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Compile Data Set for Download or QSAR

Found 229 hits Enz. Inhib. hit(s) with Target = 'Alpha-L-fucosidase I' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072685
PNG
((3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperid...)
Show SMILES CC1C(O)C(O)C(O)C(CO)N1CC=O
Show InChI InChI=1S/C9H17NO5/c1-5-7(13)9(15)8(14)6(4-12)10(5)2-3-11/h3,5-9,12-15H,2,4H2,1H3
KEGG

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1.5n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1


Bioorg Med Chem Lett 8: 3353-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104394
PNG
((4S,5R)-2-Methyl-piperidine-3,4,5-triol | CHEMBL87...)
Show SMILES CC1NC[C@@H](O)[C@H](O)C1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3?,4-,5?,6+/m1/s1
KEGG

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5n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072588
PNG
((2S,3R,4R,5R,6S)-2-Hydroxymethyl-6-methyl-piperidi...)
Show SMILES CC1NC(CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3?,4?,5-,6-,7+/m1/s1
KEGG

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5.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for inhibitory activity against alpha-L-fucosidase from bovine epididymus (sigma)


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072588
PNG
((2S,3R,4R,5R,6S)-2-Hydroxymethyl-6-methyl-piperidi...)
Show SMILES CC1NC(CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3?,4?,5-,6-,7+/m1/s1
KEGG

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5.80n/an/an/an/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine epididymis; Competitive Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072588
PNG
((2S,3R,4R,5R,6S)-2-Hydroxymethyl-6-methyl-piperidi...)
Show SMILES CC1NC(CO)[C@@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3?,4?,5-,6-,7+/m1/s1
KEGG

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5.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for inhibitory activity (competitive) against alpha-L-fucosidase from bovine kidney


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104394
PNG
((4S,5R)-2-Methyl-piperidine-3,4,5-triol | CHEMBL87...)
Show SMILES CC1NC[C@@H](O)[C@H](O)C1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3?,4-,5?,6+/m1/s1
KEGG

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6n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-L-fucosidase of bovine epididymis expressed as Ki


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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6.20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Compound was tested for inhibitory activity (competitive) against alpha-L-fucosidase from bovine kidney


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
KEGG

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6.20n/an/an/an/an/an/an/an/a


TBA

Assay Description
Tested for inhibitory activity against alpha-L-fucosidase from bovine epididymus (sigma)


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
KEGG

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6.20n/an/an/an/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine epididymis; Competitive Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104387
PNG
((4R,5R)-6-Hydroxymethyl-2-methyl-2,3,4,5-tetrahydr...)
Show SMILES CC1NC(CO)C(=O)[C@H](O)C1O
Show InChI InChI=1S/C7H13NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-5,7-10,12H,2H2,1H3/t3?,4?,5?,7-/m1/s1
KEGG

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7n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-L-fucosidase of bovine epididymis expressed as Ki


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072685
PNG
((3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperid...)
Show SMILES CC1C(O)C(O)C(O)C(CO)N1CC=O
Show InChI InChI=1S/C9H17NO5/c1-5-7(13)9(15)8(14)6(4-12)10(5)2-3-11/h3,5-9,12-15H,2,4H2,1H3
KEGG

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8n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis


Bioorg Med Chem Lett 8: 3353-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104405
PNG
(3,4-Dihydroxy-5-methyl-pyrrolidine-2-sulfonic acid...)
Show SMILES CC1NC(C(O)C1O)S(O)(=O)=O
Show InChI InChI=1S/C5H11NO5S/c1-2-3(7)4(8)5(6-2)12(9,10)11/h2-8H,1H3,(H,9,10,11)
KEGG

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10n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
KEGG

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PubMed
10n/an/an/an/an/an/an/an/a



Technische Universität Graz

Curated by ChEMBL


Assay Description
Inhibition of human liver alpha-L-fucosidase


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072685
PNG
((3,4,5-Trihydroxy-2-hydroxymethyl-6-methyl-piperid...)
Show SMILES CC1C(O)C(O)C(O)C(CO)N1CC=O
Show InChI InChI=1S/C9H17NO5/c1-5-7(13)9(15)8(14)6(4-12)10(5)2-3-11/h3,5-9,12-15H,2,4H2,1H3
KEGG

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11n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney


Bioorg Med Chem Lett 8: 3353-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403995
PNG
(CHEMBL2115269)
Show SMILES C[C@@H]1C[C@H](N)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-3-2-4(8)6(10)7(11)5(3)9/h3-7,9-11H,2,8H2,1H3/t3-,4+,5-,6-,7-/m1/s1
KEGG

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12n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
The compound was tested for the inhibitory activity against alpha-L-Fucosidase in bovine kidney


