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Compile Data Set for Download or QSAR

Found 5523 hits Enz. Inhib. hit(s) with Target = '5-lipoxygenase/FLAP' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145818
PNG
(US8952177, 174 | US9089569, 174)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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0.340n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM167060
PNG
(US9073876, 146)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F
Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)
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0.400n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9073876 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169403
PNG
(US9079866, 808)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCCC1
Show InChI InChI=1S/C21H21FN4O2S/c22-18-11-14(8-9-17(18)19-12-26-20(23)13-25-19)16-7-4-10-24-21(16)29(27,28)15-5-2-1-3-6-15/h4,7-13,15H,1-3,5-6H2,(H2,23,26)
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0.400n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145820
PNG
(US8952177, 176 | US9089569, 176)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1/C33H36F2N4O3/c1-21-16-28(35)30(36-18-21)20-42-25-10-11-29-31(17-25)39(32(37-29)26-4-2-3-5-27(26)33(40)41)19-22-6-8-24(9-7-22)38-14-12-23(34)13-15-38/h6-11,16-18,23,26-27H,2-5,12-15,19-20H2,1H3,(H,40,41)/t26-,27+/s2
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0.420n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145785
PNG
(US8952177, 139 | US9089569, 139)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1
Show InChI InChI=1/C35H31F4N3O3/c1-21-16-29(36)31(40-18-21)20-45-26-14-15-30-32(17-26)42(33(41-30)27-4-2-3-5-28(27)34(43)44)19-22-6-8-23(9-7-22)24-10-12-25(13-11-24)35(37,38)39/h6-18,27-28H,2-5,19-20H2,1H3,(H,43,44)/t27-,28+/s2
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0.470n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM167191
PNG
(US9073876, 272)
Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F
Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)
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0.5n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9073876 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145770
PNG
(US8952177, 124 | US9089569, 124)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19-/s2
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0.520n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169201
PNG
(US9079866, 602)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1S/C26H18F2N6/c27-21-9-15(5-7-19(21)23-11-33-25(29)13-31-23)17-3-1-2-4-18(17)16-6-8-20(22(28)10-16)24-12-34-26(30)14-32-24/h1-14H,(H2,29,33)(H2,30,34)
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0.600n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169405
PNG
(US9079866, 810)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCC1
Show InChI InChI=1S/C20H19FN4O2S/c21-17-10-13(7-8-16(17)18-11-25-19(22)12-24-18)15-6-3-9-23-20(15)28(26,27)14-4-1-2-5-14/h3,6-12,14H,1-2,4-5H2,(H2,22,25)
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0.600n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145769
PNG
(US8952177, 123 | US9089569, 123)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(Br)cc4F)c3c2)c(F)c1
Show InChI InChI=1/C28H25BrF3N3O3/c1-15-8-23(32)25(33-12-15)14-38-17-6-7-24-26(11-17)35(13-20-21(30)9-16(29)10-22(20)31)27(34-24)18-4-2-3-5-19(18)28(36)37/h6-12,18-19H,2-5,13-14H2,1H3,(H,36,37)/t18-,19+/s2
