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Compile Data Set for Download or QSAR

Found 806 hits Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 (51-359)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM?mit=repeat
Kd
nM
EC50/IC50
nM?mit=repeat
koff
s-1
kon
M-1s-1
pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282440
PNG
(3-(4-(4-amino-7H- pyrrolo[2,3-d] pyrimidin-5-yl) b...)
Show SMILES Nc1ncnc2[nH]cc(-c3ccc(CNc4ncc(nc4C(=O)Nc4ccc(F)cc4)C#N)cc3)c12
Show InChI InChI=1S/C25H18FN9O/c26-16-5-7-17(8-6-16)35-25(36)21-24(30-11-18(9-27)34-21)29-10-14-1-3-15(4-2-14)19-12-31-23-20(19)22(28)32-13-33-23/h1-8,11-13H,10H2,(H,29,30)(H,35,36)(H3,28,31,32,33)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282441
PNG
(2-(4-(4-amino-7H-pyrrolo [2,3-d]pyrimidin-5-yl) be...)
Show SMILES Nc1ncnc2[nH]cc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C26H19F4N7O/c27-17-5-7-18(8-6-17)37-25(38)19-9-16(26(28,29)30)11-33-23(19)32-10-14-1-3-15(4-2-14)20-12-34-24-21(20)22(31)35-13-36-24/h1-9,11-13H,10H2,(H,32,33)(H,37,38)(H3,31,34,35,36)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282442
PNG
(2-(4-(4-amino-7-(3- hydroxypropyl)-7H-pyrrolo [2,3...)
Show SMILES Nc1ncnc2n(CCCO)cc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C29H25F4N7O2/c30-20-6-8-21(9-7-20)39-28(42)22-12-19(29(31,32)33)14-36-26(22)35-13-17-2-4-18(5-3-17)23-15-40(10-1-11-41)27-24(23)25(34)37-16-38-27/h2-9,12,14-16,41H,1,10-11,13H2,(H,35,36)(H,39,42)(H2,34,37,38)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282443
PNG
(2-(4-(4-amino-7-methyl- 7H-pyrrolo[2,3-d] pyrimidi...)
Show SMILES Nc1ncnc2n(F)cc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C26H18F5N7O/c27-17-5-7-18(8-6-17)37-25(39)19-9-16(26(28,29)30)11-34-23(19)33-10-14-1-3-15(4-2-14)20-12-38(31)24-21(20)22(32)35-13-36-24/h1-9,11-13H,10H2,(H,33,34)(H,37,39)(H2,32,35,36)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282444
PNG
(2-(4-(4-amino-7-(2- hydroxyethyl)-7H-pyrrolo [2,3-...)
Show SMILES Nc1ncnc2n(CCO)cc(-c3ccc(CNc4ncc(cc4C(=O)Nc4ccc(F)cc4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C28H23F4N7O2/c29-19-5-7-20(8-6-19)38-27(41)21-11-18(28(30,31)32)13-35-25(21)34-12-16-1-3-17(4-2-16)22-14-39(9-10-40)26-23(22)24(33)36-15-37-26/h1-8,11,13-15,40H,9-10,12H2,(H,34,35)(H,38,41)(H2,33,36,37)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282447
PNG
(2-((6-(1H-pyrazolo[3,4-b] pyridin-5-yl)pyridin-3-y...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(nc2)-c2cnc3[nH]ncc3c2)cc1F
Show InChI InChI=1S/C25H19F2N7O/c26-20-5-3-15(8-21(20)27)10-32-25(35)19-2-1-7-28-24(19)30-12-16-4-6-22(29-11-16)17-9-18-14-33-34-23(18)31-13-17/h1-9,11,13-14H,10,12H2,(H,28,30)(H,32,35)(H,31,33,34)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282448
PNG
(2-((6-(1H-pyrrolo[2,3-b] pyridin-5-yl)pyridin-3-yl...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(nc2)-c2cnc3[nH]ccc3c2)cc1F
Show InChI InChI=1S/C26H20F2N6O/c27-21-5-3-16(10-22(21)28)12-34-26(35)20-2-1-8-29-25(20)32-14-17-4-6-23(31-13-17)19-11-18-7-9-30-24(18)33-15-19/h1-11,13,15H,12,14H2,(H,29,32)(H,30,33)(H,34,35)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282449
PNG
(2-[4-(4-Amino-1H-pyrazolo [3,4-d]pyrimidin-3-yl)- ...)
