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Found 137 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14754
PNG
(1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...)
Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
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0.00000800n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat lung cAMP-phosphodiesterase


J Med Chem 23: 1188-98 (1980)


Article DOI: 10.1021/jm00185a008
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221806
PNG
(CHEMBL18267)
Show SMILES Clc1ccc(CN2C3=NCCN3C(=O)c3[nH]cnc23)cc1
Show InChI InChI=1S/C14H12ClN5O/c15-10-3-1-9(2-4-10)7-20-12-11(17-8-18-12)13(21)19-6-5-16-14(19)20/h1-4,8H,5-7H2,(H,17,18)
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0.0000700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat lung cAMP-phosphodiesterase


J Med Chem 23: 1188-98 (1980)


Article DOI: 10.1021/jm00185a008
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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0.00230n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220995
PNG
(CHEMBL77788)
Show SMILES COc1ccc(\C=N\NC(C)=O)cc1OC1CCCC1
Show InChI InChI=1S/C15H20N2O3/c1-11(18)17-16-10-12-7-8-14(19-2)15(9-12)20-13-5-3-4-6-13/h7-10,13H,3-6H2,1-2H3,(H,17,18)/b16-10+
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0.0190n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221005
PNG
(CHEMBL75684)
Show SMILES CCC(=O)N\N=C(/C)c1ccc(OC)c(OC2CCCC2)c1
Show InChI InChI=1S/C17H24N2O3/c1-4-17(20)19-18-12(2)13-9-10-15(21-3)16(11-13)22-14-7-5-6-8-14/h9-11,14H,4-8H2,1-3H3,(H,19,20)/b18-12+
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0.0420n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220998
PNG
(CHEMBL76382)
Show SMILES COc1ccc(\C=N\N=C(\N)S)cc1OC1CCCC1
Show InChI InChI=1S/C14H19N3O2S/c1-18-12-7-6-10(9-16-17-14(15)20)8-13(12)19-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H3,15,17,20)/b16-9+
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0.0460n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221003
PNG
(CHEMBL432348)
Show SMILES COc1ccc(\C=N\NC(N)=O)cc1OC1CCCC1
Show InChI InChI=1S/C14H19N3O3/c1-19-12-7-6-10(9-16-17-14(15)18)8-13(12)20-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H3,15,17,18)/b16-9+
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0.0690n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220997
PNG
(CHEMBL78237)
Show SMILES COc1ccc(cc1OC1CCCC1)C(\C)=N\NC(C)=O
Show InChI InChI=1S/C16H22N2O3/c1-11(17-18-12(2)19)13-8-9-15(20-3)16(10-13)21-14-6-4-5-7-14/h8-10,14H,4-7H2,1-3H3,(H,18,19)/b17-11+
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0.0920n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221006
PNG
(CHEMBL77358)
Show SMILES COc1ccc(cc1OC1CCCC1)C(\C)=N\NC(N)=O
Show InChI InChI=1S/C15H21N3O3/c1-10(17-18-15(16)19)11-7-8-13(20-2)14(9-11)21-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H3,16,18,19)/b17-10+
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0.146n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220999
PNG
(CHEMBL77745)
Show SMILES COc1ccc(cc1OC1CCCC1)C(\C)=N\N=C(\N)S
Show InChI InChI=1S/C15H21N3O2S/c1-10(17-18-15(16)21)11-7-8-13(19-2)14(9-11)20-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H3,16,18,21)/b17-10+
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0.336n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220996
PNG
(CHEMBL76635)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=N\NC(N)=O)\c1ccccc1
Show InChI InChI=1S/C20H23N3O3/c1-25-17-12-11-15(13-18(17)26-16-9-5-6-10-16)19(22-23-20(21)24)14-7-3-2-4-8-14/h2-4,7-8,11-13,16H,5-6,9-10H2,1H3,(H3,21,23,24)/b22-19+
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1.20n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221004
PNG
(CHEMBL77999)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=N\N=C(N)N)\c1ccccc1
Show InChI InChI=1S/C20H24N4O2/c1-25-17-12-11-15(13-18(17)26-16-9-5-6-10-16)19(23-24-20(21)22)14-7-3-2-4-8-14/h2-4,7-8,11-13,16H,5-6,9-10H2,1H3,(H4,21,22,24)/b23-19+
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1.60n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221001
PNG
(CHEMBL76257)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=N\NC(C)=O)\c1ccccc1
Show InChI InChI=1S/C21H24N2O3/c1-15(24)22-23-21(16-8-4-3-5-9-16)17-12-13-19(25-2)20(14-17)26-18-10-6-7-11-18/h3-5,8-9,12-14,18H,6-7,10-11H2,1-2H3,(H,22,24)/b23-21+
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2n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220993
PNG
(CHEMBL78238)
Show SMILES COc1ccc(cc1OC1CCCC1)C(=N\N=C(\N)S)\c1ccccc1
Show InChI InChI=1S/C20H23N3O2S/c1-24-17-12-11-15(13-18(17)25-16-9-5-6-10-16)19(22-23-20(21)26)14-7-3-2-4-8-14/h2-4,7-8,11-13,16H,5-6,9-10H2,1H3,(H3,21,23,26)/b22-19+
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2.30n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221007
PNG
(CHEMBL80258)
Show SMILES CCC(=O)N\N=C\c1ccc(OC)c(OC2CCCC2)c1
Show InChI InChI=1S/C16H22N2O3/c1-3-16(19)18-17-11-12-8-9-14(20-2)15(10-12)21-13-6-4-5-7-13/h8-11,13H,3-7H2,1-2H3,(H,18,19)/b17-11+
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2.70n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221002
PNG
(CHEMBL306320)
Show SMILES COc1ccc(cc1OC1CCCC1)C(\C)=N\N=C(N)N
Show InChI InChI=1S/C15H22N4O2/c1-10(18-19-15(16)17)11-7-8-13(20-2)14(9-11)21-12-5-3-4-6-12/h7-9,12H,3-6H2,1-2H3,(H4,16,17,19)/b18-10+
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3.5n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50221000
PNG
(CHEMBL431962)
Show SMILES CCC(=O)N\N=C(/c1ccccc1)c1ccc(OC)c(OC2CCCC2)c1
Show InChI InChI=1S/C22H26N2O3/c1-3-21(25)23-24-22(16-9-5-4-6-10-16)17-13-14-19(26-2)20(15-17)27-18-11-7-8-12-18/h4-6,9-10,13-15,18H,3,7-8,11-12H2,1-2H3,(H,23,25)/b24-22+
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>5n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50220994
PNG
(CHEMBL77177)
Show SMILES COc1ccc(\C=N\N=C(N)N)cc1OC1CCCC1
Show InChI InChI=1S/C14H20N4O2/c1-19-12-7-6-10(9-17-18-14(15)16)8-13(12)20-11-4-2-3-5-11/h6-9,11H,2-5H2,1H3,(H4,15,16,18)/b17-9+
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>5n/an/an/an/an/an/an/an/a