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0.610n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145782
PNG
(US8952177, 136 | US9089569, 136)
Show SMILES CCC(CC)(Cc1nc2ccc(OCc3ncc(C)cc3F)cc2n1Cc1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C28H29BrFN3O3/c1-4-28(5-2,27(34)35)14-26-32-23-11-10-21(36-17-24-22(30)12-18(3)15-31-24)13-25(23)33(26)16-19-6-8-20(29)9-7-19/h6-13,15H,4-5,14,16-17H2,1-3H3,(H,34,35)
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0.640n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145783
PNG
(US8952177, 137 | US9089569, 137)
Show SMILES Cc1cnc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)c(F)c1
Show InChI InChI=1/C35H29F6N3O3/c1-19-12-29(38)31(42-16-19)18-47-23-10-11-30-32(15-23)44(33(43-30)24-4-2-3-5-25(24)34(45)46)17-26-27(36)13-21(14-28(26)37)20-6-8-22(9-7-20)35(39,40)41/h6-16,24-25H,2-5,17-18H2,1H3,(H,45,46)/t24-,25+/s2
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0.660n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169270
PNG
(US9079866, 675)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(c(F)c1)-c1cnc(N)nc1
Show InChI InChI=1S/C19H20FN5O2S/c1-19(2,3)25-28(26,27)16-7-5-4-6-14(16)12-8-15(20)17(22-9-12)13-10-23-18(21)24-11-13/h4-11,25H,1-3H3,(H2,21,23,24)
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0.700n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169421
PNG
(US9079866, 826)
Show SMILES CC(C)S(=O)(=O)c1ncccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C21H18FN3O2S/c1-13(2)28(26,27)21-18(4-3-8-24-21)14-5-6-17(19(22)11-14)16-10-15-7-9-23-20(15)25-12-16/h3-13H,1-2H3,(H,23,25)
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0.700n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145657
PNG
(US8952177, 11 | US9089569, 11)
Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4F)c3c2)nc1
Show InChI InChI=1/C28H27BrFN3O3/c1-17-6-9-20(31-14-17)16-36-21-10-11-25-26(13-21)33(15-18-7-8-19(29)12-24(18)30)27(32-25)22-4-2-3-5-23(22)28(34)35/h6-14,22-23H,2-5,15-16H2,1H3,(H,34,35)/t22-,23+/s2
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0.740n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145817
PNG
(US8952177, 173 | US8952177, 175 | US9089569, 175)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1/C33H35F3N4O3/c1-20-14-28(36)30(37-17-20)19-43-24-8-9-29-31(16-24)40(32(38-29)25-4-2-3-5-26(25)33(41)42)18-21-6-7-23(15-27(21)35)39-12-10-22(34)11-13-39/h6-9,14-17,22,25-26H,2-5,10-13,18-19H2,1H3,(H,41,42)/t25-,26+/s2
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0.820n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145816
PNG
(US8952177, 172 | US9089569, 172)
Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4c(F)cc(cc4F)N4CCC(F)CC4)c3c2)c(F)c1
Show InChI InChI=1/C33H34F4N4O3/c1-19-12-28(37)30(38-16-19)18-44-22-6-7-29-31(15-22)41(32(39-29)23-4-2-3-5-24(23)33(42)43)17-25-26(35)13-21(14-27(25)36)40-10-8-20(34)9-11-40/h6-7,12-16,20,23-24H,2-5,8-11,17-18H2,1H3,(H,42,43)/t23-,24+/s2
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0.840n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM167188
PNG
(US9073876, 269)
Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1
Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)
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0.900n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9073876 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM145807
