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Compile Data Set for Download or QSAR

Found 317 hits Enz. Inhib. hit(s) with Target = 'Alpha glucosidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291029
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291026
PNG
((2R,3R,4R,5S)-1-[(E)-3-(Dimethyl-phenyl-silanyl)-a...)
Show SMILES C[Si](C)(\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H27NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-8,10,14-17,19-22H,9,11-12H2,1-2H3/b10-6+/t14-,15+,16-,17-/m1/s1
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4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291020
PNG
((2R,3R,4R,5S)-1-[3-(Dimethyl-phenyl-silanyl)-propy...)
Show SMILES C[Si](C)(CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C17H29NO4Si/c1-23(2,13-7-4-3-5-8-13)10-6-9-18-11-15(20)17(22)16(21)14(18)12-19/h3-5,7-8,14-17,19-22H,6,9-12H2,1-2H3/t14-,15+,16-,17-/m1/s1
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10n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327503
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6-,7-,8-,9+,10-,11-,20+/m1/s1
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15n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330961
PNG
((2R,3S,4S)-1-((2S,3S,4R,5R,6S)-2,3,4,5,6,7-hexahyd...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C[Se+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25O9Se/c13-1-5(15)10(19)12(21)11(20)7(17)4-22-3-6(16)9(18)8(22)2-14/h5-21H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,12+,22?/m0/s1
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20n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291027
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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28n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330954
PNG
(CHEMBL1276973 | de-O-sulfonated kotalanol)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25O9S/c13-1-5(15)10(19)12(21)11(20)7(17)4-22-3-6(16)9(18)8(22)2-14/h5-21H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,12+,22?/m0/s1
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30n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327502
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
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43n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal maltase-glucoamylase


Bioorg Med Chem Lett 21: 6491-4 (2011)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327502
PNG
((1R,2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)-1-((...)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H23O8S/c12-1-5(14)10(18)11(19)7(16)4-20-3-6(15)9(17)8(20)2-13/h5-19H,1-4H2/q+1/t5-,6+,7+,8+,9-,10+,11+,20-/m0/s1
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43n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291031
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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50n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330960
PNG
((2R,3R,4R)-1-((2R,3R,4S,5R,6S)-2,3,4,5,6,7-hexahyd...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CN1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO9/c14-3-5-9(19)6(16)1-13(5)2-7(17)10(20)12(22)11(21)8(18)4-15/h5-12,14-22H,1-4H2/t5-,6-,7-,8+,9-,10-,11-,12+/m1/s1
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60n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291034
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(5-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C14H31NO4Si/c1-20(2,3)8-6-4-5-7-15-9-12(17)14(19)13(18)11(15)10-16/h11-14,16-19H,4-10H2,1-3H3/t11-,12+,13-,14-/m1/s1
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70n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330959
PNG
(CHEMBL1277153)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[Se+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12SSe/c13-1-5(15)10(19)11(20)12(24-25(21,22)23)7(17)4-26-3-6(16)9(18)8(26)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,26?/m0/s1
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80n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291023
PNG
((2R,3R,4R,5S)-1-[(E)-3-(tert-Butyl-dimethyl-silany...)
Show SMILES CC(C)(C)[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C15H31NO4Si/c1-15(2,3)21(4,5)8-6-7-16-9-12(18)14(20)13(19)11(16)10-17/h6,8,11-14,17-20H,7,9-10H2,1-5H3/b8-6+/t11-,12+,13-,14-/m1/s1
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87n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316180
PNG
((1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10-,11+,12+,25?/m0/s1
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100n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291021
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H29NO4Si/c1-19(2,3)7-5-4-6-14-8-11(16)13(18)12(17)10(14)9-15/h10-13,15-18H,4-9H2,1-3H3/t10-,11+,12-,13-/m1/s1
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316181
PNG
((1S,2R,3S,4R)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6-,7-,8-,9+,10+,11-,12-,25?/m1/s1
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130n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
PDB

