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Found 4469 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM5057
PNG
(1,2,4-Oxadiazole Analogue 4b | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(C)cc2)no1
Show InChI InChI=1S/C25H30N5O8P/c1-15-3-5-18(6-4-15)14-23-29-25(37-30-23)20(11-12-22(26)32)28-24(33)21(27-16(2)31)13-17-7-9-19(10-8-17)38-39(34,35)36/h3-10,20-21H,11-14H2,1-2H3,(H2,26,32)(H,27,31)(H,28,33)(H2,34,35,36)/t20-,21-/m0/s1
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n/an/a>5.00E+5n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM5059
PNG
(1,2,4-Oxadiazole Analogue 4d | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(Cl)cc2)no1
Show InChI InChI=1S/C24H27ClN5O8P/c1-14(31)27-20(12-15-4-8-18(9-5-15)38-39(34,35)36)23(33)28-19(10-11-21(26)32)24-29-22(30-37-24)13-16-2-6-17(25)7-3-16/h2-9,19-20H,10-13H2,1H3,(H2,26,32)(H,27,31)(H,28,33)(H2,34,35,36)/t19-,20-/m0/s1
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n/an/a>5.00E+5n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM5061
PNG
(1,2,4-Oxadiazole Analogue 4g | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(Cl)cc2Cl)no1
Show InChI InChI=1S/C24H26Cl2N5O8P/c1-13(32)28-20(10-14-2-6-17(7-3-14)39-40(35,36)37)23(34)29-19(8-9-21(27)33)24-30-22(31-38-24)11-15-4-5-16(25)12-18(15)26/h2-7,12,19-20H,8-11H2,1H3,(H2,27,33)(H,28,32)(H,29,34)(H2,35,36,37)/t19-,20-/m0/s1
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n/an/a>5.00E+5n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM92626
PNG
(Pyrido analog, 3)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc2cnc(Nc3ccccc3)nc2n(C)c1=O
Show InChI InChI=1S/C29H22F3N5O2/c1-17-11-12-22(34-26(38)18-7-6-8-20(13-18)29(30,31)32)15-23(17)24-14-19-16-33-28(35-21-9-4-3-5-10-21)36-25(19)37(2)27(24)39/h3-16H,1-2H3,(H,34,38)(H,33,35,36)
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n/an/a 2.10n/an/an/an/a7.425



Pfizer



Assay Description
A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.


Chem Biol Drug Des 80: 657-64 (2012)


Article DOI: 10.1111/j.1747-0285.2012.01443.x
BindingDB Entry DOI: 10.7270/Q2BG2MKC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM92624
PNG
(Dimethoxyquinoline, 1)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N[C@@H]4C[C@H]4c4ccccc4)nc3)c2cc1OC
Show InChI InChI=1S/C26H24N4O4/c1-32-23-13-19-20(14-24(23)33-2)27-11-10-22(19)34-17-8-9-25(28-15-17)30-26(31)29-21-12-18(21)16-6-4-3-5-7-16/h3-11,13-15,18,21H,12H2,1-2H3,(H2,28,29,30,31)/t18-,21+/m0/s1
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n/an/a 320n/an/an/an/a7.425



Pfizer



Assay Description
A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.


Chem Biol Drug Des 80: 657-64 (2012)


Article DOI: 10.1111/j.1747-0285.2012.01443.x
BindingDB Entry DOI: 10.7270/Q2BG2MKC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM92625
PNG
(Dimethoxyquinoline, 2)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cccn(Cc5ccccc5)c4=O)nc3)c2cc1OC
Show InChI InChI=1S/C29H24N4O5/c1-36-25-15-22-23(16-26(25)37-2)30-13-12-24(22)38-20-10-11-27(31-17-20)32-28(34)21-9-6-14-33(29(21)35)18-19-7-4-3-5-8-19/h3-17H,18H2,1-2H3,(H,31,32,34)
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n/an/a 100n/an/an/an/a7.425



Pfizer



Assay Description
A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.