LEAD GENE CO., LTD

Curated by ChEMBL


Assay Description
Binding affinity towards rolipram binding site on phosphodiesterase 4 using [3H]rolipram as radioligand in crude rat brain homogenate


Bioorg Med Chem Lett 13: 2355-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00405-0
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM10847
PNG
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Show SMILES Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
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5.30E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of rat lung cAMP-phosphodiesterase


J Med Chem 23: 1188-98 (1980)


Article DOI: 10.1021/jm00185a008
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219177
PNG
(CHEMBL347478)
Show SMILES Cn1c2nccc(-c3ccccc3F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(16(11-12-23-19)15-9-5-6-10-17(15)22)20(26)25(21(24)27)13-14-7-3-2-4-8-14/h2-12H,13H2,1H3
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n/an/a 491n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219178
PNG
(CHEMBL157832)
Show SMILES Cn1c2ncc(COCc3ccccc3)cc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C23H21N3O3/c1-25-21-20(22(27)26(23(25)28)14-17-8-4-2-5-9-17)12-19(13-24-21)16-29-15-18-10-6-3-7-11-18/h2-13H,14-16H2,1H3
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n/an/a 3.05E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219179
PNG
(CHEMBL156010)
Show SMILES CCOc1ccc(cc1)-c1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C23H21N3O3/c1-3-29-19-11-9-17(10-12-19)18-13-20-21(24-14-18)25(2)23(28)26(22(20)27)15-16-7-5-4-6-8-16/h4-14H,3,15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219180
PNG
(CHEMBL347429)
Show SMILES Cn1c2nccc(-c3ccc(F)cc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(17(11-12-23-19)15-7-9-16(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 70n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219822
PNG
(CHEMBL40201)
Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(C)=O
Show InChI InChI=1S/C18H13Cl2N3O3/c1-9(24)14-5-3-10-11(4-6-15(26-2)16(10)22-14)18(25)23-17-12(19)7-21-8-13(17)20/h3-8H,1-2H3,(H,21,23,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 in rat brain


