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Found 1004 hits Enz. Inhib. hit(s) with Target = 'cGMP-dependent 3',5'-cyclic phosphodiesterase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119837
PNG
(US8691986, 3)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccccc2n1
Show InChI InChI=1S/C26H24FN5O/c1-28-26(33)20-8-6-19(16-21(20)27)25-24(29-12-13-30-25)18-10-14-32(15-11-18)23-9-7-17-4-2-3-5-22(17)31-23/h2-9,12-13,16,18H,10-11,14-15H2,1H3,(H,28,33)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119848
PNG
(US8691986, 14)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ncc(Cl)cc2n1
Show InChI InChI=1S/C23H18ClFN6O/c1-26-23(32)16-3-2-13(8-17(16)25)21-22(28-7-6-27-21)14-11-31(12-14)20-5-4-18-19(30-20)9-15(24)10-29-18/h2-10,14H,11-12H2,1H3,(H,26,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119847
PNG
(US8691986, 13)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-5-2-15(11-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-3-14-10-17(25)4-6-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119846
PNG
(US8691986, 12)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)c(Cl)cc2n1
Show InChI InChI=1S/C23H17ClF2N6O/c1-27-22(33)15-3-2-12(6-17(15)25)20-21(29-5-4-28-20)14-10-32(11-14)23-30-9-13-7-18(26)16(24)8-19(13)31-23/h2-9,14H,10-11H2,1H3,(H,27,33)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119845
PNG
(US8691986, 11)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2cc(F)ccc2n1
Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-4-2-13(9-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-8-16(24)3-5-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119844
PNG
(US8691986, 10)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(Cl)cc2n1
Show InChI InChI=1S/C23H18ClFN6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 7.38E+3n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119843
PNG
(US8691986, 9)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccc(F)cc2n1
Show InChI InChI=1S/C23H18F2N6O/c1-26-22(32)17-5-3-13(8-18(17)25)20-21(28-7-6-27-20)15-11-31(12-15)23-29-10-14-2-4-16(24)9-19(14)30-23/h2-10,15H,11-12H2,1H3,(H,26,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119842
PNG
(US8691986, 8)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-6-3-15(10-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-4-14-2-5-17(25)11-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119850
PNG
(US8691986, 17 | US9718803, 5.19)
Show SMILES CNC(=O)c1cccc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21N5O/c1-25-24(30)18-7-4-6-17(13-18)22-23(27-12-11-26-22)19-14-29(15-19)21-10-9-16-5-2-3-8-20(16)28-21/h2-13,19H,14-15H2,1H3,(H,25,30)
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n/an/a 2.16E+3n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 3.30E+3n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119835
PNG
(US8691986, 1)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(Cl)cc2n1
Show InChI InChI=1S/C26H23ClFN5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119836
PNG
(US8691986, 2)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-6-3-18(14-21(20)28)25-24(30-10-11-31-25)17-8-12-33(13-9-17)23-7-4-16-2-5-19(27)15-22(16)32-23/h2-7,10-11,14-15,17H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119838
PNG
(US8691986, 4)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)20-5-2-18(15-21(20)28)25-24(30-10-11-31-25)16-8-12-33(13-9-16)23-7-3-17-14-19(27)4-6-22(17)32-23/h2-7,10-11,14-16H,8-9,12-13H2,1H3,(H,29,34)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119839
PNG
(US8691986, 5)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CCN(CC1)c1ccc2cccc(F)c2n1
Show InChI InChI=1S/C26H23F2N5O/c1-29-26(34)19-7-5-18(15-21(19)28)25-24(30-11-12-31-25)17-9-13-33(14-10-17)22-8-6-16-3-2-4-20(27)23(16)32-22/h2-8,11-12,15,17H,9-10,13-14H2,1H3,(H,29,34)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119840
PNG
(US8691986, 6)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ncc2ccccc2n1
Show InChI InChI=1S/C23H19FN6O/c1-25-22(31)17-7-6-14(10-18(17)24)20-21(27-9-8-26-20)16-12-30(13-16)23-28-11-15-4-2-3-5-19(15)29-23/h2-11,16H,12-13H2,1H3,(H,25,31)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119841
PNG
(US8691986, 7)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20FN5O/c1-26-24(31)18-8-6-16(12-19(18)25)22-23(28-11-10-27-22)17-13-30(14-17)21-9-7-15-4-2-3-5-20(15)29-21/h2-12,17H,13-14H2,1H3,(H,26,31)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM22926
PNG
(3-(6-amino-9H-purin-9-yl)nonan-2-ol | EHNA | Eryth...)
Show SMILES CCCCCCC(C(C)O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)
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Article
PubMed
n/an/a 800n/an/an/an/a7.524



