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Compile Data Set for Download or QSAR

Found 262 hits Enz. Inhib. hit(s) with Target = '15-hydroxyprostaglandin dehydrogenase [NAD+]' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50066953
PNG
(CHEMBL3403240)
Show SMILES Brc1cc(\C=C2/SC(=O)NC2=O)ccc1OCCc1ccccc1
Show InChI InChI=1S/C18H14BrNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,20,21,22)/b16-11-
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n/an/a 4n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of 15-PGDH (unknown origin) by fluorescence spectrophotometry


Bioorg Med Chem 23: 2098-103 (2015)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347953
PNG
(CHEMBL1800140 | US8637558, 15)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Br)c1
Show InChI InChI=1S/C18H20BrNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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US Patent
n/an/a 6.60n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347952
PNG
(CHEMBL1800139 | US8637558, 11)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C18H20ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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US Patent
n/an/a 7.20n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347952
PNG
(CHEMBL1800139 | US8637558, 11)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C18H20ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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n/an/a 8n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438415
PNG
(CHEMBL2414148)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCC2)c(Cl)c1
Show InChI InChI=1S/C15H14ClNO3S/c16-11-6-10(7-13-14(18)17-15(19)21-13)4-5-12(11)20-8-9-2-1-3-9/h4-7,9H,1-3,8H2,(H,17,18,19)
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n/an/a 9n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347956
PNG
(CHEMBL1800143 | US8637558, 32)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C19H22ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h8-9,11-13H,1-7,10H2,(H,21,22,23)
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n/an/a 10n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347956
PNG
(CHEMBL1800143 | US8637558, 32)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C19H22ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h8-9,11-13H,1-7,10H2,(H,21,22,23)
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US Patent
n/an/a 10.3n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438413
PNG
(CHEMBL2414150)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCC2)c(Cl)c1
Show InChI InChI=1S/C16H16ClNO3S/c17-12-7-11(8-14-15(19)18-16(20)22-14)5-6-13(12)21-9-10-3-1-2-4-10/h5-8,10H,1-4,9H2,(H,18,19,20)
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n/an/a 11n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445521
PNG
(CHEMBL3103033)
Show SMILES Clc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H18ClN3O/c20-15-5-4-6-16(12-15)23-13-21-17-11-14(7-8-18(17)23)19(24)22-9-2-1-3-10-22/h4-8,11-13H,1-3,9-10H2
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n/an/a 12n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438430
PNG
(CHEMBL2414240 | US8637558, 18)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)cc1Cl
Show InChI InChI=1S/C18H20ClNO3S/c19-15-11-14(23-9-8-12-4-2-1-3-5-12)7-6-13(15)10-16-17(21)20-18(22)24-16/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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n/an/a 13n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118019
PNG
(US8637558, 34)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(OCCC2CCCCC2)c1Cl
Show InChI InChI=1S/C18H20ClNO3S/c19-16-13(11-15-17(21)20-18(22)24-15)7-4-8-14(16)23-10-9-12-5-2-1-3-6-12/h4,7-8,11-12H,1-3,5-6,9-10H2,(H,20,21,22)
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US Patent
n/an/a 17.9n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM30884
PNG
(1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-b...)
Show SMILES Cc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347953
PNG
(CHEMBL1800140 | US8637558, 15)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)c(Br)c1
Show InChI InChI=1S/C18H20BrNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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n/an/a 19n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445516
PNG
(CHEMBL3103038)
Show SMILES Cc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O/c1-15-5-8-17(9-6-15)23-14-21-18-13-16(7-10-19(18)23)20(24)22-11-3-2-4-12-22/h5-10,13-14H,2-4,11-12H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445514
PNG
(CHEMBL3103040)
Show SMILES COc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O2/c1-25-17-8-6-16(7-9-17)23-14-21-18-13-15(5-10-19(18)23)20(24)22-11-3-2-4-12-22/h5-10,13-14H,2-4,11-12H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445520
PNG
(CHEMBL3103034)
Show SMILES COc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O2/c1-25-17-7-5-6-16(13-17)23-14-21-18-12-15(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
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n/an/a 19n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438430
PNG
(CHEMBL2414240 | US8637558, 18)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCCC2)cc1Cl
Show InChI InChI=1S/C18H20ClNO3S/c19-15-11-14(23-9-8-12-4-2-1-3-5-12)7-6-13(15)10-16-17(21)20-18(22)24-16/h6-7,10-12H,1-5,8-9H2,(H,20,21,22)
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US Patent
n/an/a 19.6n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438403
PNG
(CHEMBL2414160 | US8637558, 69)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C18H14ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,20,21,22)
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US Patent
n/an/a 19.8n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438416