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KEGG

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150n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327501
PNG
(CHEMBL1258528 | ponkoranol)
Show SMILES OC[C@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C11H22O11S2/c12-1-5(14)10(18)11(22-24(19,20)21)7(16)4-23-3-6(15)9(17)8(23)2-13/h5-18H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,23-/m0/s1
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170n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316179
PNG
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
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190n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316179
PNG
((1S,2R,3R,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6+,7+,8+,9-,10+,11+,12+,25?/m0/s1
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190n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50316178
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5R,6R-2,4,5,6,7-pentahy...)
Show SMILES OC[C@@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[S+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H24O12S2/c13-1-5(15)10(19)11(20)12(24-26(21,22)23)7(17)4-25-3-6(16)9(18)8(25)2-14/h5-20H,1-4H2/t5-,6-,7-,8-,9+,10-,11-,12-,25?/m1/s1
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200n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human maltase glucoamylase N-terminal catalytic domain


Bioorg Med Chem 18: 2829-35 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM18353
PNG
((2R,3R,4R,5S)-2-(hydroxymethyl)-1-methylpiperidine...)
Show SMILES CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3/t4-,5+,6-,7-/m1/s1
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420n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50408432
PNG
(CHEMBL2115215)
Show SMILES OC[C@H]1N[C@@H](CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4+,5-,6-,7+/m1/s1
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450n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against alpha-glucosidase


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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500n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal domain of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem Lett 20: 5686-9 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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500n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal maltase-glucoamylase


Bioorg Med Chem Lett 21: 6491-4 (2011)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50327504
PNG
(1,4-Dideoxy-1,4-[[2S,3S,4R,5S]-2,4,5,6-tetrahydrox...)
Show SMILES CO[C@H]([C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO)[C@H](O)[C@@H](O)CO
Show InChI InChI=1S/C12H25O8S/c1-20-12(11(19)6(15)2-13)8(17)5-21-4-7(16)10(18)9(21)3-14/h6-19H,2-5H2,1H3/q+1/t6-,7+,8+,9+,10-,11+,12+,21-/m0/s1
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500n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal maltase-glucoamylase by Lineweaver-Burk plot analysis