Chem Biol Drug Des 80: 657-64 (2012)


Article DOI: 10.1111/j.1747-0285.2012.01443.x
BindingDB Entry DOI: 10.7270/Q2BG2MKC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM5063
PNG
(1,2,4-Oxadiazole Analogue 4i | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2cccc3ccccc23)no1
Show InChI InChI=1S/C28H30N5O8P/c1-17(34)30-24(15-18-9-11-21(12-10-18)41-42(37,38)39)27(36)31-23(13-14-25(29)35)28-32-26(33-40-28)16-20-7-4-6-19-5-2-3-8-22(19)20/h2-12,23-24H,13-16H2,1H3,(H2,29,35)(H,30,34)(H,31,36)(H2,37,38,39)/t23-,24-/m0/s1
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n/an/a>5.00E+5n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140299
PNG
(US8912173, 25)
Show SMILES COc1ccc(cc1OC)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H21N3O4/c1-29-21-8-7-15(12-23(21)30-2)16-11-19-17(5-3-9-26-19)22(13-16)31-14-20-18(24(25)28)6-4-10-27-20/h3-13H,14H2,1-2H3,(H2,25,28)
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n/an/a 0.600n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140300
PNG
(US8912173, 26)
Show SMILES CC(=O)Nc1ccc(cn1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C23H19N5O3/c1-14(29)28-22-7-6-15(12-27-22)16-10-19-17(4-2-8-25-19)21(11-16)31-13-20-18(23(24)30)5-3-9-26-20/h2-12H,13H2,1H3,(H2,24,30)(H,27,28,29)
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n/an/a 14.2n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140301
PNG
(US8912173, 27)
Show SMILES C[C@@H](Oc1cc(Br)cc2ncccc12)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C15H15BrN2O2/c1-9(10-5-15(19)18-8-10)20-14-7-11(16)6-13-12(14)3-2-4-17-13/h2-4,6-7,9-10H,5,8H2,1H3,(H,18,19)/t9-,10-/m1/s1
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n/an/a 55.1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140302
PNG
(US8912173, 28)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc(OCC2(CC(N)=O)CC2)c2cccnc2c1
Show InChI InChI=1S/C24H26N2O5/c1-28-20-11-16(12-21(29-2)23(20)30-3)15-9-18-17(5-4-8-26-18)19(10-15)31-14-24(6-7-24)13-22(25)27/h4-5,8-12H,6-7,13-14H2,1-3H3,(H2,25,27)
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n/an/a 409n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140303
PNG
(US8912173, 29)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2ncccc2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C24H21N3O2/c1-15(19-13-24(28)27-14-19)29-23-12-18(11-22-20(23)5-3-9-26-22)16-6-7-21-17(10-16)4-2-8-25-21/h2-12,15,19H,13-14H2,1H3,(H,27,28)/t15-,19-/m1/s1
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140304
PNG
(US8912173, 30)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(NC(C)=O)nc1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C22H22N4O3/c1-13(17-10-22(28)25-12-17)29-20-9-16(8-19-18(20)4-3-7-23-19)15-5-6-21(24-11-15)26-14(2)27/h3-9,11,13,17H,10,12H2,1-2H3,(H,25,28)(H,24,26,27)/t13-,17-/m1/s1
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n/an/a 1.80n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140305
PNG
(US8912173, 31)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)C(F)(F)F)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C21H18F3N3O2/c1-12(15-9-20(28)27-11-15)29-18-8-14(7-17-16(18)3-2-6-25-17)13-4-5-19(26-10-13)21(22,23)24/h2-8,10,12,15H,9,11H2,1H3,(H,27,28)/t12-,15-/m1/s1
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n/an/a 2.5n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140306
PNG
(US8912173, 32)
Show SMILES CS(=O)(=O)c1ccc(cc1F)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C23H18FN3O4S/c1-32(29,30)22-7-6-14(10-18(22)24)15-11-19-16(4-2-8-26-19)21(12-15)31-13-20-17(23(25)28)5-3-9-27-20/h2-12H,13H2,1H3,(H2,25,28)
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n/an/a 15.5n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140307
PNG
(US8912173, 33)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)ccc2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C25H23N3O2/c1-15-5-6-18-10-17(7-8-22(18)28-15)19-11-23-21(4-3-9-26-23)24(12-19)30-16(2)20-13-25(29)27-14-20/h3-12,16,20H,13-14H2,1-2H3,(H,27,29)/t16-,20-/m1/s1
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n/an/a 0.700n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140308
PNG
(US8912173, 34)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2ccccc2n1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C24H21N3O2/c1-15(18-13-24(28)26-14-18)29-23-12-17(11-22-19(23)6-4-10-25-22)21-9-8-16-5-2-3-7-20(16)27-21/h2-12,15,18H,13-14H2,1H3,(H,26,28)/t15-,18-/m1/s1