PNG
(CHEMBL2414147)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCOC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C18H20ClNO4S/c19-14-10-12(11-16-17(21)20-18(22)25-16)6-7-15(14)24-9-8-23-13-4-2-1-3-5-13/h6-7,10-11,13H,1-5,8-9H2,(H,20,21,22)
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n/an/a 20n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438403
PNG
(CHEMBL2414160 | US8637558, 69)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C18H14ClNO3S/c19-14-10-13(11-16-17(21)20-18(22)24-16)6-7-15(14)23-9-8-12-4-2-1-3-5-12/h1-7,10-11H,8-9H2,(H,20,21,22)
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n/an/a 20n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118042
PNG
(US8637558, 66)
Show SMILES OCC(=O)C1CCC(COc2ccc(C=C3SC(O)=NC3=O)cc2)CC1
Show InChI InChI=1S/C19H21NO5S/c21-10-16(22)14-5-1-13(2-6-14)11-25-15-7-3-12(4-8-15)9-17-18(23)20-19(24)26-17/h3-4,7-9,13-14,21H,1-2,5-6,10-11H2,(H,20,23,24)
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n/an/a 20.4n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445562
PNG
(CHEMBL3102994)
Show SMILES Cc1cc(c(C)n1-c1ccc(Cl)c(Cl)c1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C19H20Cl2N4/c1-12-10-15(19-23-22-18-6-4-3-5-9-24(18)19)13(2)25(12)14-7-8-16(20)17(21)11-14/h7-8,10-11H,3-6,9H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445537
PNG
(CHEMBL3103018)
Show SMILES CC1CCCN(C1)C(=O)c1ccc2n(cnc2c1)-c1cccc(C)c1
Show InChI InChI=1S/C21H23N3O/c1-15-5-3-7-18(11-15)24-14-22-19-12-17(8-9-20(19)24)21(25)23-10-4-6-16(2)13-23/h3,5,7-9,11-12,14,16H,4,6,10,13H2,1-2H3
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445523
PNG
(CHEMBL3103032)
Show SMILES O=C(N1CCCCC1)c1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H19N3O/c23-19(21-11-5-2-6-12-21)15-9-10-18-17(13-15)20-14-22(18)16-7-3-1-4-8-16/h1,3-4,7-10,13-14H,2,5-6,11-12H2
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445515
PNG
(CHEMBL3103039)
Show SMILES Clc1ccc(cc1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C19H18ClN3O/c20-15-5-7-16(8-6-15)23-13-21-17-12-14(4-9-18(17)23)19(24)22-10-2-1-3-11-22/h4-9,12-13H,1-3,10-11H2
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n/an/a 22n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118056
PNG
(US8637558, 84)
Show SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1OCCCC1CCCCC1
Show InChI InChI=1S/C20H25NO4S/c1-24-17-12-15(13-18-19(22)21-20(23)26-18)9-10-16(17)25-11-5-8-14-6-3-2-4-7-14/h9-10,12-14H,2-8,11H2,1H3,(H,21,22,23)
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US Patent
n/an/a 22.1n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118012
PNG
(US8637558, 8)
Show SMILES OCc1cc(C=C2SC(O)=NC2=O)ccc1OCCC1CCCCC1
Show InChI InChI=1S/C19H23NO4S/c21-12-15-10-14(11-17-18(22)20-19(23)25-17)6-7-16(15)24-9-8-13-4-2-1-3-5-13/h6-7,10-11,13,21H,1-5,8-9,12H2,(H,20,22,23)
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US Patent
n/an/a 23n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347957
PNG
(CHEMBL1800144 | US8637558, 33)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C20H24ClNO3S/c21-16-12-15(13-18-19(23)22-20(24)26-18)9-10-17(16)25-11-5-4-8-14-6-2-1-3-7-14/h9-10,12-14H,1-8,11H2,(H,22,23,24)
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n/an/a 24n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347950
PNG
(CHEMBL1800138)
Show SMILES COc1cc(C=C2SC(O)=NC2=O)ccc1OCCC1CCCCC1
Show InChI InChI=1S/C19H23NO4S/c1-23-16-11-14(12-17-18(21)20-19(22)25-17)7-8-15(16)24-10-9-13-5-3-2-4-6-13/h7-8,11-13H,2-6,9-10H2,1H3,(H,20,21,22)
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n/an/a 25n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347957
PNG
(CHEMBL1800144 | US8637558, 33)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C20H24ClNO3S/c21-16-12-15(13-18-19(23)22-20(24)26-18)9-10-17(16)25-11-5-4-8-14-6-2-1-3-7-14/h9-10,12-14H,1-8,11H2,(H,22,23,24)
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US Patent
n/an/a 26.3n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347955
PNG
(CHEMBL1800142 | US8637558, 31)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C17H18ClNO3S/c18-13-8-12(9-15-16(20)19-17(21)23-15)6-7-14(13)22-10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H,19,20,21)
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US Patent
n/an/a 26.9n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445522
PNG
(CHEMBL3102860)
Show SMILES COc1ccccc1-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O2/c1-25-19-8-4-3-7-18(19)23-14-21-16-13-15(9-10-17(16)23)20(24)22-11-5-2-6-12-22/h3-4,7-10,13-14H,2,5-6,11-12H2,1H3
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n/an/a 27n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347955
PNG
(CHEMBL1800142 | US8637558, 31)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C17H18ClNO3S/c18-13-8-12(9-15-16(20)19-17(21)23-15)6-7-14(13)22-10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H,19,20,21)
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n/an/a 28n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118057
PNG
(US8637558, 89)
Show SMILES CC(CC1CCC(C)=CC1)Oc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C20H23NO3S/c1-13-3-5-15(6-4-13)11-14(2)24-17-9-7-16(8-10-17)12-18-19(22)21-20(23)25-18/h3,7-10,12,14-15H,4-6,11H2,1-2H3,(H,21,22,23)
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US Patent
n/an/a 28.4n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50378619
PNG
(CHEMBL590265 | US8637558, 3)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCc2cccs2)cc1
Show InChI InChI=1S/C16H13NO3S2/c18-15-14(22-16(19)17-15)10-11-3-5-12(6-4-11)20-8-7-13-2-1-9-21-13/h1-6,9-10H,7-8H2,(H,17,18,19)
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n/an/a 31n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15PGDH expressed in Escherichia coli BL-21 by fluorescence spectrophotometry


