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Found 56 hits Enz. Inhib. hit(s) with Target = '6-phospho-1-fructokinase' AND taxid = 5702   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446088
PNG
(CHEMBL3108870)
Show SMILES Fc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nncs2)cc1Cl
Show InChI InChI=1S/C16H12ClFN4O3S2/c17-13-7-10(1-6-14(13)18)8-15(23)20-11-2-4-12(5-3-11)27(24,25)22-16-21-19-9-26-16/h1-7,9H,8H2,(H,20,23)(H,21,22)
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52n/an/an/an/an/an/an/an/a


TBA

Assay Description
Competitive inhibition Trypanosoma brucei PFK using fructose-6-phosphate as substrate by Line-weaver Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446088
PNG
(CHEMBL3108870)
Show SMILES Fc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nncs2)cc1Cl
Show InChI InChI=1S/C16H12ClFN4O3S2/c17-13-7-10(1-6-14(13)18)8-15(23)20-11-2-4-12(5-3-11)27(24,25)22-16-21-19-9-26-16/h1-7,9H,8H2,(H,20,23)(H,21,22)
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240n/an/an/an/an/an/an/an/a


TBA

Assay Description
Mixed type inhibition Trypanosoma brucei PFK using ATP as substrate by Line-weaver Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50320388
PNG
(CHEMBL1083627 | polysin)
Show SMILES C[C@@]12CC[C@H]3C(C)(C)C(=O)CC[C@]3(C)[C@@H]1Cc1cc3ccccc3n21
Show InChI InChI=1S/C23H29NO/c1-21(2)18-9-12-23(4)19(22(18,3)11-10-20(21)25)14-16-13-15-7-5-6-8-17(15)24(16)23/h5-8,13,18-19H,9-12,14H2,1-4H3/t18-,19-,22-,23+/m0/s1
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9.00E+3n/an/an/an/an/an/an/an/a



University of Yaound£ I

Curated by ChEMBL


Assay Description
Competitive reversible inhibition of Trypanosoma brucei PFK expressed in Escherichia coli using fructose-6-phosphate by spectrophotometry analysis


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50320385
PNG
((4aR,6aR,12bS)-4,4,6a,12b-Tetramethyl-1,4a,5,6,6a,...)
Show SMILES C[C@@]12CC[C@H]3C(C)(C)C(=O)CC[C@]3(C)C1Cc1cc3ccccc3n21
Show InChI InChI=1S/C23H29NO/c1-21(2)18-9-12-23(4)19(22(18,3)11-10-20(21)25)14-16-13-15-7-5-6-8-17(15)24(16)23/h5-8,13,18-19H,9-12,14H2,1-4H3/t18-,19?,22-,23+/m0/s1
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1.00E+4n/an/an/an/an/an/an/an/a



University of Yaound£ I

Curated by ChEMBL


Assay Description
Competitive reversible inhibition of Trypanosoma brucei PFK expressed in Escherichia coli using fructose-6-phosphate by spectrophotometry analysis