Bioorg Med Chem Lett 12: 749-52 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403994
PNG
(CHEMBL2114287)
Show SMILES C[C@@H]1C[C@@H](N)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-3-2-4(8)6(10)7(11)5(3)9/h3-7,9-11H,2,8H2,1H3/t3-,4-,5-,6-,7-/m1/s1
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12n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
The compound was tested for the inhibitory activity against alpha-L-Fucosidase in bovine kidney


Bioorg Med Chem Lett 12: 749-52 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104403
PNG
((2R,3S)-2-Amino-5-methyl-piperidine-3,4-diol | CHE...)
Show SMILES CC1CN[C@@H](N)[C@H](O)C1O
Show InChI InChI=1S/C6H14N2O2/c1-3-2-8-6(7)5(10)4(3)9/h3-6,8-10H,2,7H2,1H3/t3?,4?,5-,6-/m1/s1
KEGG

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16n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118923
PNG
((1S,2S,3R)-4-Methyl-6-octylamino-cyclohexane-1,2,3...)
Show SMILES CCCCCCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C15H31NO3/c1-3-4-5-6-7-8-9-16-12-10-11(2)13(17)15(19)14(12)18/h11-19H,3-10H2,1-2H3
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16n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072687
PNG
((S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydrox...)
Show SMILES CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H23N3O6/c1-5-7(17)8(18)9(19)11(4-16,14-5)3-13-10(20)6(12)2-15/h5-9,14-19H,2-4,12H2,1H3,(H,13,20)/t5?,6-,7?,8?,9?,11?/m0/s1
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19n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine epididymis


Bioorg Med Chem Lett 8: 3353-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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29n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition constant against Alpha-Fucosidase


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072687
PNG
((S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydrox...)
Show SMILES CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H23N3O6/c1-5-7(17)8(18)9(19)11(4-16,14-5)3-13-10(20)6(12)2-15/h5-9,14-19H,2-4,12H2,1H3,(H,13,20)/t5?,6-,7?,8?,9?,11?/m0/s1
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30n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-Fucosidase obtained from Bovine kidney


Bioorg Med Chem Lett 8: 3353-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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31n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118928
PNG
((1S,2S,3R)-4-Methyl-6-phenethylamino-cyclohexane-1...)
Show SMILES CC1CC(NCCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C15H23NO3/c1-10-9-12(14(18)15(19)13(10)17)16-8-7-11-5-3-2-4-6-11/h2-6,10,12-19H,7-9H2,1H3
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32n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072687
PNG
((S)-2-Amino-3-hydroxy-N-(3,4,5-trihydroxy-2-hydrox...)
Show SMILES CC1NC(CO)(CNC(=O)[C@@H](N)CO)C(O)C(O)C1O
Show InChI InChI=1S/C11H23N3O6/c1-5-7(17)8(18)9(19)11(4-16,14-5)3-13-10(20)6(12)2-15/h5-9,14-19H,2-4,12H2,1H3,(H,13,20)/t5?,6-,7?,8?,9?,11?/m0/s1
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47n/an/an/an/an/an/an/an/a



Scripps Research Institute

Curated by ChEMBL


Assay Description
Compound was tested for inhibitory activity against alpha-1,2-Fucosidase obtained from Arthrobacter oxidans F1


Bioorg Med Chem Lett 8: 3353-8 (1999)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118921
PNG
((1R,2S,3S)-4-Heptylamino-6-methyl-cyclohexane-1,2,...)
Show SMILES CCCCCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C14H29NO3/c1-3-4-5-6-7-8-15-11-9-10(2)12(16)14(18)13(11)17/h10-18H,3-9H2,1-2H3
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PubMed
48n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118920
PNG
((1R,2S,3S)-4-Benzylamino-6-methyl-cyclohexane-1,2,...)
Show SMILES CC1CC(NCc2ccccc2)C(O)C(O)C1O
Show InChI InChI=1S/C14H21NO3/c1-9-7-11(13(17)14(18)12(9)16)15-8-10-5-3-2-4-6-10/h2-6,9,11-18H,7-8H2,1H3
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69n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118922
PNG
((1R,2S,3S)-4-Butylamino-6-methyl-cyclohexane-1,2,3...)
Show SMILES CCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C11H23NO3/c1-3-4-5-12-8-6-7(2)9(13)11(15)10(8)14/h7-15H,3-6H2,1-2H3
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74n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065257
PNG
((2R,3R,4R,5R,6S)-2-Hydroxymethyl-6-methyl-piperidi...)
Show SMILES C[C@@H]1N[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO4/c1-3-5(10)7(12)6(11)4(2-9)8-3/h3-12H,2H2,1H3/t3-,4+,5+,6+,7+/m0/s1
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80n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against alpha-L-fucosidase of bovine epididymis by colorimetric assay using the D-glucose oxidase-peroxidase method


