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Found 6281 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208973
PNG
(US9266881, 12-1)
Show SMILES Cn1cc(nc1CCn1nc2cccc(N3CCOCC3)n2c1=O)-c1ccccc1
Show InChI InChI=1S/C22H24N6O2/c1-25-16-18(17-6-3-2-4-7-17)23-19(25)10-11-27-22(29)28-20(24-27)8-5-9-21(28)26-12-14-30-15-13-26/h2-9,16H,10-15H2,1H3
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0.410 -53.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208974
PNG
(US9266881, B-1)
Show SMILES Cn1cc(nc1CCn1nc2cccc(-c3ccncc3)n2c1=O)-c1ccccc1
Show InChI InChI=1S/C23H20N6O/c1-27-16-19(17-6-3-2-4-7-17)25-21(27)12-15-28-23(30)29-20(8-5-9-22(29)26-28)18-10-13-24-14-11-18/h2-11,13-14,16H,12,15H2,1H3
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2 -49.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208959
PNG
(US9266881, 6-1)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(N3CCOCC3)n12
Show InChI InChI=1S/C21H21N5O2/c27-21-25(11-10-17-9-8-16-4-1-2-5-18(16)22-17)23-19-6-3-7-20(26(19)21)24-12-14-28-15-13-24/h1-9H,10-15H2
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2.5 -49.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208958
PNG
(US9266881, 5-1)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3ccncc3)n12
Show InChI InChI=1S/C22H17N5O/c28-22-26(15-12-18-9-8-16-4-1-2-5-19(16)24-18)25-21-7-3-6-20(27(21)22)17-10-13-23-14-11-17/h1-11,13-14H,12,15H2
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4.40 -47.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208972
PNG
(US9266881, 11-4)
Show SMILES Cn1cc(nc1CCn1nc2cccc(Br)n2c1=O)-c1ccccc1
Show InChI InChI=1S/C18H16BrN5O/c1-22-12-14(13-6-3-2-4-7-13)20-16(22)10-11-23-18(25)24-15(19)8-5-9-17(24)21-23/h2-9,12H,10-11H2,1H3
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7.20 -46.5n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208964
PNG
(US9266881, A-1)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3cccnc3)n12
Show InChI InChI=1S/C22H17N5O/c28-22-26(14-12-18-11-10-16-5-1-2-7-19(16)24-18)25-21-9-3-8-20(27(21)22)17-6-4-13-23-15-17/h1-11,13,15H,12,14H2
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9 -45.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208960
PNG
(US9266881, 7-2)
Show SMILES COc1ccc(CC(C)(O)c2cccc3nn(CCc4ccc5ccccc5n4)c(=O)n23)cc1
Show InChI InChI=1S/C27H26N4O3/c1-27(33,18-19-10-14-22(34-2)15-11-19)24-8-5-9-25-29-30(26(32)31(24)25)17-16-21-13-12-20-6-3-4-7-23(20)28-21/h3-15,33H,16-18H2,1-2H3
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11 -45.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208970
PNG
(US9266881, A-7)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(NCc3cccnc3)n12
Show InChI InChI=1S/C23H20N6O/c30-23-28(14-12-19-11-10-18-6-1-2-7-20(18)26-19)27-22-9-3-8-21(29(22)23)25-16-17-5-4-13-24-15-17/h1-11,13,15,25H,12,14,16H2
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12 -45.2n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208966
PNG
(US9266881, A-3)
Show SMILES Cc1ccc(cc1)-c1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12
Show InChI InChI=1S/C24H20N4O/c1-17-9-11-19(12-10-17)22-7-4-8-23-26-27(24(29)28(22)23)16-15-20-14-13-18-5-2-3-6-21(18)25-20/h2-14H,15-16H2,1H3
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17 -44.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208969
PNG
(US9266881, A-6)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(N3CCCCC3)n12
Show InChI InChI=1S/C22H23N5O/c28-22-26(16-13-18-12-11-17-7-2-3-8-19(17)23-18)24-20-9-6-10-21(27(20)22)25-14-4-1-5-15-25/h2-3,6-12H,1,4-5,13-16H2
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19 -44.1n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208968
PNG
(US9266881, A-5)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3ccccc3)n12
Show InChI InChI=1S/C23H18N4O/c28-23-26(16-15-19-14-13-17-7-4-5-10-20(17)24-19)25-22-12-6-11-21(27(22)23)18-8-2-1-3-9-18/h1-14H,15-16H2