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446088
PNG
(CHEMBL3108870)
Show SMILES Fc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nncs2)cc1Cl
Show InChI InChI=1S/C16H12ClFN4O3S2/c17-13-7-10(1-6-14(13)18)8-15(23)20-11-2-4-12(5-3-11)27(24,25)22-16-21-19-9-26-16/h1-7,9H,8H2,(H,20,23)(H,21,22)
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n/an/a 15n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446090
PNG
(CHEMBL3108868)
Show SMILES Fc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)cc1Cl
Show InChI InChI=1S/C17H13ClFN3O3S2/c18-14-9-11(1-6-15(14)19)10-16(23)21-12-2-4-13(5-3-12)27(24,25)22-17-20-7-8-26-17/h1-9H,10H2,(H,20,22)(H,21,23)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446091
PNG
(CHEMBL3108867)
Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nccs2)cc1Cl
Show InChI InChI=1S/C17H13Cl2N3O3S2/c18-14-6-1-11(9-15(14)19)10-16(23)21-12-2-4-13(5-3-12)27(24,25)22-17-20-7-8-26-17/h1-9H,10H2,(H,20,22)(H,21,23)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446089
PNG
(CHEMBL3108869)
Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2nncs2)cc1Cl
Show InChI InChI=1S/C16H12Cl2N4O3S2/c17-13-6-1-10(7-14(13)18)8-15(23)20-11-2-4-12(5-3-11)27(24,25)22-16-21-19-9-26-16/h1-7,9H,8H2,(H,20,23)(H,21,22)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446095
PNG
(CHEMBL3108863)
Show SMILES OC(=O)c1ccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)cc1
Show InChI InChI=1S/C21H16Cl2N2O5S/c22-18-10-1-13(11-19(18)23)12-20(26)24-15-6-8-17(9-7-15)31(29,30)25-16-4-2-14(3-5-16)21(27)28/h1-11,25H,12H2,(H,24,26)(H,27,28)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446097
PNG
(CHEMBL3108861)
Show SMILES OC(=O)c1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1
Show InChI InChI=1S/C21H16Cl2N2O5S/c22-18-9-4-13(10-19(18)23)11-20(26)24-15-5-7-17(8-6-15)31(29,30)25-16-3-1-2-14(12-16)21(27)28/h1-10,12,25H,11H2,(H,24,26)(H,27,28)
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n/an/a 260n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446100
PNG
(CHEMBL3108858)
Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccon2)cc1Cl
Show InChI InChI=1S/C17H13Cl2N3O4S/c18-14-6-1-11(9-15(14)19)10-17(23)20-12-2-4-13(5-3-12)27(24,25)22-16-7-8-26-21-16/h1-9H,10H2,(H,20,23)(H,21,22)
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n/an/a 370n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446129
PNG
(CHEMBL1394402)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)21-18(24)10-12-2-7-15(19)16(20)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446099
PNG
(CHEMBL3108859)
Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccn[nH]2)cc1Cl
Show InChI InChI=1S/C17H14Cl2N4O3S/c18-14-6-1-11(9-15(14)19)10-17(24)21-12-2-4-13(5-3-12)27(25,26)23-16-7-8-20-22-16/h1-9H,10H2,(H,21,24)(H2,20,22,23)
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n/an/a 520n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446102
PNG
(CHEMBL3108856)
Show SMILES OS(=O)(=O)c1ccc(NC(=O)Cc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C14H11Cl2NO4S/c15-12-6-1-9(7-13(12)16)8-14(18)17-10-2-4-11(5-3-10)22(19,20)21/h1-7H,8H2,(H,17,18)(H,19,20,21)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446113
PNG
(CHEMBL3108846)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(c3)C(F)(F)F)cc2)no1
Show InChI InChI=1S/C19H15ClF3N3O4S/c1-11-8-17(25-30-11)26-31(28,29)14-5-3-13(4-6-14)24-18(27)10-12-2-7-16(20)15(9-12)19(21,22)23/h2-9H,10H2,1H3,(H,24,27)(H,25,26)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446112
PNG
(CHEMBL3108847)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(F)c3)cc2)no1
Show InChI InChI=1S/C18H15ClFN3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)21-18(24)10-12-2-7-15(19)16(20)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446111
PNG
(CHEMBL3108848)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(F)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C18H15ClFN3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)21-18(24)10-12-2-7-16(20)15(19)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446094
PNG
(CHEMBL3108864)
Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2cncnc2)cc1Cl
Show InChI InChI=1S/C18H14Cl2N4O3S/c19-16-6-1-12(7-17(16)20)8-18(25)23-13-2-4-15(5-3-13)28(26,27)24-14-9-21-11-22-10-14/h1-7,9-11,24H,8H2,(H,23,25)
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TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446093
PNG
(CHEMBL3108865)
Show SMILES Oc1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1
Show InChI InChI=1S/C20H16Cl2N2O4S/c21-18-9-4-13(10-19(18)22)11-20(26)23-14-5-7-17(8-6-14)29(27,28)24-15-2-1-3-16(25)12-15/h1-10,12,24-25H,11H2,(H,23,26)
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n/an/a 1.46E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446115
PNG
(CHEMBL3108844)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)cc3)cc2)no1
Show InChI InChI=1S/C18H16ClN3O4S/c1-12-10-17(21-26-12)22-27(24,25)16-8-6-15(7-9-16)20-18(23)11-13-2-4-14(19)5-3-13/h2-10H,11H2,1H3,(H,20,23)(H,21,22)
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n/an/a 1.83E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446098
PNG
(CHEMBL3108860)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)n(C)n1
Show InChI InChI=1S/C19H18Cl2N4O3S/c1-12-9-18(25(2)23-12)24-29(27,28)15-6-4-14(5-7-15)22-19(26)11-13-3-8-16(20)17(21)10-13/h3-10,24H,11H2,1-2H3,(H,22,26)
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n/an/a 2.31E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446118
PNG
(CHEMBL3108841)
Show SMILES Cc1cc(NS(=O)(=O)Cc2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-8-18(23-28-12)24-29(26,27)11-13-2-5-15(6-3-13)22-19(25)10-14-4-7-16(20)17(21)9-14/h2-9H,10-11H2,1H3,(H,22,25)(H,23,24)
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n/an/a 2.59E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446120