University of North Carolina



Assay Description
Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.


J Biol Chem 287: 11788-97 (2012)


Article DOI: 10.1074/jbc.M111.326777
BindingDB Entry DOI: 10.7270/Q2K9364D
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50028190
PNG
(7-(2-Hydroxy-propyl)-1,3-dimethyl-3,7-dihydro-puri...)
Show SMILES CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3
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Article
PubMed
0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)


J Med Chem 26: 1514-8 (1983)


Article DOI: 10.1021/jm00364a029
BindingDB Entry DOI: 10.7270/Q21Z43F5
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50028191
PNG
((R)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...)
Show SMILES C[C@@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m1/s1
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0.600n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)


J Med Chem 26: 1514-8 (1983)


Article DOI: 10.1021/jm00364a029
BindingDB Entry DOI: 10.7270/Q21Z43F5
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50028192
PNG
((S)-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6...)
Show SMILES C[C@H](O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3/t6-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human lung low-affinity cGMP phosphodiesterases (10-50 microM/L)


J Med Chem 26: 1514-8 (1983)


Article DOI: 10.1021/jm00364a029
BindingDB Entry DOI: 10.7270/Q21Z43F5
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50444037
PNG
(CHEMBL3092564 | US8680116, 1-15)
Show SMILES O=c1[nH]c2ccc(cc2c(OCC2CCNCC2)c1-c1cccs1)C#Cc1cccnc1
Show InChI InChI=1S/C26H23N3O2S/c30-26-24(23-4-2-14-32-23)25(31-17-20-9-12-27-13-10-20)21-15-18(7-8-22(21)29-26)5-6-19-3-1-11-28-16-19/h1-4,7-8,11,14-16,20,27H,9-10,12-13,17H2,(H,29,30)
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1.30n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119685
PNG
(US8680116, 1-57)
Show SMILES CC(C)(O)C#Cc1ccc2[nH]c(=O)c(-c3cccs3)c(OCC3CCOCC3)c2c1
Show InChI InChI=1S/C24H25NO4S/c1-24(2,27)10-7-16-5-6-19-18(14-16)22(29-15-17-8-11-28-12-9-17)21(23(26)25-19)20-4-3-13-30-20/h3-6,13-14,17,27H,8-9,11-12,15H2,1-2H3,(H,25,26)
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1.80n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119686
PNG
(US8680116, 1-63)
Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)-c3ccccn3)c2cc1OC
Show InChI InChI=1S/C26H20N2O3S/c1-30-21-14-18-20(15-22(21)31-2)28-26(29)25(23-10-6-12-32-23)24(18)17-8-5-7-16(13-17)19-9-3-4-11-27-19/h3-15H,1-2H3,(H,28,29)
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34n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119682
PNG
(US8680116, 1-23)
Show SMILES CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(cc23)C#Cc2cccnc2)CC1
Show InChI InChI=1S/C27H25N3O2S/c1-30-13-10-21(11-14-30)18-32-26-22-16-19(6-7-20-4-2-12-28-17-20)8-9-23(22)29-27(31)25(26)24-5-3-15-33-24/h2-5,8-9,12,15-17,21H,10-11,13-14,18H2,1H3,(H,29,31)
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62n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119680
PNG
(US8680116, 1-13)
Show SMILES CN1CCC(COc2c(-c3cccs3)c(=O)[nH]c3ccc(Br)cc23)CC1
Show InChI InChI=1S/C20H21BrN2O2S/c1-23-8-6-13(7-9-23)12-25-19-15-11-14(21)4-5-16(15)22-20(24)18(19)17-3-2-10-26-17/h2-5,10-11,13H,6-9,12H2,1H3,(H,22,24)
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73n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119687
PNG
(US8680116, 1-85)
Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)C3CCCC3)c2cc1OC
Show InChI InChI=1S/C26H25NO3S/c1-29-21-14-19-20(15-22(21)30-2)27-26(28)25(23-11-6-12-31-23)24(19)18-10-5-9-17(13-18)16-7-3-4-8-16/h5-6,9-16H,3-4,7-8H2,1-2H3,(H,27,28)
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110n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119683
PNG
(US8680116, 1-48)
Show SMILES O=c1[nH]c2ccc(cc2c(OCc2ccccn2)c1-c1cccs1)-c1ccncc1
Show InChI InChI=1S/C24H17N3O2S/c28-24-22(21-5-3-13-30-21)23(29-15-18-4-1-2-10-26-18)19-14-17(6-7-20(19)27-24)16-8-11-25-12-9-16/h1-14H,15H2,(H,27,28)
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160n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119681
PNG
(US8680116, 1-18)
Show SMILES COc1cc2[nH]c(=O)c(-c3cccs3)c(-c3cccc(c3)C#N)c2cc1-c1ccccc1
Show InChI InChI=1S/C27H18N2O2S/c1-31-23-15-22-21(14-20(23)18-8-3-2-4-9-18)25(19-10-5-7-17(13-19)16-28)26(27(30)29-22)24-11-6-12-32-24/h2-15H,1H3,(H,29,30)
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200n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119684
PNG
(US8680116, 1-51)
Show SMILES Brc1ccc2[nH]c(=O)c(-c3cccs3)c(\C=C\c3ccccn3)c2c1
Show InChI InChI=1S/C20H13BrN2OS/c21-13-6-9-17-16(12-13)15(8-7-14-4-1-2-10-22-14)19(20(24)23-17)18-5-3-11-25-18/h1-12H,(H,23,24)/b8-7+
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900n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluorescence polarization...


