Compile Data Set for Download or QSAR

Found 206 hits Enz. Inhib. hit(s) with Target = 'Acidic mammalian chitinase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acidic mammalian chitinase (Mus musculus)	BDBM50243745 (CHEMBL4076989) Show SMILES CC(C)CN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C19H29ClN6/c1-14(2)13-26(10-7-15-3-5-16(20)6-4-15)17-8-11-25(12-9-17)19-22-18(21)23-24-19/h3-6,14,17H,7-13H2,1-2H3,(H3,21,22,23,24)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243745 (CHEMBL4076989) Show SMILES CC(C)CN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C19H29ClN6/c1-14(2)13-26(10-7-15-3-5-16(20)6-4-15)17-8-11-25(12-9-17)19-22-18(21)23-24-19/h3-6,14,17H,7-13H2,1-2H3,(H3,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM81509 (Bisdionin F) Show SMILES Cn1cnc2n(C)c(=O)n(CCCn3c(=O)n(C)c4nc[nH]c4c3=O)c(=O)c12 Show InChI InChI=1S/C16H18N8O4/c1-20-8-19-12-10(20)14(26)24(16(28)22(12)3)6-4-5-23-13(25)9-11(18-7-17-9)21(2)15(23)27/h7-8H,4-6H2,1-3H3,(H,17,18)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	420	-37.9	920	n/a	n/a	n/a	n/a	5.2	37
University of Edinburgh					Assay Description Chitnase inhibition by bisdionin compounds.				Chem Biol 18: 569-79 (2011) Article DOI: 10.1016/j.chembiol.2011.02.017 BindingDB Entry DOI: 10.7270/Q28W3BSN
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243685 (CHEMBL4084573) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1cccc2ccccc12 Show InChI InChI=1S/C26H29ClN6/c27-22-10-8-19(9-11-22)12-15-33(18-21-6-3-5-20-4-1-2-7-24(20)21)23-13-16-32(17-14-23)26-29-25(28)30-31-26/h1-11,23H,12-18H2,(H3,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243795 (CHEMBL4077644) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1Cl Show InChI InChI=1S/C22H26Cl2N6/c23-18-7-5-16(6-8-18)9-12-30(15-17-3-1-2-4-20(17)24)19-10-13-29(14-11-19)22-26-21(25)27-28-22/h1-8,19H,9-15H2,(H3,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243799 (CHEMBL4077482) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1 Show InChI InChI=1S/C22H27ClN6/c23-19-8-6-17(7-9-19)10-13-29(16-18-4-2-1-3-5-18)20-11-14-28(15-12-20)22-25-21(24)26-27-22/h1-9,20H,10-16H2,(H3,24,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243685 (CHEMBL4084573) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1cccc2ccccc12 Show InChI InChI=1S/C26H29ClN6/c27-22-10-8-19(9-11-22)12-15-33(18-21-6-3-5-20-4-1-2-7-24(20)21)23-13-16-32(17-14-23)26-29-25(28)30-31-26/h1-11,23H,12-18H2,(H3,28,29,30,31)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243746 (CHEMBL4068944) Show SMILES CC(C)CN(CCc1ccc(Br)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C19H29BrN6/c1-14(2)13-26(10-7-15-3-5-16(20)6-4-15)17-8-11-25(12-9-17)19-22-18(21)23-24-19/h3-6,14,17H,7-13H2,1-2H3,(H3,21,22,23,24)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243760 (CHEMBL4082060) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)CC1CCCCC1 Show InChI InChI=1S/C22H33ClN6/c23-19-8-6-17(7-9-19)10-13-29(16-18-4-2-1-3-5-18)20-11-14-28(15-12-20)22-25-21(24)26-27-22/h6-9,18,20H,1-5,10-16H2,(H3,24,25,26,27)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243760 (CHEMBL4082060) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)CC1CCCCC1 Show InChI InChI=1S/C22H33ClN6/c23-19-8-6-17(7-9-19)10-13-29(16-18-4-2-1-3-5-18)20-11-14-28(15-12-20)22-25-21(24)26-27-22/h6-9,18,20H,1-5,10-16H2,(H3,24,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243746 (CHEMBL4068944) Show SMILES CC(C)CN(CCc1ccc(Br)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C19H29BrN6/c1-14(2)13-26(10-7-15-3-5-16(20)6-4-15)17-8-11-25(12-9-17)19-22-18(21)23-24-19/h3-6,14,17H,7-13H2,1-2H3,(H3,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243795 (CHEMBL4077644) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1Cl Show InChI InChI=1S/C22H26Cl2N6/c23-18-7-5-16(6-8-18)9-12-30(15-17-3-1-2-4-20(17)24)19-10-13-29(14-11-19)22-26-21(25)27-28-22/h1-8,19H,9-15H2,(H3,25,26,27,28)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of [3H]WIN-35428 binding to the dopamine transporter				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243799 (CHEMBL4077482) Show SMILES Nc1n[nH]c(n1)N1CCC(CC1)N(CCc1ccc(Cl)cc1)Cc1ccccc1 Show InChI InChI=1S/C22H27ClN6/c23-19-8-6-17(7-9-19)10-13-29(16-18-4-2-1-3-5-18)20-11-14-28(15-12-20)22-25-21(24)26-27-22/h1-9,20H,10-16H2,(H3,24,25,26,27)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of [3H]GBR-12935 binding to the dopamine transporter.				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243745 (CHEMBL4076989) Show SMILES CC(C)CN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C19H29ClN6/c1-14(2)13-26(10-7-15-3-5-16(20)6-4-15)17-8-11-25(12-9-17)19-22-18(21)23-24-19/h3-6,14,17H,7-13H2,1-2H3,(H3,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243745 (CHEMBL4076989) Show SMILES CC(C)CN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C19H29ClN6/c1-14(2)13-26(10-7-15-3-5-16(20)6-4-15)17-8-11-25(12-9-17)19-22-18(21)23-24-19/h3-6,14,17H,7-13H2,1-2H3,(H3,21,22,23,24)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243744 (CHEMBL4098997) Show SMILES CCN(CCc1ccc(Br)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C17H25BrN6/c1-2-23(10-7-13-3-5-14(18)6-4-13)15-8-11-24(12-9-15)17-20-16(19)21-22-17/h3-6,15H,2,7-12H2,1H3,(H3,19,20,21,22)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50331851 (Allosamidin | CHEMBL1230997) Show SMILES CN(C)C1=N[C@@H]2[C@@H](O)[C@H](O[C@@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@@H](O)[C@H]4NC(C)=O)[C@@H](O)[C@H]3NC(C)=O)[C@@H](CO)[C@@H]2O1 Show InChI InChI=1/C25H42N4O14/c1-8(33)26-14-17(36)16(35)11(6-31)39-23(14)42-22-12(7-32)40-24(15(19(22)38)27-9(2)34)41-21-10(5-30)20-13(18(21)37)28-25(43-20)29(3)4/h10-24,30-32,35-38H,5-7H2,1-4H3,(H,26,33)(H,27,34)/t10-,11+,12+,13+,14+,15+,16+,17-,18+,19-,20-,21+,22+,23-,24-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of human chitinase				Bioorg Med Chem 18: 8334-40 (2010) Article DOI: 10.1016/j.bmc.2010.09.062 BindingDB Entry DOI: 10.7270/Q2NZ87WR