PNG
(CHEMBL3108839)
Show SMILES CN(c1cc(C)on1)S(=O)(=O)c1ccc(NC(=O)Cc2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-9-18(23-28-12)24(2)29(26,27)15-6-4-14(5-7-15)22-19(25)11-13-3-8-16(20)17(21)10-13/h3-10H,11H2,1-2H3,(H,22,25)
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n/an/a 2.91E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50336799
PNG
(5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...)
Show SMILES Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
Show InChI InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)
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n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446114
PNG
(CHEMBL3108845)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)cc3Cl)cc2)no1
Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-8-17(22-27-11)23-28(25,26)15-6-4-14(5-7-15)21-18(24)9-12-2-3-13(19)10-16(12)20/h2-8,10H,9H2,1H3,(H,21,24)(H,22,23)
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n/an/a 4.61E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446122
PNG
(CHEMBL3108837)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(cc2)C(=O)NCc2ccc(Cl)c(Cl)c2)no1
Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-8-17(22-27-11)23-28(25,26)14-5-3-13(4-6-14)18(24)21-10-12-2-7-15(19)16(20)9-12/h2-9H,10H2,1H3,(H,21,24)(H,22,23)
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n/an/a 5.16E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446104
PNG
(CHEMBL3108854)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)CCc3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-10-18(23-28-12)24-29(26,27)15-6-4-14(5-7-15)22-19(25)9-3-13-2-8-16(20)17(21)11-13/h2,4-8,10-11H,3,9H2,1H3,(H,22,25)(H,23,24)
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n/an/a 5.17E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446092
PNG
(CHEMBL3108866)
Show SMILES CN(C)c1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1
Show InChI InChI=1S/C22H21Cl2N3O3S/c1-27(2)18-5-3-4-17(14-18)26-31(29,30)19-9-7-16(8-10-19)25-22(28)13-15-6-11-20(23)21(24)12-15/h3-12,14,26H,13H2,1-2H3,(H,25,28)
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n/an/a 5.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446110
PNG
(CHEMBL3108849)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(C)c(F)c3)cc2)no1
Show InChI InChI=1S/C19H18FN3O4S/c1-12-3-4-14(10-17(12)20)11-19(24)21-15-5-7-16(8-6-15)28(25,26)23-18-9-13(2)27-22-18/h3-10H,11H2,1-2H3,(H,21,24)(H,22,23)
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n/an/a 5.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446123
PNG
(CHEMBL3108836)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NCCc3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C18H17Cl2N3O3S/c1-12-10-18(22-26-12)23-27(24,25)15-5-3-14(4-6-15)21-9-8-13-2-7-16(19)17(20)11-13/h2-7,10-11,21H,8-9H2,1H3,(H,22,23)
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446124
PNG
(CHEMBL3108835)
Show SMILES CN(C(=O)Cc1ccc(Cl)c(Cl)c1)c1ccc(cc1)S(=O)(=O)Nc1cc(C)on1
Show InChI InChI=1S/C19H17Cl2N3O4S/c1-12-9-18(22-28-12)23-29(26,27)15-6-4-14(5-7-15)24(2)19(25)11-13-3-8-16(20)17(21)10-13/h3-10H,11H2,1-2H3,(H,22,23)
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n/an/a 6.51E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446106
PNG
(CHEMBL3108852)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc4ccccc4c3)cc2)no1
Show InChI InChI=1S/C22H19N3O4S/c1-15-12-21(24-29-15)25-30(27,28)20-10-8-19(9-11-20)23-22(26)14-16-6-7-17-4-2-3-5-18(17)13-16/h2-13H,14H2,1H3,(H,23,26)(H,24,25)
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n/an/a 6.51E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446116
PNG
(CHEMBL3108843)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3cccc(Cl)c3)cc2)no1
Show InChI InChI=1S/C18H16ClN3O4S/c1-12-9-17(21-26-12)22-27(24,25)16-7-5-15(6-8-16)20-18(23)11-13-3-2-4-14(19)10-13/h2-10H,11H2,1H3,(H,20,23)(H,21,22)
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n/an/a 7.30E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446105
PNG
(CHEMBL3108853)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C17H13Cl2N3O4S/c1-10-8-16(21-26-10)22-27(24,25)13-5-3-12(4-6-13)20-17(23)11-2-7-14(18)15(19)9-11/h2-9H,1H3,(H,20,23)(H,21,22)
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n/an/a 1.46E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446128
PNG
(CHEMBL3108831)
Show SMILES Cc1cc(NS(=O)(=O)c2cccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)c2)no1
Show InChI InChI=1S/C18H15Cl2N3O4S/c1-11-7-17(22-27-11)23-28(25,26)14-4-2-3-13(10-14)21-18(24)9-12-5-6-15(19)16(20)8-12/h2-8,10H,9H2,1H3,(H,21,24)(H,22,23)
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n/an/a 1.63E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446101
PNG
(CHEMBL3108857)
Show SMILES Clc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2ccccc2)cc1Cl
Show InChI InChI=1S/C20H16Cl2N2O3S/c21-18-11-6-14(12-19(18)22)13-20(25)23-15-7-9-17(10-8-15)28(26,27)24-16-4-2-1-3-5-16/h1-12,24H,13H2,(H,23,25)
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n/an/a 1.63E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446109
PNG
(CHEMBL3108850)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(C)c(C)c3)cc2)no1
Show InChI InChI=1S/C20H21N3O4S/c1-13-4-5-16(10-14(13)2)12-20(24)21-17-6-8-18(9-7-17)28(25,26)23-19-11-15(3)27-22-19/h4-11H,12H2,1-3H3,(H,21,24)(H,22,23)
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n/an/a 1.83E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50320385
PNG
((4aR,6aR,12bS)-4,4,6a,12b-Tetramethyl-1,4a,5,6,6a,...)
Show SMILES C[C@@]12CC[C@H]3C(C)(C)C(=O)CC[C@]3(C)C1Cc1cc3ccccc3n21
Show InChI InChI=1S/C23H29NO/c1-21(2)18-9-12-23(4)19(22(18,3)11-10-20(21)25)14-16-13-15-7-5-6-8-17(15)24(16)23/h5-8,13,18-19H,9-12,14H2,1-4H3/t18-,19?,22-,23+/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of Yaound£ I

