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Found 79 hits Enz. Inhib. hit(s) with Target = '4-hydroxyphenylpyruvate dioxygenase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024721
PNG
(CHEMBL3342603)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1cccc(Cl)c1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15ClN4O3/c1-11-23-17-7-6-12(18(26)16-10-22-24(2)19(16)27)8-15(17)20(28)25(11)14-5-3-4-13(21)9-14/h3-10,27H,1-2H3
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10n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024752
PNG
(CHEMBL3343183)
Show SMILES Cc1ccc(c(Br)c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H17BrN4O3/c1-11-4-7-18(16(22)8-11)26-12(2)24-17-6-5-13(9-14(17)21(26)29)19(27)15-10-23-25(3)20(15)28/h4-10,28H,1-3H3
PDB

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11n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024719
PNG
(CHEMBL3342605)
Show SMILES Cc1cccc(c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H18N4O3/c1-12-5-4-6-15(9-12)25-13(2)23-18-8-7-14(10-16(18)21(25)28)19(26)17-11-22-24(3)20(17)27/h4-11,27H,1-3H3
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13n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024720
PNG
(CHEMBL3342604)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1cccc(Br)c1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15BrN4O3/c1-11-23-17-7-6-12(18(26)16-10-22-24(2)19(16)27)8-15(17)20(28)25(11)14-5-3-4-13(21)9-14/h3-10,27H,1-2H3
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14n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024727
PNG
(CHEMBL3342432)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccccc1F)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15FN4O3/c1-11-23-16-8-7-12(18(26)14-10-22-24(2)19(14)27)9-13(16)20(28)25(11)17-6-4-3-5-15(17)21/h3-10,27H,1-2H3
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15n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024758
PNG
(CHEMBL3342610)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(Br)cc1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15BrN4O3/c1-11-23-17-8-3-12(18(26)16-10-22-24(2)19(16)27)9-15(17)20(28)25(11)14-6-4-13(21)5-7-14/h3-10,27H,1-2H3
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18n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024728
PNG
(CHEMBL3342431)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccccc1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H16N4O3/c1-12-22-17-9-8-13(18(25)16-11-21-23(2)19(16)26)10-15(17)20(27)24(12)14-6-4-3-5-7-14/h3-11,26H,1-2H3
PDB

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19n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024722
PNG
(CHEMBL3342602)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1cccc(F)c1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15FN4O3/c1-11-23-17-7-6-12(18(26)16-10-22-24(2)19(16)27)8-15(17)20(28)25(11)14-5-3-4-13(21)9-14/h3-10,27H,1-2H3
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20n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024759
PNG
(CHEMBL3342609)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(Cl)cc1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15ClN4O3/c1-11-23-17-8-3-12(18(26)16-10-22-24(2)19(16)27)9-15(17)20(28)25(11)14-6-4-13(21)5-7-14/h3-10,27H,1-2H3
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22n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024726
PNG
(CHEMBL3342598)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccccc1Cl)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15ClN4O3/c1-11-23-16-8-7-12(18(26)14-10-22-24(2)19(14)27)9-13(16)20(28)25(11)17-6-4-3-5-15(17)21/h3-10,27H,1-2H3
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22n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024725
PNG
(CHEMBL3342599)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccccc1Br)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15BrN4O3/c1-11-23-16-8-7-12(18(26)14-10-22-24(2)19(14)27)9-13(16)20(28)25(11)17-6-4-3-5-15(17)21/h3-10,27H,1-2H3
PDB

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24n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024757
PNG
(CHEMBL3342611)
Show SMILES Cc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H18N4O3/c1-12-4-7-15(8-5-12)25-13(2)23-18-9-6-14(10-16(18)21(25)28)19(26)17-11-22-24(3)20(17)27/h4-11,27H,1-3H3
PDB

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25n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024751
PNG
(CHEMBL3343184)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(Cl)c(Cl)c1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H14Cl2N4O3/c1-10-24-17-6-3-11(18(27)14-9-23-25(2)19(14)28)7-13(17)20(29)26(10)12-4-5-15(21)16(22)8-12/h3-9,28H,1-2H3
PDB

