-7,11H,8-10H2,(H2,22,23,26)/t11-/m1/s1
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n/an/an/an/a 63n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20506
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(5-bromopyridin-2-yl)p...)
Show SMILES Brc1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C16H16Br2N4O/c17-11-5-6-15(19-9-11)22-8-7-12(10-22)20-16(23)21-14-4-2-1-3-13(14)18/h1-6,9,12H,7-8,10H2,(H2,20,21,23)/t12-/m1/s1
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n/an/an/an/a 63n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20507
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(5-chloropyridin-2-yl)...)
Show SMILES Clc1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C16H16BrClN4O/c17-13-3-1-2-4-14(13)21-16(23)20-12-7-8-22(10-12)15-6-5-11(18)9-19-15/h1-6,9,12H,7-8,10H2,(H2,20,21,23)/t12-/m1/s1
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n/an/an/an/a 50n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20508
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(5-cyanopyridin-2-yl)p...)
Show SMILES Brc1ccccc1NC(=O)N[C@@H]1CCN(C1)c1ccc(cn1)C#N
Show InChI InChI=1S/C17H16BrN5O/c18-14-3-1-2-4-15(14)22-17(24)21-13-7-8-23(11-13)16-6-5-12(9-19)10-20-16/h1-6,10,13H,7-8,11H2,(H2,21,22,24)/t13-/m1/s1
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n/an/an/an/a 200n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20509
PNG
(1-(2-bromophenyl)-3-[(3R)-1-(5-methylpyridin-2-yl)...)
Show SMILES Cc1ccc(nc1)N1CC[C@H](C1)NC(=O)Nc1ccccc1Br
Show InChI InChI=1S/C17H19BrN4O/c1-12-6-7-16(19-10-12)22-9-8-13(11-22)20-17(23)21-15-5-3-2-4-14(15)18/h2-7,10,13H,8-9,11H2,1H3,(H2,20,21,23)/t13-/m1/s1
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n/an/an/an/a>200n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 16: 3287-91 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.030
BindingDB Entry DOI: 10.7270/Q2125QX9
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20469
PNG
(3-{2-[ethyl(3-methylphenyl)amino]ethyl}-1-phenylur...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1)c1cccc(C)c1
Show InChI InChI=1S/C18H23N3O/c1-3-21(17-11-7-8-15(2)14-17)13-12-19-18(22)20-16-9-5-4-6-10-16/h4-11,14H,3,12-13H2,1-2H3,(H2,19,20,22)
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n/an/an/an/a 63n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20470
PNG
(3-{2-[ethyl(3-methylphenyl)amino]ethyl}-1-(2-methy...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1C)c1cccc(C)c1
Show InChI InChI=1S/C19H25N3O/c1-4-22(17-10-7-8-15(2)14-17)13-12-20-19(23)21-18-11-6-5-9-16(18)3/h5-11,14H,4,12-13H2,1-3H3,(H2,20,21,23)
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n/an/an/an/a 126n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20471
PNG
(3-{2-[ethyl(3-methylphenyl)amino]ethyl}-1-(2-fluor...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1F)c1cccc(C)c1
Show InChI InChI=1S/C18H22FN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 158n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20472
PNG
(1-(2-chlorophenyl)-3-{2-[ethyl(3-methylphenyl)amin...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Cl)c1cccc(C)c1
Show InChI InChI=1S/C18H22ClN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 20n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20468
