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Found 489 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ZAP-70'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM6619
PNG
(3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-...)
Show SMILES O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12
Show InChI InChI=1S/C17H16N4O2/c22-16-11-5-3-6-12(15(11)13-7-4-10-21(13)16)19-17(23)20-14-8-1-2-9-18-14/h1-3,5-6,8-9,13H,4,7,10H2,(H2,18,19,20,23)/t13-/m1/s1
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PubMed
n/an/a>1.00E+4n/an/an/an/a7.022



Banyu Tsukuba Research Institute



Assay Description
Src, Lck, Flt-1, ZAP, EGFR, FGFR1, and PFGFR-beta were assayed in the Merck research laboratory (Homogeneous proximity tyrosine kinase assays: scinti...


J Med Chem 44: 4628-40 (2001)


Article DOI: 10.1021/jm010326y
BindingDB Entry DOI: 10.7270/Q2BV7DS8
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5057
PNG
(1,2,4-Oxadiazole Analogue 4b | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(C)cc2)no1
Show InChI InChI=1S/C25H30N5O8P/c1-15-3-5-18(6-4-15)14-23-29-25(37-30-23)20(11-12-22(26)32)28-24(33)21(27-16(2)31)13-17-7-9-19(10-8-17)38-39(34,35)36/h3-10,20-21H,11-14H2,1-2H3,(H2,26,32)(H,27,31)(H,28,33)(H2,34,35,36)/t20-,21-/m0/s1
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n/an/a 6.50E+4n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5062
PNG
(1,2,4-Oxadiazole Analogue 4h | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2c(C)cc(C)cc2C)no1
Show InChI InChI=1S/C27H34N5O8P/c1-15-11-16(2)21(17(3)12-15)14-25-31-27(39-32-25)22(9-10-24(28)34)30-26(35)23(29-18(4)33)13-19-5-7-20(8-6-19)40-41(36,37)38/h5-8,11-12,22-23H,9-10,13-14H2,1-4H3,(H2,28,34)(H,29,33)(H,30,35)(H2,36,37,38)/t22-,23-/m0/s1
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n/an/a>5.00E+5n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5063
PNG
(1,2,4-Oxadiazole Analogue 4i | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2cccc3ccccc23)no1
Show InChI InChI=1S/C28H30N5O8P/c1-17(34)30-24(15-18-9-11-21(12-10-18)41-42(37,38)39)27(36)31-23(13-14-25(29)35)28-32-26(33-40-28)16-20-7-4-6-19-5-2-3-8-22(19)20/h2-12,23-24H,13-16H2,1H3,(H2,29,35)(H,30,34)(H,31,36)(H2,37,38,39)/t23-,24-/m0/s1
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n/an/a 5.50E+4n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5058
PNG
(1,2,4-Oxadiazole Analogue 4c | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(C)c1ccc(Cc2noc(n2)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccc(OP(O)(O)=O)cc2)NC(C)=O)cc1
Show InChI InChI=1S/C27H34N5O8P/c1-16(2)20-8-4-19(5-9-20)15-25-31-27(39-32-25)22(12-13-24(28)34)30-26(35)23(29-17(3)33)14-18-6-10-21(11-7-18)40-41(36,37)38/h4-11,16,22-23H,12-15H2,1-3H3,(H2,28,34)(H,29,33)(H,30,35)(H2,36,37,38)/t22-,23-/m0/s1
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n/an/a 3.60E+4n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5061
PNG
(1,2,4-Oxadiazole Analogue 4g | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(Cl)cc2Cl)no1
Show InChI InChI=1S/C24H26Cl2N5O8P/c1-13(32)28-20(10-14-2-6-17(7-3-14)39-40(35,36)37)23(34)29-19(8-9-21(27)33)24-30-22(31-38-24)11-15-4-5-16(25)12-18(15)26/h2-7,12,19-20H,8-11H2,1H3,(H2,27,33)(H,28,32)(H,29,34)(H2,35,36,37)/t19-,20-/m0/s1
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n/an/a 1.84E+5n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5060
PNG
(1,2,4-Oxadiazole Analogue 4e | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2cccc(Cl)c2)no1
Show InChI InChI=1S/C24H27ClN5O8P/c1-14(31)27-20(12-15-5-7-18(8-6-15)38-39(34,35)36)23(33)28-19(9-10-21(26)32)24-29-22(30-37-24)13-16-3-2-4-17(25)11-16/h2-8,11,19-20H,9-10,12-13H2,1H3,(H2,26,32)(H,27,31)(H,28,33)(H2,34,35,36)/t19-,20-/m0/s1
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n/an/a 9.40E+4n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM5059
PNG
(1,2,4-Oxadiazole Analogue 4d | 4-[(2S)-2-{[(1S)-3-...)
Show SMILES CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CCC(N)=O)c1nc(Cc2ccc(Cl)cc2)no1
Show InChI InChI=1S/C24H27ClN5O8P/c1-14(31)27-20(12-15-4-8-18(9-5-15)38-39(34,35)36)23(33)28-19(10-11-21(26)32)24-29-22(30-37-24)13-16-2-6-17(25)7-3-16/h2-9,19-20H,10-13H2,1H3,(H2,26,32)(H,27,31)(H,28,33)(H2,34,35,36)/t19-,20-/m0/s1
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n/an/a 2.60E+4n/an/an/an/a7.422