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25n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024716
PNG
(CHEMBL3342607)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1cccc(OC(F)(F)F)c1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H15F3N4O4/c1-11-26-17-7-6-12(18(29)16-10-25-27(2)19(16)30)8-15(17)20(31)28(11)13-4-3-5-14(9-13)32-21(22,23)24/h3-10,30H,1-2H3
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31n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024754
PNG
(CHEMBL3342614)
Show SMILES Cc1cc(Cl)ccc1-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H17ClN4O3/c1-11-8-14(22)5-7-18(11)26-12(2)24-17-6-4-13(9-15(17)21(26)29)19(27)16-10-23-25(3)20(16)28/h4-10,28H,1-3H3
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32n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024760
PNG
(CHEMBL3342608)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(F)cc1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C20H15FN4O3/c1-11-23-17-8-3-12(18(26)16-10-22-24(2)19(16)27)9-15(17)20(28)25(11)14-6-4-13(21)5-7-14/h3-10,27H,1-2H3
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34n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024718
PNG
(CHEMBL3342606)
Show SMILES COc1cccc(c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H18N4O4/c1-12-23-18-8-7-13(19(26)17-11-22-24(2)20(17)27)9-16(18)21(28)25(12)14-5-4-6-15(10-14)29-3/h4-11,27H,1-3H3
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34n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50088804
PNG
(1,3-Cyclohexanedione, 2-(2-nitro-4-(trifluoromethy...)
Show SMILES [O-][N+](=O)c1cc(ccc1C(=O)C1C(=O)CCCC1=O)C(F)(F)F
Show InChI InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
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37n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024723
PNG
(CHEMBL3342601)
Show SMILES COc1ccccc1-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H18N4O4/c1-12-23-16-9-8-13(19(26)15-11-22-24(2)20(15)27)10-14(16)21(28)25(12)17-6-4-5-7-18(17)29-3/h4-11,27H,1-3H3
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38n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024753
PNG
(CHEMBL3343182)
Show SMILES Cc1cc(F)ccc1-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H17FN4O3/c1-11-8-14(22)5-7-18(11)26-12(2)24-17-6-4-13(9-15(17)21(26)29)19(27)16-10-23-25(3)20(16)28/h4-10,28H,1-3H3
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40n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024724
PNG
(CHEMBL3342600)
Show SMILES Cc1ccccc1-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H18N4O3/c1-12-6-4-5-7-18(12)25-13(2)23-17-9-8-14(10-15(17)21(25)28)19(26)16-11-22-24(3)20(16)27/h4-11,27H,1-3H3
PDB