Show SMILES Nc1cccc2[nH]nc(-c3ccc(CNc4ncc(cc4C(=O)NCc4ccc(F)c(F)c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C28H21F5N6O/c29-20-9-6-16(10-21(20)30)13-37-27(40)19-11-18(28(31,32)33)14-36-26(19)35-12-15-4-7-17(8-5-15)25-24-22(34)2-1-3-23(24)38-39-25/h1-11,14H,12-13,34H2,(H,35,36)(H,37,40)(H,38,39)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282450
PNG
(2-[4-(4-Amino-7H-pyrrolo [2,3-d]pyrimidin-5-yl)- b...)
Show SMILES Nc1cccc2[nH]cc(-c3ccc(CNc4ncc(cc4C(=O)NCc4ccc(F)c(F)c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C29H22F5N5O/c30-22-9-6-17(10-23(22)31)13-39-28(40)20-11-19(29(32,33)34)14-38-27(20)37-12-16-4-7-18(8-5-16)21-15-36-25-3-1-2-24(35)26(21)25/h1-11,14-15,36H,12-13,35H2,(H,37,38)(H,39,40)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282451
PNG
(2-(4-(4-amino-7-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Show SMILES Cn1cc(-c2ccc(CNc3ncc(cc3C(=O)NCc3ccc(F)c(F)c3)C(F)(F)F)cc2)c2c(N)cccc12
Show InChI InChI=1S/C30H24F5N5O/c1-40-16-22(27-25(36)3-2-4-26(27)40)19-8-5-17(6-9-19)13-37-28-21(12-20(15-38-28)30(33,34)35)29(41)39-14-18-7-10-23(31)24(32)11-18/h2-12,15-16H,13-14,36H2,1H3,(H,37,38)(H,39,41)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282452
PNG
(2-(4-(4-amino-1-methyl-1H- pyrazolo[3,4-d]pyrimidi...)
Show SMILES Cn1nc(-c2ccc(CNc3ncc(cc3C(=O)NCc3ccc(F)c(F)c3)C(F)(F)F)cc2)c2c(N)cccc12
Show InChI InChI=1S/C29H23F5N6O/c1-40-24-4-2-3-23(35)25(24)26(39-40)18-8-5-16(6-9-18)13-36-27-20(12-19(15-37-27)29(32,33)34)28(41)38-14-17-7-10-21(30)22(31)11-17/h2-12,15H,13-14,35H2,1H3,(H,36,37)(H,38,41)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282453
PNG
(2-(4-(4-amino-7-(2- hydroxyethyl)-7H- pyrrolo[2,3-...)
Show SMILES Nc1cccc2n(CCO)cc(-c3ccc(CNc4ncc(cc4C(=O)NCc4ccc(F)c(F)c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C31H26F5N5O2/c32-24-9-6-19(12-25(24)33)15-40-30(43)22-13-21(31(34,35)36)16-39-29(22)38-14-18-4-7-20(8-5-18)23-17-41(10-11-42)27-3-1-2-26(37)28(23)27/h1-9,12-13,16-17,42H,10-11,14-15,37H2,(H,38,39)(H,40,43)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282454
PNG
(2-(4-(4-amino-7-(3- hydroxypropyl)-7H- pyrrolo[2,3...)
Show SMILES Nc1cccc2n(CCCO)cc(-c3ccc(CNc4ncc(cc4C(=O)NCc4ccc(F)c(F)c4)C(F)(F)F)cc3)c12
Show InChI InChI=1S/C32H28F5N5O2/c33-25-10-7-20(13-26(25)34)16-41-31(44)23-14-22(32(35,36)37)17-40-30(23)39-15-19-5-8-21(9-6-19)24-18-42(11-2-12-43)28-4-1-3-27(38)29(24)28/h1,3-10,13-14,17-18,43H,2,11-12,15-16,38H2,(H,39,40)(H,41,44)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282455
PNG
(2-(3-(5-(1H-pyrrol-2-yl)-1H- pyrrolo[2,3-b]pyridin...)