Bioorg Med Chem Lett 21: 6491-4 (2011)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291028
PNG
((2R,3R,4R,5S)-1-(Dimethyl-propyl-silanylmethyl)-2-...)
Show SMILES CCC[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-4-5-18(2,3)8-13-6-10(15)12(17)11(16)9(13)7-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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900n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291032
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)c1cccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)c1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-5-11(7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330955
PNG
((1S,2S)-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymeth...)
Show SMILES OC[C@H](OS([O-])(=O)=O)[C@H](O)C[S@@+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C9H18O9S2/c10-1-7(18-20(15,16)17)5(12)3-19-4-6(13)9(14)8(19)2-11/h5-14H,1-4H2/t5-,6-,7+,8-,9+,19-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50242271
PNG
((2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)...)
Show SMILES OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50291029
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-((E)-3-trimethylsi...)
Show SMILES C[Si](C)(C)\C=C\CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h4,6,9-12,14-17H,5,7-8H2,1-3H3/b6-4+/t9-,10+,11-,12-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330957
PNG
(7'-[(1,5-Dideoxy-1,5-imino-D-glucitol)-5-N-ammoniu...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO10/c15-3-5-9(20)10(21)6(17)1-14(5)2-7(18)11(22)13(24)12(23)8(19)4-16/h5-13,15-24H,1-4H2/t5-,6+,7-,8+,9-,10-,11-,12-,13+/m1/s1
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1.40E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330956
PNG
(7'-[(1,5-Dideoxy-1,5-imino-D-glucitol)-5-N-ammoniu...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[NH+]1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C13H27NO13S/c15-3-5-9(20)10(21)6(17)1-14(5)2-7(18)13(27-28(24,25)26)12(23)11(22)8(19)4-16/h5-13,15-23H,1-4H2,(H,24,25,26)/t5-,6+,7-,8+,9-,10-,11-,12-,13-/m1/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50291031
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(3-trimethylsilany...)
Show SMILES C[Si](C)(C)CCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H27NO4Si/c1-18(2,3)6-4-5-13-7-10(15)12(17)11(16)9(13)8-14/h9-12,14-17H,4-8H2,1-3H3/t9-,10+,11-,12-/m1/s1
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2.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291022
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-trimethylsilanylme...)
Show SMILES C[Si](C)(C)CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C10H23NO4Si/c1-16(2,3)6-11-4-8(13)10(15)9(14)7(11)5-12/h7-10,12-15H,4-6H2,1-3H3/t7-,8+,9-,10-/m1/s1
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2.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291033
PNG
((2R,3R,4R,5S)-1-[(Dimethyl-phenyl-silanyl)-methyl]...)
Show SMILES C[Si](C)(CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO)c1ccccc1
Show InChI InChI=1S/C15H25NO4Si/c1-21(2,11-6-4-3-5-7-11)10-16-8-13(18)15(20)14(19)12(16)9-17/h3-7,12-15,17-20H,8-10H2,1-2H3/t12-,13+,14-,15-/m1/s1
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2.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50291027
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(4-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccc(CN2C[C@H](O)[C@@H](O)[C@H](O)[C@H]2CO)cc1
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)12-6-4-11(5-7-12)8-17-9-14(19)16(21)15(20)13(17)10-18/h4-7,13-16,18-21H,8-10H2,1-3H3/t13-,14+,15-,16-/m1/s1
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2.60E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50366376
PNG
(CHEMBL1159523)
Show SMILES CC(=O)OCC(CO[C@H]1O[C@H](CS(O)(=O)=O)[C@@H](O)[C@H](O)[C@H]1O)OC(C)=O
Show InChI InChI=1S/C13H22O12S/c1-6(14)22-3-8(24-7(2)15)4-23-13-12(18)11(17)10(16)9(25-13)5-26(19,20)21/h8-13,16-18H,3-5H2,1-2H3,(H,19,20,21)/t8?,9-,10-,11+,12-,13+/m1/s1
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2.90E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibitory constant against yeast alpha-glucosidase


Bioorg Med Chem Lett 5: 1241-1244 (1995)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50285807
PNG
(CHEMBL2368787)
Show SMILES OC[C@@H]1N=C(NCc2ccccc2)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C13H18N2O4/c16-7-9-10(17)11(18)12(19)13(15-9)14-6-8-4-2-1-3-5-8/h1-5,9-12,16-19H,6-7H2,(H,14,15)/t9-,10+,11-,12-/m0/s1
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5.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition against beta-glucosidase in sweet almond


Bioorg Med Chem Lett 5: 2655-2660 (1995)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50408431
PNG
(CHEMBL2114210)
Show SMILES OC[C@H]1N[C@H](CO)[C@@H](O)C(O)[C@@H]1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3-,4-,5-,6-/m1/s1
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6.20E+3n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against alpha-glucosidase


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50065255
PNG
((R)-2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol |...)
Show SMILES OCC1NC(CO)[C@@H](O)C(O)C1O
Show InChI InChI=1S/C7H15NO5/c9-1-3-5(11)7(13)6(12)4(2-10)8-3/h3-13H,1-2H2/t3?,4?,5-,6?,7?/m1/s1
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6.90E+3n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity against alpha-glucosidase


J Med Chem 41: 2565-71 (1998)

More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50291024
PNG
((2R,3R,4R,5S)-2-Hydroxymethyl-1-(2-trimethylsilany...)
Show SMILES C[Si](C)(C)c1ccccc1CN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C16H27NO4Si/c1-22(2,3)14-7-5-4-6-11(14)8-17-9-13(19)16(21)15(20)12(17)10-18/h4-7,12-13,15-16,18-21H,8-10H2,1-3H3/t12-,13+,15-,16-/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibition constant against rat small intestinal glucoamylase


Bioorg Med Chem Lett 7: 355-360 (1997)

