Compile Data Set for Download or QSAR

Found 512 hits Enz. Inhib. hit(s) with Target = 'Acyl coenzyme A:cholesterol acyltransferase 1'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM182852 (US9149492, Compound 1D) Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(OC(=O)CN2CCCCCC2=O)cc1 Show InChI InChI=1S/C38H46N2O5/c1-26(2)32-14-11-15-33(27(3)4)38(32)39-35(42)24-34(41)30(22-28-12-7-5-8-13-28)23-29-17-19-31(20-18-29)45-37(44)25-40-21-10-6-9-16-36(40)43/h5,7-8,11-15,17-20,26-27,30H,6,9-10,16,21-25H2,1-4H3,(H,39,42)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
Trustees of Dartmouth College US Patent					Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM182851 (US9149492, Compound 1C) Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(OC(=O)CCCCCCN2CCCCCC2=O)cc1 Show InChI InChI=1S/C43H56N2O5/c1-31(2)37-18-15-19-38(32(3)4)43(37)44-40(47)30-39(46)35(28-33-16-9-7-10-17-33)29-34-22-24-36(25-23-34)50-42(49)21-12-5-6-13-26-45-27-14-8-11-20-41(45)48/h7,9-10,15-19,22-25,31-32,35H,5-6,8,11-14,20-21,26-30H2,1-4H3,(H,44,47)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Trustees of Dartmouth College US Patent					Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM182849 (US9149492, Compound 1A) Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccccc1 Show InChI InChI=1S/C30H35NO2/c1-21(2)26-16-11-17-27(22(3)4)30(26)31-29(33)20-28(32)25(18-23-12-7-5-8-13-23)19-24-14-9-6-10-15-24/h5-17,21-22,25H,18-20H2,1-4H3,(H,31,33)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Trustees of Dartmouth College US Patent					Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051894 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES COc1ccc(cc1)N1CCN(CCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)CC1 Show InChI InChI=1S/C35H42N4O3/c1-35(19-9-10-20-38-21-23-39(24-22-38)29-15-17-30(40-2)18-16-29)25-41-34(42-26-35)33-36-31(27-11-5-3-6-12-27)32(37-33)28-13-7-4-8-14-28/h3-8,11-18,34H,9-10,19-26H2,1-2H3,(H,36,37)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50450346 (CHEMBL300883) Show SMILES COc1ccc(cc1)-c1nc(SCCCCCN(CCCCCSc2nc(c([nH]2)-c2ccc(OC)cc2)-c2ccc(OC)cc2)C(=O)NC(C)C)[nH]c1-c1ccc(OC)cc1 Show InChI InChI=1S/C48H58N6O5S2/c1-33(2)49-48(55)54(29-9-7-11-31-60-46-50-42(34-13-21-38(56-3)22-14-34)43(51-46)35-15-23-39(57-4)24-16-35)30-10-8-12-32-61-47-52-44(36-17-25-40(58-5)26-18-36)45(53-47)37-19-27-41(59-6)28-20-37/h13-28,33H,7-12,29-32H2,1-6H3,(H,49,55)(H,50,51)(H,52,53)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
The DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM182850 (US9149492, Compound 1B) Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(O)cc1 Show InChI InChI=1S/C30H35NO3/c1-20(2)26-11-8-12-27(21(3)4)30(26)31-29(34)19-28(33)24(17-22-9-6-5-7-10-22)18-23-13-15-25(32)16-14-23/h5-16,20-21,24,32H,17-19H2,1-4H3,(H,31,34)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.3	n/a	n/a	n/a	n/a	n/a	n/a
Trustees of Dartmouth College US Patent					Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...				Citation and Details
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50285443 (Benzooxazol-2-yl-[5-(4,5-diphenyl-1H-imidazol-2-yl...) Show SMILES CCCCCCCN(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1nc2ccccc2o1 Show InChI InChI=1S/C34H40N4OS/c1-2-3-4-5-15-24-38(34-35-29-22-13-14-23-30(29)39-34)25-16-8-17-26-40-33-36-31(27-18-9-6-10-19-27)32(37-33)28-20-11-7-12-21-28/h6-7,9-14,18-23H,2-5,8,15-17,24-26H2,1H3,(H,36,37)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture				Bioorg Med Chem Lett 5: 177-180 (1995)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50360307 (CHEMBL449307) Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 Show InChI InChI=1S/C33H45N3O5/c1-6-8-15-22(4)26-20-27(37)35-30(28(24-16-11-9-12-17-24)25-18-13-10-14-19-25)32(39)34-23(5)31(38)36-29(21(3)7-2)33(40)41-26/h9-14,16-19,21-23,26,28-30H,6-8,15,20H2,1-5H3,(H,34,39)(H,35,37)(H,36,38)/t21-,22-,23+,26-,29+,30-/m0/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Tohoku University Curated by ChEMBL					Assay