Bioorg Med Chem Lett 12: 1617-9 (2002)


Article DOI: 10.1016/s0960-894x(02)00224-x
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219828
PNG
(CHEMBL607241)
Show SMILES COc1ccc(C(=O)Nc2c(C)c[n+]([O-])cc2C)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O3/c1-10-8-25(27)9-11(2)16(10)24-18(26)13-4-6-14(28-3)17-12(13)5-7-15(23-17)19(20,21)22/h4-9H,1-3H3,(H,24,26)
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n/an/a 380n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219829
PNG
(CHEMBL288195)
Show SMILES COc1ccc(C(=O)Nc2c(C)cncc2C)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C19H16F3N3O2/c1-10-8-23-9-11(2)16(10)25-18(26)13-4-6-14(27-3)17-12(13)5-7-15(24-17)19(20,21)22/h4-9H,1-3H3,(H,23,25,26)
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n/an/a 58n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219827
PNG
(CHEMBL42479)
Show SMILES COc1ccc(C(=O)Nc2ccncc2Cl)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF3N3O2/c1-26-13-4-2-10(16(25)23-12-6-7-22-8-11(12)18)9-3-5-14(17(19,20)21)24-15(9)13/h2-8H,1H3,(H,22,23,25)
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n/an/a 110n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219826
PNG
(CHEMBL607242)
Show SMILES COc1ccc(C(=O)Nc2c(F)c[n+]([O-])cc2F)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H10F5N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26)
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n/an/a 60n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219830
PNG
(CHEMBL42387)
Show SMILES COc1ccc(C(=O)Nc2c(F)cncc2F)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H10F5N3O2/c1-27-12-4-2-9(8-3-5-13(17(20,21)22)24-14(8)12)16(26)25-15-10(18)6-23-7-11(15)19/h2-7H,1H3,(H,23,25,26)
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n/an/a 38n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50114418
PNG
(8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...)
Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H10Cl2F3N3O2/c1-27-12-4-2-9(8-3-5-13(17(20,21)22)24-14(8)12)16(26)25-15-10(18)6-23-7-11(15)19/h2-7H,1H3,(H,23,25,26)
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n/an/a 7n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219270
PNG
(3,5-Dichloro-4-[(8-methoxy-2-trifluoromethyl-quino...)
Show SMILES COc1ccc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H10Cl2F3N3O3/c1-28-12-4-2-9(8-3-5-13(17(20,21)22)23-14(8)12)16(26)24-15-10(18)6-25(27)7-11(15)19/h2-7H,1H3,(H,24,26)
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n/an/a 150n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219831
PNG
(CHEMBL607240)
Show SMILES COc1ccc(C(=O)Nc2cc[n+]([O-])cc2Cl)c2ccc(nc12)C(F)(F)F
Show InChI InChI=1S/C17H11ClF3N3O3/c1-27-13-4-2-10(9-3-5-14(17(19,20)21)23-15(9)13)16(25)22-12-6-7-24(26)8-11(12)18/h2-8H,1H3,(H,22,25)
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n/an/a 370n/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of rolipram binding to PDE4 of rat brain


Bioorg Med Chem Lett 12: 1621-3 (2002)


Article DOI: 10.1016/s0960-894x(02)00225-1
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219181
PNG
(CHEMBL346928)
Show SMILES Cn1c2nccc(-c3ccccc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H17N3O2/c1-23-19-18(17(12-13-22-19)16-10-6-3-7-11-16)20(25)24(21(23)26)14-15-8-4-2-5-9-15/h2-13H,14H2,1H3
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n/an/a 1.01E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219182
PNG
(CHEMBL156054)
Show SMILES CCOc1ccc(cc1)-c1ccnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C23H21N3O3/c1-3-29-18-11-9-17(10-12-18)19-13-14-24-21-20(19)22(27)26(23(28)25(21)2)15-16-7-5-4-6-8-16/h4-14H,3,15H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219183
PNG
(CHEMBL157204)
Show SMILES CCCOc1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1C
Show InChI InChI=1S/C19H21N3O3/c1-4-10-25-15-11-20-17-16(13(15)2)18(23)22(19(24)21(17)3)12-14-8-6-5-7-9-14/h5-9,11H,4,10,12H2,1-3H3
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n/an/a 5.15E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219184
PNG
(CHEMBL157897)
Show SMILES Cn1c2ncc(Cc3ccccc3)cc2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H19N3O2/c1-24-20-19(13-18(14-23-20)12-16-8-4-2-5-9-16)21(26)25(22(24)27)15-17-10-6-3-7-11-17/h2-11,13-14H,12,15H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219185
PNG
(CHEMBL157550)
Show SMILES Cn1c2nccc(-c3cccc(c3)C(F)(F)F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-18(20(29)28(21(27)30)13-14-6-3-2-4-7-14)17(10-11-26-19)15-8-5-9-16(12-15)22(23,24)25/h2-12H,13H2,1H3
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n/an/a 950n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219185
PNG
(CHEMBL157550)
Show SMILES Cn1c2nccc(-c3cccc(c3)C(F)(F)F)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-18(20(29)28(21(27)30)13-14-6-3-2-4-7-14)17(10-11-26-19)15-8-5-9-16(12-15)22(23,24)25/h2-12H,13H2,1H3
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n/an/a 950n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219186
PNG
(CHEMBL155536)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccccc1
Show InChI InChI=1S/C21H17N3O2/c1-23-19-18(12-17(13-22-19)16-10-6-3-7-11-16)20(25)24(21(23)26)14-15-8-4-2-5-9-15/h2-13H,14H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 from rat liver at 0.3 uM (not determined)