Bioorg Med Chem 18: 1428-33 (2010)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118041
PNG
(US8637558, 65)
Show SMILES CC1CCC(COc2ccc(C=C3SC(O)=NC3=O)cc2C(F)(F)F)CC1
Show InChI InChI=1S/C19H20F3NO3S/c1-11-2-4-12(5-3-11)10-26-15-7-6-13(8-14(15)19(20,21)22)9-16-17(24)23-18(25)27-16/h6-9,11-12H,2-5,10H2,1H3,(H,23,24,25)
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US Patent
n/an/a 31.4n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445561
PNG
(CHEMBL3102995)
Show SMILES Cc1cc(c(C)n1-c1cccc(Cl)c1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C19H21ClN4/c1-13-11-17(14(2)24(13)16-8-6-7-15(20)12-16)19-22-21-18-9-4-3-5-10-23(18)19/h6-8,11-12H,3-5,9-10H2,1-2H3
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n/an/a 34n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445511
PNG
(CHEMBL3103043)
Show SMILES CC(C)(C)n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C17H23N3O/c1-17(2,3)20-12-18-14-11-13(7-8-15(14)20)16(21)19-9-5-4-6-10-19/h7-8,11-12H,4-6,9-10H2,1-3H3
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n/an/a 34n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445555
PNG
(CHEMBL3103000)
Show SMILES Cc1cc(c(C)n1-c1ccc(C)cc1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C20H24N4/c1-14-8-10-17(11-9-14)24-15(2)13-18(16(24)3)20-22-21-19-7-5-4-6-12-23(19)20/h8-11,13H,4-7,12H2,1-3H3
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n/an/a 34n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445560
PNG
(CHEMBL3102996)
Show SMILES Cc1cc(c(C)n1-c1ccc(Cl)cc1)-c1nnc2CCCCCn12
Show InChI InChI=1S/C19H21ClN4/c1-13-12-17(14(2)24(13)16-9-7-15(20)8-10-16)19-22-21-18-6-4-3-5-11-23(18)19/h7-10,12H,3-6,11H2,1-2H3
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n/an/a 38n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50445549
PNG
(CHEMBL3103006)
Show SMILES CCOC(=O)c1ccc(cc1)-n1c(C)cc(c1C)-c1nnc2CCCCCn12
Show InChI InChI=1S/C22H26N4O2/c1-4-28-22(27)17-9-11-18(12-10-17)26-15(2)14-19(16(26)3)21-24-23-20-8-6-5-7-13-25(20)21/h9-12,14H,4-8,13H2,1-3H3
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n/an/a 38n/an/an/an/an/an/a



