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Found 8714 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112513
PNG
(US8618103, I-9)
Show SMILES CC(=O)N1CC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C17H18N6O/c1-11(24)23-8-5-12(10-23)21-16-13(3-2-6-18-16)15-9-20-17-14(22-15)4-7-19-17/h2-4,6-7,9,12H,5,8,10H2,1H3,(H,18,21)(H,19,20)/t12-/m0/s1
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n/an/a 0.0397n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112514
PNG
(US8618103, I-10)
Show SMILES COC(=O)N1CC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C17H18N6O2/c1-25-17(24)23-8-5-11(10-23)21-15-12(3-2-6-18-15)14-9-20-16-13(22-14)4-7-19-16/h2-4,6-7,9,11H,5,8,10H2,1H3,(H,18,21)(H,19,20)/t11-/m0/s1
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n/an/a 0.0276n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112515
PNG
(US8618103, I-11)
Show SMILES CS(=O)(=O)N1CC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C16H18N6O2S/c1-25(23,24)22-8-5-11(10-22)20-15-12(3-2-6-17-15)14-9-19-16-13(21-14)4-7-18-16/h2-4,6-7,9,11H,5,8,10H2,1H3,(H,17,20)(H,18,19)/t11-/m0/s1
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n/an/a 0.0108n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112516
PNG
(US8618103, I-12)
Show SMILES CC(=O)N1CCCCC(C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H22N6O/c1-13(26)25-10-3-2-5-14(12-25)23-18-15(6-4-8-20-18)17-11-22-19-16(24-17)7-9-21-19/h4,6-9,11,14H,2-3,5,10,12H2,1H3,(H,20,23)(H,21,22)
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n/an/a 0.0191n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112517
PNG
(US8618103, I-13)
Show SMILES COC(=O)N1CCCCC(C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H22N6O2/c1-27-19(26)25-10-3-2-5-13(12-25)23-17-14(6-4-8-20-17)16-11-22-18-15(24-16)7-9-21-18/h4,6-9,11,13H,2-3,5,10,12H2,1H3,(H,20,23)(H,21,22)
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n/an/a 0.0106n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112518
PNG
(US8618103, I-14)
Show SMILES CS(=O)(=O)N1CCCCC(C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H22N6O2S/c1-27(25,26)24-10-3-2-5-13(12-24)22-17-14(6-4-8-19-17)16-11-21-18-15(23-16)7-9-20-18/h4,6-9,11,13H,2-3,5,10,12H2,1H3,(H,19,22)(H,20,21)
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n/an/a 0.0209n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112519
PNG
(US8618103, I-15)
Show SMILES CC(C)S(=O)(=O)N1CCC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H24N6O2S/c1-13(2)28(26,27)25-10-4-5-14(12-25)23-18-15(6-3-8-20-18)17-11-22-19-16(24-17)7-9-21-19/h3,6-9,11,13-14H,4-5,10,12H2,1-2H3,(H,20,23)(H,21,22)/t14-/m1/s1
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n/an/a 0.729n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112520
PNG
(US8618103, I-16)
Show SMILES CCS(=O)(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C17H20N6O2S/c1-2-26(24,25)23-9-6-12(11-23)21-16-13(4-3-7-18-16)15-10-20-17-14(22-15)5-8-19-17/h3-5,7-8,10,12H,2,6,9,11H2,1H3,(H,18,21)(H,19,20)/t12-/m1/s1
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n/an/a 0.247n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112521
PNG
(US8618103, I-17)
Show SMILES CCCS(=O)(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H22N6O2S/c1-2-10-27(25,26)24-9-6-13(12-24)22-17-14(4-3-7-19-17)16-11-21-18-15(23-16)5-8-20-18/h3-5,7-8,11,13H,2,6,9-10,12H2,1H3,(H,19,22)(H,20,21)/t13-/m1/s1