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50065258
PNG
((2S,3R,4S,5R)-2-Methyl-piperidine-3,4,5-triol | (2...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5+,6-/m0/s1
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80n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Inhibitory activity measured against alpha-L-fucosidase of bovine epididymis by colorimetric assay using the D-glucose oxidase-peroxidase method


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118919
PNG
((1S,2S,3R)-4-Methyl-6-nonylamino-cyclohexane-1,2,3...)
Show SMILES CCCCCCCCCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C16H33NO3/c1-3-4-5-6-7-8-9-10-17-13-11-12(2)14(18)16(20)15(13)19/h12-20H,3-11H2,1-2H3
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110n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104402
PNG
(2-Methyl-3,4-dihydro-2H-pyrrole-3,4-diol | CHEMBL8...)
Show SMILES CC1NCC(O)C1=O
Show InChI InChI=1S/C5H9NO2/c1-3-5(8)4(7)2-6-3/h3-4,6-7H,2H2,1H3
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160n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50118926
PNG
((1R,2S,3S)-4-Ethylamino-6-methyl-cyclohexane-1,2,3...)
Show SMILES CCNC1CC(C)C(O)C(O)C1O
Show InChI InChI=1S/C9H19NO3/c1-3-10-6-4-5(2)7(11)9(13)8(6)12/h5-13H,3-4H2,1-2H3
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180n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403995
PNG
(CHEMBL2115269)
Show SMILES C[C@@H]1C[C@H](N)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-3-2-4(8)6(10)7(11)5(3)9/h3-7,9-11H,2,8H2,1H3/t3-,4+,5-,6-,7-/m1/s1
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200n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
The compound was tested for the inhibitory activity against alpha-L-Fucosidase in bovine kidney


Bioorg Med Chem Lett 12: 749-52 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104390
PNG
((R)-2-((R)-2-Allyloxy-4,5-dihydroxy-6-hydroxymethy...)
Show SMILES CC1SC(O[C@H]2C(OCC=C)OC(CO)C(O)C2O)C(O)[C@H](O)C1O
Show InChI InChI=1S/C15H26O9S/c1-3-4-22-14-13(11(20)9(18)7(5-16)23-14)24-15-12(21)10(19)8(17)6(2)25-15/h3,6-21H,1,4-5H2,2H3/t6?,7?,8?,9?,10-,11?,12?,13-,14?,15?/m1/s1
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210n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-L-fucosidase of bacillus species (K40T) expressed as Ki


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104410
PNG
((2R,3R)-4-Amino-6-methyl-cyclohexane-1,2,3-triol |...)
Show SMILES CC1CC(N)[C@@H](O)[C@H](O)C1O
Show InChI InChI=1S/C7H15NO3/c1-3-2-4(8)6(10)7(11)5(3)9/h3-7,9-11H,2,8H2,1H3/t3?,4?,5?,6-,7-/m1/s1
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230n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50182797
PNG
(5-(dimethylamino)-N-(6-((2S,3R,4S,5R)-3,4,5-trihyd...)
Show SMILES C[C@H]1[C@@H](O)[C@@H](O)[C@H](O)CN1CCCCCCNS(=O)(=O)c1cccc2c(cccc12)N(C)C
Show InChI InChI=1S/C24H37N3O5S/c1-17-23(29)24(30)21(28)16-27(17)15-7-5-4-6-14-25-33(31,32)22-13-9-10-18-19(22)11-8-12-20(18)26(2)3/h8-13,17,21,23-25,28-30H,4-7,14-16H2,1-3H3/t17-,21+,23+,24-/m0/s1
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500n/an/an/an/an/an/an/an/a