Show SMILES CC(C)Oc1cc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2)cc(c1)-c1c[nH]c2ncc(cc12)-c1ccc[nH]1
Show InChI InChI=1S/C34H28F2N6O2/c1-20(2)44-25-12-22(11-23(14-25)28-19-41-33-27(28)15-24(18-40-33)31-6-4-9-37-31)17-39-32-26(5-3-10-38-32)34(43)42-16-21-7-8-29(35)30(36)13-21/h3-15,18-20H,16-17H2,1-2H3,(H,38,39)(H,42,43)/b31-24-
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282456
PNG
(2-((4-(5-(1H-pyrrol-2-yl)-1H- pyrrolo[2,3-b]pyridi...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2cc(ccn2)-c2c[nH]c3ncc(cc23)-c2ccc[nH]2)cc1F
Show InChI InChI=1S/C30H21F2N7O/c31-25-6-5-18(11-26(25)32)14-39-30(40)22-3-1-9-35-28(22)37-16-21-12-19(7-10-33-21)24-17-38-29-23(24)13-20(15-36-29)27-4-2-8-34-27/h1-13,15,17H,14,16H2,(H,35,37)(H,39,40)/b27-20-
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282457
PNG
(2-(4-(4-amino-7-methyl- 7H-pyrrolo[2,3-d] pyrimidi...)
Show SMILES Cn1c(cc2c(N)ncnc12)-c1ccc(CNc2ncc(cc2C(=O)Nc2ccc(F)cc2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H21F4N7O/c1-38-22(11-20-23(32)35-14-36-25(20)38)16-4-2-15(3-5-16)12-33-24-21(10-17(13-34-24)27(29,30)31)26(39)37-19-8-6-18(28)7-9-19/h2-11,13-14H,12H2,1H3,(H,33,34)(H,37,39)(H2,32,35,36)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282458
PNG
(2-(4-(4-amino-7-methyl- 7H-pyrrolo[2,3-d] pyrimidi...)
Show SMILES Cn1cc(-c2ccc(CNc3ncc(cc3C(=O)Nc3ccc(F)cn3)C(F)(F)F)cc2)c2c(N)ncnc12
Show InChI InChI=1S/C26H20F4N8O/c1-38-12-19(21-22(31)35-13-36-24(21)38)15-4-2-14(3-5-15)9-33-23-18(8-16(10-34-23)26(28,29)30)25(39)37-20-7-6-17(27)11-32-20/h2-8,10-13H,9H2,1H3,(H,33,34)(H2,31,35,36)(H,32,37,39)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282463
PNG
(2-((5-(4-aminoquinazolin- 6-yl)thiophen-2-yl) meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncc(cc2C(=O)NCc2ccc(F)c(F)c2)S(=O)(=O)NCCO)s1
Show InChI InChI=1S/C28H25F2N7O4S2/c29-22-4-1-16(9-23(22)30)12-34-28(39)21-11-19(43(40,41)37-7-8-38)14-33-27(21)32-13-18-3-6-25(42-18)17-2-5-24-20(10-17)26(31)36-15-35-24/h1-6,9-11,14-15,37-38H,7-8,12-13H2,(H,32,33)(H,34,39)(H2,31,35,36)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281792
PNG
(2-({[5-(4-aminopyrido[3,4-d] pyrimidin-6-yl)thioph...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(N)c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22F2N6OS/c1-15(16-4-7-21(28)22(29)12-16)35-27(36)19-3-2-10-31-26(19)32-13-18-6-9-24(37-18)17-5-8-23-20(11-17)25(30)34-14-33-23/h2-12,14-15H,13H2,1H3,(H,31,32)(H,35,36)(H2,30,33,34)/t15-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281793
PNG
((S)-N-(1-(4-fluorophenyl)ethyl)- 2-(((5-(4-(2-hydr...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(NCCO)c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C29H27FN6O2S/c1-18(19-4-7-21(30)8-5-19)36-29(38)23-3-2-12-31-27(23)33-16-22-9-11-26(39-22)20-6-10-25-24(15-20)28(32-13-14-37)35-17-34-25/h2-12,15,17-18,37H,13-14,16H2,1H3,(H,31,33)(H,36,38)(H,32,34,35)/t18-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281802
PNG
(N-(1-(3,4-difluorophenyl)ethyl)- 2-(((5-(1-methyl-...)