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50243744 (CHEMBL4098997) Show SMILES CCN(CCc1ccc(Br)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C17H25BrN6/c1-2-23(10-7-13-3-5-14(18)6-4-13)15-8-11-24(12-9-15)17-20-16(19)21-22-17/h3-6,15H,2,7-12H2,1H3,(H3,19,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50243743 (CHEMBL4072036) Show SMILES CCN(CCc1ccc(Cl)cc1)C1CCN(CC1)c1nc(N)n[nH]1 Show InChI InChI=1S/C17H25ClN6/c1-2-23(10-7-13-3-5-14(18)6-4-13)15-8-11-24(12-9-15)17-20-16(19)21-22-17/h3-6,15H,2,7-12H2,1H3,(H3,19,20,21,22)	KEGG UniProtKB/SwissProt GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics SA Curated by ChEMBL					Assay Description Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...				J Med Chem 61: 695-710 (2018) Article DOI: 10.1021/acs.jmedchem.7b01051
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349942 (5-(4-((2S,5S)-2-(4-chlorobenzyl)-5-(cyclohexylmeth...) Show SMILES CN1C[C@H](Cc2ccc(Cl)cc2)N(C[C@@H]1CC1CCCCC1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C26H40ClN7/c1-32-17-24(16-20-7-9-21(27)10-8-20)34(18-23(32)15-19-5-3-2-4-6-19)22-11-13-33(14-12-22)26-29-25(28)30-31-26/h7-10,19,22-24H,2-6,11-18H2,1H3,(H3,28,29,30,31)/t23-,24-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349943 (5-(4-((2S,5S)-2-(4-chlorobenzyl)-5-isobutyl-4-meth...) Show SMILES CC(C)C[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CN1C)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C23H36ClN7/c1-16(2)12-20-15-31(19-8-10-30(11-9-19)23-26-22(25)27-28-23)21(14-29(20)3)13-17-4-6-18(24)7-5-17/h4-7,16,19-21H,8-15H2,1-3H3,(H3,25,26,27,28)/t20-,21-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349950 (US10208020, Example 40 | methyl 2-((2S,5S)-4-(1-(5...) Show SMILES COC(=O)CN1C[C@H](Cc2ccc(Cl)cc2)N(C[C@@H]1C)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C22H32ClN7O2/c1-15-12-30(18-7-9-28(10-8-18)22-25-21(24)26-27-22)19(13-29(15)14-20(31)32-2)11-16-3-5-17(23)6-4-16/h3-6,15,18-19H,7-14H2,1-2H3,(H3,24,25,26,27)/t15-,19-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349951 (2-((2S,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)pip...) Show SMILES C[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CN1CC(O)=O)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C21H30ClN7O2/c1-14-11-29(17-6-8-27(9-7-17)21-24-20(23)25-26-21)18(12-28(14)13-19(30)31)10-15-2-4-16(22)5-3-15/h2-5,14,17-18H,6-13H2,1H3,(H,30,31)(H3,23,24,25,26)/t14-,18-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349956 (5-(4-((2S,4S)-2-(4-chlorobenzyl)-4-methoxypyrrolid...) Show SMILES CO[C@H]1C[C@H](Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C19H27ClN6O/c1-27-17-11-16(10-13-2-4-14(20)5-3-13)26(12-17)15-6-8-25(9-7-15)19-22-18(21)23-24-19/h2-5,15-17H,6-12H2,1H3,(H3,21,22,23,24)/t16-,17-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349957 ((3S,5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1C[C@@H](O)C[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C18H25ClN6O/c19-13-3-1-12(2-4-13)9-15-10-16(26)11-25(15)14-5-7-24(8-6-14)18-21-17(20)22-23-18/h1-4,14-16,26H,5-11H2,(H3,20,21,22,23)/t15-,16-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349958 ((5S)-1-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperidin...) Show SMILES CC1(O)C[C@H](Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C19H27ClN6O/c1-19(27)11-16(10-13-2-4-14(20)5-3-13)26(12-19)15-6-8-25(9-7-15)18-22-17(21)23-24-18/h2-5,15-16,27H,6-12H2,1H3,(H3,21,22,23,24)/t16-,19?