PNG
(3-(2-bromophenyl)-1-{2-[ethyl(3-methylphenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1
Show InChI InChI=1S/C18H22BrN3O/c1-3-22(15-8-6-7-14(2)13-15)12-11-20-18(23)21-17-10-5-4-9-16(17)19/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 16n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20473
PNG
(1-(3-bromophenyl)-3-{2-[ethyl(3-methylphenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1cccc(Br)c1)c1cccc(C)c1
Show InChI InChI=1S/C18H22BrN3O/c1-3-22(17-9-4-6-14(2)12-17)11-10-20-18(23)21-16-8-5-7-15(19)13-16/h4-9,12-13H,3,10-11H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 40n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20474
PNG
(1-(4-bromophenyl)-3-{2-[ethyl(3-methylphenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1ccc(Br)cc1)c1cccc(C)c1
Show InChI InChI=1S/C18H22BrN3O/c1-3-22(17-6-4-5-14(2)13-17)12-11-20-18(23)21-16-9-7-15(19)8-10-16/h4-10,13H,3,11-12H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 63n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20475
PNG
(3-{2-[ethyl(3-methylphenyl)amino]ethyl}-1-naphthal...)
Show SMILES CCN(CCNC(=O)Nc1cccc2ccccc12)c1cccc(C)c1
Show InChI InChI=1S/C22H25N3O/c1-3-25(19-11-6-8-17(2)16-19)15-14-23-22(26)24-21-13-7-10-18-9-4-5-12-20(18)21/h4-13,16H,3,14-15H2,1-2H3,(H2,23,24,26)
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n/an/an/an/a 79n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20476
PNG
(1-(2,3-dichlorophenyl)-3-{2-[ethyl(3-methylphenyl)...)
Show SMILES CCN(CCNC(=O)Nc1cccc(Cl)c1Cl)c1cccc(C)c1
Show InChI InChI=1S/C18H21Cl2N3O/c1-3-23(14-7-4-6-13(2)12-14)11-10-21-18(24)22-16-9-5-8-15(19)17(16)20/h4-9,12H,3,10-11H2,1-2H3,(H2,21,22,24)
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n/an/an/an/a 20n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20477
PNG
(1-(2,5-dichlorophenyl)-3-{2-[ethyl(3-methylphenyl)...)
Show SMILES CCN(CCNC(=O)Nc1cc(Cl)ccc1Cl)c1cccc(C)c1
Show InChI InChI=1S/C18H21Cl2N3O/c1-3-23(15-6-4-5-13(2)11-15)10-9-21-18(24)22-17-12-14(19)7-8-16(17)20/h4-8,11-12H,3,9-10H2,1-2H3,(H2,21,22,24)
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n/an/an/an/a 25n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20478
PNG
(1-(2-bromophenyl)-3-{2-[(3-methylphenyl)amino]ethy...)
Show SMILES Cc1cccc(NCCNC(=O)Nc2ccccc2Br)c1
Show InChI InChI=1S/C16H18BrN3O/c1-12-5-4-6-13(11-12)18-9-10-19-16(21)20-15-8-3-2-7-14(15)17/h2-8,11,18H,9-10H2,1H3,(H2,19,20,21)
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n/an/an/an/a>158n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20479
PNG
(1-(2-bromophenyl)-3-{2-[methyl(3-methylphenyl)amin...)
Show SMILES CN(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1
Show InChI InChI=1S/C17H20BrN3O/c1-13-6-5-7-14(12-13)21(2)11-10-19-17(22)20-16-9-4-3-8-15(16)18/h3-9,12H,10-11H2,1-2H3,(H2,19,20,22)
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n/an/an/an/a 40n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20480
PNG
(1-{2-[benzyl(3-methylphenyl)amino]ethyl}-3-(2-brom...)
Show SMILES Cc1cccc(c1)N(CCNC(=O)Nc1ccccc1Br)Cc1ccccc1
Show InChI InChI=1S/C23H24BrN3O/c1-18-8-7-11-20(16-18)27(17-19-9-3-2-4-10-19)15-14-25-23(28)26-22-13-6-5-12-21(22)24/h2-13,16H,14-15,17H2,1H3,(H2,25,26,28)