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20 -43.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208957
PNG
(US9266881, 4-1)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2c(cccn12)-c1ncco1
Show InChI InChI=1S/C20H15N5O2/c26-20-24-11-3-5-16(19-21-10-13-27-19)18(24)23-25(20)12-9-15-8-7-14-4-1-2-6-17(14)22-15/h1-8,10-11,13H,9,12H2
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22 -43.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208967
PNG
(US9266881, A-4)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2cccc(-c3cncs3)n12
Show InChI InChI=1S/C20H15N5OS/c26-20-24(11-10-15-9-8-14-4-1-2-5-16(14)22-15)23-19-7-3-6-17(25(19)20)18-12-21-13-27-18/h1-9,12-13H,10-11H2
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23 -43.6n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208954
PNG
(US9266881, 1-6)
Show SMILES Brc1cccn2c1nn(CCc1ccc3ccccc3n1)c2=O
Show InChI InChI=1S/C17H13BrN4O/c18-14-5-3-10-21-16(14)20-22(17(21)23)11-9-13-8-7-12-4-1-2-6-15(12)19-13/h1-8,10H,9,11H2
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37 -42.4n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208955
PNG
(US9266881, 2-4)
Show SMILES Brc1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12
Show InChI InChI=1S/C17H13BrN4O/c18-15-6-3-7-16-20-21(17(23)22(15)16)11-10-13-9-8-12-4-1-2-5-14(12)19-13/h1-9H,10-11H2
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59 -41.3n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208971
PNG
(US9266881, A-8)
Show SMILES CC(C)(O)c1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12
Show InChI InChI=1S/C20H20N4O2/c1-20(2,26)17-8-5-9-18-22-23(19(25)24(17)18)13-12-15-11-10-14-6-3-4-7-16(14)21-15/h3-11,26H,12-13H2,1-2H3
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72 -40.8n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208965
PNG
(US9266881, A-2)
Show SMILES Cc1cccn2c1nn(CCc1ccc3ccccc3n1)c2=O
Show InChI InChI=1S/C18H16N4O/c1-13-5-4-11-21-17(13)20-22(18(21)23)12-10-15-9-8-14-6-2-3-7-16(14)19-15/h2-9,11H,10,12H2,1H3
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74 -40.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208961
PNG
(US9266881, 8-2)
Show SMILES O=C(Nc1cccnc1)c1cccc2nn(CCc3ccc4ccccc4n3)c(=O)n12
Show InChI InChI=1S/C23H18N6O2/c30-22(26-18-6-4-13-24-15-18)20-8-3-9-21-27-28(23(31)29(20)21)14-12-17-11-10-16-5-1-2-7-19(16)25-17/h1-11,13,15H,12,14H2,(H,26,30)
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97 -40.0n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208963
PNG
(US9266881, 10-4)
Show SMILES O=c1n(CCc2ccc3ncccc3n2)nc2c(cccn12)-c1ccncc1
Show InChI InChI=1S/C21H16N6O/c28-21-26-13-2-3-17(15-7-11-22-12-8-15)20(26)25-27(21)14-9-16-5-6-18-19(24-16)4-1-10-23-18/h1-8,10-13H,9,14H2
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103 -39.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208956
PNG
(US9266881, 3-4)
Show SMILES Brc1ccc2nn(CCc3ccc4ccccc4n3)c(=O)n2c1
Show InChI InChI=1S/C17H13BrN4O/c18-13-6-8-16-20-22(17(23)21(16)11-13)10-9-14-7-5-12-3-1-2-4-15(12)19-14/h1-8,11H,9-10H2
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155 -38.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208962
PNG
(US9266881, 9-1)
Show SMILES O=c1n(CCc2ccc3ccccc3n2)nc2ccc(cn12)-c1cccnc1
Show InChI InChI=1S/C22H17N5O/c28-22-26-15-18(17-5-3-12-23-14-17)8-10-21(26)25-27(22)13-11-19-9-7-16-4-1-2-6-20(16)24-19/h1-10,12,14-15H,11,13H2
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510 -35.9n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM208975
PNG
(US9266881, 13-6)
Show SMILES O=c1n(C[C@@H]2C[C@H]2c2ccccn2)nc2cccc(N3CCOCC3)n12
Show InChI InChI=1S/C19H21N5O2/c25-19-23(13-14-12-15(14)16-4-1-2-7-20-16)21-17-5-3-6-18(24(17)19)22-8-10-26-11-9-22/h1-7,14-15H,8-13H2/t14-,15+/m0/s1
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US Patent
546 -35.7n/an/an/an/an/a7.225



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunn...