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n/an/a 0.343n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112522
PNG
(US8618103, I-18)
Show SMILES CC(C)S(=O)(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H22N6O2S/c1-12(2)27(25,26)24-9-6-13(11-24)22-17-14(4-3-7-19-17)16-10-21-18-15(23-16)5-8-20-18/h3-5,7-8,10,12-13H,6,9,11H2,1-2H3,(H,19,22)(H,20,21)/t13-/m1/s1
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n/an/a 0.573n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112523
PNG
(US8618103, I-19)
Show SMILES CC(C)CS(=O)(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H24N6O2S/c1-13(2)12-28(26,27)25-9-6-14(11-25)23-18-15(4-3-7-20-18)17-10-22-19-16(24-17)5-8-21-19/h3-5,7-8,10,13-14H,6,9,11-12H2,1-2H3,(H,20,23)(H,21,22)/t14-/m1/s1
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n/an/a 0.662n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112524
PNG
(US8618103, I-20)
Show SMILES CCC(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H20N6O/c1-2-16(25)24-9-6-12(11-24)22-17-13(4-3-7-19-17)15-10-21-18-14(23-15)5-8-20-18/h3-5,7-8,10,12H,2,6,9,11H2,1H3,(H,19,22)(H,20,21)/t12-/m1/s1
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n/an/a 0.0847n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112525
PNG
(US8618103, I-21)
Show SMILES CCCC(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H22N6O/c1-2-4-17(26)25-10-7-13(12-25)23-18-14(5-3-8-20-18)16-11-22-19-15(24-16)6-9-21-19/h3,5-6,8-9,11,13H,2,4,7,10,12H2,1H3,(H,20,23)(H,21,22)/t13-/m1/s1
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n/an/a 0.121n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112526
PNG
(US8618103, I-22)
Show SMILES CC(C)C(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H22N6O/c1-12(2)19(26)25-9-6-13(11-25)23-17-14(4-3-7-20-17)16-10-22-18-15(24-16)5-8-21-18/h3-5,7-8,10,12-13H,6,9,11H2,1-2H3,(H,20,23)(H,21,22)/t13-/m1/s1
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n/an/a 0.168n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112527
PNG
(US8618103, I-23)
Show SMILES CC(C)CC(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C20H24N6O/c1-13(2)10-18(27)26-9-6-14(12-26)24-19-15(4-3-7-21-19)17-11-23-20-16(25-17)5-8-22-20/h3-5,7-8,11,13-14H,6,9-10,12H2,1-2H3,(H,21,24)(H,22,23)/t14-/m1/s1
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n/an/a 0.153n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112528
PNG
(US8618103, I-24)
Show SMILES C[C@H]1C[C@@H](CN(C1)S(C)(=O)=O)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H22N6O2S/c1-12-8-13(11-24(10-12)27(2,25)26)22-17-14(4-3-6-19-17)16-9-21-18-15(23-16)5-7-20-18/h3-7,9,12-13H,8,10-11H2,1-2H3,(H,19,22)(H,20,21)/t12-,13-/m0/s1
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n/an/a 0.140n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112529
PNG
(US8618103, I-25)
Show SMILES CCCS(=O)(=O)N1C[C@@H](C)C[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C20H26N6O2S/c1-3-9-29(27,28)26-12-14(2)10-15(13-26)24-19-16(5-4-7-21-19)18-11-23-20-17(25-18)6-8-22-20/h4-8,11,14-15H,3,9-10,12-13H2,1-2H3,(H,21,24)(H,22,23)/t14-,15-/m0/s1
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n/an/a 0.0676n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112530
PNG
(US8618103, I-26)