PNG
(US8952177, 163 | US9089569, 163)
Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4ccc(cc4F)N4CCC(F)(F)C4)c3c2)nc1
Show InChI InChI=1/C32H33F3N4O3/c1-20-6-8-22(36-16-20)18-42-24-10-11-28-29(15-24)39(30(37-28)25-4-2-3-5-26(25)31(40)41)17-21-7-9-23(14-27(21)33)38-13-12-32(34,35)19-38/h6-11,14-16,25-26H,2-5,12-13,17-19H2,1H3,(H,40,41)/t25-,26+/s2
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0.960n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9089569 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169030
PNG
(US9079866, 431)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCc2c1
Show InChI InChI=1S/C23H24FN3O2S/c1-23(2,3)27-30(28,29)21-7-5-4-6-19(21)15-8-9-18(20(24)13-15)17-12-16-10-11-25-22(16)26-14-17/h4-9,12-14,27H,10-11H2,1-3H3,(H,25,26)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169032
PNG
(US9079866, 433)
Show SMILES COc1nc(cnc1N)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C21H23FN4O3S/c1-21(2,3)26-30(27,28)18-8-6-5-7-14(18)13-9-10-15(16(22)11-13)17-12-24-19(23)20(25-17)29-4/h5-12,26H,1-4H3,(H2,23,24)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169033
PNG
(US9079866, 434)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(n1)C#N
Show InChI InChI=1S/C21H20FN5O2S/c1-21(2,3)27-30(28,29)19-7-5-4-6-14(19)13-8-9-15(16(22)10-13)18-12-25-20(24)17(11-23)26-18/h4-10,12,27H,1-3H3,(H2,24,25)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169037
PNG
(US9079866, 438)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(-c2nnc(N)s2)c(F)c1
Show InChI InChI=1S/C18H19FN4O2S2/c1-18(2,3)23-27(24,25)15-7-5-4-6-12(15)11-8-9-13(14(19)10-11)16-21-22-17(20)26-16/h4-10,23H,1-3H3,(H2,20,22)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169040
PNG
(US9079866, 441)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(Cl)n1
Show InChI InChI=1S/C20H20ClFN4O2S/c1-20(2,3)26-29(27,28)17-7-5-4-6-13(17)12-8-9-14(15(22)10-12)16-11-24-19(23)18(21)25-16/h4-11,26H,1-3H3,(H2,23,24)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169041
PNG
(US9079866, 442)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(Br)n1
Show InChI InChI=1S/C20H20BrFN4O2S/c1-20(2,3)26-29(27,28)17-7-5-4-6-13(17)12-8-9-14(15(22)10-12)16-11-24-19(23)18(21)25-16/h4-11,26H,1-3H3,(H2,23,24)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169044
PNG
(US9079866, 445)
Show SMILES Cc1nc(cnc1N)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(C)(C)C
Show InChI InChI=1S/C21H23FN4O2S/c1-13-20(23)24-12-18(25-13)16-10-9-14(11-17(16)22)15-7-5-6-8-19(15)29(27,28)26-21(2,3)4/h5-12,26H,1-4H3,(H2,23,24)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169054
PNG
(US9079866, 455)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]cc(CO)c2c1
Show InChI InChI=1S/C24H24FN3O3S/c1-24(2,3)28-32(30,31)22-7-5-4-6-19(22)15-8-9-18(21(25)11-15)16-10-20-17(14-29)13-27-23(20)26-12-16/h4-13,28-29H,14H2,1-3H3,(H,26,27)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168961
PNG
(US9079866, 362)
Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1/C22H20FN3O3S/c1-14(13-27)26-30(28,29)21-5-3-2-4-19(21)15-6-7-18(20(23)11-15)17-10-16-8-9-24-22(16)25-12-17/h2-12,14,26-27H,13H2,1H3,(H,24,25)/t14-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168962
PNG
(US9079866, 363)
Show SMILES C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1/C22H20FN3O3S/c1-14(13-27)26-30(28,29)21-5-3-2-4-19(21)15-6-7-18(20(23)11-15)17-10-16-8-9-24-22(16)25-12-17/h2-12,14,26-27H,13H2,1H3,(H,24,25)/t14-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168965
