BindingDB PrimarySearch

Found 24 hits Enz. Inhib. hit(s) with Target = 'Acidic mammalian chitinase'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM81509 (Bisdionin F) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid UniChem Similars	MMDB Article PubMed	420	-37.9	920	n/a	n/a	n/a	n/a	5.2	37
University of Edinburgh					Assay Description Chitnase inhibition by bisdionin compounds.				Chem Biol 18: 569-79 (2011) Article DOI: 10.1016/j.chembiol.2011.02.017 BindingDB Entry DOI: 10.7270/Q28W3BSN
University of Edinburgh					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50331851 (Allosamidin \| CHEMBL1230997) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of human chitinase				Bioorg Med Chem 18: 8334-40 (2010) Article DOI: 10.1016/j.bmc.2010.09.062 BindingDB Entry DOI: 10.7270/Q2NZ87WR
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50378795 (CHEMBL1215473) Show SMILES Nc1nnc([nH]1)N1CCN(CCOc2ccc(Br)cc2)CC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of acidic mammalian chitinase after 60 mins				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM72759 (2-methyl-3-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-...) Show SMILES Cc1[nH]c2ccccc2c1CN1CCN(CC1)c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of acidic mammalian chitinase after 60 mins				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acidic mammalian chitinase (Mus musculus)	BDBM81508 (Bisdionin C) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of AMCase in BALB/c mouse lung homogenate using 4-methyumbelliferyl-beta-B-N,N'-diacetylchitobiose after 10 mins				ACS Med Chem Lett 2: 428-432 (2011) Article DOI: 10.1021/ml200008b BindingDB Entry DOI: 10.7270/Q2RJ4KH7
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438378 (CHEMBL2413400) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50173286 (5-[3-[amino-(methylcarbamoylamino)methylidene]amin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of human acidic mammalian chitinase				Bioorg Med Chem 17: 6270-8 (2009) Article DOI: 10.1016/j.bmc.2009.07.045 BindingDB Entry DOI: 10.7270/Q2TB17TJ
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50378796 (CHEMBL1215544) Show SMILES NC(=N)N1CCN(CC1)c1ccc(Cl)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of acidic mammalian chitinase after 60 mins				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438377 (CHEMBL2413401) Show SMILES NC(NN=Cc1ccco1)=NN=Cc1ccco1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM81508 (Bisdionin C) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	5.2	37
University of Edinburgh					Assay Description Chitnase inhibition by bisdionin compounds.				Chem Biol 18: 569-79 (2011) Article DOI: 10.1016/j.chembiol.2011.02.017 BindingDB Entry DOI: 10.7270/Q28W3BSN
University of Edinburgh					More data for this Ligand-Target Pair				3D Structure (crystal)
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50378797 (CHEMBL1215545) Show SMILES CCNC(=O)c1cccnc1N1CCN(C)CC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of acidic mammalian chitinase after 60 mins				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438376 (CHEMBL1541768) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438375 (CHEMBL2413402) Show SMILES CCC(=O)NC(=S)Nc1ccc2oc(nc2c1)-c1ccccc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438374 (CHEMBL2413403) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (Mus musculus)	BDBM50388141 (CHEMBL1232048) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of AMCase in BALB/c mouse lung homogenate using 4-methyumbelliferyl-beta-B-N,N'-diacetylchitobiose after 10 mins				ACS Med Chem Lett 2: 428-432 (2011) Article DOI: 10.1021/ml200008b BindingDB Entry DOI: 10.7270/Q2RJ4KH7
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438373 (CHEMBL2413404) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50438372 (CHEMBL2413405) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibition of His-tagged recombinant human acidic mammalian chitinase expressed in Escherichia coli Rosetta-gami 2 (DE3) using 4MU-(GlcNAc)2 as subst...				Bioorg Med Chem 21: 3214-20 (2013) Article DOI: 10.1016/j.bmc.2013.03.047 BindingDB Entry DOI: 10.7270/Q2SX6FMS
Kitasato University Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50027028 (2-(piperazin-1-yl)nicotinamide \| 2-Piperazin-1-yl-...) Show SMILES NC(=O)c1cccnc1N1CCNCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.02E+5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of acidic mammalian chitinase after 60 mins				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM39302 (CHEMBL228792 \| MLS000101228 \| N-(2-furanylmethyl)-...) Show SMILES C(Nc1ncnc2nc[nH]c12)c1ccco1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of human chitinase				Bioorg Med Chem 18: 8334-40 (2010) Article DOI: 10.1016/j.bmc.2010.09.062 BindingDB Entry DOI: 10.7270/Q2NZ87WR
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of human chitinase				Bioorg Med Chem 18: 8334-40 (2010) Article DOI: 10.1016/j.bmc.2010.09.062 BindingDB Entry DOI: 10.7270/Q2NZ87WR
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50331852 (8-CHLORO-1,3-DIMETHYL-3,7-DIHYDRO-1H-PURINE-2,6-DI...) Show SMILES Cn1c2nc(Cl)[nH]c2c(=O)n(C)c1=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.50E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Dundee Curated by ChEMBL					Assay Description Inhibition of human chitinase				Bioorg Med Chem 18: 8334-40 (2010) Article DOI: 10.1016/j.bmc.2010.09.062 BindingDB Entry DOI: 10.7270/Q2NZ87WR
University of Dundee Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50027028 (2-(piperazin-1-yl)nicotinamide \| 2-Piperazin-1-yl-...) Show SMILES NC(=O)c1cccnc1N1CCNCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.41E+5	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to biotinylated-acidic mammalian chitinase				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50378796 (CHEMBL1215544) Show SMILES NC(=N)N1CCN(CC1)c1ccc(Cl)cc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to biotinylated-acidic mammalian chitinase				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acidic mammalian chitinase (AMCase) (Homo sapiens (Human))	BDBM50378795 (CHEMBL1215473) Show SMILES Nc1nnc([nH]1)N1CCN(CCOc2ccc(Br)cc2)CC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.69E+3	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to biotinylated-acidic mammalian chitinase				J Med Chem 53: 6122-8 (2010) Article DOI: 10.1021/jm100533p BindingDB Entry DOI: 10.7270/Q22N538H
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)