ARIAD Pharmaceuticals, Inc.



Assay Description
Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...


J Med Chem 42: 4088-98 (1999)


Article DOI: 10.1021/jm990229t
BindingDB Entry DOI: 10.7270/Q27D2SBP
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Mus musculus)
BDBM17744
PNG
(2,6-dimethylphenyl N-[2-({3,5-dimethoxy-4-[3-(4-me...)
Show SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3cc(OC)c(OCCCN4CCN(C)CC4)c(OC)c3)n2)c(OC)c1
Show InChI InChI=1S/C37H46N6O7/c1-25-10-8-11-26(2)34(25)50-37(44)43(29-13-12-28(45-4)24-30(29)46-5)33-14-15-38-36(40-33)39-27-22-31(47-6)35(32(23-27)48-7)49-21-9-16-42-19-17-41(3)18-20-42/h8,10-15,22-24H,9,16-21H2,1-7H3,(H,38,39,40)
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n/an/a 370n/an/an/an/a7.522



Amgen



Assay Description
The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...


J Med Chem 49: 4981-91 (2006)


Article DOI: 10.1021/jm060435i
BindingDB Entry DOI: 10.7270/Q2SB440C
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26429
PNG
((2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)a...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(\C=C\C(O)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C25H24N6O5/c1-35-18-11-17(12-19(13-18)36-2)29-23-21(22(26)34)24-27-9-10-31(24)25(30-23)28-14-16-5-3-15(4-6-16)7-8-20(32)33/h3-13,29H,14H2,1-2H3,(H2,26,34)(H,28,30)(H,32,33)/b8-7+
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n/an/a 47n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26411
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-methoxypheny...)
Show SMILES COc1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1
Show InChI InChI=1S/C23H24N6O4/c1-31-16-6-4-14(5-7-16)13-26-23-28-21(19(20(24)30)22-25-8-9-29(22)23)27-15-10-17(32-2)12-18(11-15)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)
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n/an/a 230n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26412
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(3-methoxypheny...)
Show SMILES COc1cccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)c1
Show InChI InChI=1S/C23H24N6O4/c1-31-16-6-4-5-14(9-16)13-26-23-28-21(19(20(24)30)22-25-7-8-29(22)23)27-15-10-17(32-2)12-18(11-15)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)
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n/an/a 530n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26413
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(2-methoxypheny...)
Show SMILES COc1cc(Nc2nc(NCc3ccccc3OC)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-31-16-10-15(11-17(12-16)32-2)27-21-19(20(24)30)22-25-8-9-29(22)23(28-21)26-13-14-6-4-5-7-18(14)33-3/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)
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n/an/a 340n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26414
PNG
(5-{[(3,5-difluorophenyl)methyl]amino}-7-[(3,5-dime...)
Show SMILES COc1cc(Nc2nc(NCc3cc(F)cc(F)c3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C22H20F2N6O3/c1-32-16-8-15(9-17(10-16)33-2)28-20-18(19(25)31)21-26-3-4-30(21)22(29-20)27-11-12-5-13(23)7-14(24)6-12/h3-10,28H,11H2,1-2H3,(H2,25,31)(H,27,29)
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n/an/a 910n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26415
PNG
(5-{[(2,4-difluorophenyl)methyl]amino}-7-[(3,5-dime...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(F)cc3F)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C22H20F2N6O3/c1-32-15-8-14(9-16(10-15)33-2)28-20-18(19(25)31)21-26-5-6-30(21)22(29-20)27-11-12-3-4-13(23)7-17(12)24/h3-10,28H,11H2,1-2H3,(H2,25,31)(H,27,29)