US Patent US8680116 (2014)


BindingDB Entry DOI: 10.7270/Q2N29VM1
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50034908
PNG
((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Show SMILES CCCCCC[C@@H]([C@@H](C)O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)/t10-,11+/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Monash University (Parkville Campus)

Curated by ChEMBL


Assay Description
Inhibition of human phosphodiesterase 2


J Med Chem 48: 3449-62 (2005)


Article DOI: 10.1021/jm040217u
BindingDB Entry DOI: 10.7270/Q21G0N2H
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50034908
PNG
((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Show SMILES CCCCCC[C@@H]([C@@H](C)O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C14H23N5O/c1-3-4-5-6-7-11(10(2)20)19-9-18-12-13(15)16-8-17-14(12)19/h8-11,20H,3-7H2,1-2H3,(H2,15,16,17)/t10-,11+/m1/s1
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2.80E+3n/an/an/an/an/an/an/an/a



UPR 421 du CNRS

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 2


J Med Chem 40: 1768-70 (1997)


Article DOI: 10.1021/jm960827x
BindingDB Entry DOI: 10.7270/Q25T3M4T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362033
PNG
(CHEMBL1939912)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CC[C@@H](O)C3)c2c1
Show InChI InChI=1S/C18H22N4O2/c1-10-6-13(24-3)7-14-15(9-22-5-4-12(23)8-22)16-11(2)20-21-18(16)19-17(10)14/h6-7,12,23H,4-5,8-9H2,1-3H3,(H,19,20,21)/t12-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362048
PNG
(CHEMBL1940058)
Show SMILES CC(C)Oc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1
Show InChI InChI=1S/C21H28N4O2/c1-13(2)27-16-10-14(3)20-17(11-16)18(12-25-6-5-8-26-9-7-25)19-15(4)23-24-21(19)22-20/h10-11,13H,5-9,12H2,1-4H3,(H,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362047
PNG
(CHEMBL1940057)
Show SMILES COCCOc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1
Show InChI InChI=1S/C21H28N4O3/c1-14-11-16(28-10-9-26-3)12-17-18(13-25-5-4-7-27-8-6-25)19-15(2)23-24-21(19)22-20(14)17/h11-12H,4-10,13H2,1-3H3,(H,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362046
PNG
(CHEMBL1940056)
Show SMILES Cc1n[nH]c2nc3c(C)cc(O)cc3c(CN3CCCOCC3)c12
Show InChI InChI=1S/C18H22N4O2/c1-11-8-13(23)9-14-15(10-22-4-3-6-24-7-5-22)16-12(2)20-21-18(16)19-17(11)14/h8-9,23H,3-7,10H2,1-2H3,(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362043
PNG
(CHEMBL1940053)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCCOCC3)c2c1
Show InChI InChI=1S/C19H24N4O2/c1-12-9-14(24-3)10-15-16(11-23-5-4-7-25-8-6-23)17-13(2)21-22-19(17)20-18(12)15/h9-10H,4-8,11H2,1-3H3,(H,20,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362036
PNG
(CHEMBL1939915)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOC(C)C3)c2c1