Show SMILES Cn1cnc2cnc3ccc(cc3c12)-c1ccc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2)s1
Show InChI InChI=1S/C29H22F2N6OS/c1-37-16-36-25-15-33-24-8-5-18(12-21(24)27(25)37)26-9-6-19(39-26)14-34-28-20(3-2-10-32-28)29(38)35-13-17-4-7-22(30)23(31)11-17/h2-12,15-16H,13-14H2,1H3,(H,32,34)(H,35,38)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281803
PNG
((S)-N-(1-(3,4-difluorophenyl)ethyl)- 2-(((5-(1-met...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncc3ncn(C)c3c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C30H24F2N6OS/c1-17(18-5-8-23(31)24(32)13-18)37-30(39)21-4-3-11-33-29(21)35-14-20-7-10-27(40-20)19-6-9-25-22(12-19)28-26(15-34-25)36-16-38(28)2/h3-13,15-17H,14H2,1-2H3,(H,33,35)(H,37,39)/t17-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281804
PNG
(N-(3,4-difluorobenzyl)-2-(((5-(1- methyl-1H-imidaz...)
Show SMILES Cn1cnc2cnc3ccc(cc3c12)-c1ccc(CNc2ncc(cc2C(=O)NCc2ccc(F)c(F)c2)C(F)(F)F)s1
Show InChI InChI=1S/C30H21F5N6OS/c1-41-15-40-25-14-36-24-6-3-17(9-20(24)27(25)41)26-7-4-19(43-26)13-38-28-21(10-18(12-37-28)30(33,34)35)29(42)39-11-16-2-5-22(31)23(32)8-16/h2-10,12,14-15H,11,13H2,1H3,(H,37,38)(H,39,42)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281805
PNG
((S)-5-trifluoromethyl-N-(1-(3,4- difluorophenyl)et...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(s1)-c1ccc2ncc3ncn(C)c3c2c1)C(F)(F)F)c1ccc(F)c(F)c1
Show InChI InChI=1S/C31H23F5N6OS/c1-16(17-3-6-23(32)24(33)10-17)41-30(43)22-11-19(31(34,35)36)12-38-29(22)39-13-20-5-8-27(44-20)18-4-7-25-21(9-18)28-26(14-37-25)40-15-42(28)2/h3-12,14-16H,13H2,1-2H3,(H,38,39)(H,41,43)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281806
PNG
((S)-5-cyano-N-(1-(4-fluorophenyl) ethyl)-2-(((5-(1...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(s1)-c1ccc2ncc3ncn(C)c3c2c1)C#N)c1ccc(F)cc1
Show InChI InChI=1S/C31H24FN7OS/c1-18(20-3-6-22(32)7-4-20)38-31(40)25-11-19(13-33)14-35-30(25)36-15-23-8-10-28(41-23)21-5-9-26-24(12-21)29-27(16-34-26)37-17-39(29)2/h3-12,14,16-18H,15H2,1-2H3,(H,35,36)(H,38,40)/t18-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281807
PNG
((S)-2-(3-(4-amino-7H-pyrrolo[2,3- d]pyrimidin-5-yl...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1cccc(c1)-c1c[nH]c2nccc(N)c12)c1ccc(F)cc1
Show InChI InChI=1S/C28H25FN6O/c1-17(19-7-9-21(29)10-8-19)35-28(36)22-6-3-12-31-26(22)33-15-18-4-2-5-20(14-18)23-16-34-27-25(23)24(30)11-13-32-27/h2-14,16-17H,15H2,1H3,(H,31,33)(H,35,36)(H3,30,32,34)/t17-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281808
PNG
((S)-2-(3-(4-amino-7H-pyrrolo[2,3- d]pyrimidin-5-yl...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1cccc(c1)-c1c[nH]c2ncnc(N)c12)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H23F2N7O/c1-15(17-7-8-21(28)22(29)11-17)36-27(37)19-6-3-9-31-25(19)32-12-16-4-2-5-18(10-16)20-13-33-26-23(20)24(30)34-14-35-26/h2-11,13-15H,12H2,1H3,(H,31,32)(H,36,37)(H3,30,33,34,35)/t15-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281810
PNG
(2-(((5-(1H-pyrazolo[3,4-b]pyridin- 5-yl)thiophen-2...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(s2)-c2cnc3[nH]ncc3c2)cc1F
Show InChI InChI=1S/C24H18F2N6OS/c25-19-5-3-14(8-20(19)26)10-30-24(33)18-2-1-7-27-23(18)29-13-17-4-6-21(34-17)15-9-16-12-31-32-22(16)28-11-15/h1-9,11-12H,10,13H2,(H,27,29)(H,30,33)(H,28,31,32)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281813
PNG
(2-(4-(1H-pyrazolo[3,4-b]pyridin- 5-yl)benzylamino)...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(cc2)-c2cnc3[nH]ncc3c2)cc1F
Show InChI InChI=1S/C26H20F2N6O/c27-22-8-5-17(10-23(22)28)13-32-26(35)21-2-1-9-29-25(21)30-12-16-3-6-18(7-4-16)19-11-20-15-33-34-24(20)31-14-19/h1-11,14-15H,12-13H2,(H,29,30)(H,32,35)(H,31,33,34)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281814
PNG
(5-Cyano-N-[(S)-1-(4-fluoro- phenyl)-ethyl]-2-[4-(1...)