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n/an/a 150n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26416
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-[(pyridin-4-ylmet...)
Show SMILES COc1cc(Nc2nc(NCc3ccncc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C21H21N7O3/c1-30-15-9-14(10-16(11-15)31-2)26-19-17(18(22)29)20-24-7-8-28(20)21(27-19)25-12-13-3-5-23-6-4-13/h3-11,26H,12H2,1-2H3,(H2,22,29)(H,25,27)
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n/an/a 250n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26417
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-[(furan-2-ylmethy...)
Show SMILES COc1cc(Nc2nc(NCc3ccco3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C20H20N6O4/c1-28-14-8-12(9-15(10-14)29-2)24-18-16(17(21)27)19-22-5-6-26(19)20(25-18)23-11-13-4-3-7-30-13/h3-10,24H,11H2,1-2H3,(H2,21,27)(H,23,25)
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n/an/a 920n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26418
PNG
(5-[(1H-1,3-benzodiazol-2-ylmethyl)amino]-7-[(3,5-d...)
Show SMILES COc1cc(Nc2nc(NCc3nc4ccccc4[nH]3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H22N8O3/c1-33-14-9-13(10-15(11-14)34-2)27-21-19(20(24)32)22-25-7-8-31(22)23(30-21)26-12-18-28-16-5-3-4-6-17(16)29-18/h3-11,27H,12H2,1-2H3,(H2,24,32)(H,26,30)(H,28,29)
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n/an/a 200n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26419
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-sulfamoylphe...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)S(N)(=O)=O)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C22H23N7O5S/c1-33-15-9-14(10-16(11-15)34-2)27-20-18(19(23)30)21-25-7-8-29(21)22(28-20)26-12-13-3-5-17(6-4-13)35(24,31)32/h3-11,27H,12H2,1-2H3,(H2,23,30)(H,26,28)(H2,24,31,32)
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n/an/a 150n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26420
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-methanesulfo...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)S(C)(=O)=O)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O5S/c1-33-16-10-15(11-17(12-16)34-2)27-21-19(20(24)30)22-25-8-9-29(22)23(28-21)26-13-14-4-6-18(7-5-14)35(3,31)32/h4-12,27H,13H2,1-3H3,(H2,24,30)(H,26,28)
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n/an/a 190n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26421
PNG
(imidazo[1,2-c]pyrimidine-8-carboxamide, 10t | meth...)
Show SMILES COC(=O)c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1
Show InChI InChI=1S/C24H24N6O5/c1-33-17-10-16(11-18(12-17)34-2)28-21-19(20(25)31)22-26-8-9-30(22)24(29-21)27-13-14-4-6-15(7-5-14)23(32)35-3/h4-12,28H,13H2,1-3H3,(H2,25,31)(H,27,29)
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n/an/a 420n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26422
PNG
(4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]imi...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)C(O)=O)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H22N6O5/c1-33-16-9-15(10-17(11-16)34-2)27-20-18(19(24)30)21-25-7-8-29(21)23(28-20)26-12-13-3-5-14(6-4-13)22(31)32/h3-11,27H,12H2,1-2H3,(H2,24,30)(H,26,28)(H,31,32)
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n/an/a 180n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26423
PNG