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n/an/a 0.400n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140309
PNG
(US8912173, 35)
Show SMILES Cc1cc(ccc1S(C)(=O)=O)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H21N3O4S/c1-15-11-16(7-8-23(15)32(2,29)30)17-12-20-18(5-3-9-26-20)22(13-17)31-14-21-19(24(25)28)6-4-10-27-21/h3-13H,14H2,1-2H3,(H2,25,28)
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n/an/a 1.70n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140310
PNG
(US8912173, 36)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(cc1)S(=O)(=O)C(F)(F)F
Show InChI InChI=1S/C23H16F3N3O4S/c24-23(25,26)34(31,32)16-7-5-14(6-8-16)15-11-19-17(3-1-9-28-19)21(12-15)33-13-20-18(22(27)30)4-2-10-29-20/h1-12H,13H2,(H2,27,30)
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n/an/a 11.8n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140311
PNG
(US8912173, 37)
Show SMILES C[C@@H](Oc1cc(I)cc2ncccc12)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C15H15IN2O2/c1-9(10-5-15(19)18-8-10)20-14-7-11(16)6-13-12(14)3-2-4-17-13/h2-4,6-7,9-10H,5,8H2,1H3,(H,18,19)/t9-,10-/m1/s1
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n/an/a 31.9n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140312
PNG
(US8912173, 38)
Show SMILES COc1cc(cc(OC)c1OC)-c1cc(OCC2(CC#N)CC2)c2cccnc2c1
Show InChI InChI=1S/C24H24N2O4/c1-27-21-13-17(14-22(28-2)23(21)29-3)16-11-19-18(5-4-10-26-19)20(12-16)30-15-24(6-7-24)8-9-25/h4-5,10-14H,6-8,15H2,1-3H3
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n/an/a 503n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140313
PNG
(US8912173, 39)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc2[nH]cnc2c1
Show InChI InChI=1S/C23H17N5O2/c24-23(29)17-4-2-8-26-21(17)12-30-22-11-15(10-19-16(22)3-1-7-25-19)14-5-6-18-20(9-14)28-13-27-18/h1-11,13H,12H2,(H2,24,29)(H,27,28)
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n/an/a 4n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140314
PNG
(US8912173, 40)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1
Show InChI InChI=1S/C27H26N4O3/c28-27(32)23-4-2-10-30-25(23)18-34-26-16-21(15-24-22(26)3-1-9-29-24)20-7-5-19(6-8-20)17-31-11-13-33-14-12-31/h1-10,15-16H,11-14,17-18H2,(H2,28,32)
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n/an/a 3.40n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140315
PNG
(US8912173, 41)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2[nH]cnc2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C22H20N4O2/c1-13(16-10-22(27)24-11-16)28-21-9-15(8-19-17(21)3-2-6-23-19)14-4-5-18-20(7-14)26-12-25-18/h2-9,12-13,16H,10-11H2,1H3,(H,24,27)(H,25,26)/t13-,16-/m1/s1
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140316
PNG
(US8912173, 42)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2cnn(C)c2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C23H22N4O2/c1-14(18-11-23(28)25-12-18)29-22-10-17(8-20-19(22)4-3-7-24-20)15-5-6-16-13-26-27(2)21(16)9-15/h3-10,13-14,18H,11-12H2,1-2H3,(H,25,28)/t14-,18-/m1/s1
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n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140317
PNG
(US8912173, 43)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C26H29N3O3/c1-18(22-15-26(30)28-16-22)32-25-14-21(13-24-23(25)3-2-8-27-24)20-6-4-19(5-7-20)17-29-9-11-31-12-10-29/h2-8,13-14,18,22H,9-12,15-17H2,1H3,(H,28,30)/t18-,22-/m1/s1
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140318
PNG
(US8912173, 44)
Show SMILES Cn1ncc2ccc(cc12)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H19N5O2/c1-29-22-11-15(6-7-16(22)13-28-29)17-10-20-18(4-2-8-26-20)23(12-17)31-14-21-19(24(25)30)5-3-9-27-21/h2-13H,14H2,1H3,(H2,25,30)
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n/an/a 1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140319
PNG
(US8912173, 45)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C25H23N5O3/c26-25(31)20-4-2-8-28-22(20)16-33-23-14-18(13-21-19(23)3-1-7-27-21)17-5-6-24(29-15-17)30-9-11-32-12-10-30/h1-8,13-15H,9-12,16H2,(H2,26,31)
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n/an/a 1.60n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140320
PNG
(US8912173, 46)
Show SMILES Cn1cc(cn1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C20H17N5O2/c1-25-11-14(10-24-25)13-8-17-15(4-2-6-22-17)19(9-13)27-12-18-16(20(21)26)5-3-7-23-18/h2-11H,12H2,1H3,(H2,21,26)