National Center for Advancing Translational Sciences

Curated by ChEMBL


Assay Description
Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay


Bioorg Med Chem Lett 24: 630-5 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438402
PNG
(CHEMBL2414161 | US8637558, 70)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H16ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,21,22,23)
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n/an/a 38n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438402
PNG
(CHEMBL2414161 | US8637558, 70)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C19H16ClNO3S/c20-15-11-14(12-17-18(22)21-19(23)25-17)8-9-16(15)24-10-4-7-13-5-2-1-3-6-13/h1-3,5-6,8-9,11-12H,4,7,10H2,(H,21,22,23)
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US Patent
n/an/a 38.1n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438426
PNG
(CHEMBL2414244)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCC2CCCC2)cc1Cl
Show InChI InChI=1S/C17H18ClNO3S/c18-14-10-13(22-8-7-11-3-1-2-4-11)6-5-12(14)9-15-16(20)19-17(21)23-15/h5-6,9-11H,1-4,7-8H2,(H,19,20,21)
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Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition of human GST-fused 15-PGDH expressed in Escherichia coli BL21 using PGE2 as substrate assessed as formation of NADH by fluorescence spectr...


Bioorg Med Chem 21: 4477-84 (2013)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50378637
PNG
(CHEMBL84603 | US8637558, 35)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCC2)cc1
Show InChI InChI=1S/C16H17NO3S/c18-15-14(21-16(19)17-15)9-11-5-7-13(8-6-11)20-10-12-3-1-2-4-12/h5-9,12H,1-4,10H2,(H,17,18,19)
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US Patent
n/an/a 42.5n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM118047
PNG
(US8637558, 75)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(OCCCc2ccccc2)c1Cl
Show InChI InChI=1S/C19H16ClNO3S/c20-17-14(12-16-18(22)21-19(23)25-16)9-4-10-15(17)24-11-5-8-13-6-2-1-3-7-13/h1-4,6-7,9-10,12H,5,8,11H2,(H,21,22,23)
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US Patent
n/an/a 44.9n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50378637
PNG
(CHEMBL84603 | US8637558, 35)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCC2CCCC2)cc1
Show InChI InChI=1S/C16H17NO3S/c18-15-14(21-16(19)17-15)9-11-5-7-13(8-6-11)20-10-12-3-1-2-4-12/h5-9,12H,1-4,10H2,(H,17,18,19)
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n/an/a 45n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15PGDH expressed in Escherichia coli BL-21 by fluorescence spectrophotometry


Bioorg Med Chem 18: 1428-33 (2010)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50347954
PNG
(CHEMBL1800141 | US8637558, 30)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OC2CCCCC2)c(Cl)c1
Show InChI InChI=1S/C16H16ClNO3S/c17-12-8-10(9-14-15(19)18-16(20)22-14)6-7-13(12)21-11-4-2-1-3-5-11/h6-9,11H,1-5H2,(H,18,19,20)
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n/an/a 47n/an/an/an/an/an/a



Chosun University

Curated by ChEMBL


Assay Description
Inhibition of human 15-PGDH expressed in Escherichia coli using PGE2 as substrate and NAD+ as coenzyme assessed as formation of NADH by spectrophotom...


J Med Chem 54: 5260-4 (2011)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438404
PNG
(CHEMBL2414159 | US8637558, 68)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C17H12ClNO3S/c18-13-8-12(9-15-16(20)19-17(21)23-15)6-7-14(13)22-10-11-4-2-1-3-5-11/h1-9H,10H2,(H,19,20,21)
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US Patent
n/an/a 47.5n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM50438401
PNG
(CHEMBL2414162 | US8637558, 71)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(OCCCCc2ccccc2)c(Cl)c1
Show InChI InChI=1S/C20H18ClNO3S/c21-16-12-15(13-18-19(23)22-20(24)26-18)9-10-17(16)25-11-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,9-10,12-13H,4-5,8,11H2,(H,22,23,24)
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US Patent
n/an/a 47.5n/an/an/an/an/an/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)

More data for this
Ligand-Target Pair
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