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Found 7 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1B' AND taxid = 9595   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50005835
PNG
((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Show SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C14H21N3O2S/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3/h4-5,8-9,15-16H,6-7,10H2,1-3H3
MMDB

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PubMed
6.40n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50064784
PNG
((S)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES COc1ccc(cc1)N1CCN(CC[C@@H]2OCCc3cc(ccc23)C(N)=O)CC1
Show InChI InChI=1S/C23H29N3O3/c1-28-20-5-3-19(4-6-20)26-13-11-25(12-14-26)10-8-22-21-7-2-18(23(24)27)16-17(21)9-15-29-22/h2-7,16,22H,8-15H2,1H3,(H2,24,27)/t22-/m0/s1
MMDB

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PubMed
3.02E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50064786
PNG
((S)-1-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)...)
Show SMILES CNC(=O)c1ccc2[C@H](CCN3CCN(CC3)c3ccc(OC)cc3)OCCc2c1
Show InChI InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m0/s1
MMDB

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PubMed
5.78E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50064785
PNG
(1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccc(cc1)N1CCN(CCC2OCCc3cc(ccc23)C(N)=O)CC1
Show InChI InChI=1S/C23H29N3O3/c1-28-20-5-3-19(4-6-20)26-13-11-25(12-14-26)10-8-22-21-7-2-18(23(24)27)16-17(21)9-15-29-22/h2-7,16,22H,8-15H2,1H3,(H2,24,27)
MMDB

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5.86E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50051562
PNG
(1-(2-Isochroman-1-yl-ethyl)-4-(4-methoxy-phenyl)-p...)
Show SMILES COc1ccc(cc1)N1CCN(CCC2OCCc3ccccc23)CC1
Show InChI InChI=1S/C22H28N2O2/c1-25-20-8-6-19(7-9-20)24-15-13-23(14-16-24)12-10-22-21-5-3-2-4-18(21)11-17-26-22/h2-9,22H,10-17H2,1H3
MMDB

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PC sid
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Article
PubMed
7.24E+3n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50064783
PNG
((R)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES COc1ccc(cc1)N1CCN(CC[C@H]2OCCc3cc(ccc23)C(N)=O)CC1
Show InChI InChI=1S/C23H29N3O3/c1-28-20-5-3-19(4-6-20)26-13-11-25(12-14-26)10-8-22-21-7-2-18(23(24)27)16-17(21)9-15-29-22/h2-7,16,22H,8-15H2,1H3,(H2,24,27)/t22-/m1/s1
MMDB

UniProtKB/SwissProt

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PubMed
2.60E+4n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Gorilla gorilla gorilla)
BDBM50064787
PNG
((R)-1-{2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-eth...)
Show SMILES CNC(=O)c1ccc2[C@@H](CCN3CCN(CC3)c3ccc(OC)cc3)OCCc2c1
Show InChI InChI=1S/C24H31N3O3/c1-25-24(28)19-3-8-22-18(17-19)10-16-30-23(22)9-11-26-12-14-27(15-13-26)20-4-6-21(29-2)7-5-20/h3-8,17,23H,9-16H2,1-2H3,(H,25,28)/t23-/m1/s1
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
1.50E+5n/an/an/an/an/an/an/an/a



Pharmacia & Upjohn

Curated by ChEMBL


Assay Description
The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...


Citation and Details
More data for this
Ligand-Target Pair