PNG
(US9079866, 366)
Show SMILES OCCNS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C21H18FN3O3S/c22-19-12-14(18-3-1-2-4-20(18)29(27,28)25-9-10-26)5-6-17(19)16-11-15-7-8-23-21(15)24-13-16/h1-8,11-13,25-26H,9-10H2,(H,23,24)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168966
PNG
(US9079866, 367)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1
Show InChI InChI=1S/C23H22FN3O2S/c1-23(2,3)27-30(28,29)21-7-5-4-6-19(21)15-8-9-18(20(24)13-15)17-12-16-10-11-25-22(16)26-14-17/h4-14,27H,1-3H3,(H,25,26)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168970
PNG
(US9079866, 371)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C22H21FN4O2S/c1-22(2,3)27-30(28,29)20-7-5-4-6-15(20)14-8-9-16(17(23)12-14)19-13-25-21-18(26-19)10-11-24-21/h4-13,27H,1-3H3,(H,24,25)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168972
PNG
(US9079866, 373)
Show SMILES CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C22H21FN4O2S/c1-3-27(4-2)30(28,29)21-8-6-5-7-16(21)15-9-10-17(18(23)13-15)20-14-25-22-19(26-20)11-12-24-22/h5-14H,3-4H2,1-2H3,(H,24,25)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168973
PNG
(US9079866, 374)
Show SMILES Fc1cc(ccc1-c1cnc2[nH]ccc2n1)-c1ccccc1S(=O)(=O)N1CCCCC1
Show InChI InChI=1S/C23H21FN4O2S/c24-19-14-16(8-9-18(19)21-15-26-23-20(27-21)10-11-25-23)17-6-2-3-7-22(17)31(29,30)28-12-4-1-5-13-28/h2-3,6-11,14-15H,1,4-5,12-13H2,(H,25,26)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168977
PNG
(US9079866, 378)
Show SMILES C[C@@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1/C21H19FN4O3S/c1-13(12-27)26-30(28,29)20-5-3-2-4-15(20)14-6-7-16(17(22)10-14)19-11-24-21-18(25-19)8-9-23-21/h2-11,13,26-27H,12H2,1H3,(H,23,24)/t13-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168978
PNG
(US9079866, 379)
Show SMILES CNS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1S/C19H15FN4O2S/c1-21-27(25,26)18-5-3-2-4-13(18)12-6-7-14(15(20)10-12)17-11-23-19-16(24-17)8-9-22-19/h2-11,21H,1H3,(H,22,23)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168979
PNG
(US9079866, 380)
Show SMILES C[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2n1
Show InChI InChI=1/C21H19FN4O3S/c1-13(12-27)26-30(28,29)20-5-3-2-4-15(20)14-6-7-16(17(22)10-14)19-11-24-21-18(25-19)8-9-23-21/h2-11,13,26-27H,12H2,1H3,(H,23,24)/t13-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168991
PNG
(US9079866, 392)
Show SMILES Fc1cc(ccc1-c1cnc2NCCOc2c1)-c1ccccc1S(=O)(=O)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C23H22FN3O5S2/c24-20-13-16(5-6-18(20)17-14-21-23(26-15-17)25-7-10-32-21)19-3-1-2-4-22(19)34(30,31)27-8-11-33(28,29)12-9-27/h1-6,13-15H,7-12H2,(H,25,26)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168992
PNG
(US9079866, 393)
Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc2NCCOc2c1
Show InChI InChI=1S/C23H24FN3O3S/c1-23(2,3)27-31(28,29)21-7-5-4-6-18(21)15-8-9-17(19(24)12-15)16-13-20-22(26-14-16)25-10-11-30-20/h4-9,12-14,27H,10-11H2,1-3H3,(H,25,26)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168914
PNG
(US9079866, 315)
Show SMILES Nc1ncc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CC(O)(C1)C(F)(F)F
Show InChI InChI=1S/C20H16F4N4O3S/c21-16-7-12(5-6-14(16)13-8-26-18(25)27-9-13)15-3-1-2-4-17(15)32(30,31)28-10-19(29,11-28)20(22,23)24/h1-9,29H,10-11H2,(H2,25,26,27)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168948
PNG
(US9079866, 349)