Show SMILES CC(C)CS(=O)(=O)N1C[C@@H](C)C[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C21H28N6O2S/c1-14(2)13-30(28,29)27-11-15(3)9-16(12-27)25-20-17(5-4-7-22-20)19-10-24-21-18(26-19)6-8-23-21/h4-8,10,14-16H,9,11-13H2,1-3H3,(H,22,25)(H,23,24)/t15-,16-/m0/s1
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n/an/a 0.0700n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112531
PNG
(US8618103, I-27)
Show SMILES CC(C)CCS(=O)(=O)N1CC[C@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C20H26N6O2S/c1-14(2)7-11-29(27,28)26-10-6-15(13-26)24-19-16(4-3-8-21-19)18-12-23-20-17(25-18)5-9-22-20/h3-5,8-9,12,14-15H,6-7,10-11,13H2,1-2H3,(H,21,24)(H,22,23)/t15-/m1/s1
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n/an/a 0.811n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112532
PNG
(US8618103, I-28)
Show SMILES CC(C)S(=O)(=O)N1C[C@@H](C)C[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C20H26N6O2S/c1-13(2)29(27,28)26-11-14(3)9-15(12-26)24-19-16(5-4-7-21-19)18-10-23-20-17(25-18)6-8-22-20/h4-8,10,13-15H,9,11-12H2,1-3H3,(H,21,24)(H,22,23)/t14-,15-/m0/s1
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n/an/a 0.223n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112533
PNG
(US8618103, I-29)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C20H26N6O2S/c1-14(2)13-29(27,28)26-10-4-5-15(12-26)24-19-16(6-3-8-21-19)18-11-23-20-17(25-18)7-9-22-20/h3,6-9,11,14-15H,4-5,10,12-13H2,1-2H3,(H,21,24)(H,22,23)/t15-/m0/s1
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n/an/a 0.108n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112534
PNG
(US8618103, I-30)
Show SMILES CC(=O)N1CCCC(C1)Nc1nc(C)ccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H22N6O/c1-12-5-6-15(17-10-21-19-16(24-17)7-8-20-19)18(22-12)23-14-4-3-9-25(11-14)13(2)26/h5-8,10,14H,3-4,9,11H2,1-2H3,(H,20,21)(H,22,23)
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n/an/a 0.0876n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112535
PNG
(US8618103, I-31)
Show SMILES Cc1ccc(c(NC2CCCN(C2)S(C)(=O)=O)n1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H22N6O2S/c1-12-5-6-14(16-10-20-18-15(23-16)7-8-19-18)17(21-12)22-13-4-3-9-24(11-13)27(2,25)26/h5-8,10,13H,3-4,9,11H2,1-2H3,(H,19,20)(H,21,22)
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n/an/a 0.0464n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112536
PNG
(US8618103, I-32)
Show SMILES CC(C)(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C21H28N6O2S/c1-21(2,3)14-30(28,29)27-11-5-6-15(13-27)25-19-16(7-4-9-22-19)18-12-24-20-17(26-18)8-10-23-20/h4,7-10,12,15H,5-6,11,13-14H2,1-3H3,(H,22,25)(H,23,24)/t15-/m0/s1
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n/an/a 0.0245n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112537
PNG
(US8618103, I-33)
Show SMILES FC(F)(F)CN1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H19F3N6/c19-18(20,21)11-27-8-2-3-12(10-27)25-16-13(4-1-6-22-16)15-9-24-17-14(26-15)5-7-23-17/h1,4-7,9,12H,2-3,8,10-11H2,(H,22,25)(H,23,24)/t12-/m0/s1
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n/an/a 0.0350n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112538
PNG
(US8618103, I-34)
Show SMILES CCS(=O)(=O)N1CCCC(C1)Nc1nc(C)ccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H24N6O2S/c1-3-28(26,27)25-10-4-5-14(12-25)23-18-15(7-6-13(2)22-18)17-11-21-19-16(24-17)8-9-20-19/h6-9,11,14H,3-5,10,12H2,1-2H3,(H,20,21)(H,22,23)