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei PFK expressed in Escherichia coli


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50270350
PNG
(2,5-Anhydro-1-deoxy-1-(3,4-dichlorobenzylamino)-D-...)
Show SMILES O[C@H]1[C@H](O)[C@H](O[C@@H]1CNCc1ccc(Cl)c(Cl)c1)C(=O)NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H20Cl4N2O4/c21-12-3-1-10(5-14(12)23)7-25-9-16-17(27)18(28)19(30-16)20(29)26-8-11-2-4-13(22)15(24)6-11/h1-6,16-19,25,27-28H,7-9H2,(H,26,29)/t16-,17-,18+,19+/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei phosphofructokinase


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50320387
PNG
(CHEMBL1086376 | polyveoline)
Show SMILES C[C@@]12CC[C@H]3C(C)(C)[C@H](O)CC[C@]3(C)[C@@H]1C[C@@H]1Nc3ccccc3[C@H]21
Show InChI InChI=1S/C23H33NO/c1-21(2)17-9-11-23(4)18(22(17,3)12-10-19(21)25)13-16-20(23)14-7-5-6-8-15(14)24-16/h5-8,16-20,24-25H,9-13H2,1-4H3/t16-,17-,18-,19+,20-,22-,23+/m0/s1
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n/an/a 3.00E+4n/an/an/an/an/an/a



University of Yaound£ I

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei PFK expressed in Escherichia coli