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58n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024748
PNG
(CHEMBL3343187)
Show SMILES Cc1ccc(c(C)c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C22H20N4O3/c1-12-5-8-19(13(2)9-12)26-14(3)24-18-7-6-15(10-16(18)22(26)29)20(27)17-11-23-25(4)21(17)28/h5-11,28H,1-4H3
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59n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024756
PNG
(CHEMBL3342612)
Show SMILES COc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H18N4O4/c1-12-23-18-9-4-13(19(26)17-11-22-24(2)20(17)27)10-16(18)21(28)25(12)14-5-7-15(29-3)8-6-14/h4-11,27H,1-3H3
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60n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024743
PNG
(CHEMBL3342416)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3cccc(C)c3)c(=O)c2c1
Show InChI InChI=1S/C22H20N4O3/c1-12-6-5-7-16(10-12)26-14(3)23-18-9-8-15(11-17(18)21(26)28)20(27)19-13(2)24-25(4)22(19)29/h5-11,29H,1-4H3
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74n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024744
PNG
(CHEMBL3342415)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccccc3F)c(=O)c2c1
Show InChI InChI=1S/C21H17FN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-8-9-16-14(10-13)20(28)26(12(2)23-16)17-7-5-4-6-15(17)22/h4-10,29H,1-3H3
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79n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024733
PNG
(CHEMBL3342426)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(C)cc3F)c(=O)c2c1
Show InChI InChI=1S/C22H19FN4O3/c1-11-5-8-18(16(23)9-11)27-13(3)24-17-7-6-14(10-15(17)21(27)29)20(28)19-12(2)25-26(4)22(19)30/h5-10,30H,1-4H3
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81n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024747
PNG
(CHEMBL3342412)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccccc3Cl)c(=O)c2c1
Show InChI InChI=1S/C21H17ClN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-8-9-16-14(10-13)20(28)26(12(2)23-16)17-7-5-4-6-15(17)22/h4-10,29H,1-3H3
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86n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024731
PNG
(CHEMBL3342428)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(C)cc3Br)c(=O)c2c1
Show InChI InChI=1S/C22H19BrN4O3/c1-11-5-8-18(16(23)9-11)27-13(3)24-17-7-6-14(10-15(17)21(27)29)20(28)19-12(2)25-26(4)22(19)30/h5-10,30H,1-4H3
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87n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024749
PNG
(CHEMBL3343186)
Show SMILES Cc1ccc(c(Cl)c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H17ClN4O3/c1-11-4-7-18(16(22)8-11)26-12(2)24-17-6-5-13(9-14(17)21(26)29)19(27)15-10-23-25(3)20(15)28/h4-10,28H,1-3H3
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90n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024740
PNG
(CHEMBL3342419)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3cccc(F)c3)c(=O)c2c1
Show InChI InChI=1S/C21H17FN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-7-8-17-16(9-13)20(28)26(12(2)23-17)15-6-4-5-14(22)10-15/h4-10,29H,1-3H3
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90n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024741
PNG
(CHEMBL3342418)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3cccc(Br)c3)c(=O)c2c1
Show InChI InChI=1S/C21H17BrN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-7-8-17-16(9-13)20(28)26(12(2)23-17)15-6-4-5-14(22)10-15/h4-10,29H,1-3H3
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93n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024729
PNG
(CHEMBL3342430)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(C)cc3Cl)c(=O)c2c1
Show InChI InChI=1S/C22H19ClN4O3/c1-11-5-8-18(16(23)9-11)27-13(3)24-17-7-6-14(10-15(17)21(27)29)20(28)19-12(2)25-26(4)22(19)30/h5-10,30H,1-4H3
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109n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024737
PNG
(CHEMBL3342422)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(Br)cc3)c(=O)c2c1
Show InChI InChI=1S/C21H17BrN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-4-9-17-16(10-13)20(28)26(12(2)23-17)15-7-5-14(22)6-8-15/h4-10,29H,1-3H3
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130n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024736
PNG
(CHEMBL3342423)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(C)cc3)c(=O)c2c1
Show InChI InChI=1S/C22H20N4O3/c1-12-5-8-16(9-6-12)26-14(3)23-18-10-7-15(11-17(18)21(26)28)20(27)19-13(2)24-25(4)22(19)29/h5-11,29H,1-4H3
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156n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024755
PNG
(CHEMBL3342613)
Show SMILES Cc1nc2ccc(cc2c(=O)n1-c1ccc(OC(F)(F)F)cc1)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H15F3N4O4/c1-11-26-17-8-3-12(18(29)16-10-25-27(2)19(16)30)9-15(17)20(31)28(11)13-4-6-14(7-5-13)32-21(22,23)24/h3-10,30H,1-2H3
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160n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024734
PNG
(CHEMBL3342425)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(C)cc3C)c(=O)c2c1
Show InChI InChI=1S/C23H22N4O3/c1-12-6-9-19(13(2)10-12)27-15(4)24-18-8-7-16(11-17(18)22(27)29)21(28)20-14(3)25-26(5)23(20)30/h6-11,30H,1-5H3
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161n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024750
PNG
(CHEMBL3343185)
Show SMILES Cc1ccc(c(F)c1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C21H17FN4O3/c1-11-4-7-18(16(22)8-11)26-12(2)24-17-6-5-13(9-14(17)21(26)29)19(27)15-10-23-25(3)20(15)28/h4-10,28H,1-3H3
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170n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024742
PNG
(CHEMBL3342417)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3cccc(Cl)c3)c(=O)c2c1
Show InChI InChI=1S/C21H17ClN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-7-8-17-16(9-13)20(28)26(12(2)23-17)15-6-4-5-14(22)10-15/h4-10,29H,1-3H3
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173n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024730
PNG
(CHEMBL3342429)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(Cl)cc3C)c(=O)c2c1
Show InChI InChI=1S/C22H19ClN4O3/c1-11-9-15(23)6-8-18(11)27-13(3)24-17-7-5-14(10-16(17)21(27)29)20(28)19-12(2)25-26(4)22(19)30/h5-10,30H,1-4H3
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177n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024745
PNG
(CHEMBL3342414)
Show SMILES COc1ccccc1-n1c(C)nc2ccc(cc2c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C22H20N4O4/c1-12-19(22(29)25(3)24-12)20(27)14-9-10-16-15(11-14)21(28)26(13(2)23-16)17-7-5-6-8-18(17)30-4/h5-11,29H,1-4H3
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207n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024732
PNG
(CHEMBL3342427)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(F)cc3C)c(=O)c2c1
Show InChI InChI=1S/C22H19FN4O3/c1-11-9-15(23)6-8-18(11)27-13(3)24-17-7-5-14(10-16(17)21(27)29)20(28)19-12(2)25-26(4)22(19)30/h5-10,30H,1-4H3
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219n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024735
PNG
(CHEMBL3342424)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(Cl)cc3)c(=O)c2c1
Show InChI InChI=1S/C21H17ClN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-4-9-17-16(10-13)20(28)26(12(2)23-17)15-7-5-14(22)6-8-15/h4-10,29H,1-3H3
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237n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024738
PNG
(CHEMBL3342421)
Show SMILES COc1ccc(cc1)-n1c(C)nc2ccc(cc2c1=O)C(=O)c1c(C)nn(C)c1O
Show InChI InChI=1S/C22H20N4O4/c1-12-19(22(29)25(3)24-12)20(27)14-5-10-18-17(11-14)21(28)26(13(2)23-18)15-6-8-16(30-4)9-7-15/h5-11,29H,1-4H3
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238n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024739
PNG
(CHEMBL3342420)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccc(F)cc3)c(=O)c2c1
Show InChI InChI=1S/C21H17FN4O3/c1-11-18(21(29)25(3)24-11)19(27)13-4-9-17-16(10-13)20(28)26(12(2)23-17)15-7-5-14(22)6-8-15/h4-10,29H,1-3H3
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247n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50024746
PNG
(CHEMBL3342413)
Show SMILES Cc1nn(C)c(O)c1C(=O)c1ccc2nc(C)n(-c3ccccc3C)c(=O)c2c1
Show InChI InChI=1S/C22H20N4O3/c1-12-7-5-6-8-18(12)26-14(3)23-17-10-9-15(11-16(17)21(26)28)20(27)19-13(2)24-25(4)22(19)29/h5-11,29H,1-4H3
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248n/an/an/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrop...