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50346088
PNG
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-
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n/an/a 110n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219180
PNG
(CHEMBL347429)
Show SMILES Cn1c2nccc(-c3ccc(F)cc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(17(11-12-23-19)15-7-9-16(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 755n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219181
PNG
(CHEMBL346928)
Show SMILES Cn1c2nccc(-c3ccccc3)c2c(=O)n(Cc2ccccc2)c1=O
Show InChI InChI=1S/C21H17N3O2/c1-23-19-18(17(12-13-22-19)16-10-6-3-7-11-16)20(25)24(21(23)26)14-15-8-4-2-5-9-15/h2-13H,14H2,1H3
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n/an/a 430n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219187
PNG
(CHEMBL156985)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccccc1F
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-17(11-15(12-23-19)16-9-5-6-10-18(16)22)20(26)25(21(24)27)13-14-7-3-2-4-8-14/h2-12H,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219188
PNG
(CHEMBL346569)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H16F3N3O2/c1-27-19-18(20(29)28(21(27)30)13-14-6-3-2-4-7-14)11-16(12-26-19)15-8-5-9-17(10-15)22(23,24)25/h2-12H,13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219189
PNG
(CHEMBL436416)
Show SMILES CCCOCc1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C19H21N3O3/c1-3-9-25-13-15-10-16-17(20-11-15)21(2)19(24)22(18(16)23)12-14-7-5-4-6-8-14/h4-8,10-11H,3,9,12-13H2,1-2H3
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n/an/a 4.48E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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n/an/a 2n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219190
PNG
(CHEMBL154936)
Show SMILES CCCCOc1ccnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c12
Show InChI InChI=1S/C19H21N3O3/c1-3-4-12-25-15-10-11-20-17-16(15)18(23)22(19(24)21(17)2)13-14-8-6-5-7-9-14/h5-11H,3-4,12-13H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50346088
PNG
((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Show SMILES COc1ccc(cc1OC1CCCC1)[C@]1(CC[C@@H](CC1)C(O)=O)C#N
Show InChI InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)/t14-,20-
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n/an/a 180n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Binding affinity to rolipram binding site in isolated rat brain by rolipram binding assay


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219191
PNG
(CHEMBL156928)
Show SMILES Cn1c2ncc(cc2c(=O)n(Cc2ccccc2)c1=O)-c1ccc(F)cc1
Show InChI InChI=1S/C21H16FN3O2/c1-24-19-18(11-16(12-23-19)15-7-9-17(22)10-8-15)20(26)25(21(24)27)13-14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 5.75E+3n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50219192
PNG
(CHEMBL156742)
Show SMILES CCOC(=O)c1cnc2n(C)c(=O)n(Cc3ccccc3)c(=O)c2c1
Show InChI InChI=1S/C18H17N3O4/c1-3-25-17(23)13-9-14-15(19-10-13)20(2)18(24)21(16(14)22)11-12-7-5-4-6-8-12/h4-10H,3,11H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Korea Institute of Science and Technology

Curated by ChEMBL


Assay Description
Concentration for inhibitory activity against phosphodiesterase 4 from rat liver


Bioorg Med Chem Lett 11: 611-4 (2001)


Article DOI: 10.1016/s0960-894x(00)00681-8
More data for this
Ligand-Target Pair
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