Description Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages				Bioorg Med Chem Lett 22: 696-9 (2011)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50175765 (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...) Show SMILES CCCCn1c2ncccc2c(-c2cccc(OCCCO)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O Show InChI InChI=1S/C34H43N5O4/c1-6-7-15-39-32-26(13-9-14-36-32)29(23-11-8-12-25(18-23)43-17-10-16-40)31(33(39)41)38-34(42)37-30-27(21(2)3)19-24(35)20-28(30)22(4)5/h8-9,11-14,18-22,40H,6-7,10,15-17,35H2,1-5H3,(H2,37,38,42)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50436124 (CHEMBL2397474) Show SMILES CCCCCCCCCN(CC(C)(C)C)C(=O)N[C@H]1CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H]1OC(C)(C)OCC1(C)C Show InChI InChI=1S/C33H61N3O6/c1-9-10-11-12-13-14-17-22-36(23-31(2,3)4)30(39)35-25-18-15-16-19-26(25)41-27(37)20-21-34-29(38)28-32(5,6)24-40-33(7,8)42-28/h25-26,28H,9-24H2,1-8H3,(H,34,38)(H,35,39)/t25-,26-,28-/m0/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Kumamoto University Curated by ChEMBL					Assay Description Inhibition of macrophage ACAT (unknown origin)				Bioorg Med Chem 21: 3831-8 (2013)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276493 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...) Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C33H41F3N4O2/c1-21(2)26-18-25(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-24(17-23)33(34,35)36)13-15-40(16-14-32)28-11-6-7-12-29(28)42-5/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276562 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...) Show SMILES CCCCOc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1 Show InChI InChI=1S/C36H50N4O3/c1-7-8-20-43-33-15-10-9-14-32(33)40-18-16-36(17-19-40,27-12-11-13-29(21-27)42-6)24-38-35(41)39-34-30(25(2)3)22-28(37)23-31(34)26(4)5/h9-15,21-23,25-26H,7-8,16-20,24,37H2,1-6H3,(H2,38,39,41)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50079716 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from canine liver				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276483 (1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...) Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1 Show InChI InChI=1S/C32H41N3O2/c1-23(2)28-15-10-16-29(24(3)4)30(28)34-31(36)33-22-32(25-11-9-14-27(21-25)37-5)17-19-35(20-18-32)26-12-7-6-8-13-26/h6-16,21,23-24H,17-20,22H2,1-5H3,(H2,33,34,36)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50051901 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit gut				Bioorg Med Chem Lett 2: 375-380 (1992)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50079716 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from rabbit liver				Citation and Details
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50079716 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from canine adrenal gland				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276487 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...) Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-10-9-11-26(18-24)39-5)14-16-37(17-15-33)29-12-7-8-13-30(29)40-6/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM182848 (US9149492, Eflucimibe (F12511)) Show SMILES CCCCCCCCCCCCS[C@H](C(=O)Nc1cc(C)c(O)c(C)c1C)c1ccccc1 Show InChI InChI=1S/C29H43NO2S/c1-5-6-7-8-9-10-11-12-13-17-20-33-28(25-18-15-14-16-19-25)29(32)30-26-21-22(2)27(31)24(4)23(26)3/h14-16,18-19,21,28,31H,5-13,17,20H2,1-4H3,(H,30,32)/t28-/m0/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Trustees of Dartmouth College US Patent					Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite...				