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Found 409 hits Enz. Inhib. hit(s) with Target = 'AXL receptor tyrosine kinase' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50355491
PNG
(CHEMBL1835870)
Show SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1
Show InChI InChI=1S/C23H29N7O/c24-22-27-23(28-30(22)21-3-1-2-12-25-21)26-19-8-4-17(5-9-19)18-6-10-20(11-7-18)29-13-15-31-16-14-29/h1-5,8-9,12,18,20H,6-7,10-11,13-16H2,(H3,24,26,27,28)/t18-,20-
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40n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of AXL


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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63n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to AXL (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50306682
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of AXL in human HEK293 cells assessed as growth factor-induced autophosphorylation by sandwich ELISA method


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM28031
PNG
(BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)
Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1
Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
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n/an/a 1.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384584
PNG
(CHEMBL2036807)
Show SMILES N[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H40N8/c32-26-12-8-24(9-13-26)22-39-30-28(21-35-31(36-30)34-16-4-7-23-5-2-1-3-6-23)29(37-39)25-10-14-27(15-11-25)38-19-17-33-18-20-38/h1-3,5-6,10-11,14-15,21,24,26,33H,4,7-9,12-13,16-20,22,32H2,(H,34,35,36)/t24-,26-
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n/an/a 1.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384582
PNG
(CHEMBL2036805)
Show SMILES N[C@H]1CC[C@H](Cn2nc(-c3ccc(nc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C30H39N9/c31-25-11-8-23(9-12-25)21-39-29-26(20-35-30(36-29)33-14-4-7-22-5-2-1-3-6-22)28(37-39)24-10-13-27(34-19-24)38-17-15-32-16-18-38/h1-3,5-6,10,13,19-20,23,25,32H,4,7-9,11-12,14-18,21,31H2,(H,33,35,36)/t23-,25-
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n/an/a 3.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384583
PNG
(CHEMBL2036806)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H38N8/c1-2-3-12-29-26-30-17-23-24(20-6-10-22(11-7-20)33-15-13-28-14-16-33)32-34(25(23)31-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21,28H,2-5,8-9,12-16,18,27H2,1H3,(H,29,30,31)/t19-,21-
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM180278
PNG
(US9133162, Example 9)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)cc2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H30N4O5/c1-20-28(30(37)35(34(20)4)22-8-6-5-7-9-22)29(36)33-21-10-12-23(13-11-21)40-27-16-17-32-26-18-24(14-15-25(26)27)39-19-31(2,3)38/h5-18,38H,19H2,1-4H3,(H,33,36)
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US Patent
n/an/a 5n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC

US Patent


Assay Description
Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...


US Patent US9133162 (2015)

More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50393544
PNG
(CHEMBL2158230 | US8697716, 34)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CCN(CCN2CCOCC2)CC1)c1ncc([nH]1)C#N
Show InChI InChI=1S/C28H36N6O2/c29-19-24-20-30-27(31-24)28(35)32-26-7-6-23(18-25(26)22-4-2-1-3-5-22)21-8-10-33(11-9-21)12-13-34-14-16-36-17-15-34/h4,6-7,18,20-21H,1-3,5,8-17H2,(H,30,31)(H,32,35)
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n/an/a 6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of AXL


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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n/an/a 6.40n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Axl after 11 mins by fluorescence polarization


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM27917
PNG
(4-cyano-N-[4-(4-methylpiperazin-1-yl)-2-(4-methylp...)
Show SMILES CC1CCN(CC1)c1cc(ccc1NC(=O)c1cc(c[nH]1)C#N)N1CCN(C)CC1
Show InChI InChI=1S/C23H30N6O/c1-17-5-7-29(8-6-17)22-14-19(28-11-9-27(2)10-12-28)3-4-20(22)26-23(30)21-13-18(15-24)16-25-21/h3-4,13-14,16-17,25H,5-12H2,1-2H3,(H,26,30)
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TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM180270
PNG
(US9133162, Example 1)
Show SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C
Show InChI InChI=1S/C31H29FN4O5/c1-19-28(30(38)36(35(19)4)21-8-6-5-7-9-21)29(37)34-20-10-13-27(24(32)16-20)41-26-14-15-33-25-17-22(11-12-23(25)26)40-18-31(2,3)39/h5-17,39H,18H2,1-4H3,(H,34,37)
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US Patent
n/an/a 11n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC

US Patent


Assay Description
Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...


