Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50346374![]() (3-(2-(4-(naphthalen-1-yl)piperazin-1-yl)ethyl)benz...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.000178 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli Federico II Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain cortex homogenates after 30 mins by liquid scintillation counting | Eur J Med Chem 46: 2206-16 (2011) Article DOI: 10.1016/j.ejmech.2011.03.001 BindingDB Entry DOI: 10.7270/Q2M32W4J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50368723![]() (Metanopirone | Sediel | TANDOSPIRONE HYDROCHLORIDE...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | 0.00270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Asahi Chemical Industry Company, Ltd. Curated by ChEMBL | Assay Description Binding affinity by measuring displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat hippocampus | J Med Chem 36: 3526-32 (1994) Article DOI: 10.1021/jm00075a006 BindingDB Entry DOI: 10.7270/Q2D21Z74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50208446![]() (CHEMBL3884161) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Huazhong University of Science and Technology Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting analy... | Eur J Med Chem 124: 713-728 (2016) Article DOI: 10.1016/j.ejmech.2016.09.008 BindingDB Entry DOI: 10.7270/Q2SQ92C5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50145613![]() (CHEMBL3764390) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.0113 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Farmacia Universit£ di Napoli"Federico II" Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain cortex incubated for 30 mins by liquid scintillation counting analysis | Eur J Med Chem 110: 133-50 (2016) Article DOI: 10.1016/j.ejmech.2016.01.021 BindingDB Entry DOI: 10.7270/Q24X59N9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50208470![]() (CHEMBL3885003) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Huazhong University of Science and Technology Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cerebral cortex incubated for 30 mins by liquid scintillation counting analy... | Eur J Med Chem 124: 713-728 (2016) Article DOI: 10.1016/j.ejmech.2016.09.008 BindingDB Entry DOI: 10.7270/Q2SQ92C5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50369022![]() (CHEMBL1788197) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | <0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50171884![]() (4-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propoxy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of [3H]-8-OH-DPAT binding to Serotonin 5-HT1A receptor from rat brain cortex | J Med Chem 48: 5495-503 (2005) Article DOI: 10.1021/jm050246k BindingDB Entry DOI: 10.7270/Q2TM79N5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50316964![]() (CHEMBL1086961 | N'-cyano-N-(3-(4-(pyridin-2-yl)pip...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.0380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli Federico II Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat brain cortex after 30 mins liquid scintillation spectrometer | Bioorg Med Chem Lett 20: 2978-82 (2010) Article DOI: 10.1016/j.bmcl.2010.02.106 BindingDB Entry DOI: 10.7270/Q2QR4X80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50035336![]() (8-(Phenethyl-propyl-amino)-6,7,8,9-tetrahydro-3H-b...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50062262![]() (2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement. | J Med Chem 41: 157-66 (1998) Article DOI: 10.1021/jm970296s BindingDB Entry DOI: 10.7270/Q2TX3DH6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50062937![]() (CHEMBL3397908) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.0450 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Displacement of [3H]MPPF from 5HT1A receptor in Sprague-Dawley rat hippocampal membrane fraction incubated for 60 mins by scintillation counting meth... | Bioorg Med Chem Lett 25: 998-1008 (2015) Article DOI: 10.1016/j.bmcl.2014.12.076 BindingDB Entry DOI: 10.7270/Q28S4RMQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50057433![]() (CHEMBL278806 | [2-(5-Fluoro-chroman-8-yloxy)-ethyl...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor | J Med Chem 40: 1252-7 (1997) Article DOI: 10.1021/jm960760d BindingDB Entry DOI: 10.7270/Q20R9Q26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50068362![]() (3-Methoxy-N-{2-[4-(2-methoxy-phenyl)-piperazin-1-y...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor from rat hippocampal membranes | J Med Chem 45: 5727-35 (2002) Article DOI: 10.1021/jm020952a BindingDB Entry DOI: 10.7270/Q2TT4RQC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136352![]() (US8859534, 38) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.0640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50062268![]() (6-Iodo-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement. | J Med Chem 41: 157-66 (1998) Article DOI: 10.1021/jm970296s BindingDB Entry DOI: 10.7270/Q2TX3DH6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50062268![]() (6-Iodo-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0690 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pennsylvania Curated by ChEMBL | Assay Description In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement. | J Med Chem 41: 157-66 (1998) Article DOI: 10.1021/jm970296s BindingDB Entry DOI: 10.7270/Q2TX3DH6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50029246![]() (1-[5-(4-Benzofuran-7-yl-piperazin-1-ylmethyl)-thio...