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50360306 (CHEMBL505016) Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 Show InChI InChI=1S/C33H45N3O5/c1-6-8-15-22(4)26-20-27(37)35-30(28(24-16-11-9-12-17-24)25-18-13-10-14-19-25)32(39)34-23(5)31(38)36-29(21(3)7-2)33(40)41-26/h9-14,16-19,21-23,26,28-30H,6-8,15,20H2,1-5H3,(H,34,39)(H,35,37)(H,36,38)/t21-,22-,23-,26-,29+,30-/m0/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Tohoku University Curated by ChEMBL					Assay Description Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages				Bioorg Med Chem Lett 22: 696-9 (2011)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051901 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50028866 (CHEMBL297271 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-ind...) Show SMILES Oc1ccc(cc1)[C@H]1Cc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)/t26-,28-/m1/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT)				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276485 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...) Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1 Show InChI InChI=1S/C32H42N4O2/c1-22(2)28-19-25(33)20-29(23(3)4)30(28)35-31(37)34-21-32(24-10-9-13-27(18-24)38-5)14-16-36(17-15-32)26-11-7-6-8-12-26/h6-13,18-20,22-23H,14-17,21,33H2,1-5H3,(H2,34,35,37)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50051901 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required for the inhibition of rabbit arterial Acyl coenzyme A:cholesterol acyltransferase				Bioorg Med Chem Lett 2: 375-380 (1992)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276494 (1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(2-me...) Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)25-19-24(34)20-26(23(3)4)31(25)36-32(38)35-21-33(27-11-7-9-13-29(27)39-5)15-17-37(18-16-33)28-12-8-10-14-30(28)40-6/h7-14,19-20,22-23H,15-18,21,34H2,1-6H3,(H2,35,36,38)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50079716 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Azwell Inc. Curated by ChEMBL					Assay Description Compound was tested for inhibitory activity against ACAT from rabbit liver				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276484 (1-(2,6-diisopropylphenyl)-3-((1-(2-methoxyphenyl)-...) Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H43N3O3/c1-23(2)27-13-10-14-28(24(3)4)31(27)35-32(37)34-22-33(25-11-9-12-26(21-25)38-5)17-19-36(20-18-33)29-15-7-8-16-30(29)39-6/h7-16,21,23-24H,17-20,22H2,1-6H3,(H2,34,35,37)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276565 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...) Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCC(F)(F)F Show InChI InChI=1S/C34H43F3N4O3/c1-22(2)27-18-25(38)19-28(23(3)4)31(27)40-32(42)39-20-33(24-9-8-10-26(17-24)43-5)13-15-41(16-14-33)29-11-6-7-12-30(29)44-21-34(35,36)37/h6-12,17-19,22-23H,13-16,20-21,38H2,1-5H3,(H2,39,40,42)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276488 (1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...) Show SMILES COc1cccc(c1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1 Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-18-25(34)19-30(23(3)4)31(29)36-32(38)35-21-33(24-9-7-11-27(17-24)39-5)13-15-37(16-14-33)26-10-8-12-28(20-26)40-6/h7-12,17-20,22-23H,13-16,21,34H2,1-6H3,(H2,35,36,38)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276563 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...) Show SMILES COc1ccc(cc1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-11-13-26(39-5)14-12-24)15-17-37(18-16-33)29-9-7-8-10-30(29)40-6/h7-14,19-20,22-23H,15-18,21,34H2,1-6H3,(H2,35,36,38)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50285435 (Benzooxazol-2-yl-{5-[4,5-bis-(4-dimethylamino-phen...) Show SMILES CCN(CCCCCSc1nc(c([nH]1)-c1ccc(cc1)N(C)C)-c1ccc(cc1)N(C)C)c1nc2ccccc2o1 Show InChI InChI=1S/C33H40N6OS/c1-6-39(33-34-28-12-8-9-13-29(28)40-33)22-10-7-11-23-41-32-35-30(24-14-18-26(19-15-24)37(2)3)31(36-32)25-16-20-27(21-17-25)38(4)5/h8-9,12-21H,6-7,10-11,22-23H2,1-5H3,(H,35,36)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture				Bioorg Med Chem Lett 5: 177-180 (1995)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051898 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES CC1(CCCCN2CCN(CC2)c2nccs2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C31H37N5O2S/c1-31(14-8-9-16-35-17-19-36(20-18-35)30-32-15-21-39-30)22-37-29(38-23-31)28-33-26(24-10-4-2-5-11-24)27(34-28)25-12-6-3-7-13-25/h2-7,10-13,15,21,29H,8-9,14,16-20,22-23H2,1H3,(H,33,34)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051888 (CHEMBL284378 | {4-[2-(4,5-Diphenyl-1H-imidazol-2-y...) Show SMILES CN(CCCCC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C30H34N4O2/c1-30(18-10-12-20-34(2)25-17-9-11-19-31-25)21-35-29(36-22-30)28-32-26(23-13-5-3-6-14-23)27(33-28)24-15-7-4-8-16-24/h3-9,11,13-17,19,29H,10,12,18,20-22H2,1-2H3,(H,32,33)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051901 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicate				Bioorg Med Chem Lett 2: 375-380 (1992)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50089627 (12-hydroxy-4,6a,12b-trimethyl-3,6-di(methylcarbony...) Show SMILES CC(=O)OC[C@]1(C)[C@H](CC[C@@]2(C)C1C[C@H](OC(C)=O)[C@@]1(C)Oc3cc(oc(=O)c3[C@H](O)C21)-c1cccnc1)OC(C)=O Show InChI InChI=1S/C31H37NO10/c1-16(33)38-15-30(5)22-13-24(40-18(3)35)31(6)27(29(22,4)10-9-23(30)39-17(2)34)26(36)25-21(42-31)12-20(41-28(25)37)19-8-7-11-32-14-19/h7-8,11-12,14,22-24,26-27,36H,9-10,13,15H2,1-6H3/t22?,23-,24-,26-,27?,29-,30-,31+/m0/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Kitasato University Curated by ChEMBL					Assay Description Inhibitory activity of the compound against acyl-CoA:cholesterol acyltransferase (ACAT)				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051883 (1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES Cc1cc(C)n(CCCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C30H36N4O2/c1-22-19-23(2)34(33-22)18-12-6-11-17-30(3)20-35-29(36-21-30)28-31-26(24-13-7-4-8-14-24)27(32-28)25-15-9-5-10-16-25/h4-5,7-10,13-16,19,29H,6,11-12,17-18,20-21H2,1-3H3,(H,31,32)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50450357 (CHEMBL48164) Show SMILES CC(C)NC(=O)N(CCCCCSc1nc(c([nH]1)-c1ccccc1)-c1ccccc1)CCCCCSc1nc(c([nH]1)-c1ccc(cc1)N(C)C)-c1ccc(cc1)N(C)C Show InChI InChI=1S/C48H60N8OS2/c1-35(2)49-48(57)56(31-15-9-17-33-58-46-50-42(36-19-11-7-12-20-36)43(51-46)37-21-13-8-14-22-37)32-16-10-18-34-59-47-52-44(38-23-27-40(28-24-38)54(3)4)45(53-47)39-25-29-41(30-26-39)55(5)6/h7-8,11-14,19-30,35H,9-10,15-18,31-34H2,1-6H3,(H,49,57)(H,50,51)(H,52,53)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
The DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture				Citation and Details
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051890 (2-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES CC1(CCCCN2CCc3ccccc3C2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C33H37N3O2/c1-33(19-10-11-20-36-21-18-25-12-8-9-17-28(25)22-36)23-37-32(38-24-33)31-34-29(26-13-4-2-5-14-26)30(35-31)27-15-6-3-7-16-27/h2-9,12-17,32H,10-11,18-24H2,1H3,(H,34,35)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50450361 (CHEMBL300913) Show SMILES COc1ccc(cc1)-c1nc(SCCCCCN(Cc2ccccn2)C(=O)NC(C)C)[nH]c1-c1ccc(OC)cc1 Show InChI InChI=1S/C32H39N5O3S/c1-23(2)34-32(38)37(22-26-10-6-7-19-33-26)20-8-5-9-21-41-31-35-29(24-11-15-27(39-3)16-12-24)30(36-31)25-13-17-28(40-4)18-14-25/h6-7,10-19,23H,5,8-9,20-22H2,1-4H3,(H,34,38)(H,35,36)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
The DuPont Merck Pharmaceutical Company Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture				Citation and Details
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50285432 (1N,1N-dimethyl-4-[2-{5-[4,5-di(4-dimethylaminophen...) Show SMILES CN(C)c1ccc(cc1)-c1nc(SCCCCCSc2nc(c([nH]2)-c2ccc(cc2)N(C)C)-c2ccc(cc2)N(C)C)[nH]c1-c1ccc(cc1)N(C)C Show InChI InChI=1S/C43H52N8S2/c1-48(2)34-20-12-30(13-21-34)38-39(31-14-22-35(23-15-31)49(3)4)45-42(44-38)52-28-10-9-11-29-53-43-46-40(32-16-24-36(25-17-32)50(5)6)41(47-43)33-18-26-37(27-19-33)51(7)8/h12-27H,9-11,28-29H2,1-8H3,(H,44,45)(H,46,47)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture				Bioorg Med Chem Lett 5: 177-180 (1995)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50051901 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required for the inhibition of cholesterol O-acyl transferase (ACAT) from cholesterol fed rabbit liver				Bioorg Med Chem Lett 2: 375-380 (1992)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50284874 (1-(2,6-Diisopropyl-phenyl)-3-((4R,5R)-4,5-dimethyl...) Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(O[C@H](C)[C@@H](C)O1)c1ccccc1 Show InChI InChI=1S/C25H34N2O3/c1-16(2)21-13-10-14-22(17(3)4)23(21)27-24(28)26-15-25(20-11-8-7-9-12-20)29-18(5)19(6)30-25/h7-14,16-19H,15H2,1-6H3,(H2,26,27,28)/t18-,19-/m1/s1	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against acylcoA: cholesterol acyltransferase (ACAT) in microsomes from monkey liver				Bioorg Med Chem Lett 5: 1581-1586 (1995)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50276564 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...) Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC(F)(F)F Show InChI InChI=1S/C33H41F3N4O3/c1-21(2)26-18-24(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-25(17-23)42-5)13-15-40(16-14-32)28-11-6-7-12-29(28)43-33(34,35)36/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of ACAT in human HepG2 cells				Bioorg Med Chem Lett 19: 1062-5 (2009)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Homo sapiens (human))	BDBM50051901 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from human liver				Bioorg Med Chem Lett 2: 375-380 (1992)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051904 (4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES CC1(CCCCN2CCSCC2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C28H35N3O2S/c1-28(14-8-9-15-31-16-18-34-19-17-31)20-32-27(33-21-28)26-29-24(22-10-4-2-5-11-22)25(30-26)23-12-6-3-7-13-23/h2-7,10-13,27H,8-9,14-21H2,1H3,(H,29,30)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50285447 (CHEMBL53397 | {5-[4,5-Bis-(4-methoxy-phenyl)-1H-im...) Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2cc(ccc2o1)C(C)(C)C Show InChI InChI=1S/C37H46N4O3S/c1-7-8-22-41(36-38-31-25-28(37(2,3)4)16-21-32(31)44-36)23-10-9-11-24-45-35-39-33(26-12-17-29(42-5)18-13-26)34(40-35)27-14-19-30(43-6)20-15-27/h12-21,25H,7-11,22-24H2,1-6H3,(H,39,40)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture				Bioorg Med Chem Lett 5: 177-180 (1995)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051891 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES CC1(CCCCN2CCN(CC2)c2ccccc2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C34H40N4O2/c1-34(19-11-12-20-37-21-23-38(24-22-37)29-17-9-4-10-18-29)25-39-33(40-26-34)32-35-30(27-13-5-2-6-14-27)31(36-32)28-15-7-3-8-16-28/h2-10,13-18,33H,11-12,19-26H2,1H3,(H,35,36)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus)	BDBM50285420 (Benzooxazol-2-yl-{5-[4,5-bis-(4-methoxy-phenyl)-1H...) Show SMILES CCCCN(CCCCCSc1nc(c([nH]1)-c1ccc(OC)cc1)-c1ccc(OC)cc1)c1nc2ccccc2o1 Show InChI InChI=1S/C33H38N4O3S/c1-4-5-21-37(33-34-28-11-7-8-12-29(28)40-33)22-9-6-10-23-41-32-35-30(24-13-17-26(38-2)18-14-24)31(36-32)25-15-19-27(39-3)20-16-25/h7-8,11-20H,4-6,9-10,21-23H2,1-3H3,(H,35,36)	MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture				Bioorg Med Chem Lett 5: 177-180 (1995)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051908 (2-(4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methy...) Show SMILES CC1(CCCCN2CCN(CC2)c2ncccn2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C32H38N6O2/c1-32(15-8-9-18-37-19-21-38(22-20-37)31-33-16-10-17-34-31)23-39-30(40-24-32)29-35-27(25-11-4-2-5-12-25)28(36-29)26-13-6-3-7-14-26/h2-7,10-14,16-17,30H,8-9,15,18-24H2,1H3,(H,35,36)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair
Acyl Cholesterol Acyltransferase 1 (ACAT-1) (Homo sapiens (human))	BDBM50051881 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) Show SMILES Cc1cc(C)n(CCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C29H34N4O2/c1-21-18-22(2)33(32-21)17-11-10-16-29(3)19-34-28(35-20-29)27-30-25(23-12-6-4-7-13-23)26(31-27)24-14-8-5-9-15-24/h4-9,12-15,18,28H,10-11,16-17,19-20H2,1-3H3,(H,30,31)	KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ...				J Med Chem 39: 1423-32 (1996)
					More data for this Ligand-Target Pair

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