(5-{[(4-carbamoylphenyl)methyl]amino}-7-[(3,5-dimet...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(cc3)C(N)=O)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H23N7O4/c1-33-16-9-15(10-17(11-16)34-2)28-21-18(20(25)32)22-26-7-8-30(22)23(29-21)27-12-13-3-5-14(6-4-13)19(24)31/h3-11,28H,12H2,1-2H3,(H2,24,31)(H2,25,32)(H,27,29)
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n/an/a 660n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26424
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-({[4-(hydroxymeth...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(CO)cc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O4/c1-32-17-9-16(10-18(11-17)33-2)27-21-19(20(24)31)22-25-7-8-29(22)23(28-21)26-12-14-3-5-15(13-30)6-4-14/h3-11,27,30H,12-13H2,1-2H3,(H2,24,31)(H,26,28)
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n/an/a 690n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26425
PNG
(imidazo[1,2-c]pyrimidine-8-carboxamide, 20 | tert-...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(=O)OC(C)(C)C)cc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C28H32N6O5/c1-28(2,3)39-22(35)12-17-6-8-18(9-7-17)16-31-27-33-25(23(24(29)36)26-30-10-11-34(26)27)32-19-13-20(37-4)15-21(14-19)38-5/h6-11,13-15,32H,12,16H2,1-5H3,(H2,29,36)(H,31,33)
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n/an/a 3.20E+3n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26426
PNG
(2-{4-[({8-carbamoyl-7-[(3,5-dimethoxyphenyl)amino]...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(O)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C24H24N6O5/c1-34-17-10-16(11-18(12-17)35-2)28-22-20(21(25)33)23-26-7-8-30(23)24(29-22)27-13-15-5-3-14(4-6-15)9-19(31)32/h3-8,10-12,28H,9,13H2,1-2H3,(H2,25,33)(H,27,29)(H,31,32)
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n/an/a 240n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26427
PNG
(5-({[4-(carbamoylmethyl)phenyl]methyl}amino)-7-[(3...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(N)=O)cc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C24H25N7O4/c1-34-17-10-16(11-18(12-17)35-2)29-22-20(21(26)33)23-27-7-8-31(23)24(30-22)28-13-15-5-3-14(4-6-15)9-19(25)32/h3-8,10-12,29H,9,13H2,1-2H3,(H2,25,32)(H2,26,33)(H,28,30)
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n/an/a 480n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26428
PNG
(ethyl (2E)-3-{4-[({8-carbamoyl-7-[(3,5-dimethoxyph...)
Show SMILES CCOC(=O)\C=C\c1ccc(CNc2nc(Nc3cc(OC)cc(OC)c3)c(C(N)=O)c3nccn23)cc1
Show InChI InChI=1S/C27H28N6O5/c1-4-38-22(34)10-9-17-5-7-18(8-6-17)16-30-27-32-25(23(24(28)35)26-29-11-12-33(26)27)31-19-13-20(36-2)15-21(14-19)37-3/h5-15,31H,4,16H2,1-3H3,(H2,28,35)(H,30,32)/b10-9+
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n/an/a 88n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26409
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(1S)-1-phenylet...)
Show SMILES COc1cc(Nc2nc(N[C@@H](C)c3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O3/c1-14(15-7-5-4-6-8-15)26-23-28-21(19(20(24)30)22-25-9-10-29(22)23)27-16-11-17(31-2)13-18(12-16)32-3/h4-14,27H,1-3H3,(H2,24,30)(H,26,28)/t14-/m0/s1
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n/an/a 930n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26408
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(1R)-1-phenylet...)
Show SMILES COc1cc(Nc2nc(N[C@H](C)c3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O3/c1-14(15-7-5-4-6-8-15)26-23-28-21(19(20(24)30)22-25-9-10-29(22)23)27-16-11-17(31-2)13-18(12-16)32-3/h4-14,27H,1-3H3,(H2,24,30)(H,26,28)/t14-/m1/s1