US Patent US9133162 (2015)

More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50355499
PNG
(CHEMBL1908395 | CHEMBL1908842)
Show SMILES CN(C)CC(=O)N1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)
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n/an/a 12n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of AXL


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384581
PNG
(CHEMBL2036804)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C25H37N9/c1-2-3-10-28-25-30-16-21-23(19-6-9-22(29-15-19)33-13-11-27-12-14-33)32-34(24(21)31-25)17-18-4-7-20(26)8-5-18/h6,9,15-16,18,20,27H,2-5,7-8,10-14,17,26H2,1H3,(H,28,30,31)/t18-,20-
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50055496
PNG
(CHEMBL3326006)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1
Show InChI InChI=1/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)/t23-,24-
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n/an/a 14n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin) by Off-chip Mobility Shift Assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382441
PNG
(CHEMBL2023349)
Show SMILES Nc1nc(Nc2ccc3CCC(CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1
Show InChI InChI=1S/C30H34N8/c31-29-33-30(32-24-13-10-20-11-14-25(15-12-22(20)18-24)37-16-3-4-17-37)36-38(29)27-19-23-8-5-7-21-6-1-2-9-26(21)28(23)35-34-27/h1-2,6,9-10,13,18-19,25H,3-5,7-8,11-12,14-17H2,(H3,31,32,33,36)
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TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50055490
PNG
(CHEMBL3326007)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cn([C@H]3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1
Show InChI InChI=1/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24-,25-
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n/an/a 15n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin) by Off-chip Mobility Shift Assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384585
PNG
(CHEMBL2036809)
Show SMILES N[C@H]1CC[C@H](Cn2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C27H31FN6/c28-22-12-10-21(11-13-22)25-24-17-31-27(30-16-4-7-19-5-2-1-3-6-19)32-26(24)34(33-25)18-20-8-14-23(29)15-9-20/h1-3,5-6,10-13,17,20,23H,4,7-9,14-16,18,29H2,(H,30,31,32)/t20-,23-
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50393541
PNG
(CHEMBL2158227)
Show SMILES CS(=O)(=O)CCN1CCC(CC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCCCC1
Show InChI InChI=1S/C25H31N5O3S/c1-34(32,33)14-13-30-11-9-18(10-12-30)20-7-8-23(22(15-20)19-5-3-2-4-6-19)29-25(31)24-27-17-21(16-26)28-24/h5,7-8,15,17-18H,2-4,6,9-14H2,1H3,(H,27,28)(H,29,31)
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n/an/a 16n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of AXL


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382443
PNG
(CHEMBL2023351)
Show SMILES COc1cc2c(Oc3cc(NS(=O)(=O)c4cc(F)ccc4F)ccc3F)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C31H32F3N3O5S/c1-20-9-13-37(14-10-20)12-3-15-41-30-19-26-23(18-29(30)40-2)27(8-11-35-26)42-28-17-22(5-7-24(28)33)36-43(38,39)31-16-21(32)4-6-25(31)34/h4-8,11,16-20,36H,3,9-10,12-15H2,1-2H3
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TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM180273
PNG
(US9133162, Example 4)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4c(C)n(C)n(-c5ccccc5)c4=O)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C32H31FN4O6/c1-19-29(31(39)37(36(19)4)21-9-7-6-8-10-21)30(38)35-20-11-12-26(23(33)15-20)43-25-13-14-34-24-17-28(42-18-32(2,3)40)27(41-5)16-22(24)25/h6-17,40H,18H2,1-5H3,(H,35,38)
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US Patent
n/an/a 17n/an/an/an/an/an/a



SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC

US Patent


Assay Description
Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...


US Patent US9133162 (2015)

More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM191640
PNG
(US9186318, 9)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCC(=O)NO
Show InChI InChI=1S/C31H28F2N4O7/c1-42-26-16-21-23(17-27(26)43-14-2-3-28(38)37-41)34-13-10-24(21)44-25-9-8-20(15-22(25)33)36-30(40)31(11-12-31)29(39)35-19-6-4-18(32)5-7-19/h4-10,13,15-17,41H,2-3,11-12,14H2,1H3,(H,35,39)(H,36,40)(H,37,38)
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US Patent
n/an/a 19n/an/an/an/an/an/a



Beijing Konruns Pharmaceutical Co., Ltd

US Patent


Assay Description
This example shows that the inhibitory activity of the compound, N1'-[3-fluoro-4-[[7-[4-(hydroxyamino)-4-oxobutoxy]-6-methoxy-4-quinolyl]oxy]phenyl]-...