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n/an/a 0.161n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112539
PNG
(US8618103, I-35)
Show SMILES Cc1ccc(c(NC2CCCN(C2)S(=O)(=O)CC2CC2)n1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C21H26N6O2S/c1-14-4-7-17(19-11-23-21-18(26-19)8-9-22-21)20(24-14)25-16-3-2-10-27(12-16)30(28,29)13-15-5-6-15/h4,7-9,11,15-16H,2-3,5-6,10,12-13H2,1H3,(H,22,23)(H,24,25)
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n/an/a 0.167n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112540
PNG
(US8618103, I-36)
Show SMILES Cc1ccc(c(NC2CCCN(C2)S(=O)(=O)CC(C)(C)C)n1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C22H30N6O2S/c1-15-7-8-17(19-12-24-21-18(27-19)9-10-23-21)20(25-15)26-16-6-5-11-28(13-16)31(29,30)14-22(2,3)4/h7-10,12,16H,5-6,11,13-14H2,1-4H3,(H,23,24)(H,25,26)
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n/an/a 0.134n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112541
PNG
(US8618103, I-37)
Show SMILES CS(=O)(=O)N1CCCC(CC1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H22N6O2S/c1-27(25,26)24-10-3-4-13(7-11-24)22-17-14(5-2-8-19-17)16-12-21-18-15(23-16)6-9-20-18/h2,5-6,8-9,12-13H,3-4,7,10-11H2,1H3,(H,19,22)(H,20,21)
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n/an/a 0.00890n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112542
PNG
(US8618103, I-38)
Show SMILES O=S(=O)(CC1CC1)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C20H24N6O2S/c27-29(28,13-14-5-6-14)26-10-2-3-15(12-26)24-19-16(4-1-8-21-19)18-11-23-20-17(25-18)7-9-22-20/h1,4,7-9,11,14-15H,2-3,5-6,10,12-13H2,(H,21,24)(H,22,23)/t15-/m0/s1
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n/an/a 0.0413n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112543
PNG
(US8618103, I-39)
Show SMILES CC(=O)N1CCCC(C1)Nc1nc(C)ccc1-c1cnc2[nH]cc(Cl)c2n1
Show InChI InChI=1S/C19H21ClN6O/c1-11-5-6-14(16-9-22-19-17(25-16)15(20)8-21-19)18(23-11)24-13-4-3-7-26(10-13)12(2)27/h5-6,8-9,13H,3-4,7,10H2,1-2H3,(H,21,22)(H,23,24)
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n/an/a 0.147n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112544
PNG
(US8618103, I-40)
Show SMILES Cc1ccc(c(NC2CCCN(C2)S(=O)(=O)CC2CC2)n1)-c1cnc2[nH]cc(Cl)c2n1
Show InChI InChI=1S/C21H25ClN6O2S/c1-13-4-7-16(18-10-24-21-19(27-18)17(22)9-23-21)20(25-13)26-15-3-2-8-28(11-15)31(29,30)12-14-5-6-14/h4,7,9-10,14-15H,2-3,5-6,8,11-12H2,1H3,(H,23,24)(H,25,26)
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n/an/a 0.154n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112545
PNG
(US8618103, I-41)
Show SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1nccnc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C16H19N7O2S/c1-26(24,25)23-8-2-3-11(10-23)21-16-14(17-6-7-19-16)13-9-20-15-12(22-13)4-5-18-15/h4-7,9,11H,2-3,8,10H2,1H3,(H,18,20)(H,19,21)/t11-/m0/s1
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n/an/a 0.0359n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112546
PNG
(US8618103, I-42)
Show SMILES O=S(=O)(CC#N)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C18H19N7O2S/c19-6-10-28(26,27)25-9-2-3-13(12-25)23-17-14(4-1-7-20-17)16-11-22-18-15(24-16)5-8-21-18/h1,4-5,7-8,11,13H,2-3,9-10,12H2,(H,20,23)(H,21,22)/t13-/m0/s1
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n/an/a 0.0880n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112547
