Found 77 hits Enz. Inhib. hit(s) with Target = 'Adrenaline alpha2' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Adrenaline alpha2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | Reactome pathway
UniProtKB/SwissProt
GoogleScholar
| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | Reactome pathway
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| CHEMBL
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PC sid
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| Article
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420215
(CHEMBL339858)Show SMILES CC(C)N1\C(=C/c2cc[n+](C(C)C)c3ccccc23)C=Cc2ccccc12 Show InChI InChI=1S/C25H27N2/c1-18(2)26-16-15-21(23-10-6-8-12-25(23)26)17-22-14-13-20-9-5-7-11-24(20)27(22)19(3)4/h5-19H,1-4H3/q+1 | Reactome pathway
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| Article
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| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
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| 390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
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| 420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
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| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
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| 605 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells |
J Biol Chem 273: 30915-20 (1998)
Article DOI: 10.1074/jbc.273.47.30915
BindingDB Entry DOI: 10.7270/Q2V40WGS |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420192
(CHEMBL2074851)Show SMILES CC[n+]1c(CC2C=C(C)N=C(N2C)c2ccccc2)ccc2ccccc12 Show InChI InChI=1S/C24H26N3/c1-4-27-21(15-14-19-10-8-9-13-23(19)27)17-22-16-18(2)25-24(26(22)3)20-11-6-5-7-12-20/h5-16,22H,4,17H2,1-3H3/q+1 | Reactome pathway
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| Article
PubMed
| 861 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing NIH3T3 cells |
Toxicol Sci 47: 181-6 (1999)
Article DOI: 10.1093/toxsci/47.2.181
BindingDB Entry DOI: 10.7270/Q2F1910T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM81945
(CAS_39484 | CHEMBL105891 | CHEMBL108926 | CHEMBL27...)Show InChI InChI=1S/C12H12N/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11/h2-10H,1H3/q+1 | Reactome pathway
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| 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM86278
(MCL-202)Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2[C@@H](C1)c1cccc(C)c1 Show InChI InChI=1S/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3/t15-/m0/s1 | Reactome pathway
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| 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard University
Curated by PDSP Ki Database
| |
Eur J Pharmacol 474: 137-40 (2003)
Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM16173
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15) | Reactome pathway
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| 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50014407
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2 | Reactome pathway
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| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by PDSP Ki Database
| |
Eur J Pharmacol 168: 387-92 (1989)
Article DOI: 10.1016/0014-2999(89)90802-9
BindingDB Entry DOI: 10.7270/Q23R0RC5 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway
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| 9.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM86694
(N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyform...)Show InChI InChI=1S/C11H14ClN3O2/c12-10-7-9(13-8-14-16)1-2-11(10)15-3-5-17-6-4-15/h1-2,7-8,16H,3-6H2,(H,13,14) | Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 314: 77-85 (2005)
Article DOI: 10.1124/jpet.105.083964
BindingDB Entry DOI: 10.7270/Q2MW2FQQ |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50416487
(CHEMBL1236196 | TETRABUTYLAMMONIUM)Show InChI InChI=1S/C16H36N/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4/h5-16H2,1-4H3/q+1 | Reactome pathway
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| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (electrogenicity) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50017681
((1S,2R,4S,5R)-2-[(S)-Hydroxy-(6-methoxy-quinolin-4...)Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13?,14?,19?,20-/m0/s1 | Reactome pathway
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| 1.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50028893
(4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutana...)Show InChI InChI=1S/C21H29N3O/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25) | Reactome pathway
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| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM39344
(4-amino-N-[2-(diethylamino)ethyl]benzamide;hydroch...)Show InChI InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17) | Reactome pathway
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| 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM82070
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1 | Reactome pathway
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| 5.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50149890