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]WB-4101 | J Med Chem 38: 4198-210 (1995) Article DOI: 10.1021/jm00021a009 BindingDB Entry DOI: 10.7270/Q2GX4C61 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50035342![]() (8-Pyrrolidin-1-yl-6,7,8,9-tetrahydro-3H-benzo[e]in...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50359955![]() (CHEMBL1927089) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0842 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli"Federico II" Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from Sprague-Dawley rat brain cortex serotonin 5-HT1A receptor after 30 mins by liquid scintillation counting | Eur J Med Chem 47: 520-9 (2012) Article DOI: 10.1016/j.ejmech.2011.11.023 BindingDB Entry DOI: 10.7270/Q29S1RFN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50094670![]() (1-(4-Dipropylamino-1,3,4,5-tetrahydro-benzo[cd]ind...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.0880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition constant of 50 microM forskolin-stimulated cAMP accumulation against 5-hydroxytryptamine 1A receptor | J Med Chem 43: 4701-10 (2001) Article DOI: 10.1021/jm000339w BindingDB Entry DOI: 10.7270/Q2HT2NM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50262788![]() (2-[[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]thi...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0940 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Catania Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in CRL:CD(SD)BR-COBS rat hippocampus | J Med Chem 51: 4529-38 (2008) Article DOI: 10.1021/jm800176x BindingDB Entry DOI: 10.7270/Q2Q81CWG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50035363![]() (8-[Propyl-(2-thiophen-2-yl-ethyl)-amino]-6,7,8,9-t...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136326![]() (US8859534, 12) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50057432![]() (CHEMBL25215 | [2-(Chroman-8-yloxy)-ethyl]-[4-(4-me...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor | J Med Chem 40: 1252-7 (1997) Article DOI: 10.1021/jm960760d BindingDB Entry DOI: 10.7270/Q20R9Q26 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50034281![]() (Bicyclo[2.2.1]heptane-2-carboxylic acid {2-[4-(2-m...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
FAES, S.A. Curated by ChEMBL | Assay Description In vitro ability to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor sites of rat brain cortex. | J Med Chem 38: 1273-7 (1995) Article DOI: 10.1021/jm00008a005 BindingDB Entry DOI: 10.7270/Q2H9947K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM10755![]() (14C-5-hydroxy tryptamine creatinine disulfate | 2-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by PDSP Ki Database | J Pharmacol Exp Ther 283: 1305-22 (1997) Article DOI: 10.1021/acschembio.5b00370 BindingDB Entry DOI: 10.7270/Q25Q4TMX | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50029326![]() (8-{3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R.W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Affinity against the 5-hydroxytryptamine receptor 1A using [3H]WB-4101. | J Med Chem 38: 4211-22 (1995) Article DOI: 10.1021/jm00021a010 BindingDB Entry DOI: 10.7270/Q2C53MH2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50145616![]() (CHEMBL3763331) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dipartimento di Farmacia Universit£ di Napoli"Federico II" Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from 5HT1A receptor in Sprague-Dawley rat brain cortex incubated for 30 mins by liquid scintillation counting analysis | Eur J Med Chem 110: 133-50 (2016) Article DOI: 10.1016/j.ejmech.2016.01.021 BindingDB Entry DOI: 10.7270/Q24X59N9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136354![]() (US8859534, 40) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136317![]() (US8859534, 3) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50020178![]() (CHEMBL294633 | CHEMBL555633 | N-[2-(4-Benzofuran-7...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Duphar Research Laboratories Curated by ChEMBL | Assay Description Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena... | J Med Chem 37: 2761-73 (1994) Article DOI: 10.1021/jm00043a015 BindingDB Entry DOI: 10.7270/Q2DJ5G84 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50020178![]() (CHEMBL294633 | CHEMBL555633 | N-[2-(4-Benzofuran-7...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma Curated by ChEMBL | Assay Description Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si... | J Med Chem 40: 300-12 (1997) Article DOI: 10.1021/jm960496o BindingDB Entry DOI: 10.7270/Q27W6B96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50065578![]() (CHEMBL419147 | [2-(6-Fluoro-2H-chromen-8-yloxy)-et...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.159 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand. | J Med Chem 41: 2765-78 (1998) Article DOI: 10.1021/jm9707840 BindingDB Entry DOI: 10.7270/Q2K073CQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50107249![]() (1-[2-(7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università Bari Curated by ChEMBL | Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes | J Med Chem 44: 4431-42 (2001) Article DOI: 10.1021/jm010866v BindingDB Entry DOI: 10.7270/Q2NC60GV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50122242![]() (4-Chloro-5-{4-[2-(2-ethoxy-phenoxy)-ethyl]-piperaz...