US Patent US9186318 (2015)

More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382414
PNG
(CHEMBL2022975)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)N4CCCC4)n3)cc2)CC1
Show InChI InChI=1S/C26H32ClN7O2S/c1-32-14-16-33(17-15-32)19-20-8-10-21(11-9-20)29-26-28-18-22(27)25(31-26)30-23-6-2-3-7-24(23)37(35,36)34-12-4-5-13-34/h2-3,6-11,18H,4-5,12-17,19H2,1H3,(H2,28,29,30,31)
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n/an/a 19n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50055498
PNG
(CHEMBL3326004)
Show SMILES CCCCNc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(c(F)c1)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1/C27H37FN6O3S/c1-3-4-11-29-27-30-17-22-23(18-34(26(22)31-27)20-6-8-21(35)9-7-20)19-5-10-25(24(28)16-19)38(36,37)33-14-12-32(2)13-15-33/h5,10,16-18,20-21,35H,3-4,6-9,11-15H2,1-2H3,(H,29,30,31)/t20-,21-
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n/an/a 22n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin) by Off-chip Mobility Shift Assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382425
PNG
(CHEMBL2022968)
Show SMILES CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl
Show InChI InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
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n/an/a 27n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50431281
PNG
(CHEMBL2347987)
Show SMILES CC(C)S(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl
Show InChI InChI=1S/C25H31ClN6OS/c1-18(2)34(33)23-7-5-4-6-22(23)29-24-21(26)16-27-25(30-24)28-20-10-8-19(9-11-20)17-32-14-12-31(3)13-15-32/h4-11,16,18H,12-15,17H2,1-3H3,(H2,27,28,29,30)
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n/an/a 27n/an/an/an/an/an/a



Centre Universitaire

Curated by ChEMBL


Assay Description
Inhibition of AXL (unknown origin) phosphorylation expressed in mouse NIH/3T3 cells after 2 hrs by immunoprecipitation assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50443560
PNG
(CHEMBL3091723)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1ccc2c(NC(=O)C22CCN(C)CC2)c1)c1c(Cl)ccc(F)c1Cl
Show InChI InChI=1S/C26H25Cl2FN4O2/c1-14(22-18(27)5-6-19(29)23(22)28)35-21-12-16(13-31-24(21)30)15-3-4-17-20(11-15)32-25(34)26(17)7-9-33(2)10-8-26/h3-6,11-14H,7-10H2,1-2H3,(H2,30,31)(H,32,34)/t14-/m1/s1
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n/an/a 29n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human AXL (unknown origin) using EAIYAAPFAKKK peptide as substrate by nanoliter kinase assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382442
PNG
(CHEMBL2023350)
Show SMILES CN1CCC(CC1)n1cc(c(C)n1)-c1cnc(N)c(c1)-c1nc2ccccc2o1
Show InChI InChI=1S/C22H24N6O/c1-14-18(13-28(26-14)16-7-9-27(2)10-8-16)15-11-17(21(23)24-12-15)22-25-19-5-3-4-6-20(19)29-22/h3-6,11-13,16H,7-10H2,1-2H3,(H2,23,24)
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n/an/a 30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382431
PNG
(CHEMBL2022974)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NC4CC4)n3)cc2)CC1
Show InChI InChI=1S/C26H30ClN7O/c1-33-12-14-34(15-13-33)17-18-6-8-20(9-7-18)30-26-28-16-22(27)24(32-26)31-23-5-3-2-4-21(23)25(35)29-19-10-11-19/h2-9,16,19H,10-15,17H2,1H3,(H,29,35)(H2,28,30,31,32)
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n/an/a 32n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50055497
PNG
(CHEMBL3326005)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(-c2cn([C@H]3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)c(F)c1
Show InChI InChI=1/C28H37FN6O3S/c1-33-12-14-34(15-13-33)39(37,38)22-8-9-23(26(29)16-22)25-18-35(20-4-6-21(36)7-5-20)27-24(25)17-31-28(32-27)30-11-10-19-2-3-19/h8-9,16-21,36H,2-7,10-15H2,1H3,(H,30,31,32)/t20-,21-
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n/an/a 32n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin) by Off-chip Mobility Shift Assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384594
PNG
(CHEMBL2036630)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(OC)cc1
Show InChI InChI=1S/C20H26N6O/c1-22-20-23-11-17-18(14-5-9-16(27-2)10-6-14)25-26(19(17)24-20)12-13-3-7-15(21)8-4-13/h5-6,9-11,13,15H,3-4,7-8,12,21H2,1-2H3,(H,22,23,24)
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n/an/a 36n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384576
PNG
(CHEMBL2036808)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15-,18-
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n/an/a 37n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384576
PNG
(CHEMBL2036808)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15-,18-
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n/an/a 37n/an/an/an/an/an/a