(CHEMBL9324 | tetraethylammonium)Show InChI InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1 | Reactome pathway
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| 5.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50367247
(QUININE | Quinamm | Quinsan | cid_3034034)Show SMILES COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 | Reactome pathway
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| 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | Reactome pathway
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| 1.71E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50403559
(Brumetadina | CIMETIDINE)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway
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| 1.98E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing NIH3T3 cells |
Toxicol Sci 47: 181-6 (1999)
Article DOI: 10.1093/toxsci/47.2.181
BindingDB Entry DOI: 10.7270/Q2F1910T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM10755
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2 | Reactome pathway
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| 2.42E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420178
(GUANIDINE) | Reactome pathway
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| 2.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MPP+ uptake in OCT2-expressing HEK293 cells |
Mol Pharmacol 56: 1-10 (1999)
Article DOI: 10.1124/mol.56.1.1
BindingDB Entry DOI: 10.7270/Q2KK9D21 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM55121
(3-HYDROXYTYRAMINE HYDROCHLORIDE | 4-(2-aminoethyl)...)Show InChI InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2 | Reactome pathway
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| 3.47E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | Reactome pathway
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| 3.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Heidelberg
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of MPP+ uptake in OCT2-expressing HEK293 cells |
Mol Pharmacol 56: 1-10 (1999)
Article DOI: 10.1124/mol.56.1.1
BindingDB Entry DOI: 10.7270/Q2KK9D21 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420177
(NICOTINYL METHYLAMIDE)Show InChI InChI=1S/C7H8N2O/c1-8-7(10)6-3-2-4-9-5-6/h2-5H,1H3,(H,8,10) | Reactome pathway
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| 4.03E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50373877
(Betaxin | CA inhibitor, 3 | THIAMINE (VIT B1) | Th...)Show InChI InChI=1S/C12H17N4OS/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15)/q+1 | Reactome pathway
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| 6.46E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420178
(GUANIDINE) | Reactome pathway
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| 7.14E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT2-expressing MDCK cells |
J Pharmacol Exp Ther 287: 800-5 (1998)
BindingDB Entry DOI: 10.7270/Q2D79CQ4 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50028111
(Cis-Platinum(II) | Cisplatin(cis-Diammenedichlorop...)Show InChI InChI=1S/2ClH.2H2N.Pt/h2*1H;2*1H2;/q;;2*-1;+4/p-2 | Reactome pathway
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| 9.25E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas M. D. Anderson Cancer Center
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing NIH3T3 cells |
Toxicol Sci 47: 181-6 (1999)
Article DOI: 10.1093/toxsci/47.2.181
BindingDB Entry DOI: 10.7270/Q2F1910T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50029050
((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)Show InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1 | Reactome pathway
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| 1.19E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420192
(CHEMBL2074851)Show SMILES CC[n+]1c(CC2C=C(C)N=C(N2C)c2ccccc2)ccc2ccccc12 Show InChI InChI=1S/C24H26N3/c1-4-27-21(15-14-19-10-8-9-13-23(19)27)17-22-16-18(2)25-24(26(22)3)20-11-6-5-7-12-20/h5-16,22H,4,17H2,1-3H3/q+1 | Reactome pathway
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manitoba
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells |
J Pharmacol Exp Ther 303: 959-68 (2002)
Article DOI: 10.1124/jpet.102.038885
BindingDB Entry DOI: 10.7270/Q28W3FTB |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420192
(CHEMBL2074851)Show SMILES CC[n+]1c(CC2C=C(C)N=C(N2C)c2ccccc2)ccc2ccccc12 Show InChI InChI=1S/C24H26N3/c1-4-27-21(15-14-19-10-8-9-13-23(19)27)17-22-16-18(2)25-24(26(22)3)20-11-6-5-7-12-20/h5-16,22H,4,17H2,1-3H3/q+1 | Reactome pathway
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| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manitoba
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells |
J Pharmacol Exp Ther 303: 959-68 (2002)
Article DOI: 10.1124/jpet.102.038885
BindingDB Entry DOI: 10.7270/Q28W3FTB |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM8903
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1 | Reactome pathway
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| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells |
J Biol Chem 273: 32776-86 (1998)
Article DOI: 10.1074/jbc.273.49.32776
BindingDB Entry DOI: 10.7270/Q2ZK5KHT |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420181
(CHEMBL2074704)Show InChI InChI=1S/C20H44N/c1-5-9-13-17-21(18-14-10-6-2,19-15-11-7-3)20-16-12-8-4/h5-20H2,1-4H3/q+1 | Reactome pathway
