Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50466752![]() (CHEMBL4281138) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste... | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182852![]() (US9149492, Compound 1D) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182851![]() (US9149492, Compound 1C) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182849![]() (US9149492, Compound 1A) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50462683![]() (CHEMBL4247249) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste... | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50462683![]() (CHEMBL4247249) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50466740![]() (CHEMBL4282905) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste... | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051894![]() (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50450346![]() (CHEMBL300883) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a | |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture | Bioorg Med Chem Lett 5: 173-6 (1995) BindingDB Entry DOI: 10.7270/Q2T72HDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182850![]() (US9149492, Compound 1B) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50360307![]() (CHEMBL449307) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University Curated by ChEMBL | Assay Description Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages | Bioorg Med Chem Lett 22: 696-9 (2011) Article DOI: 10.1016/j.bmcl.2011.10.045 BindingDB Entry DOI: 10.7270/Q2ZC839D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50285443![]() (Benzooxazol-2-yl-[5-(4,5-diphenyl-1H-imidazol-2-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture | Bioorg Med Chem Lett 5: 177-180 (1995) Article DOI: 10.1016/0960-894X(95)00003-C BindingDB Entry DOI: 10.7270/Q2PG1RQJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50069900![]() (2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in human monocytes-derived macrophages reduction in cholesteryl oleate formation preincubated for 2 hrs followed by [14C]-oleic a... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182847![]() (US9149492, K-604) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Company, Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT in human J774A.1 cells assessed as reduction in esterified-cholesterol accumulation after 18 hrs in presence of 25-hydroxycholeste... | J Med Chem 61: 10635-10650 (2018) Article DOI: 10.1021/acs.jmedchem.8b01256 BindingDB Entry DOI: 10.7270/Q2J38W80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50462702![]() (CHEMBL4241747) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50175765![]() (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276562![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276493![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50436124![]() (CHEMBL2397474) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University Curated by ChEMBL | Assay Description Inhibition of macrophage ACAT (unknown origin) | Bioorg Med Chem 21: 3831-8 (2013) Article DOI: 10.1016/j.bmc.2013.04.025 BindingDB Entry DOI: 10.7270/Q2PV6MR1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276483![]() (1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50079716![]() ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc. Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against ACAT from canine liver | Bioorg Med Chem Lett 9: 2039-42 (1999) Article DOI: 10.1016/s0960-894x(99)00330-3 BindingDB Entry DOI: 10.7270/Q2FF3RJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051901![]() (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from cholesterol fed rabbit gut | Bioorg Med Chem Lett 2: 375-380 (1992) Article DOI: 10.1016/S0960-894X(00)80149-3 BindingDB Entry DOI: 10.7270/Q2MP535G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50079716![]() ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc. Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against ACAT from rabbit liver | Bioorg Med Chem Lett 9: 2039-42 (1999) Article DOI: 10.1016/s0960-894x(99)00330-3 BindingDB Entry DOI: 10.7270/Q2FF3RJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50079716![]() ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc. Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against ACAT from canine adrenal gland | Bioorg Med Chem Lett 9: 2039-42 (1999) Article DOI: 10.1016/s0960-894x(99)00330-3 BindingDB Entry DOI: 10.7270/Q2FF3RJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276487![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM182848![]() (US9149492, Eflucimibe (F12511)) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Dartmouth College US Patent | Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... | US Patent US9149492 (2015) BindingDB Entry DOI: 10.7270/Q2N015BF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50462684![]() (CHEMBL4243015) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051901![]() (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276485![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50360306![]() (CHEMBL505016) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University Curated by ChEMBL | Assay Description Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages | Bioorg Med Chem Lett 22: 696-9 (2011) Article DOI: 10.1016/j.bmcl.2011.10.045 BindingDB Entry DOI: 10.7270/Q2ZC839D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50028866![]() (CHEMBL297271 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-ind...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) | J Med Chem 24: 496-9 (1981) Article DOI: 10.1021/jm00137a004 BindingDB Entry DOI: 10.7270/Q2K64JTV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276494![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(2-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50079716![]() ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc. Curated by ChEMBL | Assay Description Compound was tested for inhibitory activity against ACAT from rabbit liver | Bioorg Med Chem Lett 9: 2039-42 (1999) Article DOI: 10.1016/s0960-894x(99)00330-3 BindingDB Entry DOI: 10.7270/Q2FF3RJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051901![]() (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration required for the inhibition of rabbit arterial Acyl coenzyme A:cholesterol acyltransferase | Bioorg Med Chem Lett 2: 375-380 (1992) Article DOI: 10.1016/S0960-894X(00)80149-3 BindingDB Entry DOI: 10.7270/Q2MP535G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50462661![]() (CHEMBL4240947) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276484![]() (1-(2,6-diisopropylphenyl)-3-((1-(2-methoxyphenyl)-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276565![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50462653![]() (CHEMBL4245998) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276488![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50276563![]() (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd Curated by ChEMBL | Assay Description Inhibition of ACAT in human HepG2 cells | Bioorg Med Chem Lett 19: 1062-5 (2009) Article DOI: 10.1016/j.bmcl.2009.01.020 BindingDB Entry DOI: 10.7270/Q2R78F3M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051888![]() (CHEMBL284378 | {4-[2-(4,5-Diphenyl-1H-imidazol-2-y...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50285435![]() (Benzooxazol-2-yl-{5-[4,5-bis-(4-dimethylamino-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase in J774 Macrophage cell culture | Bioorg Med Chem Lett 5: 177-180 (1995) Article DOI: 10.1016/0960-894X(95)00003-C BindingDB Entry DOI: 10.7270/Q2PG1RQJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051898![]() (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051901![]() (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicate | Bioorg Med Chem Lett 2: 375-380 (1992) Article DOI: 10.1016/S0960-894X(00)80149-3 BindingDB Entry DOI: 10.7270/Q2MP535G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50089627![]() (12-hydroxy-4,6a,12b-trimethyl-3,6-di(methylcarbony...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University Curated by ChEMBL | Assay Description Inhibitory activity of the compound against acyl-CoA:cholesterol acyltransferase (ACAT) | Bioorg Med Chem Lett 10: 1315-6 (2000) Article DOI: 10.1016/s0960-894x(00)00218-3 BindingDB Entry DOI: 10.7270/Q23B5ZCD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50462652![]() (CHEMBL4248936) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholestero... | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051890![]() (2-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM50051883![]() (1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer Curated by ChEMBL | Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ... | J Med Chem 39: 1423-32 (1996) Article DOI: 10.1021/jm9505876 BindingDB Entry DOI: 10.7270/Q2TB160C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50450357![]() (CHEMBL48164) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | CHEMBL PC cid PC sid UniChem Similars | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a | |
DuPont Pharmaceuticals Company Curated by ChEMBL | Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) in J774 Macrophage cell culture | Bioorg Med Chem Lett 5: 173-6 (1995) BindingDB Entry DOI: 10.7270/Q2T72HDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl coenzyme A:cholesterol acyltransferase 1 (Mus musculus) | BDBM50069900![]() (2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Kowa Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of ACAT1 in mouse IC21 cells in absence of BSA | Bioorg Med Chem 26: 4001-4013 (2018) Article DOI: 10.1016/j.bmc.2018.06.024 BindingDB Entry DOI: 10.7270/Q22F7R3T | |||||||||||
More data for this Ligand-Target Pair |
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