Show SMILES Fc1ccc(CNC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]ncc3c2)C#N)cc1
Show InChI InChI=1S/C27H20FN7O/c28-23-7-3-18(4-8-23)13-33-27(36)24-9-19(11-29)14-31-26(24)30-12-17-1-5-20(6-2-17)21-10-22-16-34-35-25(22)32-15-21/h1-10,14-16H,12-13H2,(H,30,31)(H,33,36)(H,32,34,35)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281815
PNG
(N-(3,4-Difluoro-benzyl)-2-[4- (1H-pyrazolo[3,4-b[p...)
Show SMILES Fc1ccc(CNC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]ncc3c2)C(F)(F)F)cc1F
Show InChI InChI=1S/C27H19F5N6O/c28-22-6-3-16(7-23(22)29)11-36-26(39)21-9-20(27(30,31)32)14-35-25(21)33-10-15-1-4-17(5-2-15)18-8-19-13-37-38-24(19)34-12-18/h1-9,12-14H,10-11H2,(H,33,35)(H,36,39)(H,34,37,38)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281816
PNG
(2-[4-(4-Amino-7-methyl-7H- pyrrolo[2,3-d]pyrimidin...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(cc1)-c1cn(C)c2ncnc(N)c12)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H25F2N7O/c1-16(19-9-10-22(29)23(30)12-19)36-28(38)20-4-3-11-32-26(20)33-13-17-5-7-18(8-6-17)21-14-37(2)27-24(21)25(31)34-15-35-27/h3-12,14-16H,13H2,1-2H3,(H,32,33)(H,36,38)(H2,31,34,35)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281817
PNG
(N-[(S)-1-(3,4-Difluoro-phenyl)- ethyl]-2-[4-(1H-py...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(cc1)-c1cnc2[nH]ncc2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C27H22F2N6O/c1-16(19-8-9-23(28)24(29)12-19)34-27(36)22-3-2-10-30-26(22)31-13-17-4-6-18(7-5-17)20-11-21-15-33-35-25(21)32-14-20/h2-12,14-16H,13H2,1H3,(H,30,31)(H,34,36)(H,32,33,35)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281819
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)NCc2ccc(F)cc2)s1
Show InChI InChI=1S/C26H21FN6OS/c27-18-6-3-16(4-7-18)13-31-26(34)20-2-1-11-29-25(20)30-14-19-8-10-23(35-19)17-5-9-22-21(12-17)24(28)33-15-32-22/h1-12,15H,13-14H2,(H,29,30)(H,31,34)(H2,28,32,33)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281820
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)NCc2ccc(F)cc2F)s1
Show InChI InChI=1S/C26H20F2N6OS/c27-17-5-3-16(21(28)11-17)12-32-26(35)19-2-1-9-30-25(19)31-13-18-6-8-23(36-18)15-4-7-22-20(10-15)24(29)34-14-33-22/h1-11,14H,12-13H2,(H,30,31)(H,32,35)(H2,29,33,34)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281821
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)NCc2cccc(F)c2)s1
Show InChI InChI=1S/C26H21FN6OS/c27-18-4-1-3-16(11-18)13-31-26(34)20-5-2-10-29-25(20)30-14-19-7-9-23(35-19)17-6-8-22-21(12-17)24(28)33-15-32-22/h1-12,15H,13-14H2,(H,29,30)(H,31,34)(H2,28,32,33)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281823
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)NCc2cc(F)c(F)cc2F)s1
Show InChI InChI=1S/C26H19F3N6OS/c27-19-10-21(29)20(28)9-15(19)11-33-26(36)17-2-1-7-31-25(17)32-12-16-4-6-23(37-16)14-3-5-22-18(8-14)24(30)35-13-34-22/h1-10,13H,11-12H2,(H,31,32)(H,33,36)(H2,30,34,35)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281828
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)NCc2ccc(F)c(F)c2F)s1
Show InChI InChI=1S/C26H19F3N6OS/c27-19-6-3-15(22(28)23(19)29)11-33-26(36)17-2-1-9-31-25(17)32-12-16-5-8-21(37-16)14-4-7-20-18(10-14)24(30)35-13-34-20/h1-10,13H,11-12H2,(H,31,32)(H,33,36)(H2,30,34,35)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281833
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(s1)-c1ccc2ncnc(N)c2c1)c1cccc(F)c1
Show InChI InChI=1S/C27H23FN6OS/c1-16(17-4-2-5-19(28)12-17)34-27(35)21-6-3-11-30-26(21)31-14-20-8-10-24(36-20)18-7-9-23-22(13-18)25(29)33-15-32-23/h2-13,15-16H,14H2,1H3,(H,30,31)(H,34,35)(H2,29,32,33)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM281835
PNG
(2-({[5-(4-aminoquinazolin-6- yl)thiophen-2-yl]meth...)