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More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50072265
PNG
(CHEMBL3408320)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C16H18N4O3/c1-4-19-12-7-6-10(8-13(12)20(5-2)16(19)23)14(21)11-9-17-18(3)15(11)22/h6-9,22H,4-5H2,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50072237
PNG
(CHEMBL3408314)
Show SMILES CCn1c2cc(ccc2n(C)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C15H16N4O3/c1-4-19-12-7-9(5-6-11(12)17(2)15(19)22)13(20)10-8-16-18(3)14(10)21/h5-8,21H,4H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50072264
PNG
(CHEMBL3408319)
Show SMILES CCCn1c2cc(ccc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-8-21-14-9-11(6-7-13(14)20(5-2)17(21)24)15(22)12-10-18-19(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 22n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50072269
PNG
(CHEMBL3408324)
Show SMILES CCCn1c2ccc(cc2n(CC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C17H20N4O3/c1-4-8-21-13-7-6-11(9-14(13)20(5-2)17(21)24)15(22)12-10-18-19(3)16(12)23/h6-7,9-10,23H,4-5,8H2,1-3H3
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n/an/a 39n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
4-hydroxyphenylpyruvate dioxygenase


(Homo sapiens)
BDBM50072270
PNG
(CHEMBL3408325)
Show SMILES CCCn1c2ccc(cc2n(CCC)c1=O)C(=O)c1cnn(C)c1O
Show InChI InChI=1S/C18H22N4O3/c1-4-8-21-14-7-6-12(10-15(14)22(9-5-2)18(21)25)16(23)13-11-19-20(3)17(13)24/h6-7,10-11,24H,4-5,8-9H2,1-3H3
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n/an/a 40n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged HPPD expressed in Escherichia coli BL21(DE3) by UV/visible plate reader analysis


Citation and Details
More data for this
Ligand-Target Pair
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