/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349959 (5-(4-((3S,8aS)-3-(4-chlorobenzyl)hexahydropyrrolo[...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1C[C@@H]2CCCN2C[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C21H30ClN7/c22-16-5-3-15(4-6-16)12-19-13-28-9-1-2-18(28)14-29(19)17-7-10-27(11-8-17)21-24-20(23)25-26-21/h3-6,17-19H,1-2,7-14H2,(H3,23,24,25,26)/t18-,19-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349960 ((3R,5S)-1-(1-(5-amino-1H-1,2,4-triazol-3-yl)piperi...) Show SMILES Nc1nc(n[nH]1)N1CCC(CC1)N1C[C@H](O)C[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C18H25ClN6O/c19-13-3-1-12(2-4-13)9-15-10-16(26)11-25(15)14-5-7-24(8-6-14)18-21-17(20)22-23-18/h1-4,14-16,26H,5-11H2,(H3,20,21,22,23)/t15-,16+/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349961 (3-(4-((2S,4R)-2-(4-chlorobenzyl)-4-methoxypyrrolid...) Show SMILES CO[C@@H]1C[C@H](Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1n[nH]c(N)n1 Show InChI InChI=1/C19H27ClN6O/c1-27-17-11-16(10-13-2-4-14(20)5-3-13)26(12-17)15-6-8-25(9-7-15)19-22-18(21)23-24-19/h2-5,15-17H,6-12H2,1H3,(H3,21,22,23,24)/t16-,17+/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349965 ((S)-5-(4-(3-(4-chlorobenzyl)-6-methylene-1,4-oxaze...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CC(=C)COC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C20H27ClN6O/c1-14-11-27(17-6-8-26(9-7-17)20-23-19(22)24-25-20)18(13-28-12-14)10-15-2-4-16(21)5-3-15/h2-5,17-18H,1,6-13H2,(H3,22,23,24,25)/t18-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349967 ((S)-5-(4-(3-(4-chlorobenzyl)-1-methyl-2,3-dihydro-...) Show SMILES CN1C[C@H](Cc2ccc(Cl)cc2)N(Cc2ccccc12)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C24H30ClN7/c1-30-16-21(14-17-6-8-19(25)9-7-17)32(15-18-4-2-3-5-22(18)30)20-10-12-31(13-11-20)24-27-23(26)28-29-24/h2-9,20-21H,10-16H2,1H3,(H3,26,27,28,29)/t21-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349968 ((S)-5-(4-(7-chloro-3-(4-chlorobenzyl)-1-methyl-2,3...) Show SMILES CN1C[C@H](Cc2ccc(Cl)cc2)N(Cc2cc(Cl)ccc12)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C24H29Cl2N7/c1-31-15-21(12-16-2-4-18(25)5-3-16)33(14-17-13-19(26)6-7-22(17)31)20-8-10-32(11-9-20)24-28-23(27)29-30-24/h2-7,13,20-21H,8-12,14-15H2,1H3,(H3,27,28,29,30)/t21-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349969 ((S)-5-(4-(3-(4-chlorobenzyl)-2,3-dihydrobenzo[f][1...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1Cc2ccccc2OC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C23H27ClN6O/c24-18-7-5-16(6-8-18)13-20-15-31-21-4-2-1-3-17(21)14-30(20)19-9-11-29(12-10-19)23-26-22(25)27-28-23/h1-8,19-20H,9-15H2,(H3,25,26,27,28)/t20-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349970 ((S)-5-(4-(3-(4-chlorobenzyl)-7-fluoro-2,3-dihydrob...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1Cc2cc(F)ccc2OC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C23H26ClFN6O/c24-17-3-1-15(2-4-17)11-20-14-32-21-6-5-18(25)12-16(21)13-31(20)19-7-9-30(10-8-19)23-27-22(26)28-29-23/h1-6,12,19-20H,7-11,13-14H2,(H3,26,27,28,29)/t20-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349971 ((S)-5-(4-(7-chloro-3-(4-chlorobenzyl)-2,3-dihydrob...