BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 24 hits Enz. Inhib. hit(s) with Target = 'Ubiquitin C-terminal Hydrolase L3 (UCH-L3)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23428
PNG
(ChemBridge CNS-Set 6699002, 8 | N-cyclopropyl-2-[(...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N(CC(=O)NC1CC1)c1ccc(C)cc1
Show InChI InChI=1S/C19H22N2O4S/c1-14-3-7-16(8-4-14)21(13-19(22)20-15-5-6-15)26(23,24)18-11-9-17(25-2)10-12-18/h3-4,7-12,15H,5-6,13H2,1-2H3,(H,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.01E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23421
PNG
(1-benzyl-3-hydroxy-4-[(5-methylfuran-2-yl)carbonyl...)
Show SMILES Cc1ccc(o1)C(=O)C1C(N(Cc2ccccc2)C(=O)C1=O)c1cccnc1
Show InChI InChI=1S/C22H18N2O4/c1-14-9-10-17(28-14)20(25)18-19(16-8-5-11-23-12-16)24(22(27)21(18)26)13-15-6-3-2-4-7-15/h2-12,18-19H,13H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.03E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23431
PNG
(ChemBridge CNS-Set 7977303, 3 | N-{4-[5-(furan-2-y...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)C1=NN(C(C1)c1ccco1)C(=O)c1ccco1
Show InChI InChI=1S/C19H17N3O5S/c1-28(24,25)21-14-8-6-13(7-9-14)15-12-16(17-4-2-10-26-17)22(20-15)19(23)18-5-3-11-27-18/h2-11,16,21H,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23430
PNG
(4-({[5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl...)
Show SMILES Nc1nc(CSc2nnc(-c3ccco3)n2-c2ccccc2)cs1
Show InChI InChI=1S/C16H13N5OS2/c17-15-18-11(9-23-15)10-24-16-20-19-14(13-7-4-8-22-13)21(16)12-5-2-1-3-6-12/h1-9H,10H2,(H2,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.87E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23429
PNG
(2-[benzene(3-methoxyphenyl)sulfonamido]-N-cyclopen...)
Show SMILES COc1cccc(c1)N(CC(=O)NC1CCCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H24N2O4S/c1-26-18-11-7-10-17(14-18)22(15-20(23)21-16-8-5-6-9-16)27(24,25)19-12-3-2-4-13-19/h2-4,7,10-14,16H,5-6,8-9,15H2,1H3,(H,21,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.86E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23423
PNG
(5-({[5-(1H-indol-3-yl)-4-methyl-4H-1,2,4-triazol-3...)
Show SMILES Cn1c(SCc2nc(no2)-c2cccs2)nnc1-c1c[nH]c2ccccc12
Show InChI InChI=1S/C18H14N6OS2/c1-24-17(12-9-19-13-6-3-2-5-11(12)13)21-22-18(24)27-10-15-20-16(23-25-15)14-7-4-8-26-14/h2-9,19H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23427
PNG
(5-(4-fluorophenyl)-3-hydroxy-4-[(5-methylfuran-2-y...)
Show SMILES Cc1ccc(o1)C(=O)C1C(N(Cc2cccnc2)C(=O)C1=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H17FN2O4/c1-13-4-9-17(29-13)20(26)18-19(15-5-7-16(23)8-6-15)25(22(28)21(18)27)12-14-3-2-10-24-11-14/h2-11,18-19H,12H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.23E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23426
PNG
(3-hydroxy-5-(4-methoxyphenyl)-1-(1,3,4-thiadiazol-...)
Show SMILES COc1ccc(cc1)C1C(C(=O)c2cccs2)C(=O)C(=O)N1c1nncs1
Show InChI InChI=1S/C18H13N3O4S2/c1-25-11-6-4-10(5-7-11)14-13(15(22)12-3-2-8-26-12)16(23)17(24)21(14)18-20-19-9-27-18/h2-9,13-14H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.54E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23425
PNG
(ChemBridge CNS-Set 7909542, 5 | N-{3-[1-acetyl-5-(...)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)C1=NN(C(C1)c1cccs1)C(C)=O
Show InChI InChI=1S/C17H19N3O3S2/c1-3-25(22,23)19-14-7-4-6-13(10-14)15-11-16(17-8-5-9-24-17)20(18-15)12(2)21/h4-10,16,19H,3,11H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.31E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM23424
PNG
(ChemBridge CNS-Set 6382507, 4 | N-cyclopropyl-2-[(...)
Show SMILES COc1ccc(cc1)N(CC(=O)NC1CC1)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H22N2O4S/c1-14-3-11-18(12-4-14)26(23,24)21(13-19(22)20-15-5-6-15)16-7-9-17(25-2)10-8-16/h3-4,7-12,15H,5-6,13H2,1-2H3,(H,20,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>3.34E+5n/an/an/an/a7.822



Waseda University



Assay Description
Enzyme reactions were carried out on Costar 96-well black assay plates. After the reaction, AMC fluorescence (excitation wavelength: 355 nm, emission...