PNG
(US8618103, I-43)
Show SMILES Cn1ccc2ncc(nc12)-c1cccnc1N[C@H]1CCCN(C1)S(C)(=O)=O
Show InChI InChI=1S/C18H22N6O2S/c1-23-10-7-15-18(23)22-16(11-20-15)14-6-3-8-19-17(14)21-13-5-4-9-24(12-13)27(2,25)26/h3,6-8,10-11,13H,4-5,9,12H2,1-2H3,(H,19,21)/t13-/m0/s1
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n/an/a 1.96n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112549
PNG
(US8618103, I-45)
Show SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ncc2n1
Show InChI InChI=1S/C16H19N7O2S/c1-26(24,25)23-7-3-4-11(10-23)20-15-12(5-2-6-17-15)13-8-18-16-14(21-13)9-19-22-16/h2,5-6,8-9,11H,3-4,7,10H2,1H3,(H,17,20)(H,18,19,22)/t11-/m0/s1
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n/an/a 0.859n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112550
PNG
(US8618103, I-46)
Show SMILES CCCS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ncc2n1
Show InChI InChI=1S/C18H23N7O2S/c1-2-9-28(26,27)25-8-4-5-13(12-25)22-17-14(6-3-7-19-17)15-10-20-18-16(23-15)11-21-24-18/h3,6-7,10-11,13H,2,4-5,8-9,12H2,1H3,(H,19,22)(H,20,21,24)/t13-/m0/s1
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n/an/a 0.833n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112551
PNG
(US8618103, I-47)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ncc2n1
Show InChI InChI=1S/C19H25N7O2S/c1-13(2)12-29(27,28)26-8-4-5-14(11-26)23-18-15(6-3-7-20-18)16-9-21-19-17(24-16)10-22-25-19/h3,6-7,9-10,13-14H,4-5,8,11-12H2,1-2H3,(H,20,23)(H,21,22,25)/t14-/m0/s1
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n/an/a 1n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112552
PNG
(US8618103, I-48)
Show SMILES CCCS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2cc[nH]c2n1
Show InChI InChI=1S/C19H24N6O2S/c1-2-11-28(26,27)25-10-4-5-14(13-25)23-18-15(6-3-8-20-18)17-12-22-16-7-9-21-19(16)24-17/h3,6-9,12,14H,2,4-5,10-11,13H2,1H3,(H,20,23)(H,21,24)/t14-/m0/s1
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n/an/a 0.310n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112553
PNG
(US8618103, I-49)
Show SMILES CCCS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2ccn(C)c2n1
Show InChI InChI=1S/C20H26N6O2S/c1-3-12-29(27,28)26-10-5-6-15(14-26)23-19-16(7-4-9-21-19)18-13-22-17-8-11-25(2)20(17)24-18/h4,7-9,11,13,15H,3,5-6,10,12,14H2,1-2H3,(H,21,23)/t15-/m0/s1
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n/an/a 1n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112554
PNG
(US8618103, I-50)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2ccn(C)c2n1
Show InChI InChI=1S/C21H28N6O2S/c1-15(2)14-30(28,29)27-10-5-6-16(13-27)24-20-17(7-4-9-22-20)19-12-23-18-8-11-26(3)21(18)25-19/h4,7-9,11-12,15-16H,5-6,10,13-14H2,1-3H3,(H,22,24)/t16-/m0/s1
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n/an/a 0.580n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112555
PNG
(US8618103, I-51)
Show SMILES CCCS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2nc[nH]c2n1
Show InChI InChI=1S/C18H23N7O2S/c1-2-9-28(26,27)25-8-4-5-13(11-25)23-16-14(6-3-7-19-16)15-10-20-17-18(24-15)22-12-21-17/h3,6-7,10,12-13H,2,4-5,8-9,11H2,1H3,(H,19,23)(H,20,21,22,24)/t13-/m0/s1
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n/an/a 1n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112556
PNG
(US8618103, I-52)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2nc[nH]c2n1
