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Compile Data Set for Download or QSAR

Found 153 hits Enz. Inhib. hit(s) with Target = 'Acetyl-CoA carboxylase 1 (ACC1)' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365279
PNG
(CHEMBL1958360)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-12-24-25-19(14)16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)13-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
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n/an/a 7n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314903
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cn[nH]c1
Show InChI InChI=1S/C25H23N5O3/c1-15-8-17(9-18-12-28-29-23(15)18)24(32)30-6-4-25(5-7-30)11-21(31)20-10-16(2-3-22(20)33-25)19-13-26-27-14-19/h2-3,8-10,12-14H,4-7,11H2,1H3,(H,26,27)(H,28,29)
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n/an/a 7.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314904
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1-methyl-1...)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cnn(C)c1
Show InChI InChI=1S/C26H25N5O3/c1-16-9-18(10-19-13-27-29-24(16)19)25(33)31-7-5-26(6-8-31)12-22(32)21-11-17(3-4-23(21)34-26)20-14-28-30(2)15-20/h3-4,9-11,13-15H,5-8,12H2,1-2H3,(H,27,29)
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n/an/a 7.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365287
PNG
(CHEMBL1958368)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]cc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C24H28N4O3/c1-5-28-16(4)22-21(26-28)19(29)12-24(31-22)6-8-27(9-7-24)23(30)17-10-14(2)20-18(11-17)15(3)13-25-20/h10-11,13,25H,5-9,12H2,1-4H3
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n/an/a 9.10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365292
PNG
(CHEMBL1958373)
Show SMILES Cc1cc(cc2[nH]cnc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-14-9-15(10-16-19(14)25-13-24-16)21(30)27-7-5-23(6-8-27)11-17(29)20-18(31-23)12-28(26-20)22(2,3)4/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
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n/an/a 9.60n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365293
PNG
(CHEMBL1958374)
Show SMILES Cc1nc2c(C)cc(cc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C24H29N5O3/c1-14-10-16(11-17-20(14)26-15(2)25-17)22(31)28-8-6-24(7-9-28)12-18(30)21-19(32-24)13-29(27-21)23(3,4)5/h10-11,13H,6-9,12H2,1-5H3,(H,25,26)
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n/an/a 10n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365284
PNG
(CHEMBL1958365)
Show SMILES CCOc1cc(cc2c(C)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C24H29N5O4/c1-5-29-15(4)22-21(27-29)18(30)13-24(33-22)7-9-28(10-8-24)23(31)16-11-17-14(3)25-26-20(17)19(12-16)32-6-2/h11-12H,5-10,13H2,1-4H3,(H,25,26)
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n/an/a 11.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365281
PNG
(CHEMBL1958362)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C23H27N5O3/c1-5-28-15(4)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)14(3)24-25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365290
PNG
(CHEMBL1958371)
Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c2n1