Show SMILES Nc1ncnc2ccc(cc12)-c1ccc(CNc2ncccc2C(=O)NCc2cc(F)c(F)c(F)c2)s1
Show InChI InChI=1S/C26H19F3N6OS/c27-19-8-14(9-20(28)23(19)29)11-33-26(36)17-2-1-7-31-25(17)32-12-16-4-6-22(37-16)15-3-5-21-18(10-15)24(30)35-13-34-21/h1-10,13H,11-12H2,(H,31,32)(H,33,36)(H2,30,34,35)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282467
PNG
(3-amino-6-(4-((5-cyano- 3-((S)-1-(4-fluorophenyl) ...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(cc1)-c1cnc(N)c(n1)C(=O)NCC(O)CO)c1ccc(F)cc1
Show InChI InChI=1S/C29H30FN7O4/c1-17(19-8-10-21(30)11-9-19)36-28(40)23-3-2-12-32-27(23)34-13-18-4-6-20(7-5-18)24-15-33-26(31)25(37-24)29(41)35-14-22(39)16-38/h2-12,15,17,22,38-39H,13-14,16H2,1H3,(H2,31,33)(H,32,34)(H,35,41)(H,36,40)/t17-,22?/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282472
PNG
(6-(4-(4-amino-7H-pyrrolo [2,3-d]pyrimidin-5-yl) be...)
Show SMILES Nc1ncnc2[nH]cc(-c3ccc(CNc4ncc(cc4-c4nccs4)C#N)cc3)c12
Show InChI InChI=1S/C22H16N8S/c23-8-14-7-16(22-25-5-6-31-22)20(27-10-14)26-9-13-1-3-15(4-2-13)17-11-28-21-18(17)19(24)29-12-30-21/h1-7,10-12H,9H2,(H,26,27)(H3,24,28,29,30)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282473
PNG
(3-((S)-1-(4-(3-amino-1H- pyrazolo[3,4-b]pyridin- 5...)
Show SMILES C[C@H](NC(=O)c1nc(cnc1N[C@H](CO)c1ccc(cc1)-c1cnc2[nH]nc(N)c2c1)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H23F2N9O2/c1-14(17-6-7-21(29)22(30)9-17)35-28(41)24-27(34-12-19(10-31)36-24)37-23(13-40)16-4-2-15(3-5-16)18-8-20-25(32)38-39-26(20)33-11-18/h2-9,11-12,14,23,40H,13H2,1H3,(H,34,37)(H,35,41)(H3,32,33,38,39)/t14-,23+/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282474
PNG
(N-((5-fluoropyridin-3-yl) methyl)-2-((5-(1-methyl-...)
Show SMILES Cn1cnc2cnc3ccc(cc3c12)-c1ccc(CNc2ncccc2C(=O)NCc2cncc(F)c2)s1
Show InChI InChI=1S/C28H22FN7OS/c1-36-16-35-24-15-32-23-6-4-18(10-22(23)26(24)36)25-7-5-20(38-25)14-33-27-21(3-2-8-31-27)28(37)34-12-17-9-19(29)13-30-11-17/h2-11,13,15-16H,12,14H2,1H3,(H,31,33)(H,34,37)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282475
PNG
(2-(4-(6-amino-5-methylpyridin-3-yl)benzylamino)-N-...)