Show InChI InChI=1S/C19H25N7O2S/c1-13(2)11-29(27,28)26-8-4-5-14(10-26)24-17-15(6-3-7-20-17)16-9-21-18-19(25-16)23-12-22-18/h3,6-7,9,12-14H,4-5,8,10-11H2,1-2H3,(H,20,24)(H,21,22,23,25)/t14-/m0/s1
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n/an/a 3n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112557
PNG
(US8618103, I-53)
Show SMILES CC(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]ncc2n1
Show InChI InChI=1S/C17H19N7O/c1-11(25)24-7-3-4-12(10-24)21-16-13(5-2-6-18-16)14-8-19-17-15(22-14)9-20-23-17/h2,5-6,8-9,12H,3-4,7,10H2,1H3,(H,18,21)(H,19,20,23)/t12-/m0/s1
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n/an/a 10n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112558
PNG
(US8618103, I-54)
Show SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2cc[nH]c2n1
Show InChI InChI=1S/C17H20N6O2S/c1-26(24,25)23-9-3-4-12(11-23)21-16-13(5-2-7-18-16)15-10-20-14-6-8-19-17(14)22-15/h2,5-8,10,12H,3-4,9,11H2,1H3,(H,18,21)(H,19,22)/t12-/m0/s1
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n/an/a 1.23n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112559
PNG
(US8618103, I-55)
Show SMILES CC(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2ccn(C)c2n1
Show InChI InChI=1S/C19H22N6O/c1-13(26)25-9-4-5-14(12-25)22-18-15(6-3-8-20-18)17-11-21-16-7-10-24(2)19(16)23-17/h3,6-8,10-11,14H,4-5,9,12H2,1-2H3,(H,20,22)/t14-/m0/s1
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n/an/a 10n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112560
PNG
(US8618103, I-56)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1nccnc1-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H25N7O2S/c1-13(2)12-29(27,28)26-9-3-4-14(11-26)24-19-17(20-7-8-22-19)16-10-23-18-15(25-16)5-6-21-18/h5-8,10,13-14H,3-4,9,11-12H2,1-2H3,(H,21,23)(H,22,24)/t14-/m0/s1
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n/an/a 0.0797n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112561
PNG
(US8618103, I-57)
Show SMILES CC(C)CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2cc[nH]c2n1
Show InChI InChI=1S/C20H26N6O2S/c1-14(2)13-29(27,28)26-10-4-5-15(12-26)24-19-16(6-3-8-21-19)18-11-23-17-7-9-22-20(17)25-18/h3,6-9,11,14-15H,4-5,10,12-13H2,1-2H3,(H,21,24)(H,22,25)/t15-/m0/s1
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n/an/a 0.192n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112562
PNG
(US8618103, I-58)
Show SMILES CC(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2cc[nH]c2n1
Show InChI InChI=1S/C18H20N6O/c1-12(25)24-9-3-4-13(11-24)22-17-14(5-2-7-19-17)16-10-21-15-6-8-20-18(15)23-16/h2,5-8,10,13H,3-4,9,11H2,1H3,(H,19,22)(H,20,23)/t13-/m0/s1
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n/an/a 10n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM112564
PNG
(US8618103, I-60)
Show SMILES CS(=O)(=O)N1CCC[C@@H](C1)Nc1ncccc1-c1cnc2[nH]cc(C#N)c2n1
Show InChI InChI=1S/C18H19N7O2S/c1-28(26,27)25-7-3-4-13(11-25)23-17-14(5-2-6-20-17)15-10-22-18-16(24-15)12(8-19)9-21-18/h2,5-6,9-10,13H,3-4,7,11H2,1H3,(H,20,23)(H,21,22)/t13-/m0/s1
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n/an/a 0.124n/an/an/an/a7.2n/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.


US Patent US8618103 (2013)


BindingDB Entry DOI: 10.7270/Q25H7DZH
More data for this
Ligand-Target Pair
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