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n/an/a 2n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140321
PNG
(US8912173, 47)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1cnn(C)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C19H20N4O2/c1-12(14-8-19(24)21-9-14)25-18-7-13(15-10-22-23(2)11-15)6-17-16(18)4-3-5-20-17/h3-7,10-12,14H,8-9H2,1-2H3,(H,21,24)/t12-,14-/m1/s1
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140322
PNG
(US8912173, 48)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(nc1)N1CCOCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C24H26N4O3/c1-16(19-13-24(29)27-15-19)31-22-12-18(11-21-20(22)3-2-6-25-21)17-4-5-23(26-14-17)28-7-9-30-10-8-28/h2-6,11-12,14,16,19H,7-10,13,15H2,1H3,(H,27,29)/t16-,19-/m1/s1
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n/an/a 0.100n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140323
PNG
(US8912173, 49)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(cn1)C(F)(F)F)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C21H18F3N3O2/c1-12(14-9-20(28)27-10-14)29-19-8-13(7-18-16(19)3-2-6-25-18)17-5-4-15(11-26-17)21(22,23)24/h2-8,11-12,14H,9-10H2,1H3,(H,27,28)/t12-,14-/m1/s1
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n/an/a 0.5n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140324
PNG
(US8912173, 50)
Show SMILES CCN(Cc1ccc(cc1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1)C(C)=O
Show InChI InChI=1S/C27H26N4O3/c1-3-31(18(2)32)16-19-8-10-20(11-9-19)21-14-24-22(6-4-12-29-24)26(15-21)34-17-25-23(27(28)33)7-5-13-30-25/h4-15H,3,16-17H2,1-2H3,(H2,28,33)
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n/an/a 1.60n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140325
PNG
(US8912173, 51)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN(C)C(C)=O)cc1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C25H27N3O3/c1-16(21-13-25(30)27-14-21)31-24-12-20(11-23-22(24)5-4-10-26-23)19-8-6-18(7-9-19)15-28(3)17(2)29/h4-12,16,21H,13-15H2,1-3H3,(H,27,30)/t16-,21-/m1/s1
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n/an/a 0n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140326
PNG
(US8912173, 52)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc2C(=O)NCCc2c1
Show InChI InChI=1S/C25H20N4O3/c26-24(30)20-4-2-9-28-22(20)14-32-23-13-17(12-21-19(23)3-1-8-27-21)15-5-6-18-16(11-15)7-10-29-25(18)31/h1-6,8-9,11-13H,7,10,14H2,(H2,26,30)(H,29,31)
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n/an/a 7.70n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140327
PNG
(US8912173, 53)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2C(=O)NCCc2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C24H23N3O3/c1-14(18-12-23(28)27-13-18)30-22-11-17(10-21-20(22)3-2-7-25-21)15-4-5-19-16(9-15)6-8-26-24(19)29/h2-5,7,9-11,14,18H,6,8,12-13H2,1H3,(H,26,29)(H,27,28)/t14-,18-/m1/s1
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n/an/a 0.900n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140328
PNG
(US8912173, 54)
Show SMILES NC(=O)c1cccnc1COc1cc(cc2ncccc12)-c1ccc(CN2CCCCC2=O)cc1
Show InChI InChI=1S/C28H26N4O3/c29-28(34)23-6-4-13-31-25(23)18-35-26-16-21(15-24-22(26)5-3-12-30-24)20-10-8-19(9-11-20)17-32-14-2-1-7-27(32)33/h3-6,8-13,15-16H,1-2,7,14,17-18H2,(H2,29,34)
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n/an/a 2.20n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140329
PNG
(US8912173, 55)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCCCC2=O)cc1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C27H29N3O3/c1-18(22-15-26(31)29-16-22)33-25-14-21(13-24-23(25)5-4-11-28-24)20-9-7-19(8-10-20)17-30-12-3-2-6-27(30)32/h4-5,7-11,13-14,18,22H,2-3,6,12,15-17H2,1H3,(H,29,31)/t18-,22-/m1/s1
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n/an/a 0.300n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140330
PNG
(US8912173, 56)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1
Show InChI InChI=1S/C22H22N4O3/c1-13(16-10-21(27)26-12-16)29-20-9-15(8-19-17(20)4-3-7-24-19)14-5-6-18(25-11-14)22(28)23-2/h3-9,11,13,16H,10,12H2,1-2H3,(H,23,28)(H,26,27)/t13-,16-/m1/s1
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n/an/a 1.40n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140331
PNG
(US8912173, 57)