Show InChI InChI=1S/C19H24N4O2/c1-11-7-14(24-4)8-15-16(10-23-5-6-25-12(2)9-23)17-13(3)21-22-19(17)20-18(11)15/h7-8,12H,5-6,9-10H2,1-4H3,(H,20,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50362035
PNG
(CHEMBL1939914)
Show SMILES COc1cc(C)c2nc3[nH]nc(C)c3c(CN3CCOCC3)c2c1
Show InChI InChI=1S/C18H22N4O2/c1-11-8-13(23-3)9-14-15(10-22-4-6-24-7-5-22)16-12(2)20-21-18(16)19-17(11)14/h8-9H,4-7,10H2,1-3H3,(H,19,20,21)
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>1.00E+4n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]cAMP from PDE2A by competitive binding assay


Bioorg Med Chem Lett 22: 235-9 (2011)


Article DOI: 10.1016/j.bmcl.2011.11.023
BindingDB Entry DOI: 10.7270/Q2862GWC
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150119
PNG
(CHEMBL3769414)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)-c3cccc(F)n3)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C29H26FN7O/c1-35-28(38)25-26(31-20-7-3-2-4-8-20)36(34-27(25)37-23-11-5-10-22(23)33-29(35)37)17-18-13-15-19(16-14-18)21-9-6-12-24(30)32-21/h2-4,6-9,12-16,22-23,31H,5,10-11,17H2,1H3/t22-,23+/m1/s1
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1.80E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150264
PNG
(CHEMBL3769817)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)-c3ccccn3)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C29H27N7O/c1-34-28(37)25-26(31-21-8-3-2-4-9-21)35(33-27(25)36-24-12-7-11-23(24)32-29(34)36)18-19-13-15-20(16-14-19)22-10-5-6-17-30-22/h2-6,8-10,13-17,23-24,31H,7,11-12,18H2,1H3/t23-,24+/m1/s1
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2.40E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150171
PNG
(CHEMBL3770470)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)-c3ccccc3)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C30H28N6O/c1-34-29(37)26-27(31-23-11-6-3-7-12-23)35(33-28(26)36-25-14-8-13-24(25)32-30(34)36)19-20-15-17-22(18-16-20)21-9-4-2-5-10-21/h2-7,9-12,15-18,24-25,31H,8,13-14,19H2,1H3/t24-,25+/m1/s1
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3.70E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150239
PNG
(CHEMBL3769461)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(cc3)C(F)(F)F)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C25H23F3N6O/c1-32-23(35)20-21(29-17-6-3-2-4-7-17)33(14-15-10-12-16(13-11-15)25(26,27)28)31-22(20)34-19-9-5-8-18(19)30-24(32)34/h2-4,6-7,10-13,18-19,29H,5,8-9,14H2,1H3/t18-,19+/m1/s1
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3.90E+4n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50150238
PNG
(CHEMBL3770107)
Show SMILES CN1C2=N[C@@H]3CCC[C@@H]3N2c2nn(Cc3ccc(nc3)C(F)(F)F)c(Nc3ccccc3)c2C1=O
Show InChI InChI=1S/C24H22F3N7O/c1-32-22(35)19-20(29-15-6-3-2-4-7-15)33(13-14-10-11-18(28-12-14)24(25,26)27)31-21(19)34-17-9-5-8-16(17)30-23(32)34/h2-4,6-7,10-12,16-17,29H,5,8-9,13H2,1H3/t16-,17+/m1/s1
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>1.00E+5n/an/an/an/an/an/an/an/a