Centre Universitaire

Curated by ChEMBL


Assay Description
Inhibition of AXL (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382433
PNG
(CHEMBL2022977)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccc(F)cc4S(=O)(=O)N4CCCC4)n3)cc2)CC1
Show InChI InChI=1S/C26H31ClFN7O2S/c1-33-12-14-34(15-13-33)18-19-4-7-21(8-5-19)30-26-29-17-22(27)25(32-26)31-23-9-6-20(28)16-24(23)38(36,37)35-10-2-3-11-35/h4-9,16-17H,2-3,10-15,18H2,1H3,(H2,29,30,31,32)
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n/an/a 37n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50444070
PNG
(CHEMBL3092795)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNC2CCCCC2)cn1
Show InChI InChI=1S/C26H40N6O/c1-2-3-15-27-26-30-18-23(25(32-26)31-21-10-12-22(33)13-11-21)24-14-9-19(17-29-24)16-28-20-7-5-4-6-8-20/h9,14,17-18,20-22,28,33H,2-8,10-13,15-16H2,1H3,(H2,27,30,31,32)/t21-,22-
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n/an/a 38n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384611
PNG
(CHEMBL2036787)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C27H32N6/c28-23-15-13-21(14-16-23)19-33-26-24(25(32-33)22-11-5-2-6-12-22)18-30-27(31-26)29-17-7-10-20-8-3-1-4-9-20/h1-6,8-9,11-12,18,21,23H,7,10,13-17,19,28H2,(H,29,30,31)
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n/an/a 38n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384608
PNG
(CHEMBL2036801)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C25H28N6/c26-21-13-11-19(12-14-21)17-31-24-22(23(30-31)20-9-5-2-6-10-20)16-28-25(29-24)27-15-18-7-3-1-4-8-18/h1-10,16,19,21H,11-15,17,26H2,(H,27,28,29)
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n/an/a 38n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 40n/an/an/an/an/an/a



Heinrich-Heine-Universit£t D£sseldorf

Curated by ChEMBL


Assay Description
Inhibition of AXL (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384610
PNG
(CHEMBL2036803)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C26H30N6/c27-22-13-11-20(12-14-22)18-32-25-23(24(31-32)21-9-5-2-6-10-21)17-29-26(30-25)28-16-15-19-7-3-1-4-8-19/h1-10,17,20,22H,11-16,18,27H2,(H,28,29,30)
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384603
PNG
(CHEMBL2036796)
Show SMILES CCCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C23H32N6/c1-2-3-7-14-25-23-26-15-20-21(18-8-5-4-6-9-18)28-29(22(20)27-23)16-17-10-12-19(24)13-11-17/h4-6,8-9,15,17,19H,2-3,7,10-14,16,24H2,1H3,(H,25,26,27)
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384598
PNG
(CHEMBL2036788)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C25H28N6/c1-27-25-28-15-22-23(20-11-9-19(10-12-20)18-5-3-2-4-6-18)30-31(24(22)29-25)16-17-7-13-21(26)14-8-17/h2-6,9-12,15,17,21H,7-8,13-14,16,26H2,1H3,(H,27,28,29)
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382439
PNG
(CHEMBL2023347)
Show SMILES CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N(C)C2CCN(C)CC2)ncc1Cl
Show InChI InChI=1S/C25H32ClN7O2S/c1-31(2)36(34,35)23-8-6-5-7-22(23)29-24-21(26)17-27-25(30-24)28-18-9-11-19(12-10-18)33(4)20-13-15-32(3)16-14-20/h5-12,17,20H,13-16H2,1-4H3,(H2,27,28,29,30)
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TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384577
PNG
(CHEMBL2036791)
Show SMILES CNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C22H31N9/c1-24-22-27-13-18-20(16-4-7-19(26-12-16)30-10-8-25-9-11-30)29-31(21(18)28-22)14-15-2-5-17(23)6-3-15/h4,7,12-13,15,17,25H,2-3,5-6,8-11,14,23H2,1H3,(H,24,27,28)
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50384609
PNG
(CHEMBL2036802)
Show SMILES COc1ccc(CNc2ncc3c(nn(CC4CCC(N)CC4)c3n2)-c2ccccc2)cc1
Show InChI InChI=1S/C26H30N6O/c1-33-22-13-9-18(10-14-22)15-28-26-29-16-23-24(20-5-3-2-4-6-20)31-32(25(23)30-26)17-19-7-11-21(27)12-8-19/h2-6,9-10,13-14,16,19,21H,7-8,11-12,15,17,27H2,1H3,(H,28,29,30)
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TBA