Show InChI InChI=1S/C23H27N5O3/c1-13(2)28-12-19-21(26-28)18(29)11-23(31-19)5-7-27(8-6-23)22(30)16-9-14(3)20-17(10-16)15(4)24-25-20/h9-10,12-13H,5-8,11H2,1-4H3,(H,24,25)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314943
PNG
(1-(3,7-dimethyl-1H-indazole-5-carbonyl)-5'-isoprop...)
Show SMILES CC(C)Oc1nccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c12
Show InChI InChI=1S/C25H28N4O4/c1-14(2)32-23-21-19(30)13-25(33-20(21)5-8-26-23)6-9-29(10-7-25)24(31)17-11-15(3)22-18(12-17)16(4)27-28-22/h5,8,11-12,14H,6-7,9-10,13H2,1-4H3,(H,27,28)
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314929
PNG
(6-(3,5-dimethylisoxazol-4-yl)-1'-(7-methyl-1H-inda...)
Show SMILES Cc1noc(C)c1-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1
Show InChI InChI=1S/C27H26N4O4/c1-15-10-19(11-20-14-28-29-25(15)20)26(33)31-8-6-27(7-9-31)13-22(32)21-12-18(4-5-23(21)34-27)24-16(2)30-35-17(24)3/h4-5,10-12,14H,6-9,13H2,1-3H3,(H,28,29)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365294
PNG
(CHEMBL1955895)
Show SMILES Cn1ncc2ccc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C(C)(C)C
Show InChI InChI=1S/C23H27N5O3/c1-22(2,3)28-14-19-20(25-28)18(29)12-23(31-19)7-9-27(10-8-23)21(30)15-5-6-16-13-24-26(4)17(16)11-15/h5-6,11,13-14H,7-10,12H2,1-4H3
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n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365285
PNG
(CHEMBL1958366)
Show SMILES CCOc1cc(cc2c(CC)n[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C25H31N5O4/c1-5-18-17-12-16(13-20(33-7-3)21(17)27-26-18)24(32)29-10-8-25(9-11-29)14-19(31)22-23(34-25)15(4)30(6-2)28-22/h12-13H,5-11,14H2,1-4H3,(H,26,27)
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n/an/a 13n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365277
PNG
(CHEMBL1958359)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCC1
Show InChI InChI=1S/C24H27N5O3/c1-15-10-16(11-17-13-25-26-21(15)17)23(31)28-8-6-24(7-9-28)12-19(30)22-20(32-24)14-29(27-22)18-4-2-3-5-18/h10-11,13-14,18H,2-9,12H2,1H3,(H,25,26)
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n/an/a 14n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365276
PNG
(CHEMBL1958358)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCC1
Show InChI InChI=1S/C23H25N5O3/c1-14-9-15(10-16-12-24-25-20(14)16)22(30)27-7-5-23(6-8-27)11-18(29)21-19(31-23)13-28(26-21)17-3-2-4-17/h9-10,12-13,17H,2-8,11H2,1H3,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314896
PNG
(5-methoxy-1'-(2-phenyl-1H-benzo[d]imidazole-5-carb...)
Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3ccccc3)CC(=O)c12
Show InChI InChI=1S/C28H25N3O4/c1-34-23-8-5-9-24-25(23)22(32)17-28(35-24)12-14-31(15-13-28)27(33)19-10-11-20-21(16-19)30-26(29-20)18-6-3-2-4-7-18/h2-11,16H,12-15,17H2,1H3,(H,29,30)
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n/an/a 16n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50127711
PNG
(CHEMBL3629719)
Show SMILES C[C@@H]1N(CCC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OCC(C)(C)C
Show InChI InChI=1/C24H34N4O3/c1-16-12-18(13-19-14-25-26-20(16)19)21(29)27-9-6-24(7-10-27)8-11-28(17(24)2)22(30)31-15-23(3,4)5/h12-14,17H,6-11,15H2,1-5H3,(H,25,26)/t17-/s2
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n/an/a 16n/an/an/an/an/an/a



Pfizer

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365295
PNG
(CHEMBL1955896)
Show SMILES CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c3ccc4nc[nH]c4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-21(2,3)27-12-18-19(25-27)17(28)11-22(30-18)6-8-26(9-7-22)20(29)14-4-5-15-16(10-14)24-13-23-15/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,24)
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n/an/a 17n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314928
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...)
Show SMILES Cc1ncc(o1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1
Show InChI InChI=1S/C26H24N4O4/c1-15-9-18(10-19-13-28-29-24(15)19)25(32)30-7-5-26(6-8-30)12-21(31)20-11-17(3-4-22(20)34-26)23-14-27-16(2)33-23/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,28,29)
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50439637
PNG
(CHEMBL2419601)
Show SMILES CC(C)(C)n1cc2OC3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-21(2,3)27-13-18-19(25-27)17(28)11-22(30-18)6-8-26(9-7-22)20(29)14-4-5-16-15(10-14)12-23-24-16/h4-5,10,12-13H,6-9,11H2,1-3H3,(H,23,24)
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n/an/a 17n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant ACC1


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314886
PNG
(1'-(7-ethyl-1H-indazole-5-carbonyl)-6,7-dimethylsp...)
Show SMILES CCc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(C)c(C)cc1O2
Show InChI InChI=1S/C25H27N3O3/c1-4-17-11-18(12-19-14-26-27-23(17)19)24(30)28-7-5-25(6-8-28)13-21(29)20-9-15(2)16(3)10-22(20)31-25/h9-12,14H,4-8,13H2,1-3H3,(H,26,27)
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n/an/a 17.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314905
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1H-pyrazol...)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1cc[nH]n1
Show InChI InChI=1S/C25H23N5O3/c1-15-10-17(11-18-14-27-29-23(15)18)24(32)30-8-5-25(6-9-30)13-21(31)19-12-16(2-3-22(19)33-25)20-4-7-26-28-20/h2-4,7,10-12,14H,5-6,8-9,13H2,1H3,(H,26,28)(H,27,29)
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n/an/a 18n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314907
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(5-methyl-1...)
Show SMILES Cc1cc(n[nH]1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1
Show InChI InChI=1S/C26H25N5O3/c1-15-9-18(11-19-14-27-30-24(15)19)25(33)31-7-5-26(6-8-31)13-22(32)20-12-17(3-4-23(20)34-26)21-10-16(2)28-29-21/h3-4,9-12,14H,5-8,13H2,1-2H3,(H,27,30)(H,28,29)
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n/an/a 18n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314927
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(2-methylox...)
Show SMILES Cc1nc(co1)-c1ccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2c1
Show InChI InChI=1S/C26H24N4O4/c1-15-9-18(10-19-13-27-29-24(15)19)25(32)30-7-5-26(6-8-30)12-22(31)20-11-17(3-4-23(20)34-26)21-14-33-16(2)28-21/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,27,29)
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n/an/a 19n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314901
PNG
(5-methoxy-1'-(2-(1-methyl-1H-pyrazol-3-yl)-1H-benz...)
Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3ccn(C)n3)CC(=O)c12
Show InChI InChI=1S/C26H25N5O4/c1-30-11-8-18(29-30)24-27-17-7-6-16(14-19(17)28-24)25(33)31-12-9-26(10-13-31)15-20(32)23-21(34-2)4-3-5-22(23)35-26/h3-8,11,14H,9-10,12-13,15H2,1-2H3,(H,27,28)
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n/an/a 19n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365291
PNG
(CHEMBL1958372)
Show SMILES Cc1n[nH]c2c(C)cc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(C3CCOC3)c(C)c1O2
Show InChI InChI=1S/C25H29N5O4/c1-14-10-17(11-19-15(2)26-27-21(14)19)24(32)29-7-5-25(6-8-29)12-20(31)22-23(34-25)16(3)30(28-22)18-4-9-33-13-18/h10-11,18H,4-9,12-13H2,1-3H3,(H,26,27)
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n/an/a 21n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365274
PNG
(CHEMBL1958356)
Show SMILES CC(C)n1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-13(2)27-12-18-20(25-27)17(28)10-22(30-18)4-6-26(7-5-22)21(29)15-8-14(3)19-16(9-15)11-23-24-19/h8-9,11-13H,4-7,10H2,1-3H3,(H,23,24)
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n/an/a 22n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314924
PNG
(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Show SMILES Cc1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2cc1C
Show InChI InChI=1S/C24H25N3O3/c1-14-9-19-20(28)12-24(30-21(19)10-15(14)2)4-6-27(7-5-24)23(29)17-8-16(3)22-18(11-17)13-25-26-22/h8-11,13H,4-7,12H2,1-3H3,(H,25,26)
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n/an/a 22n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314940
PNG
(5'-isobutoxy-1-(7-methyl-1H-indazole-5-carbonyl)sp...)
Show SMILES CC(C)COc1nccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c12
Show InChI InChI=1S/C25H28N4O4/c1-15(2)14-32-23-21-19(30)12-25(33-20(21)4-7-26-23)5-8-29(9-6-25)24(31)17-10-16(3)22-18(11-17)13-27-28-22/h4,7,10-11,13,15H,5-6,8-9,12,14H2,1-3H3,(H,27,28)
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n/an/a 23n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50034371
PNG
(CHEMBL3359265)
Show SMILES CC(C)n1ncc2CC3(CCN(CC3)C(=O)c3ccc4nc(C)[nH]c4c3)CC(=O)c12
Show InChI InChI=1S/C23H27N5O2/c1-14(2)28-21-17(13-24-28)11-23(12-20(21)29)6-8-27(9-7-23)22(30)16-4-5-18-19(10-16)26-15(3)25-18/h4-5,10,13-14H,6-9,11-12H2,1-3H3,(H,25,26)
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n/an/a 24n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant ACC1 assessed as incorporation of [14C]bicarbonate into [14C]malonyl-CoA by radiometric assay


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314931
PNG
(1-(7-methyl-1H-indazole-5-carbonyl)-6'-(1-methyl-1...)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ncc1O2)-c1cnn(C)c1
Show InChI InChI=1S/C25H24N6O3/c1-15-7-16(8-17-11-27-29-23(15)17)24(33)31-5-3-25(4-6-31)10-21(32)19-9-20(26-13-22(19)34-25)18-12-28-30(2)14-18/h7-9,11-14H,3-6,10H2,1-2H3,(H,27,29)
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n/an/a 24.6n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314924
PNG
(6,7-dimethyl-1'-(7-methyl-1H-indazole-5-carbonyl)s...)
Show SMILES Cc1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2cc1C
Show InChI InChI=1S/C24H25N3O3/c1-14-9-19-20(28)12-24(30-21(19)10-15(14)2)4-6-27(7-5-24)23(29)17-8-16(3)22-18(11-17)13-25-26-22/h8-11,13H,4-7,12H2,1-3H3,(H,25,26)
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n/an/a 25n/an/an/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat recombinant ACC1


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50127710
PNG
(CHEMBL3629720)
Show SMILES C[C@H]1N(CCC11CCN(CC1)C(=O)c1cc(C)c2[nH]ncc2c1)C(=O)OCC(C)(C)C
Show InChI InChI=1/C24H34N4O3/c1-16-12-18(13-19-14-25-26-20(16)19)21(29)27-9-6-24(7-10-27)8-11-28(17(24)2)22(30)31-15-23(3,4)5/h12-14,17H,6-11,15H2,1-5H3,(H,25,26)/t17-/s2
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n/an/a 26n/an/an/an/an/an/a



Pfizer

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 preincubated for 10 mins followed by acetyl-CoA/KHCO3/[14C]-NaHCO3/ATP addition measured after 20 mins by liquid scintil...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314897
PNG
(5-methoxy-1'-(2-(pyridin-2-yl)-1H-benzo[d]imidazol...)
Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3ccccn3)CC(=O)c12
Show InChI InChI=1S/C27H24N4O4/c1-34-22-6-4-7-23-24(22)21(32)16-27(35-23)10-13-31(14-11-27)26(33)17-8-9-18-20(15-17)30-25(29-18)19-5-2-3-12-28-19/h2-9,12,15H,10-11,13-14,16H2,1H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314898
PNG
(5-methoxy-1'-(2-(pyridin-3-yl)-1H-benzo[d]imidazol...)
Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)-c3cccnc3)CC(=O)c12
Show InChI InChI=1S/C27H24N4O4/c1-34-22-5-2-6-23-24(22)21(32)15-27(35-23)9-12-31(13-10-27)26(33)17-7-8-19-20(14-17)30-25(29-19)18-4-3-11-28-16-18/h2-8,11,14,16H,9-10,12-13,15H2,1H3,(H,29,30)
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n/an/a 26n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50388655
PNG
(CHEMBL2059303)
Show SMILES CCNC(=O)Nc1sc2c(OC)cccc2c1C(=O)N1CCC(CC1)N1CCCC2(C1)C(=O)N1CCCCN1C2=O
Show InChI InChI=1S/C29H38N6O5S/c1-3-30-28(39)31-24-22(20-8-6-9-21(40-2)23(20)41-24)25(36)32-16-10-19(11-17-32)33-13-7-12-29(18-33)26(37)34-14-4-5-15-35(34)27(29)38/h6,8-9,19H,3-5,7,10-18H2,1-2H3,(H2,30,31,39)
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n/an/a 28n/an/an/an/an/an/a



Takeda Pharmaceutical Company, Ltd

Curated by ChEMBL


Assay Description
Inhibition of rat ACC1


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365272
PNG
(CHEMBL1958354)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)17(28)11-22(30-20)5-7-26(8-6-22)21(29)15-9-13(2)18-16(10-15)12-23-24-18/h9-10,12H,4-8,11H2,1-3H3,(H,23,24)
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n/an/a 28n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365280
PNG
(CHEMBL1958361)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3ccc4[nH]nc(C)c4c3)CC2=O)c1C
Show InChI InChI=1S/C22H25N5O3/c1-4-27-14(3)20-19(25-27)18(28)12-22(30-20)7-9-26(10-8-22)21(29)15-5-6-17-16(11-15)13(2)23-24-17/h5-6,11H,4,7-10,12H2,1-3H3,(H,23,24)
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n/an/a 29n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314938
PNG
(5'-isopropoxy-1-(7-methyl-1H-indazole-5-carbonyl)s...)
Show SMILES CC(C)Oc1nccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c12
Show InChI InChI=1S/C24H26N4O4/c1-14(2)31-22-20-18(29)12-24(32-19(20)4-7-25-22)5-8-28(9-6-24)23(30)16-10-15(3)21-17(11-16)13-26-27-21/h4,7,10-11,13-14H,5-6,8-9,12H2,1-3H3,(H,26,27)
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n/an/a 30n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365283
PNG
(CHEMBL1958364)
Show SMILES CCc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C23H27N5O3/c1-4-15-10-16(11-17-13-24-25-19(15)17)22(30)27-8-6-23(7-9-27)12-18(29)20-21(31-23)14(3)28(5-2)26-20/h10-11,13H,4-9,12H2,1-3H3,(H,24,25)
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n/an/a 31n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314906
PNG
(1'-(7-methyl-1H-indazole-5-carbonyl)-6-(1-methyl-1...)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1cc(ccc1O2)-c1ccn(C)n1
Show InChI InChI=1S/C26H25N5O3/c1-16-11-18(12-19-15-27-28-24(16)19)25(33)31-9-6-26(7-10-31)14-22(32)20-13-17(3-4-23(20)34-26)21-5-8-30(2)29-21/h3-5,8,11-13,15H,6-7,9-10,14H2,1-2H3,(H,27,28)
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n/an/a 31n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365289
PNG
(CHEMBL1958370)
Show SMILES CCn1nc2c(OC3(CCN(CC3)C(=O)c3cc(C)c4nc(C)[nH]c4c3)CC2=O)c1C
Show InChI InChI=1S/C23H27N5O3/c1-5-28-14(3)21-20(26-28)18(29)12-23(31-21)6-8-27(9-7-23)22(30)16-10-13(2)19-17(11-16)24-15(4)25-19/h10-11H,5-9,12H2,1-4H3,(H,24,25)
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n/an/a 34n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314939
PNG
(5'-methoxy-7'-methyl-1-(7-methyl-1H-indazole-5-car...)
Show SMILES COc1nc(C)cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c12
Show InChI InChI=1S/C23H24N4O4/c1-13-8-15(10-16-12-24-26-20(13)16)22(29)27-6-4-23(5-7-27)11-17(28)19-18(31-23)9-14(2)25-21(19)30-3/h8-10,12H,4-7,11H2,1-3H3,(H,24,26)
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n/an/a 34n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314889
PNG
(5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...)
Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3ccc4nc([nH]c4c3)C(N)=O)CC(=O)c12
Show InChI InChI=1S/C23H22N4O5/c1-31-17-3-2-4-18-19(17)16(28)12-23(32-18)7-9-27(10-8-23)22(30)13-5-6-14-15(11-13)26-21(25-14)20(24)29/h2-6,11H,7-10,12H2,1H3,(H2,24,29)(H,25,26)
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n/an/a 35n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314926
PNG
(6,7-dimethyl-1'-(3-methyl-1H-indazole-6-carbonyl)s...)
Show SMILES Cc1n[nH]c2cc(ccc12)C(=O)N1CCC2(CC1)CC(=O)c1cc(C)c(C)cc1O2
Show InChI InChI=1S/C24H25N3O3/c1-14-10-19-21(28)13-24(30-22(19)11-15(14)2)6-8-27(9-7-24)23(29)17-4-5-18-16(3)25-26-20(18)12-17/h4-5,10-12H,6-9,13H2,1-3H3,(H,25,26)
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n/an/a 36n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365282
PNG
(CHEMBL1958363)
Show SMILES CCc1n[nH]c2ccc(cc12)C(=O)N1CCC2(CC1)CC(=O)c1nn(CC)c(C)c1O2
Show InChI InChI=1S/C23H27N5O3/c1-4-17-16-12-15(6-7-18(16)25-24-17)22(30)27-10-8-23(9-11-27)13-19(29)20-21(31-23)14(3)28(5-2)26-20/h6-7,12H,4-5,8-11,13H2,1-3H3,(H,24,25)
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n/an/a 36n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314888
PNG
(1'-(3,7-dimethyl-1H-indazole-5-carbonyl)-5-methoxy...)
Show SMILES COc1cccc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]nc(C)c4c3)CC(=O)c12
Show InChI InChI=1S/C24H25N3O4/c1-14-11-16(12-17-15(2)25-26-22(14)17)23(29)27-9-7-24(8-10-27)13-18(28)21-19(30-3)5-4-6-20(21)31-24/h4-6,11-12H,7-10,13H2,1-3H3,(H,25,26)
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n/an/a 42n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50314894
PNG
(5-(5-methoxy-4-oxospiro[chroman-2,4'-piperidine]-1...)
Show SMILES CNC(=O)c1cc2cc(ccc2[nH]1)C(=O)N1CCC2(CC1)CC(=O)c1c(OC)cccc1O2
Show InChI InChI=1S/C25H25N3O5/c1-26-23(30)18-13-16-12-15(6-7-17(16)27-18)24(31)28-10-8-25(9-11-28)14-19(29)22-20(32-2)4-3-5-21(22)33-25/h3-7,12-13,27H,8-11,14H2,1-2H3,(H,26,30)
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n/an/a 43n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of rat liver ACC1 after 7 mins by liquid scintillation counter


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365278
PNG
(CHEMBL1955891)
Show SMILES Cc1cc(cc2cn[nH]c12)C(=O)N1CCC2(CC1)CC(=O)c1nn(cc1O2)C1CCCCC1
Show InChI InChI=1S/C25H29N5O3/c1-16-11-17(12-18-14-26-27-22(16)18)24(32)29-9-7-25(8-10-29)13-20(31)23-21(33-25)15-30(28-23)19-5-3-2-4-6-19/h11-12,14-15,19H,2-10,13H2,1H3,(H,26,27)
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n/an/a 46n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
Acetyl-CoA carboxylase 1 (ACC1)


(Rattus norvegicus (Rat))
BDBM50365273
PNG
(CHEMBL1958355)
Show SMILES CCCn1cc2OC3(CCN(CC3)C(=O)c3cc(C)c4[nH]ncc4c3)CC(=O)c2n1
Show InChI InChI=1S/C22H25N5O3/c1-3-6-27-13-18-20(25-27)17(28)11-22(30-18)4-7-26(8-5-22)21(29)15-9-14(2)19-16(10-15)12-23-24-19/h9-10,12-13H,3-8,11H2,1-2H3,(H,23,24)
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n/an/a 48n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of rat liver Acetyl-CoA carboxylase 1 using acetyl-CoA as substrate preincubated for 10 mins prior substrate addition measured after 20 mi...


Citation and Details
More data for this
Ligand-Target Pair
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