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| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM8582
((1S,2R,10S,11S,14S,15S)-14-(2-hydroxyacetyl)-2,15-...)Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O3/c1-20-9-7-14(23)11-13(20)3-4-15-16-5-6-18(19(24)12-22)21(16,2)10-8-17(15)20/h11,15-18,22H,3-10,12H2,1-2H3/t15-,16-,17-,18+,20-,21-/m0/s1 | Reactome pathway
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| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells |
J Biol Chem 273: 32776-86 (1998)
Article DOI: 10.1074/jbc.273.49.32776
BindingDB Entry DOI: 10.7270/Q2ZK5KHT |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420192
(CHEMBL2074851)Show SMILES CC[n+]1c(CC2C=C(C)N=C(N2C)c2ccccc2)ccc2ccccc12 Show InChI InChI=1S/C24H26N3/c1-4-27-21(15-14-19-10-8-9-13-23(19)27)17-22-16-18(2)25-24(26(22)3)20-11-6-5-7-12-20/h5-16,22H,4,17H2,1-3H3/q+1 | Reactome pathway
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| n/a | n/a | 2.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
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| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
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| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Medical College of Georgia
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells |
J Biol Chem 273: 32776-86 (1998)
Article DOI: 10.1074/jbc.273.49.32776
BindingDB Entry DOI: 10.7270/Q2ZK5KHT |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50151860
(4-Acetylamino-N-(2-diethylamino-ethyl)-benzamide |...)Show InChI InChI=1S/C15H23N3O2/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19) | Reactome pathway
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| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50416487
(CHEMBL1236196 | TETRABUTYLAMMONIUM)Show InChI InChI=1S/C16H36N/c1-5-9-13-17(14-10-6-2,15-11-7-3)16-12-8-4/h5-16H2,1-4H3/q+1 | Reactome pathway
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| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50420179
(CHEMBL2074857)Show InChI InChI=1S/C12H28N/c1-5-9-13(10-6-2,11-7-3)12-8-4/h5-12H2,1-4H3/q+1 | Reactome pathway
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| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50010859
(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)Show InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 | Reactome pathway
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DrugBank
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 50 uM) in OCT2-expressing MDCK cells |
Pharm Res 18: 1528-34 (2001)
Article DOI: 10.1023/a:1013070128668
BindingDB Entry DOI: 10.7270/Q28G8N0T |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway
UniProtKB/SwissProt
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CHEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50170653
((11beta)-11,21-dihydroxypregn-4-ene-3,20-dione | 1...)Show SMILES C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO Show InChI InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1 | Reactome pathway
UniProtKB/SwissProt
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CHEBI
CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition pramipexole uptake in rOCT2-injected oocytes |
Drug Metab Dispos 33: 495-9 (2005)
Article DOI: 10.1124/dmd.104.002519
BindingDB Entry DOI: 10.7270/Q24B32KW |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50367247
(QUININE | Quinamm | Quinsan | cid_3034034)Show SMILES COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1 | Reactome pathway
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CHEBI
DrugBank
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Manitoba
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (in the presence of bicarbonate) (TEA: 20 uM) in OCT2-expressing HEK293 cells |
J Pharmacol Exp Ther 303: 959-68 (2002)
Article DOI: 10.1124/jpet.102.038885
BindingDB Entry DOI: 10.7270/Q28W3FTB |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM39687
((2E)-1-ethyl-2-[(1-ethyl-2-quinolin-1-iumyl)methyl...)Show InChI InChI=1S/C23H23N2/c1-3-24-20(15-13-18-9-5-7-11-22(18)24)17-21-16-14-19-10-6-8-12-23(19)25(21)4-2/h5-17H,3-4H2,1-2H3/q+1 | Reactome pathway
UniProtKB/SwissProt
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CHEBI
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.38E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 100 uM) in Xenopus laevis oocytes |
Biochim Biophys Acta 1417: 224-31 (1999)
Article DOI: 10.1016/s0005-2736(99)00005-x
BindingDB Entry DOI: 10.7270/Q2WS8VJ5 |
More data for this
Ligand-Target Pair | |
Adrenaline alpha2
(RAT) | BDBM50017681
((1S,2R,4S,5R)-2-[(S)-Hydroxy-(6-methoxy-quinolin-4...)Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13?,14?,19?,20-/m0/s1 | Reactome pathway
UniProtKB/SwissProt
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CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Anatomy of the Bayerische Julius-Maximilians-Universit£t
Curated by ChEMBL
| Assay Description
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes |
Am J Physiol Renal Physiol 281: 454-68 (2001)
Article DOI: 10.1152/ajprenal.2001.281.3.F454
BindingDB Entry DOI: 10.7270/Q2BR8TF3 |
More data for this
Ligand-Target Pair | |
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