US Patent US9266881 (2016)


BindingDB Entry DOI: 10.7270/Q2154FVR
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119835
PNG
(US8691986, 1)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(Cl)cc2n1
Show InChI InChI=1S/C26H23ClFN5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 28.7n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119836
PNG
(US8691986, 2)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 6.30n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119837
PNG
(US8691986, 3)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C26H24FN5O/c1-28-26(33)20-8-6-19(16-21(20)27)25-24(29-12-13-30-25)18-10-14-32(15-11-18)23-9-7-17-4-2-3-5-22(17)31-23/h2-9,12-13,16,18H,10-11,14-15H2,1H3,(H,28,33)
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n/an/a 3.10n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119838
PNG
(US8691986, 4)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-5-2-18(15-21(20)28)25-24(30-10-11-31-25)16-8-12-33(13-9-16)23-7-3-17-14-19(27)4-6-22(17)32-23/h2-7,10-11,14-16H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 2.80n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119839
PNG
(US8691986, 5)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cccc(F)c2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)19-7-5-18(15-21(19)28)25-24(30-11-12-31-25)17-9-13-33(14-10-17)22-8-6-16-3-2-4-20(27)23(16)32-22/h2-8,11-12,15,17H,9-10,13-14H2,1H3,(H,29,34)
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n/an/a 7.5n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119840
PNG
(US8691986, 6)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccccc2n1
Show InChI InChI=1S/C23H19FN6O/c1-25-22(31)17-7-6-14(10-18(17)24)20-21(27-9-8-26-20)16-12-30(13-16)23-28-11-15-4-2-3-5-19(15)29-23/h2-11,16H,12-13H2,1H3,(H,25,31)
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n/an/a 7.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119841
PNG
(US8691986, 7)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20FN5O/c1-26-24(31)18-8-6-16(12-19(18)25)22-23(28-11-10-27-22)17-13-30(14-17)21-9-7-15-4-2-3-5-20(15)29-21/h2-12,17H,13-14H2,1H3,(H,26,31)
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n/an/a 4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119842
PNG
(US8691986, 8)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-6-3-15(10-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-4-14-2-5-17(25)11-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 0.5n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119843
PNG
(US8691986, 9)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(F)cc2n1
Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 30.9n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119850
PNG
(US8691986, 17 | US9718803, 5.19)
Show SMILES CNC(=O)c1cccc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21N5O/c1-25-24(30)18-7-4-6-17(13-18)22-23(27-12-11-26-22)19-14-29(15-19)21-10-9-16-5-2-3-8-20(16)28-21/h2-13,19H,14-15H2,1H3,(H,25,30)
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n/an/a 2n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 2.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119848
PNG
(US8691986, 14)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ncc(Cl)cc2n1
Show InChI InChI=1S/C23H18ClFN6O/c1-26-23(32)16-3-2-13(8-17(16)25)21-22(28-7-6-27-21)14-11-31(12-14)20-5-4-18-19(30-20)9-15(24)10-29-18/h2-10,14H,11-12H2,1H3,(H,26,32)
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n/an/a 3.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119847
PNG
(US8691986, 13)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-5-2-15(11-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-3-14-10-17(25)4-6-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.70n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119846
PNG
(US8691986, 12)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)c(Cl)cc2n1
Show InChI InChI=1S/C23H17ClF2N6O/c1-27-22(33)15-3-2-12(6-17(15)25)20-21(29-5-4-28-20)14-10-32(11-14)23-30-9-13-7-18(26)16(24)8-19(13)31-23/h2-9,14H,10-11H2,1H3,(H,27,33)
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n/an/a 3.90n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119845
PNG
(US8691986, 11)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)ccc2n1
Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-4-2-13(9-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-8-16(24)3-5-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 16.6n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119844
