Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332698![]() (US10196378, Compound C01) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332699![]() (US10196378, Compound C02) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332700![]() (US10196378, Compound C03) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332702![]() (US10196378, Compound C05) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | <1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332701![]() (US10196378, Compound C04) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332703![]() (US10196378, Compound C06) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM332704![]() (US10196378, Compound C07) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | 119 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Regents of the University of Michigan US Patent | Assay Description The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state. | US Patent US10196378 (2019) BindingDB Entry DOI: 10.7270/Q2ZG6VCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM25117![]() (AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...) | PDB GoogleScholar | Purchase CHEBI PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.418 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Pfizer Inc US Patent | Assay Description Axitinib was tested using a Z′-LYTE Screening Protocol (Invitrogen, Carlsbad, Calif.). Axitinib was prepared in 100% DMSO, and added to the rea... | US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM25117![]() (AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...) | PDB GoogleScholar | Purchase CHEBI PC cid PC sid UniChem Patents | US Patent | n/a | n/a | 0.551 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Pfizer Inc US Patent | Assay Description Axitinib was tested with the Caliper LabChip3000 assay (Caliper Life Science, Hopkinton, Mass.), which is a mobility-shift assay (MSA) that combines ... | US Patent US9205078 (2015) BindingDB Entry DOI: 10.7270/Q2K64GVG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50322535![]() (3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...) | PDB GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM206084![]() (US9255107, 3) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.12 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM206085![]() (US9255107, 5) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.28 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM378885![]() (US10266537, Compound 93) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Chuan University US Patent | Assay Description The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot... | US Patent US10266537 (2019) BindingDB Entry DOI: 10.7270/Q21C2065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM206087![]() (US9255107, 9) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.45 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM206089![]() (US9255107, 19) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.81 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM81734![]() (PPY-A) | PDB GoogleScholar | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ARIAD Pharmaceuticals Inc | Assay Description Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET... | Chem Biol Drug Des 70: 171-81 (2007) Article DOI: 10.1111/j.1747-0285.2007.00556.x BindingDB Entry DOI: 10.7270/Q228063T | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM81735![]() (PPY-B) | PDB GoogleScholar | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ARIAD Pharmaceuticals Inc | Assay Description Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET... | Chem Biol Drug Des 70: 171-81 (2007) Article DOI: 10.1111/j.1747-0285.2007.00556.x BindingDB Entry DOI: 10.7270/Q228063T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260151![]() (US9522910, Table 1 Compound 1: 4-methyl-N-{4-[(4-m...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260157![]() (US9522910, Table 1 Compound 8: 4-fluoro-N-{4-[(4-m...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260158![]() (US9522910, Table 1 Compound 7: 3-{2-[2-methyl-5-({...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260156![]() (US9522910, Table 1 Compound 6: 3-{2-[2-methyl-5-({...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260155![]() (US9522910, Table 1 Compound 5: 4-methyl-N-{4-[(4-m...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260154![]() (US9522910, Table 1 Compound 4: 3-{2-[2-methyl-5-({...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260153![]() (US9522910, Table 1 Compound 3: 3-{2-[2-methyl-5-({...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM260152![]() (US9522910, Table 1 Compound 2: 3-[2-(1H-1,3-benzod...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | <20 | n/a | n/a | n/a | n/a | n/a | n/a |
OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU “FUSION PHARMA” US Patent | Assay Description Kinase activity and inhibition was measured by established protocols (see e.g. Braunwalder et al., A Solid-Phase Assay for the Determination of Prote... | US Patent US9522910 (2016) BindingDB Entry DOI: 10.7270/Q2542MHG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM206086![]() (US9255107, 6) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 39.4 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM81736![]() (PPY-C) | PDB GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ARIAD Pharmaceuticals Inc | Assay Description Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET... | Chem Biol Drug Des 70: 171-81 (2007) Article DOI: 10.1111/j.1747-0285.2007.00556.x BindingDB Entry DOI: 10.7270/Q228063T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM206088![]() (US9255107, 18) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 57.9 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50086442![]() (CHEMBL3426233 | US10266537, Compound 121) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 133 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Chuan University US Patent | Assay Description The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot... | US Patent US10266537 (2019) BindingDB Entry DOI: 10.7270/Q21C2065 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50294011![]() ((E)-3-(2-(6-(Cyclopropylamino)-9H-purin-9-yl)vinyl...) | PDB GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 478 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM13216![]() (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ARIAD Pharmaceuticals Inc | Assay Description Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET... | Chem Biol Drug Des 70: 171-81 (2007) Article DOI: 10.1111/j.1747-0285.2007.00556.x BindingDB Entry DOI: 10.7270/Q228063T | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM13530![]() (4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
NANJING SANHOME PHARMACEUTICAL CO., LTD. US Patent | Assay Description Serially diluting the compound of the present invention from 1 uM initial concentration in three-fold fashion and formulating 10 concentrations (50.8... | US Patent US9255107 (2016) BindingDB Entry DOI: 10.7270/Q22806F9 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50237710![]() (4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM82130![]() (Dasatinib) | PDB GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50244526![]() (9-(2-(1H-indol-4-yl)vinyl)-N-(4-(dimethylphosphory...) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50244430![]() (9-(2,6-dimethylstyryl)-N-(4-(dimethylphosphoryl)ph...) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50293992![]() ((E)-3-(2-(Purin-9-yl)vinyl)-4-methyl-N-(3-(4-methy...) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50244569![]() (AP24283 | CHEMBL510893 | N-(4-(dimethylphosphoryl)...) | PDB GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM13216![]() (BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 25 |
ARIAD Pharmaceuticals Inc | Assay Description Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET... | Chem Biol Drug Des 70: 171-81 (2007) Article DOI: 10.1111/j.1747-0285.2007.00556.x BindingDB Entry DOI: 10.7270/Q228063T | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM50244527![]() (9-(2-(1H-indazol-4-yl)vinyl)-N-(4-(dimethylphospho...) | PDB GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ARIAD Pharmaceuticals Inc | Assay Description In vitro kinase assay using Abl, Abl T315I or Src kinase. | Chem Biol Drug Des 75: 18-28 (2010) Article DOI: 10.1111/j.1747-0285.2009.00905.x BindingDB Entry DOI: 10.7270/Q2MC8XHX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM13534![]() (CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM4814![]() (CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM13535![]() (4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...) | PDB MMDB B.MOAD GoogleScholar | Purchase CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Ambit, Inc. | Assay Description Competition binding assay was used to measure the interaction between the phage-tagged kinase, immobilized competitive ligand, and unlinked test comp... | Proc Natl Acad Sci U S A 102: 11011-6 (2005) Article DOI: 10.1073/pnas.0504952102 BindingDB Entry DOI: 10.7270/Q29C6VNB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM21079![]() (1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-...) | PDB GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.70E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM31085![]() (1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...) | PDB GoogleScholar | Purchase PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | 2.30 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM26300![]() (2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...) | PDB GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM13533![]() (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB GoogleScholar | Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 42 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM25118![]() ((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...) | PDB GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 630 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM31088![]() (1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...) | PDB GoogleScholar | Purchase PC cid PC sid PDB UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ABL Mutant (T315I) (Homo sapiens (Human)) | BDBM4779![]() (CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid UniChem Patents Similars | PCBioAssay | n/a | n/a | n/a | 550 | n/a | n/a | n/a | 7.4 | 25 |
Ambit Biosciences Curated by PubChem BioAssay | Assay Description Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity... | PubChem Bioassay (2008) BindingDB Entry DOI: 10.7270/Q2NC5ZHH | |||||||||||
More data for this Ligand-Target Pair |
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