Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM50159165![]() ((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...) | PDB GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 7.20 | -46.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of North Carolina | Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM21130![]() (N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...) | PDB GoogleScholar | Purchase CHEBI PC cid PC sid UniChem Patents Similars | Article PubMed | 11 | -45.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of North Carolina | Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM214798![]() (Dynorphin A (1-17) | YGGFLRRIRPKLK) | PDB GoogleScholar | Purchase PC cid PC sid UniChem | Article PubMed | 48 | -41.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of North Carolina | Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM214799![]() (1xx) | PDB GoogleScholar | PC cid PC sid UniChem | Article PubMed | 110 | -39.7 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
University of North Carolina | Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM214799![]() (1xx) | PDB GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 65 | n/a | n/a | 7.4 | n/a |
University of North Carolina | Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM50159165![]() ((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...) | PDB GoogleScholar | Purchase CHEBI CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | 7.4 | n/a |
University of North Carolina | Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM21130![]() (N-methyl-2-phenyl-N-[(5R,7S,8S)-7-(pyrrolidin-1-yl...) | PDB GoogleScholar | Purchase CHEBI PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.20 | n/a | n/a | 7.4 | n/a |
University of North Carolina | Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM214798![]() (Dynorphin A (1-17) | YGGFLRRIRPKLK) | PDB GoogleScholar | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 44 | n/a | n/a | 7.4 | n/a |
University of North Carolina | Assay Description HEK293T cells were co-transfected with plasmids encoding the cAMP biosensor GloSensor-22F (Promega) and the different human KOR variants as described... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
κ opioid receptor (KOR E297A) (Homo sapiens (Human)) | BDBM50001714![]() (2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(1S,2...) | PDB GoogleScholar | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.980 | n/a | n/a | n/a | 7.4 | 25 |
University of North Carolina | Assay Description Radioligand binding assays were performed as previously detailed [Yan et al., Biochemistry, 48:6898-6908]. In brief, crude cell membranes were prepar... | J Biol Chem 288: 34470-83 (2013) Article DOI: 10.1074/jbc.M113.515668 BindingDB Entry DOI: 10.7270/Q2P849RP | |||||||||||
More data for this Ligand-Target Pair |