Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amiloride-sensitive cation channel 2, neuronal (Homo sapiens (Human)) | BDBM50096642![]() (CHEMBL3577296) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 6.7 | n/a |
Bogomoletz Institute of Physiology of NAS Ukraine Curated by ChEMBL | Assay Description Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 6.7 by standard whole cell patch clamp... | J Med Chem 58: 4449-61 (2015) Article DOI: 10.1021/jm5017329 BindingDB Entry DOI: 10.7270/Q2FT8NTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amiloride-sensitive cation channel 2, neuronal (Homo sapiens (Human)) | BDBM50348098![]() (CHEMBL1800430) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of ASIC1a | Bioorg Med Chem Lett 21: 4255-8 (2011) Article DOI: 10.1016/j.bmcl.2011.05.064 BindingDB Entry DOI: 10.7270/Q2DZ08P8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50157090![]() (6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of ASIC1a in rat dorsal root ganglion neurons assessed as reduction in peak current preincubated for 120 secs followed by acid medium stim... | Bioorg Med Chem 26: 3158-3165 (2018) Article DOI: 10.1016/j.bmc.2018.04.042 BindingDB Entry DOI: 10.7270/Q2PZ5CBD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amiloride-sensitive cation channel 2, neuronal (Homo sapiens (Human)) | BDBM50096642![]() (CHEMBL3577296) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.34E+3 | n/a | n/a | n/a | n/a | 5.0 | n/a |
Bogomoletz Institute of Physiology of NAS Ukraine Curated by ChEMBL | Assay Description Inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current at pH 5.0 by standard whole cell patch clamp... | J Med Chem 58: 4449-61 (2015) Article DOI: 10.1021/jm5017329 BindingDB Entry DOI: 10.7270/Q2FT8NTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510034![]() (CHEMBL4593063) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510055![]() (CHEMBL4440787) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510050![]() (CHEMBL4463485) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510056![]() (CHEMBL4450681) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510052![]() (CHEMBL4446500) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510049![]() (CHEMBL4590631) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510051![]() (CHEMBL4527919) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510053![]() (CHEMBL4591499) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510054![]() (CHEMBL4445209) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510036![]() (CHEMBL4555958) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510037![]() (CHEMBL4463769) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510048![]() (CHEMBL4442568) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510047![]() (CHEMBL4517411) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510046![]() (CHEMBL4440380) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510045![]() (CHEMBL4587871) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510044![]() (CHEMBL4462808) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510043![]() (CHEMBL4524195) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510042![]() (CHEMBL4593172) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510041![]() (CHEMBL4476781) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510040![]() (CHEMBL4469611) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1/2 (Mus musculus) | BDBM50510034![]() (CHEMBL4593063) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.25-stimulated mouse ASIC1a/2a heterodimer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence... | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510057![]() (CHEMBL4538655) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510035![]() (CHEMBL4528810) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510038![]() (CHEMBL4518161) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50510039![]() (CHEMBL4456021) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM16173![]() (3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anhui Medical University Curated by ChEMBL | Assay Description Inhibition of ASIC1 in Sprague-Dawley rat articular chondrocytes assessed as decrease in acid-induced intracellular calcium level by Fluo-3AM dye bas... | Bioorg Med Chem 26: 3158-3165 (2018) Article DOI: 10.1016/j.bmc.2018.04.042 BindingDB Entry DOI: 10.7270/Q2PZ5CBD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Acid-sensing ion channel 1 (Mus musculus) | BDBM50000999![]() (CHEBI:81724 | DIMINAZENE) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase DrugBank KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Promidis Curated by ChEMBL | Assay Description Inhibition of pH 6.6-stimulated mouse ASIC1a homomer expressed in CHOK1 cells assessed as reduction in channel activation by VSD fluorescence assay | ACS Med Chem Lett 10: 627-632 (2019) Article DOI: 10.1021/acsmedchemlett.8b00591 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.35E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.35E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.9 by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50074922![]() ((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50250133![]() (BUTIBUFEN | Butibufen) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.82E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50169044![]() ((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.88E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.4 by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50169047![]() ((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50250130![]() (CHEMBL4083814) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.17E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.13E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50009859![]() ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEBI CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.13E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes at pH 6.7 by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50250132![]() (CHEMBL4080879) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50295285![]() ((4-Isobutyl-phenyl)-acetic acid | 2-(4-isobutylphe...) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.02E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid-sensing ion channel 1 (Rattus norvegicus) | BDBM50250131![]() (CHEMBL190275) | PDB Reactome pathway UniProtKB/SwissProt GoogleScholar | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1.00E+7 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Inhibition of rat ASIC1a receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.7-gated currents by two electrode voltage clamp | J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amiloride-sensitive cation channel 2, neuronal (Homo sapiens (Human)) | BDBM50096642![]() (CHEMBL3577296) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a |
Bogomoletz Institute of Physiology of NAS Ukraine Curated by ChEMBL | Assay Description Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50... | J Med Chem 58: 4449-61 (2015) Article DOI: 10.1021/jm5017329 BindingDB Entry DOI: 10.7270/Q2FT8NTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amiloride-sensitive cation channel 2, neuronal (Homo sapiens (Human)) | BDBM50096642![]() (CHEMBL3577296) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.5 | n/a | n/a | n/a | n/a |
Bogomoletz Institute of Physiology of NAS Ukraine Curated by ChEMBL | Assay Description Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50... | J Med Chem 58: 4449-61 (2015) Article DOI: 10.1021/jm5017329 BindingDB Entry DOI: 10.7270/Q2FT8NTK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amiloride-sensitive cation channel 2, neuronal (Homo sapiens (Human)) | BDBM50096642![]() (CHEMBL3577296) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 6.40 | n/a | n/a | n/a | n/a |
Bogomoletz Institute of Physiology of NAS Ukraine Curated by ChEMBL | Assay Description Orthosteric non-competitive inhibition of human ASIC1a endogenously expressed in HEK293 cells clamped at -100 mV gated ionic current assessed as EC50... | J Med Chem 58: 4449-61 (2015) Article DOI: 10.1021/jm5017329 BindingDB Entry DOI: 10.7270/Q2FT8NTK | |||||||||||
More data for this Ligand-Target Pair |