More data for this
Ligand-Target Pair
Alpha glucosidase


(Homo sapiens (Human))
BDBM19459
PNG
(5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1coc2cc(O)cc(O)c2c1=O
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
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1.04E+4n/an/an/an/an/an/an/an/a



SUN Yat-sen (Zhongshan) University

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase by genistein


Bioorg Med Chem Lett 14: 2947-50 (2004)

More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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2.50E+4n/an/an/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-glucosidase of yeast


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50287006
PNG
(Azepane-3,4,5,6-tetraol | CHEMBL13922)
Show SMILES O[C@H]1CNC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-3-1-7-2-4(9)6(11)5(3)10/h3-11H,1-2H2/t3-,4-,5+,6+/m0/s1
PDB

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KEGG

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Article
2.94E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of alpha-glucosidase from yeast.


Bioorg Med Chem Lett 6: 1117-1122 (1996)

More data for this
Ligand-Target Pair
Alpha glucosidase


(Homo sapiens)
BDBM50076963
PNG
((3R,5R)-2-Hydroxymethyl-1-methyl-piperidine-3,4,5-...)
Show SMILES CN1CC(O)C(O)C(O)C1CO
Show InChI InChI=1S/C7H15NO4/c1-8-2-5(10)7(12)6(11)4(8)3-9/h4-7,9-12H,2-3H2,1H3
PDB

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PubMed
5.40E+4n/an/an/an/an/an/an/an/a



Ohio State University

Curated by ChEMBL


Assay Description
Inhibitory potency for brewer's yeast alpha-glucosidase in 0.1 M sodium phosphate buffer at pH 6.55.


Citation and Details
More data for this
Ligand-Target Pair
Lysosomal alpha-glucosidase


(Homo sapiens)
BDBM50070029
PNG
((2Z)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-...)
Show SMILES OCC1OC(=NOC(=O)Nc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C13H16N2O7/c16-6-8-9(17)10(18)11(19)12(21-8)15-22-13(20)14-7-4-2-1-3-5-7/h1-5,8-11,16-19H,6H2,(H,14,20)
PDB

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PubMed
7.50E+4n/an/an/an/an/an/an/an/a



S.E.S.N.A.B., Pole Sciences et Technologie, Universit� de La Rochelle. therisod@icmo.u-psud.fr

Curated by ChEMBL


Assay Description
The compound was tested for its inhibitory activity against Alpha-glucosidase


Citation and Details
More data for this
Ligand-Target Pair
Alpha glucosidase


(Homo sapiens)
BDBM50350757
PNG
(CHEMBL1818432)
Show SMILES OC[C@@H]1CNC[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c8-3-4-1-7-2-5(9)6(4)10/h4-10H,1-3H2/t4-,5+,6+/m0/s1
PDB

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PubMed
8.60E+4n/an/an/an/an/an/an/an/a



Technische Universit£t Berlin

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-glucosidase of yeast


Citation and Details
More data for this
Ligand-Target Pair
Maltase-glucoamylase


(Homo sapiens (Human))
BDBM50330958
PNG
((2R,3R,4R,5R,6S)-1-((2R,3R,4R)-3,4-dihydroxy-2-(hy...)
Show SMILES OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](OS([O-])(=O)=O)[C@H](O)C[NH+]1C[C@@H](O)[C@H](O)[C@H]1CO
Show InChI InChI=1S/C12H25NO12S/c14-3-5-9(19)6(16)1-13(5)2-7(17)12(25-26(22,23)24)11(21)10(20)8(18)4-15/h5-12,14-21H,1-4H2,(H,22,23,24)/t5-,6-,7-,8+,9-,10-,11-,12-/m1/s1
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PubMed
9.00E+4n/an/an/an/an/an/an/an/a



Simon Fraser University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant N-terminal subunit of maltase-glucoamylase after 60 mins by glucose oxidase assay


Bioorg Med Chem 18: 7794-8 (2010)

More data for this
Ligand-Target Pair
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