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n/an/an/an/a>200n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20481
PNG
(N-(2-{[(2-bromophenyl)carbamoyl]amino}ethyl)-N-(3-...)
Show SMILES CC(=O)N(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1
Show InChI InChI=1S/C18H20BrN3O2/c1-13-6-5-7-15(12-13)22(14(2)23)11-10-20-18(24)21-17-9-4-3-8-16(17)19/h3-9,12H,10-11H2,1-2H3,(H2,20,21,24)
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n/an/an/an/a>251n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20482
PNG
(1-(2-bromophenyl)-3-{2-[ethyl(phenyl)amino]ethyl}u...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1ccccc1
Show InChI InChI=1S/C17H20BrN3O/c1-2-21(14-8-4-3-5-9-14)13-12-19-17(22)20-16-11-7-6-10-15(16)18/h3-11H,2,12-13H2,1H3,(H2,19,20,22)
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n/an/an/an/a 63n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20483
PNG
(1-(2-bromophenyl)-3-{2-[ethyl(2-methylphenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1ccccc1C
Show InChI InChI=1S/C18H22BrN3O/c1-3-22(17-11-7-4-8-14(17)2)13-12-20-18(23)21-16-10-6-5-9-15(16)19/h4-11H,3,12-13H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 126n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20484
PNG
(1-(2-bromophenyl)-3-{2-[ethyl(4-methylphenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1ccc(C)cc1
Show InChI InChI=1S/C18H22BrN3O/c1-3-22(15-10-8-14(2)9-11-15)13-12-20-18(23)21-17-7-5-4-6-16(17)19/h4-11H,3,12-13H2,1-2H3,(H2,20,21,23)
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n/an/an/an/a 8n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20485
PNG
(1-(2-bromophenyl)-3-{2-[ethyl(3-fluorophenyl)amino...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1cccc(F)c1
Show InChI InChI=1S/C17H19BrFN3O/c1-2-22(14-7-5-6-13(19)12-14)11-10-20-17(23)21-16-9-4-3-8-15(16)18/h3-9,12H,2,10-11H2,1H3,(H2,20,21,23)
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n/an/an/an/a 25n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20486
PNG
(1-(2-bromophenyl)-3-{2-[(3,4-difluorophenyl)(ethyl...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1ccc(F)c(F)c1
Show InChI InChI=1S/C17H18BrF2N3O/c1-2-23(12-7-8-14(19)15(20)11-12)10-9-21-17(24)22-16-6-4-3-5-13(16)18/h3-8,11H,2,9-10H2,1H3,(H2,21,22,24)
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n/an/an/an/a 16n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20487
PNG
(1-(2-bromophenyl)-3-{2-[ethyl(3-fluoro-4-methylphe...)
Show SMILES CCN(CCNC(=O)Nc1ccccc1Br)c1ccc(C)c(F)c1
Show InChI InChI=1S/C18H21BrFN3O/c1-3-23(14-9-8-13(2)16(20)12-14)11-10-21-18(24)22-17-7-5-4-6-15(17)19/h4-9,12H,3,10-11H2,1-2H3,(H2,21,22,24)
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n/an/an/an/a 6n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))
BDBM20489
PNG
(1-(2-bromophenyl)-3-{2-[ethyl(methyl)(3-methylphen...)
Show SMILES CC[N+](C)(CCNC(=O)Nc1ccccc1Br)c1cccc(C)c1
Show InChI InChI=1S/C19H24BrN3O/c1-4-23(3,16-9-7-8-15(2)14-16)13-12-21-19(24)22-18-11-6-5-10-17(18)20/h5-11,14H,4,12-13H2,1-3H3,(H-,21,22,24)/p+1
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n/an/an/an/a 100n/an/a7.225