PNG
(US8691986, 10)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(Cl)cc2n1
Show InChI InChI=1S/C23H18ClFN6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 5.90n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.30n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125522
PNG
(US8772316, 4)
Show SMILES COc1cc2c(C)[nH]c(=O)c(Cc3cccc(Oc4ccccc4)c3)c2cc1OC
Show InChI InChI=1S/C25H23NO4/c1-16-20-14-23(28-2)24(29-3)15-21(20)22(25(27)26-16)13-17-8-7-11-19(12-17)30-18-9-5-4-6-10-18/h4-12,14-15H,13H2,1-3H3,(H,26,27)
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n/an/a 140n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125523
PNG
(US8772316, 6)
Show SMILES CCc1[nH]c(=O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H23NO4/c1-4-21-18-14-25(30-3)24(29-2)13-17(18)20(26(28)27-21)12-15-9-10-23-19(11-15)16-7-5-6-8-22(16)31-23/h5-11,13-14H,4,12H2,1-3H3,(H,27,28)
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n/an/a 0.120n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125524
PNG
(US8772316, 7)
Show SMILES CCCc1[nH]c(=O)c(Cc2ccc3oc4ccccc4c3c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H25NO4/c1-4-7-22-19-15-26(31-3)25(30-2)14-18(19)21(27(29)28-22)13-16-10-11-24-20(12-16)17-8-5-6-9-23(17)32-24/h5-6,8-12,14-15H,4,7,13H2,1-3H3,(H,28,29)
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n/an/a 0.5n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125525
PNG
(US8772316, 8)
Show SMILES CCc1[nH]c(=O)c(Cc2cccc(c2)-c2ccccc2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H25NO3/c1-4-23-21-16-25(30-3)24(29-2)15-20(21)22(26(28)27-23)14-17-9-8-12-19(13-17)18-10-6-5-7-11-18/h5-13,15-16H,4,14H2,1-3H3,(H,27,28)
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n/an/a 6.71E+3n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125526
PNG
(US8772316, 9)
Show SMILES CCc1[nH]c(=O)c(Cc2cccc(c2)-c2ccc(OC)cc2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H27NO4/c1-5-24-22-16-26(32-4)25(31-3)15-21(22)23(27(29)28-24)14-17-7-6-8-19(13-17)18-9-11-20(30-2)12-10-18/h6-13,15-16H,5,14H2,1-4H3,(H,28,29)
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n/an/a 1.06E+4n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125527
PNG
(US8772316, 10)
Show SMILES CCc1[nH]c(=O)c(Cc2cccc(c2)-c2cccc(N)c2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C26H26N2O3/c1-4-23-21-15-25(31-3)24(30-2)14-20(21)22(26(29)28-23)12-16-7-5-8-17(11-16)18-9-6-10-19(27)13-18/h5-11,13-15H,4,12,27H2,1-3H3,(H,28,29)
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n/an/a 52n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125528
PNG
(US8772316, 11)
Show SMILES COc1cc2c(C)[nH]c(=O)c(Cc3ccncc3)c2cc1OC
Show InChI InChI=1S/C18H18N2O3/c1-11-13-9-16(22-2)17(23-3)10-14(13)15(18(21)20-11)8-12-4-6-19-7-5-12/h4-7,9-10H,8H2,1-3H3,(H,20,21)
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n/an/a 223n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125529
PNG
(US8772316, 12)
Show SMILES COc1cc2c(C)[nH]c(=O)c(Cc3cccc(n3)-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C24H22N2O3/c1-15-18-13-22(28-2)23(29-3)14-19(18)20(24(27)25-15)12-17-10-7-11-21(26-17)16-8-5-4-6-9-16/h4-11,13-14H,12H2,1-3H3,(H,25,27)
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n/an/a 94n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125530
PNG
(US8772316, 13)
Show SMILES COc1ccc(cc1)-c1cccc(Cc2c3cc(OC)c(OC)cc3c(C)[nH]c2=O)n1
Show InChI InChI=1S/C25H24N2O4/c1-15-19-13-23(30-3)24(31-4)14-20(19)21(25(28)26-15)12-17-6-5-7-22(27-17)16-8-10-18(29-2)11-9-16/h5-11,13-14H,12H2,1-4H3,(H,26,28)
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n/an/a 50n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125531
PNG
(US8772316, 14)
Show SMILES COc1cc2c(C)[nH]c(=O)c(Cc3cccc(n3)-c3ccncc3)c2cc1OC
Show InChI InChI=1S/C23H21N3O3/c1-14-17-12-21(28-2)22(29-3)13-18(17)19(23(27)25-14)11-16-5-4-6-20(26-16)15-7-9-24-10-8-15/h4-10,12-13H,11H2,1-3H3,(H,25,27)
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n/an/a 100n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125532
PNG
(US8772316, 15)
Show SMILES COc1cc2c(C)[nH]c(=O)c(Cc3cncc(c3)-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C24H22N2O3/c1-15-19-11-22(28-2)23(29-3)12-20(19)21(24(27)26-15)10-16-9-18(14-25-13-16)17-7-5-4-6-8-17/h4-9,11-14H,10H2,1-3H3,(H,26,27)
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n/an/a 97n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair
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