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1Cc2cc(Cl)ccc2OC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C23H26Cl2N6O/c24-17-3-1-15(2-4-17)11-20-14-32-21-6-5-18(25)12-16(21)13-31(20)19-7-9-30(10-8-19)23-27-22(26)28-29-23/h1-6,12,19-20H,7-11,13-14H2,(H3,26,27,28,29)/t20-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349972 ((S)-5-(4-(7,9-dichloro-3-(4-chlorobenzyl)-2,3-dihy...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1Cc2cc(Cl)cc(Cl)c2OC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C23H25Cl3N6O/c24-16-3-1-14(2-4-16)9-19-13-33-21-15(10-17(25)11-20(21)26)12-32(19)18-5-7-31(8-6-18)23-28-22(27)29-30-23/h1-4,10-11,18-19H,5-9,12-13H2,(H3,27,28,29,30)/t19-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349973 ((S)-5-(4-(3-(4-chlorobenzyl)-2,3-dihydropyrido[4,3...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1Cc2ccncc2OC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C22H26ClN7O/c23-17-3-1-15(2-4-17)11-19-14-31-20-12-25-8-5-16(20)13-30(19)18-6-9-29(10-7-18)22-26-21(24)27-28-22/h1-5,8,12,18-19H,6-7,9-11,13-14H2,(H3,24,26,27,28)/t19-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	Article US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US10208020 (2019) Article DOI: 10.1021/jm050736c BindingDB Entry DOI: 10.7270/Q2RR21C4
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349919 ((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...) Show SMILES NC(=O)[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C19H26ClN7O2/c20-13-3-1-12(2-4-13)9-15-11-29-16(17(21)28)10-27(15)14-5-7-26(8-6-14)19-23-18(22)24-25-19/h1-4,14-16H,5-11H2,(H2,21,28)(H3,22,23,24,25)/t15?,16-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349920 (5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(methoxymethyl)...) Show SMILES COC[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C20H29ClN6O2/c1-28-13-18-11-27(17(12-29-18)10-14-2-4-15(21)5-3-14)16-6-8-26(9-7-16)20-23-19(22)24-25-20/h2-5,16-18H,6-13H2,1H3,(H3,22,23,24,25)/t17?,18-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349921 (5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(ethoxymethyl)m...) Show SMILES CCOC[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C21H31ClN6O2/c1-2-29-14-19-12-28(18(13-30-19)11-15-3-5-16(22)6-4-15)17-7-9-27(10-8-17)21-24-20(23)25-26-21/h3-6,17-19H,2,7-14H2,1H3,(H3,23,24,25,26)/t18?,19-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349922 ((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)piperi...) Show SMILES CNC(=O)[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C20H28ClN7O2/c1-23-18(29)17-11-28(16(12-30-17)10-13-2-4-14(21)5-3-13)15-6-8-27(9-7-15)20-24-19(22)25-26-20/h2-5,15-17H,6-12H2,1H3,(H,23,29)(H3,22,24,25,26)/t16?,17-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349923 (2-((2R,5S)-4-(1-(5-amino-4H-1,2,4-triazol-3-yl)pip...) Show SMILES CC(C)(O)[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C21H31ClN6O2/c1-21(2,29)18-12-28(17(13-30-18)11-14-3-5-15(22)6-4-14)16-7-9-27(10-8-16)20-24-19(23)25-26-20/h3-6,16-18,29H,7-13H2,1-2H3,(H3,23,24,25,26)/t17?,18-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349924 (5-(4-((2R,5S)-5-(4-chlorobenzyl)-2-(2-methoxypropa...) Show SMILES COC(C)(C)[C@H]1CN(C(Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C22H33ClN6O2/c1-22(2,30-3)19-13-29(18(14-31-19)12-15-4-6-16(23)7-5-15)17-8-10-28(11-9-17)21-25-20(24)26-27-21/h4-7,17-19H,8-14H2,1-3H3,(H3,24,25,26,27)/t18?,19-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349925 ((R)-5-(2-(4-chlorobenzyl)-[1,4′-bipiperidin]...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CCCCC1Cc1ccc(Cl)cc1 Show InChI InChI=1/C19H27ClN6/c20-15-6-4-14(5-7-15)13-17-3-1-2-10-26(17)16-8-11-25(12-9-16)19-22-18(21)23-24-19/h4-7,16-17H,1-3,8-13H2,(H3,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349926 (US10208020, Example 16 | US9944624, Ex. 16 | ethyl...) Show SMILES CCOC(=O)C1CCC(Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C22H31ClN6O2/c1-2-31-20(30)16-5-8-19(13-15-3-6-17(23)7-4-15)29(14-16)18-9-11-28(12-10-18)22-25-21(24)26-27-22/h3-4,6-7,16,18-19H,2,5,8-14H2,1H3,(H3,24,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349927 ((6R)-1′-(5-amino-4H-1,2,4-triazol-3-yl)-6-(4...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CC(CCC1Cc1ccc(Cl)cc1)C(O)=O Show InChI InChI=1/C20H27ClN6O2/c21-15-4-1-13(2-5-15)11-17-6-3-14(18(28)29)12-27(17)16-7-9-26(10-8-16)20-23-19(22)24-25-20/h1-2,4-5,14,16-17H,3,6-12H2,(H,28,29)(H3,22,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349928 ((6R)-1′-(5-amino-4H-1,2,4-triazol-3-yl)-6-(4...) Show SMILES CC1(CCC(Cc2ccc(Cl)cc2)N(C1)C1CCN(CC1)c1nnc(N)[nH]1)C(O)=O Show InChI InChI=1/C21H29ClN6O2/c1-21(18(29)30)9-6-17(12-14-2-4-15(22)5-3-14)28(13-21)16-7-10-27(11-8-16)20-24-19(23)25-26-20/h2-5,16-17H,6-13H2,1H3,(H,29,30)(H3,23,24,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349929 (5-((2S,4R)-2-(4-chlorobenzyl)-4-methoxy-[1,4′...) Show SMILES CO[C@@H]1CCN(C(Cc2ccc(Cl)cc2)C1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C20H29ClN6O/c1-28-18-8-11-27(17(13-18)12-14-2-4-15(21)5-3-14)16-6-9-26(10-7-16)20-23-19(22)24-25-20/h2-5,16-18H,6-13H2,1H3,(H3,22,23,24,25)/t17?,18-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349930 (5-((2S,4S)-2-(4-chlorobenzyl)-4-methoxy-[1,4′...) Show SMILES CO[C@H]1CCN(C(Cc2ccc(Cl)cc2)C1)C1CCN(CC1)c1nnc(N)[nH]1 Show InChI InChI=1/C20H29ClN6O/c1-28-18-8-11-27(17(13-18)12-14-2-4-15(21)5-3-14)16-6-9-26(10-7-16)20-23-19(22)24-25-20/h2-5,16-18H,6-13H2,1H3,(H3,22,23,24,25)/t17?,18-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM349934 ((R)-5-(4-(2-(4-chlorobenzyl)pyrrolidin-1-yl)piperi...) Show SMILES Nc1nnc([nH]1)N1CCC(CC1)N1CCC[C@@H]1Cc1ccc(Cl)cc1 Show InChI InChI=1/C18H25ClN6/c19-14-5-3-13(4-6-14)12-16-2-1-9-25(16)15-7-10-24(11-8-15)18-21-17(20)22-23-18/h3-6,15-16H,1-2,7-12H2,(H3,20,21,22,23)/t16-/s2	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
OncoArendi Therapeutics S.A. US Patent					Assay Description An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...				US Patent US9944624 (2018)
					More data for this Ligand-Target Pair

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