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446126
PNG
(CHEMBL3108833)
Show SMILES Cc1cc(NS(=O)(=O)CCNC(=O)Cc2ccc(Cl)c(Cl)c2)no1
Show InChI InChI=1S/C14H15Cl2N3O4S/c1-9-6-13(18-23-9)19-24(21,22)5-4-17-14(20)8-10-2-3-11(15)12(16)7-10/h2-3,6-7H,4-5,8H2,1H3,(H,17,20)(H,18,19)
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n/an/a 3.26E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446127
PNG
(CHEMBL3108832)
Show SMILES Cc1cc(NS(=O)(=O)C2CCN(CC2)C(=O)Cc2ccc(Cl)c(Cl)c2)no1
Show InChI InChI=1S/C17H19Cl2N3O4S/c1-11-8-16(20-26-11)21-27(24,25)13-4-6-22(7-5-13)17(23)10-12-2-3-14(18)15(19)9-12/h2-3,8-9,13H,4-7,10H2,1H3,(H,20,21)
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n/an/a 3.30E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446117
PNG
(CHEMBL3108842)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccccc3)cc2)no1
Show InChI InChI=1S/C18H17N3O4S/c1-13-11-17(20-25-13)21-26(23,24)16-9-7-15(8-10-16)19-18(22)12-14-5-3-2-4-6-14/h2-11H,12H2,1H3,(H,19,22)(H,20,21)
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n/an/a 3.66E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446103
PNG
(CHEMBL3108855)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NC(=O)C(C)(C)c3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C20H19Cl2N3O4S/c1-12-10-18(24-29-12)25-30(27,28)15-7-5-14(6-8-15)23-19(26)20(2,3)13-4-9-16(21)17(22)11-13/h4-11H,1-3H3,(H,23,26)(H,24,25)
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n/an/a 3.66E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446121
PNG
(CHEMBL3108838)
Show SMILES Cc1cc(NS(=O)(=O)c2ccc(NS(=O)(=O)Cc3ccc(Cl)c(Cl)c3)cc2)no1
Show InChI InChI=1S/C17H15Cl2N3O5S2/c1-11-8-17(20-27-11)22-29(25,26)14-5-3-13(4-6-14)21-28(23,24)10-12-2-7-15(18)16(19)9-12/h2-9,21H,10H2,1H3,(H,20,22)
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n/an/a 3.70E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50270447
PNG
((2S,3S,4S,5R)-N-(3,4-dichlorobenzyl)-5-((cyclohept...)
Show SMILES O[C@H]1[C@H](O)[C@H](O[C@@H]1CNC1CCCCCC1)C(=O)NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H28Cl2N2O4/c21-14-8-7-12(9-15(14)22)10-24-20(27)19-18(26)17(25)16(28-19)11-23-13-5-3-1-2-4-6-13/h7-9,13,16-19,23,25-26H,1-6,10-11H2,(H,24,27)/t16-,17-,18+,19+/m1/s1
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n/an/a 4.90E+4n/an/an/an/an/an/a



University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei phosphofructokinase


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50270348
PNG
((2S,3S,4S,5R)-5-((3,4-dichlorobenzylamino)methyl)-...)
Show SMILES O[C@H]1[C@H](O)[C@H](O[C@@H]1CNCc1ccc(Cl)c(Cl)c1)C(=O)NCC=C
Show InChI InChI=1S/C16H20Cl2N2O4/c1-2-5-20-16(23)15-14(22)13(21)12(24-15)8-19-7-9-3-4-10(17)11(18)6-9/h2-4,6,12-15,19,21-22H,1,5,7-8H2,(H,20,23)/t12-,13-,14+,15+/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of Trypanosoma brucei phosphofructokinase


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446108
PNG
(CHEMBL3108851)
Show SMILES COc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2cc(C)on2)cc1C
Show InChI InChI=1S/C20H21N3O5S/c1-13-10-15(4-9-18(13)27-3)12-20(24)21-16-5-7-17(8-6-16)29(25,26)23-19-11-14(2)28-22-19/h4-11H,12H2,1-3H3,(H,21,24)(H,22,23)
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n/an/a>5.70E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446107
PNG
(CHEMBL1873990)
Show SMILES COc1ccc(CC(=O)Nc2ccc(cc2)S(=O)(=O)Nc2cc(C)on2)cc1OC
Show InChI InChI=1S/C20H21N3O6S/c1-13-10-19(22-29-13)23-30(25,26)16-7-5-15(6-8-16)21-20(24)12-14-4-9-17(27-2)18(11-14)28-3/h4-11H,12H2,1-3H3,(H,21,24)(H,22,23)
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n/an/a>5.70E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
6-phospho-1-fructokinase


(Trypanosoma brucei)
BDBM50446096
PNG
(CHEMBL3108862)
Show SMILES CCOC(=O)c1cccc(NS(=O)(=O)c2ccc(NC(=O)Cc3ccc(Cl)c(Cl)c3)cc2)c1
Show InChI InChI=1S/C23H20Cl2N2O5S/c1-2-32-23(29)16-4-3-5-18(14-16)27-33(30,31)19-9-7-17(8-10-19)26-22(28)13-15-6-11-20(24)21(25)12-15/h3-12,14,27H,2,13H2,1H3,(H,26,28)
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n/an/a>5.70E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assay


Citation and Details
More data for this
Ligand-Target Pair
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