Show SMILES CCC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1
Show InChI InChI=1S/C22H24FN3O2S/c1-4-22(2,3)26-29(27,28)20-8-6-5-7-18(20)15-9-11-17(19(23)13-15)16-10-12-21(24)25-14-16/h5-14,26H,4H2,1-3H3,(H2,24,25)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM168952
PNG
(US9079866, 353)
Show SMILES CC1(CCC1)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1ccc(N)nc1
Show InChI InChI=1S/C22H22FN3O2S/c1-22(11-4-12-22)26-29(27,28)20-6-3-2-5-18(20)15-7-9-17(19(23)13-15)16-8-10-21(24)25-14-16/h2-3,5-10,13-14,26H,4,11-12H2,1H3,(H2,24,25)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM60476
PNG
(US9079866, 150)
Show SMILES CC(C)(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1/C22H25FN4O3S/c1-22(2,3)20(13-28)27-31(29,30)19-7-5-4-6-15(19)14-8-9-16(17(23)10-14)18-11-26-21(24)12-25-18/h4-12,20,27-28H,13H2,1-3H3,(H2,24,26)/t20-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM60477
PNG
(US9079866, 159)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1[C@H](O)Cc2ccccc12
Show InChI InChI=1/C25H21FN4O3S/c26-20-11-16(9-10-19(20)21-13-29-24(27)14-28-21)17-6-3-4-8-23(17)34(32,33)30-25-18-7-2-1-5-15(18)12-22(25)31/h1-11,13-14,22,25,30-31H,12H2,(H2,27,29)/t22-,25-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM60478
PNG
(US9079866, 170)
Show SMILES C[C@H](CC#N)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1
Show InChI InChI=1/C20H18FN5O2S/c1-13(8-9-22)26-29(27,28)19-5-3-2-4-15(19)14-6-7-16(17(21)10-14)18-11-25-20(23)12-24-18/h2-7,10-13,26H,8H2,1H3,(H2,23,25)/t13-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM47234
PNG
(US9079866, 117)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC[C@H](O)c1ccccc1
Show InChI InChI=1/C24H21FN4O3S/c25-20-12-17(10-11-19(20)21-13-28-24(26)15-27-21)18-8-4-5-9-23(18)33(31,32)29-14-22(30)16-6-2-1-3-7-16/h1-13,15,22,29-30H,14H2,(H2,26,28)/t22-/s2
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169155
PNG
(US9079866, 556)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1nccc(N)n1)C(F)(F)F
Show InChI InChI=1S/C21H14F4N6O/c22-15-7-11(1-3-14(15)16-9-30-19(27)10-29-16)13-4-2-12(21(23,24)25)8-17(13)32-20-28-6-5-18(26)31-20/h1-10H,(H2,27,30)(H2,26,28,31)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169122
PNG
(US9079866, 523)
Show SMILES Nc1nccc(Oc2ccccc2-c2ccc(c(F)c2)-c2cnc3[nH]ccc3c2)n1
Show InChI InChI=1S/C23H16FN5O/c24-19-12-14(5-6-17(19)16-11-15-7-9-26-22(15)28-13-16)18-3-1-2-4-20(18)30-21-8-10-27-23(25)29-21/h1-13H,(H,26,28)(H2,25,27,29)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169123
PNG
(US9079866, 524)
Show SMILES Nc1ccnc(Oc2ccccc2-c2ccc(c(F)c2)-c2cnc3[nH]ccc3c2)n1
Show InChI InChI=1S/C23H16FN5O/c24-19-12-14(5-6-17(19)16-11-15-7-9-26-22(15)28-13-16)18-3-1-2-4-20(18)30-23-27-10-8-21(25)29-23/h1-13H,(H,26,28)(H2,25,27,29)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
5-lipoxygenase/FLAP


(Homo sapiens (Human))
BDBM169134
PNG
(US9079866, 535)
Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1cc(N)ncn1
Show InChI InChI=1S/C20H15FN6O/c21-15-7-12(5-6-14(15)16-9-25-19(23)10-24-16)13-3-1-2-4-17(13)28-20-8-18(22)26-11-27-20/h1-11H,(H2,23,25)(H2,22,26,27)
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1n/an/an/an/an/an/an/an/a



JANSSEN PHARMACEUTICA NV

US Patent


Assay Description
The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...


US Patent US9079866 (2015)

More data for this
Ligand-Target Pair
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