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Found 40 Enz. Inhib. hit(s) with Target = 'Vitamin K epoxide reductase complex subunit 1'
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKi:  600nM ΔG°:  -36.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKi:  1.80E+3nM ΔG°:  -34.1kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1-like protein 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKi:  3.26E+4nM ΔG°:  -26.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1-like protein 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataKi:  5.20E+4nM ΔG°:  -25.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, standard reactions were performed in 200 mM Hepes buffer, pH 7.4, containing 150 mM KCl, 1 mM dithiothreitol, 0.25 to 2 g liter-1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235661(CHEMBL4088796)
Affinity DataKi:  20nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235671(CHEMBL4097212)
Affinity DataKi:  20nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235667(CHEMBL4080688)
Affinity DataKi:  20nMAssay Description:Inhibition of endothelin-converting enzyme in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235670(CHEMBL4079988)
Affinity DataKi:  30nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235673(CHEMBL4060572)
Affinity DataKi:  50nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235668(CHEMBL4098946)
Affinity DataKi:  50nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235672(CHEMBL4061606)
Affinity DataKi:  60nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235664(CHEMBL4083422)
Affinity DataKi:  90nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235674(CHEMBL4070018)
Affinity DataKi:  90nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235665(CHEMBL4104227)
Affinity DataKi:  100nMAssay Description:Inhibition of Endothelin-converting enzyme of guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235669(CHEMBL4080910)
Affinity DataKi:  200nMAssay Description:Inhibition of VKORC1 in rat liver microsomes in presence of 0.003 to 0.2 mM vitamin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM768(4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one | CH...)
Affinity DataKi:  200nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235663(CHEMBL4070271)
Affinity DataKi:  260nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235662(CHEMBL4091210)
Affinity DataKi:  3.90E+3nMAssay Description:In vitro displacement of [3H]-LY 278584 from rat cerebral cortex 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015554(7a-Hydroxymethyl-1a-(3,7,11,15-tetramethyl-hexadec...)
Affinity DataKi:  8.00E+3nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50018515(2-Fluoromethyl-2-hydroxy-3-methyl-3-(3,7,11,15-tet...)
Affinity DataKi:  1.60E+4nMAssay Description:Binding affinity of the compound for vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015552(7a-Fluoromethyl-1a-(3,7,11,15-tetramethyl-hexadec-...)
Affinity DataKi:  1.70E+4nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Rattus norvegicus (Rat))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50235666(CHEMBL4104918)
Affinity DataKi:  2.20E+4nMAssay Description:Inhibition of neutral endopeptidase in human umbilical vein endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015556(2,7-Dioxo-1a-(3,7,11,15-tetramethyl-hexadec-2-enyl...)
Affinity DataKi:  2.60E+4nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015559(1a-(1-Hydroxy-3,7,11,15-tetramethyl-hexadec-2-enyl...)
Affinity DataKi:  4.30E+4nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50386849(CHEMBL2048091)
Affinity DataKi:  4.48E+4nMAssay Description:Inhibition of VKORC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015557(1a-(1-Hydroxy-3,7,11,15-tetramethyl-hexadecyl)-7a-...)
Affinity DataKi:  6.30E+4nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015555(7a-Difluoromethyl-1a-(3,7,11,15-tetramethyl-hexade...)
Affinity DataKi:  6.30E+4nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50386852(CHEMBL2048084)
Affinity DataKi:  6.89E+4nMAssay Description:Inhibition of VKORC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015553(7a-Chloromethyl-1a-(3,7,11,15-tetramethyl-hexadec-...)
Affinity DataKi:  7.40E+4nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50386850(CHEMBL2048092)
Affinity DataKi:  7.42E+4nMAssay Description:Inhibition of VKORC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50386851(CHEMBL2048096)
Affinity DataKi:  7.96E+4nMAssay Description:Inhibition of VKORC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50015558(1a-(1-Fluoro-3,7,11,15-tetramethyl-hexadecyl)-7a-m...)
Affinity DataKi:  1.00E+5nMAssay Description:Apparent kinetic constant of the compound for Vitamin K epoxide reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50535486(CHEMBL4463800)
Affinity DataIC50:  1.93E+3nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50166638(13-(4-phenylphenyl)-4,12,14-trioxapentacyclo[11.7....)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration against beef liver Vitamin K epoxide reductase (vitamin K 2,3-epoxide reductase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50535485(CHEMBL4594145)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50343352(2-hydroxy-3-(3-oxo-1-phenylbutyl)-4H-chromen-4-one...)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50535488(CHEMBL4443961)
Affinity DataIC50:  90nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50535487(CHEMBL4530669)
Affinity DataIC50:  58nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Bos taurus)
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50166637(2'-Biphenyl-4-yl-4-hydroxy-3',4'-dihydro-2'H-[3,4'...)
Affinity DataIC50:  40nMAssay Description:Inhibitory concentration against beef liver Vitamin K epoxide reductase (vitamin K 2,3-epoxide reductase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVitamin K epoxide reductase complex subunit 1(Homo sapiens (Human))
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon

LigandPNGBDBM50535484(CHEMBL4517532)
Affinity DataIC50:  59nMAssay Description:Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed