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Compile Data Set for Download or QSAR

Found 49 hits Enz. Inhib. hit(s) with Target = 'Acid-sensing ion channel 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens (Human))
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
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n/an/a 27n/an/an/an/a6.7n/a



Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp...


J Med Chem 58: 4449-61 (2015)


Article DOI: 10.1021/jm5017329
BindingDB Entry DOI: 10.7270/Q2FT8NTK
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens (Human))
BDBM50348098
PNG
(CHEMBL1800430)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCNCc2c1
Show InChI InChI=1S/C20H17ClN2S/c21-20-17-6-4-14(10-18(17)24-19(20)11-22)2-1-13-3-5-15-7-8-23-12-16(15)9-13/h3-6,9-10,23H,7-8,11-12,22H2
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n/an/a 224n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC1a


Bioorg Med Chem Lett 21: 4255-8 (2011)


Article DOI: 10.1016/j.bmcl.2011.05.064
BindingDB Entry DOI: 10.7270/Q2DZ08P8
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50157090
PNG
(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Anhui Medical University

Curated by ChEMBL


Assay Description
Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stim...


Bioorg Med Chem 26: 3158-3165 (2018)


Article DOI: 10.1016/j.bmc.2018.04.042
BindingDB Entry DOI: 10.7270/Q2PZ5CBD
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens (Human))
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
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n/an/a 7.34E+3n/an/an/an/a5.0n/a



Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL


Assay Description
Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp...


J Med Chem 58: 4449-61 (2015)


Article DOI: 10.1021/jm5017329
BindingDB Entry DOI: 10.7270/Q2FT8NTK
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510034
PNG
(CHEMBL4593063)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-4-3-5-16(19)10-15)13(2)22(21-12)17-8-6-14(11-20)7-9-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510055
PNG
(CHEMBL4440787)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C18H14FN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510050
PNG
(CHEMBL4463485)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc2NCCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(15-4-3-5-16(20)10-15)13(2)23(22-12)17-6-7-18-14(11-17)8-9-21-18/h3-7,10-11,21H,8-9H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510056
PNG
(CHEMBL4450681)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CCN)cc1
Show InChI InChI=1S/C19H20FN3/c1-13-19(16-5-7-17(20)8-6-16)14(2)23(22-13)18-9-3-15(4-10-18)11-12-21/h3-10H,11-12,21H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510052
PNG
(CHEMBL4446500)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)c(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H20FN3/c1-12-4-7-16(10-18(12)20)19-13(2)22-23(14(19)3)17-8-5-15(11-21)6-9-17/h4-10H,11,21H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510049
PNG
(CHEMBL4590631)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H21N3/c1-13-4-8-17(9-5-13)19-14(2)21-22(15(19)3)18-10-6-16(12-20)7-11-18/h4-11H,12,20H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510051
PNG
(CHEMBL4527919)
Show SMILES CN1Cc2ncnc(c2C1)-n1nc(C)c(c1C)-c1cccc(F)c1
Show InChI InChI=1S/C18H18FN5/c1-11-17(13-5-4-6-14(19)7-13)12(2)24(22-11)18-15-8-23(3)9-16(15)20-10-21-18/h4-7,10H,8-9H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510053
PNG
(CHEMBL4591499)
Show SMILES Cc1nn(c(C)c1-c1ccc(C)nc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H20N4/c1-12-4-7-16(11-20-12)18-13(2)21-22(14(18)3)17-8-5-15(10-19)6-9-17/h4-9,11H,10,19H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510054
PNG
(CHEMBL4445209)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cn1
Show InChI InChI=1S/C17H17FN4/c1-11-17(14-4-6-15(18)7-5-14)12(2)22(21-11)16-8-3-13(9-19)10-20-16/h3-8,10H,9,19H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510036
PNG
(CHEMBL4555958)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1cccc(CN)c1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-6-8-16(19)9-7-15)13(2)22(21-12)17-5-3-4-14(10-17)11-20/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510037
PNG
(CHEMBL4463769)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ncnc2CNCc12
Show InChI InChI=1S/C17H16FN5/c1-10-16(12-4-3-5-13(18)6-12)11(2)23(22-10)17-14-7-19-8-15(14)20-9-21-17/h3-6,9,19H,7-8H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510048
PNG
(CHEMBL4442568)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ncnc2CNCc12
Show InChI InChI=1S/C17H16FN5/c1-10-16(12-3-5-13(18)6-4-12)11(2)23(22-10)17-14-7-19-8-15(14)20-9-21-17/h3-6,9,19H,7-8H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510047
PNG
(CHEMBL4517411)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)nc1
Show InChI InChI=1S/C17H17FN4/c1-11-17(13-3-5-14(18)6-4-13)12(2)22(21-11)16-8-7-15(9-19)20-10-16/h3-8,10H,9,19H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510046
PNG
(CHEMBL4440380)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(15-3-6-16(20)7-4-15)13(2)23(22-12)17-8-5-14-9-10-21-18(14)11-17/h3-8,11,21H,9-10H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510045
PNG
(CHEMBL4587871)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CNCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(14-3-6-17(20)7-4-14)13(2)23(22-12)18-8-5-15-10-21-11-16(15)9-18/h3-9,21H,10-11H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510044
PNG
(CHEMBL4462808)
Show SMILES CC(N)c1ccc(cc1)-n1nc(C)c(c1C)-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3/c1-12(21)15-6-10-18(11-7-15)23-14(3)19(13(2)22-23)16-4-8-17(20)9-5-16/h4-12H,21H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510043
PNG
(CHEMBL4524195)
Show SMILES Cc1nn(Cc2ccc(CN)cc2)c(C)c1-c1ccc(F)cc1
Show InChI InChI=1S/C19H20FN3/c1-13-19(17-7-9-18(20)10-8-17)14(2)23(22-13)12-16-5-3-15(11-21)4-6-16/h3-10H,11-12,21H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510042
PNG
(CHEMBL4593172)
Show SMILES NCc1ccc(cc1)-n1cc(cn1)-c1ccc(F)cc1
Show InChI InChI=1S/C16H14FN3/c17-15-5-3-13(4-6-15)14-10-19-20(11-14)16-7-1-12(9-18)2-8-16/h1-8,10-11H,9,18H2
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510041
PNG
(CHEMBL4476781)
Show SMILES Cc1nn(c(C)c1-c1ccc(CN)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H22N4/c1-13-19(17-7-3-15(11-20)4-8-17)14(2)23(22-13)18-9-5-16(12-21)6-10-18/h3-10H,11-12,20-21H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510040
PNG
(CHEMBL4469611)
Show SMILES Cc1nn(c(C)c1-c1ccc(cc1)C(F)(F)F)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H18F3N3/c1-12-18(15-5-7-16(8-6-15)19(20,21)22)13(2)25(24-12)17-9-3-14(11-23)4-10-17/h3-10H,11,23H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1/2


(Mus musculus)
BDBM50510034
PNG
(CHEMBL4593063)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-4-3-5-16(19)10-15)13(2)22(21-12)17-8-6-14(11-20)7-9-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence...


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510057
PNG
(CHEMBL4538655)
Show SMILES COc1ccc(cc1)-c1c(C)nn(c1C)-c1ccc(CN)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-19(16-6-10-18(23-3)11-7-16)14(2)22(21-13)17-8-4-15(12-20)5-9-17/h4-11H,12,20H2,1-3H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510035
PNG
(CHEMBL4528810)
Show SMILES Cc1nn(c(C)c1-c1cccc(F)c1)-c1ccc2CNCc2c1
Show InChI InChI=1S/C19H18FN3/c1-12-19(14-4-3-5-17(20)8-14)13(2)23(22-12)18-7-6-15-10-21-11-16(15)9-18/h3-9,21H,10-11H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510038
PNG
(CHEMBL4518161)
Show SMILES Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18FN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Mus musculus)
BDBM50510039
PNG
(CHEMBL4456021)
Show SMILES Cc1nn(c(C)c1-c1ccc(Cl)cc1)-c1ccc(CN)cc1
Show InChI InChI=1S/C18H18ClN3/c1-12-18(15-5-7-16(19)8-6-15)13(2)22(21-12)17-9-3-14(11-20)4-10-17/h3-10H,11,20H2,1-2H3
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Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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n/an/a 3.02E+4n/an/an/an/an/an/a



Anhui Medical University

Curated by ChEMBL


Assay Description
Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye bas...


Bioorg Med Chem 26: 3158-3165 (2018)


Article DOI: 10.1016/j.bmc.2018.04.042
BindingDB Entry DOI: 10.7270/Q2PZ5CBD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Acid-sensing ion channel 1


(Mus musculus)
BDBM50000999
PNG
(CHEBI:81724 | DIMINAZENE)
Show SMILES NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1
Show InChI InChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
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n/an/a 5.69E+4n/an/an/an/an/an/a



Promidis

Curated by ChEMBL


Assay Description
Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay


ACS Med Chem Lett 10: 627-632 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00591
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 1.35E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 1.35E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50074922
PNG
((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Show SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1
Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
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n/an/a 1.70E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50250133
PNG
(BUTIBUFEN | Butibufen)
Show SMILES CCC(C(O)=O)c1ccc(CC(C)C)cc1
Show InChI InChI=1S/C14H20O2/c1-4-13(14(15)16)12-7-5-11(6-8-12)9-10(2)3/h5-8,10,13H,4,9H2,1-3H3,(H,15,16)
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n/an/a 1.82E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50169044
PNG
((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
Show SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1
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n/an/a 2.88E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 2.95E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 2.95E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 2.95E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50169047
PNG
((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...)
Show SMILES CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
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n/an/a 3.47E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50250130
PNG
(CHEMBL4083814)
Show SMILES CC(C)Cc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C11H14O2/c1-8(2)7-9-3-5-10(6-4-9)11(12)13/h3-6,8H,7H2,1-2H3,(H,12,13)
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n/an/a 4.17E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 5.13E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 5.13E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50250132
PNG
(CHEMBL4080879)
Show SMILES CC(C)Cc1ccc(cc1)C(F)C(O)=O
Show InChI InChI=1S/C12H15FO2/c1-8(2)7-9-3-5-10(6-4-9)11(13)12(14)15/h3-6,8,11H,7H2,1-2H3,(H,14,15)
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n/an/a 9.55E+5n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50295285
PNG
((4-Isobutyl-phenyl)-acetic acid | 2-(4-isobutylphe...)
Show SMILES CC(C)Cc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)
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n/an/a 1.02E+6n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Acid-sensing ion channel 1


(Rattus norvegicus)
BDBM50250131
PNG
(CHEMBL190275)
Show SMILES CC(C(O)=O)c1ccc(C)cc1
Show InChI InChI=1S/C10H12O2/c1-7-3-5-9(6-4-7)8(2)10(11)12/h3-6,8H,1-2H3,(H,11,12)
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n/an/a<1.00E+7n/an/an/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp


J Med Chem 60: 8192-8200 (2017)


Article DOI: 10.1021/acs.jmedchem.7b01072
BindingDB Entry DOI: 10.7270/Q2N58PSV
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens (Human))
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
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n/an/an/an/a 6.20n/an/an/an/a



Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL


Assay Description
Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...


J Med Chem 58: 4449-61 (2015)


Article DOI: 10.1021/jm5017329
BindingDB Entry DOI: 10.7270/Q2FT8NTK
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens (Human))
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
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n/an/an/an/a 6.5n/an/an/an/a



Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL


Assay Description
Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...


J Med Chem 58: 4449-61 (2015)


Article DOI: 10.1021/jm5017329
BindingDB Entry DOI: 10.7270/Q2FT8NTK
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 2, neuronal


(Homo sapiens (Human))
BDBM50096642
PNG
(CHEMBL3577296)
Show SMILES CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Show InChI InChI=1S/C23H27ClN4O2/c1-3-27(4-2)11-12-28(15-16-5-8-18(24)9-6-16)19-10-7-17-13-20(22(25)26)23(29)30-21(17)14-19/h5-10,13-14H,3-4,11-12,15H2,1-2H3,(H3,25,26)
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n/an/an/an/a 6.40n/an/an/an/a



Bogomoletz Institute of Physiology of NAS Ukraine

Curated by ChEMBL


Assay Description
Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50...


J Med Chem 58: 4449-61 (2015)


Article DOI: 10.1021/jm5017329
BindingDB Entry DOI: 10.7270/Q2FT8NTK
More data for this
Ligand-Target Pair