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor receptor in rat cerebral cortex using [3H]-8-OH-DPAT | Bioorg Med Chem Lett 13: 171-3 (2002) Article DOI: 10.1016/s0960-894x(02)00932-0 BindingDB Entry DOI: 10.7270/Q2TM79GX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136363![]() (US8859534, 49) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136325![]() (US8859534, 11) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (5HT1A) (Cricetulus griseus (Chinese hamster) (Cricetulus b...) | BDBM136362![]() (US8859534, 48) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Acturum Life Science AB US Patent | Assay Description Assays that were used to measure affinity of the compounds of the present invention for 5-HT1A and 5-HT1B receptors are described in J. Recept Signal... | US Patent US8859534 (2014) BindingDB Entry DOI: 10.7270/Q23R0RKV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50056378![]() (3-Amino-2-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Catania Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampus membranes | Bioorg Med Chem Lett 10: 1089-92 (2000) Article DOI: 10.1016/s0960-894x(00)00165-7 BindingDB Entry DOI: 10.7270/Q25D8R2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1 (5-HT1) receptor (Rattus norvegicus (rat)) | BDBM50218388![]() (CHEMBL78986) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Welfide Corporation Curated by ChEMBL | Assay Description Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement. | Bioorg Med Chem Lett 10: 2457-61 (2001) Article DOI: 10.1016/s0960-894x(00)00492-3 BindingDB Entry DOI: 10.7270/Q2VT1SN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50065555![]() (CHEMBL96578 | [2-(6-Fluoro-2-methyl-chroman-8-ylox...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.188 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Yamanouchi Pharmaceutical Company, Ltd. Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 1A receptor on rat hippocampus using [3H]-8-OH-DPAT as radioligand. | J Med Chem 41: 2765-78 (1998) Article DOI: 10.1021/jm9707840 BindingDB Entry DOI: 10.7270/Q2K073CQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin 1 (5-HT1) receptor (Rattus norvegicus (rat)) | BDBM50218397![]() (CHEMBL83611) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Welfide Corporation Curated by ChEMBL | Assay Description Binding affinity at 5-hydroxytryptamine 1A receptor from striata of wistar rats by [3H]- 8-OH -DPAT displacement. | Bioorg Med Chem Lett 10: 2457-61 (2001) Article DOI: 10.1016/s0960-894x(00)00492-3 BindingDB Entry DOI: 10.7270/Q2VT1SN2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50088696![]() (3-Amino-6-ethyl-2-{3-[4-(2-methoxy-phenyl)-piperaz...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Catania Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampus membranes | Bioorg Med Chem Lett 10: 1089-92 (2000) Article DOI: 10.1016/s0960-894x(00)00165-7 BindingDB Entry DOI: 10.7270/Q25D8R2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50061649![]() (2-{[3-(Benzooxazol-5-yloxy)-propylamino]-methyl}-c...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity to rat hippocampal 5-hydroxytryptamine 1A receptor was determined using [3H]8-OH-DPAT as radioligand | J Med Chem 40: 4235-56 (1998) Article DOI: 10.1021/jm9703653 BindingDB Entry DOI: 10.7270/Q2KP82TD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50107235![]() (CHEMBL138109 | [3-(5-Methoxy-naphthalen-1-yl)-prop...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università Bari Curated by ChEMBL | Assay Description Binding was determined on 5-hydroxytryptamine 1A receptor in rat hippocampal membranes | J Med Chem 44: 4431-42 (2001) Article DOI: 10.1021/jm010866v BindingDB Entry DOI: 10.7270/Q2NC60GV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50039829![]() (CHEMBL92242 | Cyclohexanecarboxylic acid [2-(4-ben...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Duphar Research Laboratories Curated by ChEMBL | Assay Description Binding affinity to displace [3H]2-(di-N-propylamino)-8-hydroxy-tetralin from 5-hydroxytryptamine 1A (5-HT1A) receptor in rat frontal cortex homogena... | J Med Chem 37: 2761-73 (1994) Article DOI: 10.1021/jm00043a015 BindingDB Entry DOI: 10.7270/Q2DJ5G84 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50035320![]() ((+/-)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50035305![]() ((S)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50035303![]() ((R)-8-Dipropylamino-6,7,8,9-tetrahydro-3H-benzo[e]...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Rattus norvegicus (rat)) | BDBM50369020![]() (CHEMBL1788200) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Upjohn Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against cloned mammalian 5-hydroxytryptamine 1A receptor expressed in CHO cells, by using [3H]8-OH-DPAT as radioligand. | J Med Chem 38: 2217-30 (1995) Article DOI: 10.1021/jm00012a022 BindingDB Entry DOI: 10.7270/Q28G8MBW | |||||||||||
More data for this Ligand-Target Pair |
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