Intra-Cellular Therapies, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant full length human PDE2A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assay


J Med Chem 59: 1149-64 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01751
BindingDB Entry DOI: 10.7270/Q2X068W7
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM50058210
PNG
(CHEMBL445098 | [9-(2-Fluoro-benzyl)-9H-purin-6-yl]...)
Show SMILES CNc1ncnc2n(Cc3ccccc3F)cnc12
Show InChI InChI=1S/C13H12FN5/c1-15-12-11-13(17-7-16-12)19(8-18-11)6-9-4-2-3-5-10(9)14/h2-5,7-8H,6H2,1H3,(H,15,16,17)
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1.22E+5n/an/an/an/an/an/an/an/a



UPR 421 du CNRS

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 2


J Med Chem 40: 1768-70 (1997)


Article DOI: 10.1021/jm960827x
BindingDB Entry DOI: 10.7270/Q25T3M4T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM14361
PNG
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)
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>2.00E+5n/an/an/an/an/an/an/an/a



UPR 421 du CNRS

Curated by ChEMBL


Assay Description
Inhibition of Phosphodiesterase 2


J Med Chem 40: 1768-70 (1997)


Article DOI: 10.1021/jm960827x
BindingDB Entry DOI: 10.7270/Q25T3M4T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM9049
PNG
(US8829010, 35 | US8829010, 55)
Show SMILES Cn1ncc(-c2nn(C)c3ncnc(N4CCC4)c23)c1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C20H18F3N7/c1-28-17(12-4-6-13(7-5-12)20(21,22)23)14(10-26-28)16-15-18(29(2)27-16)24-11-25-19(15)30-8-3-9-30/h4-7,10-11H,3,8-9H2,1-2H3
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n/an/a 1.48n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...


US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM9153
PNG
(US8829010, 58 | US8829010, 59)
Show SMILES CNc1ncnc2n(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F3N7/c1-22-16-13-14(26-28(3)17(13)24-9-23-16)12-8-25-27(2)15(12)10-4-6-11(7-5-10)18(19,20)21/h4-9H,1-3H3,(H,22,23,24)
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n/an/a 27n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
In the present assay, the activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximi...


US Patent US8829010 (2014)


BindingDB Entry DOI: 10.7270/Q2PR7TNH
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM47122
PNG
(US8598155, 10 | US8598155, 3)
Show SMILES CNc1ncnn2c(C)nc(-c3cnn(C)c3-c3ccc(cc3)C(F)(F)F)c12
Show InChI InChI=1S/C18H16F3N7/c1-10-26-14(16-17(22-2)23-9-25-28(10)16)13-8-24-27(3)15(13)11-4-6-12(7-5-11)18(19,20)21/h4-9H,1-3H3,(H,22,23,25)
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n/an/a 1.30n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM107766
PNG
(US8598155, 1)
Show SMILES Cc1nc(-c2cnn(C)c2-c2ccc(C)cc2)c2c(ncnn12)N1CCC1
Show InChI InChI=1S/C20H21N7/c1-13-5-7-15(8-6-13)18-16(11-22-25(18)3)17-19-20(26-9-4-10-26)21-12-23-27(19)14(2)24-17/h5-8,11-12H,4,9-10H2,1-3H3
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n/an/a 1.31n/an/an/an/an/an/a



Pfizer Inc.

US Patent


Assay Description
The activity of the test substances on human full-length PDE2A3 enzyme was determined using the [3H]-cGMP scintillation proximity assay (SPA) modifie...


US Patent US8598155 (2013)


BindingDB Entry DOI: 10.7270/Q26T0K8C
More data for this
Ligand-Target Pair
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