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n/an/a 410n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26407
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-[(2-phenylethyl)a...)
Show SMILES COc1cc(Nc2nc(NCCc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O3/c1-31-17-12-16(13-18(14-17)32-2)27-21-19(20(24)30)22-25-10-11-29(22)23(28-21)26-9-8-15-6-4-3-5-7-15/h3-7,10-14,27H,8-9H2,1-2H3,(H2,24,30)(H,26,28)
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n/an/a 5.10E+3n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26406
PNG
(5-[benzyl(methyl)amino]-7-[(3,5-dimethoxyphenyl)am...)
Show SMILES COc1cc(Nc2nc(N(C)Cc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C23H24N6O3/c1-28(14-15-7-5-4-6-8-15)23-27-21(19(20(24)30)22-25-9-10-29(22)23)26-16-11-17(31-2)13-18(12-16)32-3/h4-13,26H,14H2,1-3H3,(H2,24,30)
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n/an/a 5.50E+3n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26405
PNG
(5-(benzylamino)-7-[(3,5-dimethoxyphenyl)amino]imid...)
Show SMILES COc1cc(Nc2nc(NCc3ccccc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C22H22N6O3/c1-30-16-10-15(11-17(12-16)31-2)26-20-18(19(23)29)21-24-8-9-28(21)22(27-20)25-13-14-6-4-3-5-7-14/h3-12,26H,13H2,1-2H3,(H2,23,29)(H,25,27)
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n/an/a 400n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26404
PNG
(5-[(2-aminoethyl)amino]-7-[(3,5-dimethoxyphenyl)am...)
Show SMILES COc1cc(Nc2nc(NCCN)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C17H21N7O3/c1-26-11-7-10(8-12(9-11)27-2)22-15-13(14(19)25)16-20-5-6-24(16)17(23-15)21-4-3-18/h5-9,22H,3-4,18H2,1-2H3,(H2,19,25)(H,21,23)
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n/an/a 3.50E+3n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26403
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-[(2-hydroxyethyl)...)
Show SMILES COc1cc(Nc2nc(NCCO)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C17H20N6O4/c1-26-11-7-10(8-12(9-11)27-2)21-15-13(14(18)25)16-19-3-5-23(16)17(22-15)20-4-6-24/h3,5,7-9,21,24H,4,6H2,1-2H3,(H2,18,25)(H,20,22)
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n/an/a 1.90E+3n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26402
PNG
(5-amino-7-[(3,5-dimethoxyphenyl)amino]imidazo[1,2-...)
Show SMILES COc1cc(Nc2nc(N)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C15H16N6O3/c1-23-9-5-8(6-10(7-9)24-2)19-13-11(12(16)22)14-18-3-4-21(14)15(17)20-13/h3-7,19H,1-2H3,(H2,16,22)(H2,17,20)
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n/an/a 1.00E+4n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26401
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-(methylsulfanyl)i...)
Show SMILES COc1cc(Nc2nc(SC)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C16H17N5O3S/c1-23-10-6-9(7-11(8-10)24-2)19-14-12(13(17)22)15-18-4-5-21(15)16(20-14)25-3/h4-8,19H,1-3H3,(H2,17,22)
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n/an/a 3.00E+3n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM26410
PNG
(7-[(3,5-dimethoxyphenyl)amino]-5-{[(4-fluorophenyl...)
Show SMILES COc1cc(Nc2nc(NCc3ccc(F)cc3)n3ccnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C22H21FN6O3/c1-31-16-9-15(10-17(11-16)32-2)27-20-18(19(24)30)21-25-7-8-29(21)22(28-20)26-12-13-3-5-14(23)6-4-13/h3-11,27H,12H2,1-2H3,(H2,24,30)(H,26,28)
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n/an/a 220n/an/an/an/a7.630