Bioorg Med Chem 15: 6810-8 (2007)


Article DOI: 10.1016/j.bmc.2007.07.016
BindingDB Entry DOI: 10.7270/Q2ZK5DZK
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326016
PNG
(3-amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]py...)
Show SMILES Nc1c(sc2[nH]c(=O)c(cc12)C(O)=O)C(=O)c1ccccc1
Show InChI InChI=1S/C15H10N2O4S/c16-10-8-6-9(15(20)21)13(19)17-14(8)22-12(10)11(18)7-4-2-1-3-5-7/h1-6H,16H2,(H,17,19)(H,20,21)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.00E+5n/an/an/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM53421
PNG
(4-Cyclohexyl-2-phenyl-quinazoline | 4-cyclohexyl-2...)
Show SMILES C1CCC(CC1)c1nc(nc2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H20N2/c1-3-9-15(10-4-1)19-17-13-7-8-14-18(17)21-20(22-19)16-11-5-2-6-12-16/h2,5-8,11-15H,1,3-4,9-10H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326015
PNG
(5-(4-butylphenyl)-4-(4-isopropylphenyl)-4H-1,2,4-t...)
Show SMILES CCCCc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc(cc1)C(C)C
Show InChI InChI=1S/C21H25N3S/c1-4-5-6-16-7-9-18(10-8-16)20-22-23-21(25)24(20)19-13-11-17(12-14-19)15(2)3/h7-15H,4-6H2,1-3H3,(H,23,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.70E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM24778
PNG
(2-methyl-1,4-dihydronaphthalene-1,4-dione | 2-meth...)
Show SMILES CC1=CC(=O)c2ccccc2C1=O
Show InChI InChI=1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.10E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326014
PNG
(3-(acetoxyimino)-1-(3,4-dichlorobenzyl)-5-iodoindo...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(I)cc12
Show InChI InChI=1S/C17H11Cl2IN2O3/c1-9(23)25-21-16-12-7-11(20)3-5-15(12)22(17(16)24)8-10-2-4-13(18)14(19)6-10/h2-7H,8H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.30E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326013
PNG
(3-(acetoxyimino)-5-bromo-1-(2,5-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-13-7-11(18)2-5-15(13)22(17(16)24)8-10-6-12(19)3-4-14(10)20/h2-7H,8H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50326012
PNG
(3-(acetoxyimino)-5-bromo-1-(3,4-dichlorobenzyl)ind...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2ccc(Cl)c(Cl)c2)c2ccc(Br)cc12
Show InChI InChI=1S/C17H11BrCl2N2O3/c1-9(23)25-21-16-12-7-11(18)3-5-15(12)22(17(16)24)8-10-2-4-13(19)14(20)6-10/h2-7H,8H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.70E+4n/an/an/an/an/an/a



Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of UCHL3 in human H1299 cells


Nat Chem Biol 3: 697-705 (2007)


Article DOI: 10.1038/nchembio.2007.43
BindingDB Entry DOI: 10.7270/Q2KW5G7P
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50069762
PNG
(CHEMBL3182437 | ML323)
Show SMILES CC(C)c1ccccc1-c1ncc(C)c(NCc2ccc(cc2)-n2ccnn2)n1
Show InChI InChI=1S/C23H24N6/c1-16(2)20-6-4-5-7-21(20)23-24-14-17(3)22(27-23)25-15-18-8-10-19(11-9-18)29-13-12-26-28-29/h4-14,16H,15H2,1-3H3,(H,24,25,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.14E+5n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM65524
PNG
((-)-Aricine | Heterophylline (VAN) | Quinovatine)
Show SMILES COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@H]12
Show InChI InChI=1S/C22H26N2O4/c1-12-17-10-24-7-6-15-14-5-4-13(26-2)8-19(14)23-21(15)20(24)9-16(17)18(11-28-12)22(25)27-3/h4-5,8,11-12,16-17,20,23H,6-7,9-10H2,1-3H3/t12-,16-,17-,20-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.14E+5n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM200235
PNG
(Rifampicin | cid_5381226)
Show SMILES CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2C(=O)\C(=C\NN4CCN(C)CC4)C(NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)=C(O)c2c(O)c3C
Show InChI InChI=1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,44,49-51,53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,28-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.48E+4n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50442907
PNG
(Acetyl Isogambogic Acid | CHEMBL3039433)
Show SMILES CC(=O)Oc1c2C=CC(C)(CCC=C(C)C)Oc2c(CC=C(C)C)c2O[C@@]34C5C[C@@H](C=C3C(=O)c12)C(=O)C4(C\C=C(/C)C(O)=O)OC5(C)C
Show InChI InChI=1S/C40H46O9/c1-21(2)11-10-16-38(9)17-15-27-32(47-38)26(13-12-22(3)4)34-30(33(27)46-24(6)41)31(42)28-19-25-20-29-37(7,8)49-39(35(25)43,40(28,29)48-34)18-14-23(5)36(44)45/h11-12,14-15,17,19,25,29H,10,13,16,18,20H2,1-9H3,(H,44,45)/b23-14+/t25-,29?,38?,39?,40-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.54E+4n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM50242207
PNG
(CHEMBL455364 | Mangiferin)
Show SMILES OC[C@H]1O[C@@H](Oc2c(O)cc3oc4cc(O)c(O)cc4c(=O)c3c2O)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C19H18O12/c20-4-11-14(25)16(27)17(28)19(30-11)31-18-8(23)3-10-12(15(18)26)13(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,14,16-17,19-23,25-28H,4H2/t11-,14-,16+,17-,19+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.26E+4n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM65518
PNG
(5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-...)
Show SMILES CC(=O)ON=C1C(=O)N(Cc2cc(Cl)ccc2Cl)c2ccc(Cl)cc12
Show InChI InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.41E+4n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair
Ubiquitin C-terminal Hydrolase L3 (UCH-L3)


(Homo sapiens (human))
BDBM205457
PNG
((2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9...)
Show SMILES CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O
Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,31H,9-14,16H2,1-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.21E+4n/an/an/an/an/an/a



University of Delaware



Assay Description
Ubiquitin-7-amino-4-methylcoumarin (Ub-AMC) was generated as previously described.(7) The enzymatic reaction was conducted in fluorometric assay buff...


ACS Chem Biol 12: 2399-2407 (2017)


Article DOI: 10.1021/acschembio.7b00543
BindingDB Entry DOI: 10.7270/Q21J97WD
More data for this
Ligand-Target Pair