Assay Description
Inhibition of Axl using KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluid capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50444072
PNG
(CHEMBL3092793)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(cn1)C(=O)NC1CCN(C)CC1
Show InChI InChI=1S/C26H39N7O2/c1-3-4-13-27-26-29-17-22(24(32-26)30-19-6-8-21(34)9-7-19)23-10-5-18(16-28-23)25(35)31-20-11-14-33(2)15-12-20/h5,10,16-17,19-21,34H,3-4,6-9,11-15H2,1-2H3,(H,31,35)(H2,27,29,30,32)/t19-,21-
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n/an/a 61n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50425832
PNG
(CHEMBL2312290)
Show SMILES COc1ccc(CCNc2ncc(C(=O)NCCCN3CCCC3=O)c(NC3CCCC3)n2)cc1OC
Show InChI InChI=1S/C27H38N6O4/c1-36-22-11-10-19(17-23(22)37-2)12-14-29-27-30-18-21(25(32-27)31-20-7-3-4-8-20)26(35)28-13-6-16-33-15-5-9-24(33)34/h10-11,17-18,20H,3-9,12-16H2,1-2H3,(H,28,35)(H2,29,30,31,32)
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n/an/a 61n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of Axl (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50382430
PNG
(CHEMBL2022973)
Show SMILES CN1CCN(Cc2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)N4CCCC4)n3)cc2)CC1
Show InChI InChI=1S/C27H32ClN7O/c1-33-14-16-34(17-15-33)19-20-8-10-21(11-9-20)30-27-29-18-23(28)25(32-27)31-24-7-3-2-6-22(24)26(36)35-12-4-5-13-35/h2-3,6-11,18H,4-5,12-17,19H2,1H3,(H2,29,30,31,32)
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TBA

Assay Description
Inhibition of human recombinant His-tagged AXL kinase using fluorescein-labelled poly-GT as substrate after 60 mins by TR-FRET analysis


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50444074
PNG
(CHEMBL3092791)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CN(C)C)cn1
Show InChI InChI=1S/C22H34N6O/c1-4-5-12-23-22-25-14-19(20-11-6-16(13-24-20)15-28(2)3)21(27-22)26-17-7-9-18(29)10-8-17/h6,11,13-14,17-18,29H,4-5,7-10,12,15H2,1-3H3,(H2,23,25,26,27)/t17-,18-
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n/an/a 63n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50444068
PNG
(CHEMBL3092797)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(CNCCO)cn1
Show InChI InChI=1S/C22H34N6O2/c1-2-3-10-24-22-26-15-19(20-9-4-16(14-25-20)13-23-11-12-29)21(28-22)27-17-5-7-18(30)8-6-17/h4,9,14-15,17-18,23,29-30H,2-3,5-8,10-13H2,1H3,(H2,24,26,27,28)/t17-,18-
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University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
AXL receptor tyrosine kinase


(Homo sapiens (Human))
BDBM50444073
PNG
(CHEMBL3092792)
Show SMILES CCCCNc1ncc(c(N[C@H]2CC[C@H](O)CC2)n1)-c1ccc(cn1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C23H34N6O4S/c1-2-3-10-24-23-26-16-20(22(28-23)27-17-4-6-18(30)7-5-17)21-9-8-19(15-25-21)34(31,32)29-11-13-33-14-12-29/h8-9,15-18,30H,2-7,10-14H2,1H3,(H2,24,26,27,28)/t17-,18-
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University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of Axl kinase (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 as substrate after 180 mins by microfluidic capillary electrophoresis assay


Citation and Details
More data for this
Ligand-Target Pair
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