Kissei Pharmaceutical Company



Assay Description
A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...


Bioorg Med Chem 17: 284-94 (2009)


Article DOI: 10.1016/j.bmc.2008.10.070
BindingDB Entry DOI: 10.7270/Q2FQ9TXB
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50275935
PNG
((S)-2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-...)
Show SMILES C[C@@H](CO)NC(=O)c1sc(nc1C)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C20H23N5O2S/c1-11-7-12(2)9-15(8-11)24-20-21-6-5-16(25-20)19-23-14(4)17(28-19)18(27)22-13(3)10-26/h5-9,13,26H,10H2,1-4H3,(H,22,27)(H,21,24,25)/t13-/m0/s1
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240n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50275934
PNG
((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2ncc(CO)s2)c1
Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-8-13(9-21)22-15/h3-8,21H,9H2,1-2H3,(H,17,19,20)
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270n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50276018
PNG
(1-(3-(cyclopenta-1,3-dienyl)benzyl)-3,5-diethylben...)
Show SMILES COc1cc(Nc2nccc(n2)-c2nccs2)cc(OC)c1
Show InChI InChI=1S/C15H14N4O2S/c1-20-11-7-10(8-12(9-11)21-2)18-15-17-4-3-13(19-15)14-16-5-6-22-14/h3-9H,1-2H3,(H,17,18,19)
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318n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50276064
PNG
(CHEMBL470780 | N-(3,5-dimethylphenyl)-4-(5-methylt...)
Show SMILES Cc1cnc(s1)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C16H16N4S/c1-10-6-11(2)8-13(7-10)19-16-17-5-4-14(20-16)15-18-9-12(3)21-15/h4-9H,1-3H3,(H,17,19,20)
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410n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50276015
PNG
(CHEMBL509161 | N-(3,5-dimethylphenyl)-4-(thiazol-2...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nccs2)c1
Show InChI InChI=1S/C15H14N4S/c1-10-7-11(2)9-12(8-10)18-15-17-4-3-13(19-15)14-16-5-6-20-14/h3-9H,1-2H3,(H,17,18,19)
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419n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50276065
PNG
((2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)thia...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2nc(CO)cs2)c1
Show InChI InChI=1S/C16H16N4OS/c1-10-5-11(2)7-12(6-10)19-16-17-4-3-14(20-16)15-18-13(8-21)9-22-15/h3-7,9,21H,8H2,1-2H3,(H,17,19,20)
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450n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50249318
PNG
(2-(2-(2-(3,5-dimethylphenylamino)pyrimidin-4-yl)-4...)
Show SMILES Cc1nc(sc1CCO)-c1ccnc(Nc2cc(C)cc(C)c2)n1
Show InChI InChI=1S/C18H20N4OS/c1-11-8-12(2)10-14(9-11)21-18-19-6-4-15(22-18)17-20-13(3)16(24-17)5-7-23/h4,6,8-10,23H,5,7H2,1-3H3,(H,19,21,22)
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560n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50249286
PNG
(3-(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trif...)
Show SMILES OCCCOc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)11-8-12(10-13(9-11)26-6-1-5-25)23-16-22-3-2-14(24-16)15-21-4-7-27-15/h2-4,7-10,25H,1,5-6H2,(H,22,23,24)
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677n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50275356
PNG
(3-(4-(4-(hydroxymethyl)thiazol-2-yl)pyrimidin-2-yl...)
Show SMILES OCc1csc(n1)-c1ccnc(Nc2cc(O)cc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C15H11F3N4O2S/c16-15(17,18)8-3-9(5-11(24)4-8)21-14-19-2-1-12(22-14)13-20-10(6-23)7-25-13/h1-5,7,23-24H,6H2,(H,19,21,22)
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680n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50275358
PNG
((2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyr...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nc(CO)cs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C16H13F3N4OS/c1-9-4-10(16(17,18)19)6-11(5-9)22-15-20-3-2-13(23-15)14-21-12(7-24)8-25-14/h2-6,8,24H,7H2,1H3,(H,20,22,23)
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750n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50276017
PNG
(3-(4-(thiazol-2-yl)pyrimidin-2-ylamino)-5-(trifluo...)
Show SMILES Oc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C14H9F3N4OS/c15-14(16,17)8-5-9(7-10(22)6-8)20-13-19-2-1-11(21-13)12-18-3-4-23-12/h1-7,22H,(H,19,20,21)
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754n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (human))
BDBM50249416
PNG
(CHEMBL471776 | N-(3-methyl-5-(trifluoromethyl)phen...)
Show SMILES Cc1cc(Nc2nccc(n2)-c2nccs2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4S/c1-9-6-10(15(16,17)18)8-11(7-9)21-14-20-3-2-12(22-14)13-19-4-5-23-13/h2-8H,1H3,(H,20,21,22)
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891n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAP70 (unknown origin)


Bioorg Med Chem Lett 18: 6231-5 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.106
BindingDB Entry DOI: 10.7270/Q25Q4VZT
More data for this
Ligand-Target Pair
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