Show SMILES COc1ccc(cn1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C22H18N4O3/c1-28-21-7-6-14(12-26-21)15-10-18-16(4-2-8-24-18)20(11-15)29-13-19-17(22(23)27)5-3-9-25-19/h2-12H,13H2,1H3,(H2,23,27)
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n/an/a 22.3n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140332
PNG
(US8912173, 58)
Show SMILES CN(Cc1ccc(cc1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1)C(C)=O
Show InChI InChI=1S/C26H24N4O3/c1-17(31)30(2)15-18-7-9-19(10-8-18)20-13-23-21(5-3-11-28-23)25(14-20)33-16-24-22(26(27)32)6-4-12-29-24/h3-14H,15-16H2,1-2H3,(H2,27,32)
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n/an/a 1.60n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140333
PNG
(US8912173, 59)
Show SMILES CNC(=O)c1ccc(cn1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C23H19N5O3/c1-25-23(30)18-7-6-14(12-28-18)15-10-19-16(4-2-8-26-19)21(11-15)31-13-20-17(22(24)29)5-3-9-27-20/h2-12H,13H2,1H3,(H2,24,29)(H,25,30)
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n/an/a 39.1n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140342
PNG
(US8912173, 68)
Show SMILES CCN(Cc1ccc(cc1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1)C(C)=O
Show InChI InChI=1S/C26H29N3O3/c1-4-29(18(3)30)16-19-7-9-20(10-8-19)21-12-24-23(6-5-11-27-24)25(13-21)32-17(2)22-14-26(31)28-15-22/h5-13,17,22H,4,14-16H2,1-3H3,(H,28,31)/t17-,22-/m1/s1
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140355
PNG
(US8912173, 80)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C28H27N5O3/c1-32-12-14-33(15-13-32)28(35)20-8-6-19(7-9-20)21-16-24-22(4-2-10-30-24)26(17-21)36-18-25-23(27(29)34)5-3-11-31-25/h2-11,16-17H,12-15,18H2,1H3,(H2,29,34)
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n/an/a 63.2n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140356
PNG
(US8912173, 81)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2ncn(C)c2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C23H22N4O2/c1-14(17-11-23(28)25-12-17)29-22-10-16(8-20-18(22)4-3-7-24-20)15-5-6-19-21(9-15)27(2)13-26-19/h3-10,13-14,17H,11-12H2,1-2H3,(H,25,28)/t14-,17-/m1/s1
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n/an/a 1.60n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140357
PNG
(US8912173, 82)
Show SMILES Cn1cnc2ccc(cc12)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H19N5O2/c1-29-14-28-19-7-6-15(11-22(19)29)16-10-20-17(4-2-8-26-20)23(12-16)31-13-21-18(24(25)30)5-3-9-27-21/h2-12,14H,13H2,1H3,(H2,25,30)
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n/an/a 8.10n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140358
PNG
(US8912173, 83)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(cn2c1)C(F)(F)F)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C23H19F3N4O2/c1-13(16-9-22(31)28-10-16)32-19-8-15(7-18-17(19)3-2-6-27-18)14-4-5-21-29-20(23(24,25)26)12-30(21)11-14/h2-8,11-13,16H,9-10H2,1H3,(H,28,31)/t13-,16-/m1/s1
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n/an/a 5.30n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140359
PNG
(US8912173, 84)
Show SMILES Cc1nc2ccc(cc2s1)-c1cc(OCc2ncccc2C(N)=O)c2cccnc2c1
Show InChI InChI=1S/C24H18N4O2S/c1-14-28-19-7-6-15(12-23(19)31-14)16-10-20-17(4-2-8-26-20)22(11-16)30-13-21-18(24(25)29)5-3-9-27-21/h2-12H,13H2,1H3,(H2,25,29)
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n/an/a 11.7n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140360
PNG
(US8912173, 85)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc2nc(C)sc2c1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C23H21N3O2S/c1-13(17-11-23(27)25-12-17)28-21-9-16(8-20-18(21)4-3-7-24-20)15-5-6-19-22(10-15)29-14(2)26-19/h3-10,13,17H,11-12H2,1-2H3,(H,25,27)/t13-,17-/m1/s1
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (human))
BDBM140361
PNG
(US8912173, 86)
Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(c(Cl)c1)C1(N)CC1)[C@H]1CNC(=O)C1
Show InChI InChI=1S/C24H24ClN3O2/c1-14(17-12-23(29)28-13-17)30-22-11-16(10-21-18(22)3-2-8-27-21)15-4-5-19(20(25)9-15)24(26)6-7-24/h2-5,8-11,14,17H,6-7,12-13,26H2,1H3,(H,28,29)/t14-,17-/m1/s1
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n/an/a 0.200n/an/an/an/a7.5-80



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8912173 (2014)


BindingDB Entry DOI: 10.7270/Q2TX3D3T
More data for this
Ligand-Target Pair
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