Show SMILES Cc1cc(cnc1N)-c1ccc(CNc2ncc(cc2C(=O)NCc2ccc(F)c(F)c2)C(F)(F)F)cc1
Show InChI InChI=1S/C27H22F5N5O/c1-15-8-19(13-34-24(15)33)18-5-2-16(3-6-18)11-35-25-21(10-20(14-36-25)27(30,31)32)26(38)37-12-17-4-7-22(28)23(29)9-17/h2-10,13-14H,11-12H2,1H3,(H2,33,34)(H,35,36)(H,37,38)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282476
PNG
(5-cyano-N-(3,4-difluorobenzyl)-2-(4-(2-oxo-2,3-dih...)
Show SMILES C[C@H](NC(=O)c1cc(cnc1NCc1ccc(cc1)-c1cnc2[nH]c(=O)[nH]c2c1)C#N)c1ccc(F)c(F)c1
Show InChI InChI=1S/C28H19F2N7O2/c1-15(19-6-7-22(29)23(30)9-19)35-27(38)21-8-17(11-31)13-33-25(21)32-12-16-2-4-18(5-3-16)20-10-24-26(34-14-20)37-28(39)36-24/h2-10,13-15H,12H2,1H3,(H,32,33)(H,35,38)/t15-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282477
PNG
((S)-N-(1-(4-fluorophenyl) ethyl)-3-(4-(2-oxo-2,3- ...)
Show SMILES C[C@H](NC(=O)c1nccnc1NCc1ccc(cc1)-c1cnc2[nH]c(=O)[nH]c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H20FN7O2/c1-15(17-6-8-20(27)9-7-17)32-25(35)22-24(29-11-10-28-22)30-13-16-2-4-18(5-3-16)19-12-21-23(31-14-19)34-26(36)33-21/h2-12,14-15H,13H2,1H3,(H,29,30)(H,32,35)/t15-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282478
PNG
(5-cyano-N-(4-fluorobenzyl)- 2-(4-(2-oxo-2,3-dihydr...)
Show SMILES Fc1ccc(CNC(=O)c2cc(cnc2NCc2ccc(cc2)-c2cnc3[nH]c(=O)[nH]c3c2)C#N)cc1
Show InChI InChI=1S/C27H18FN7O2/c28-21-7-3-17(4-8-21)13-33-26(36)22-9-18(11-29)14-31-24(22)30-12-16-1-5-19(6-2-16)20-10-23-25(32-15-20)35-27(37)34-23/h1-10,14-15H,12-13H2,(H,30,31)(H,33,36)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282479
PNG
((S)-N-(1-(4-fluorophenyl) ethyl)-2-(4-(2-oxo-2,3- ...)
Show SMILES C[C@H](NC(=O)c1cccnc1NCc1ccc(cc1)-c1cnc2[nH]c(=O)[nH]c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C27H21FN6O2/c1-16(18-8-10-21(28)11-9-18)32-26(35)22-3-2-12-29-24(22)30-14-17-4-6-19(7-5-17)20-13-23-25(31-15-20)34-27(36)33-23/h2-13,15-16H,14H2,1H3,(H,29,30)(H,32,35)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
3-phosphoinositide-dependent protein kinase 1 (51-359)


(Homo sapiens (Human))
BDBM282480
PNG
(N-(4-fluorobenzyl)-2-(4-(2- oxo-2,3-dihydro-1H-imi...)
Show SMILES Fc1ccc(CNC(=O)c2cccnc2NCc2ccc(cc2)-c2cnc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C26H19FN6O2/c27-20-9-5-17(6-10-20)14-31-25(34)21-2-1-11-28-23(21)29-13-16-3-7-18(8-4-16)19-12-22-24(30-15-19)33-26(35)32-22/h1-12,15H,13-14H2,(H,28,29)(H,31,34)
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Sunesis Pharmaceuticals, Inc.; Millenium Pharmaceuticals, Inc.

US Patent


Assay Description
PDK1 (amino acids 51-359) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) were expressed as N-terminally tagged GST fusi...


US Patent US10030016 (2018)

More data for this
Ligand-Target Pair
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