GSK



Assay Description
One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h...


Bioorg Med Chem Lett 14: 3631-4 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.028
BindingDB Entry DOI: 10.7270/Q24T6GM8
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20286
PNG
(5-I-RTX | 5-iodoresiniferatoxin | [(1R,2R,6R,10S,1...)
Show SMILES COc1cc(CC(=O)OCC2=C[C@H]3[C@H]4OC5(Cc6ccccc6)O[C@]4(C[C@@H](C)[C@]3(O5)[C@@H]3C=C(C)C(=O)[C@@]3(O)C2)C(C)=C)cc(I)c1O
Show InChI InChI=1S/C37H39IO9/c1-20(2)35-16-22(4)37-26(33(35)45-36(46-35,47-37)18-23-9-7-6-8-10-23)12-25(17-34(42)29(37)11-21(3)32(34)41)19-44-30(39)15-24-13-27(38)31(40)28(14-24)43-5/h6-14,22,26,29,33,40,42H,1,15-19H2,2-5H3/t22-,26+,29-,33-,34-,35-,36?,37-/m1/s1
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0.610 -54.7n/an/a 12.2n/an/a7.437



Seoul National University



Assay Description
Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...


J Med Chem 51: 57-67 (2008)


Article DOI: 10.1021/jm701049p
BindingDB Entry DOI: 10.7270/Q2222S1N
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20314
PNG
((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-c...)
Show SMILES C[C@H](C(=O)NC[C@H](COC(=O)C(C)(C)C)Cc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C29H41ClN2O5S/c1-19(22-11-14-25(24(30)16-22)32-38(8,35)36)26(33)31-17-21(18-37-27(34)29(5,6)7)15-20-9-12-23(13-10-20)28(2,3)4/h9-14,16,19,21,32H,15,17-18H2,1-8H3,(H,31,33)/t19-,21+/m0/s1
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1.83 -51.9n/an/a 5.20n/an/a7.437



Seoul National University



Assay Description
Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...


J Med Chem 51: 57-67 (2008)


Article DOI: 10.1021/jm701049p
BindingDB Entry DOI: 10.7270/Q2222S1N
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20311
PNG
((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-c...)
Show SMILES C[C@H](C(=O)NC[C@@H](COC(=O)C(C)(C)C)Cc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C29H41ClN2O5S/c1-19(22-11-14-25(24(30)16-22)32-38(8,35)36)26(33)31-17-21(18-37-27(34)29(5,6)7)15-20-9-12-23(13-10-20)28(2,3)4/h9-14,16,19,21,32H,15,17-18H2,1-8H3,(H,31,33)/t19-,21-/m0/s1
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3.29 -50.4n/an/a 12.1n/an/a7.437



Seoul National University



Assay Description
Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...


J Med Chem 51: 57-67 (2008)


Article DOI: 10.1021/jm701049p
BindingDB Entry DOI: 10.7270/Q2222S1N
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20291
PNG
(2-[(4-tert-butylphenyl)methyl]-3-[2-(3-chloro-4-me...)
Show SMILES CC(C(=O)NCC(COC(=O)C(C)(C)C)Cc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(Cl)c1
Show InChI InChI=1S/C29H41ClN2O5S/c1-19(22-11-14-25(24(30)16-22)32-38(8,35)36)26(33)31-17-21(18-37-27(34)29(5,6)7)15-20-9-12-23(13-10-20)28(2,3)4/h9-14,16,19,21,32H,15,17-18H2,1-8H3,(H,31,33)
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3.60 -50.1n/an/a 12.3n/an/a7.437



Seoul National University



Assay Description
Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...


J Med Chem 51: 57-67 (2008)


Article DOI: 10.1021/jm701049p
BindingDB Entry DOI: 10.7270/Q2222S1N
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20313
PNG
((2R)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-f...)
Show SMILES C[C@H](C(=O)NC[C@H](COC(=O)C(C)(C)C)Cc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1
Show InChI InChI=1S/C29H41FN2O5S/c1-19(22-11-14-25(24(30)16-22)32-38(8,35)36)26(33)31-17-21(18-37-27(34)29(5,6)7)15-20-9-12-23(13-10-20)28(2,3)4/h9-14,16,19,21,32H,15,17-18H2,1-8H3,(H,31,33)/t19-,21+/m0/s1
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4.12 -49.8n/an/a 0.580n/an/a7.437



Seoul National University



Assay Description
Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...


J Med Chem 51: 57-67 (2008)


Article DOI: 10.1021/jm701049p
BindingDB Entry DOI: 10.7270/Q2222S1N
More data for this
Ligand-Target Pair
Vanilloid receptor


(Rattus norvegicus (rat))
BDBM20310
PNG
((2S)-2-[(4-tert-butylphenyl)methyl]-3-[(2S)-2-(3-f...)
Show SMILES C[C@H](C(=O)NC[C@@H](COC(=O)C(C)(C)C)Cc1ccc(cc1)C(C)(C)C)c1ccc(NS(C)(=O)=O)c(F)c1
Show InChI InChI=1S/C29H41FN2O5S/c1-19(22-11-14-25(24(30)16-22)32-38(8,35)36)26(33)31-17-21(18-37-27(34)29(5,6)7)15-20-9-12-23(13-10-20)28(2,3)4/h9-14,16,19,21,32H,15,17-18H2,1-8H3,(H,31,33)/t19-,21-/m0/s1
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6.26 -48.7n/an/a 10.9n/an/a7.437



Seoul National University



Assay Description
Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...


J Med Chem 51: 57-67 (2008)


Article DOI: 10.1021/jm701049p
BindingDB Entry DOI: 10.7270/Q2222S1N
More data for this
Ligand-Target Pair
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