Technische Universität Graz

Curated by ChEMBL


Assay Description
Inhibition of human liver alpha-L-fucosidase


Citation and Details
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104399
PNG
((R)-4-Benzylamino-5-methyl-cyclopentane-1,2,3-trio...)
Show SMILES CC1C(O)[C@@H](O)C(O)C1NCc1ccccc1
Show InChI InChI=1S/C13H19NO3/c1-8-10(12(16)13(17)11(8)15)14-7-9-5-3-2-4-6-9/h2-6,8,10-17H,7H2,1H3/t8?,10?,11?,12?,13-/m1/s1
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680n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104395
PNG
((4R,5R)-6-Hydrazino-2-methyl-2,3,4,5-tetrahydro-py...)
Show SMILES CC1N=C(NN)[C@@H](O)[C@H](O)C1O
Show InChI InChI=1S/C6H13N3O3/c1-2-3(10)4(11)5(12)6(8-2)9-7/h2-5,10-12H,7H2,1H3,(H,8,9)/t2?,3?,4-,5+/m1/s1
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820n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403994
PNG
(CHEMBL2114287)
Show SMILES C[C@@H]1C[C@@H](N)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-3-2-4(8)6(10)7(11)5(3)9/h3-7,9-11H,2,8H2,1H3/t3-,4-,5-,6-,7-/m1/s1
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1.00E+3n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403111
PNG
(CHEMBL1289015)
Show SMILES C[C@@H]1N[C@@H](CO)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(2-8)7-3/h3-10H,2H2,1H3/t3-,4-,5+,6-/m0/s1
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1.40E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104401
PNG
(2-Methyl-pyrrolidine-3,4-diol | CHEMBL314405)
Show SMILES CC1NCC(O)C1O
Show InChI InChI=1S/C5H11NO2/c1-3-5(8)4(7)2-6-3/h3-8H,2H2,1H3
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2.00E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104392
PNG
((6S,7R)-2-Butylamino-4,7-bis-hydroxymethyl-[1,3]di...)
Show SMILES CCCCNC1N[C@H](CO)[C@H](O)C(O)[C@H](CO)N1
Show InChI InChI=1S/C11H25N3O4/c1-2-3-4-12-11-13-7(5-15)9(17)10(18)8(6-16)14-11/h7-18H,2-6H2,1H3/t7-,8+,9+,10?,11?/m1/s1
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2.80E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50110400
PNG
(1-Aminomethyl-5-methyl-cyclohexane-1,2,3,4-tetraol...)
Show SMILES CC1CC(O)(CN)C(O)C(O)C1O
Show InChI InChI=1S/C8H17NO4/c1-4-2-8(13,3-9)7(12)6(11)5(4)10/h4-7,10-13H,2-3,9H2,1H3
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2.80E+3n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
The compound was tested for the inhibitory activity against alpha-L-Fucosidase in bovine kidney


Bioorg Med Chem Lett 12: 749-52 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403995
PNG
(CHEMBL2115269)
Show SMILES C[C@@H]1C[C@H](N)[C@@H](O)[C@H](O)[C@@H]1O
Show InChI InChI=1S/C7H15NO3/c1-3-2-4(8)6(10)7(11)5(3)9/h3-7,9-11H,2,8H2,1H3/t3-,4+,5-,6-,7-/m1/s1
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2.90E+3n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
Binding affinity against alpha-L-fucosidase in bovine kidney was determined


Bioorg Med Chem Lett 12: 2811-4 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50403938
PNG
(CHEMBL2114150)
Show SMILES CC(C)NC(=O)c1cc(oc1C)[C@@H]1NC[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H20N2O4/c1-6(2)15-13(18)8-4-10(19-7(8)3)11-12(17)9(16)5-14-11/h4,6,9,11-12,14,16-17H,5H2,1-3H3,(H,15,18)/t9-,11+,12-/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibition constant (Competitive) of the compound against alpha-l-Fucosidase from Bovine epididymis


Bioorg Med Chem Lett 12: 2335-9 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50110400
PNG
(1-Aminomethyl-5-methyl-cyclohexane-1,2,3,4-tetraol...)
Show SMILES CC1CC(O)(CN)C(O)C(O)C1O
Show InChI InChI=1S/C8H17NO4/c1-4-2-8(13,3-9)7(12)6(11)5(4)10/h4-7,10-13H,2-3,9H2,1H3
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3.00E+3n/an/an/an/an/an/an/an/a



Keio University

Curated by ChEMBL


Assay Description
The compound was tested for the inhibitory activity against alpha-L-Fucosidase in bovine kidney


Bioorg Med Chem Lett 12: 749-52 (2002)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104397
PNG
(5-(3,4-Dihydroxy-pyrrolidin-2-yl)-2-methyl-furan-3...)
Show SMILES CC(C)NC(=O)c1cc(oc1C)C1NCC(O)C1O
Show InChI InChI=1S/C13H20N2O4/c1-6(2)15-13(18)8-4-10(19-7(8)3)11-12(17)9(16)5-14-11/h4,6,9,11-12,14,16-17H,5H2,1-3H3,(H,15,18)
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3.00E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-L-Fucosidase of bovine epididymis expressed as Ki


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104396
PNG
(5-(3,4-Dihydroxy-pyrrolidin-2-yl)-2-methyl-furan-3...)
Show SMILES CCNC(=O)c1cc(oc1C)C1NCC(O)C1O
Show InChI InChI=1S/C12H18N2O4/c1-3-13-12(17)7-4-9(18-6(7)2)10-11(16)8(15)5-14-10/h4,8,10-11,14-16H,3,5H2,1-2H3,(H,13,17)
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3.20E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-L-Fucosidase of bovine epididymis expressed as Ki


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104398
PNG
((R)-2-Methyl-6-(4-nitro-phenylsulfanyl)-tetrahydro...)
Show SMILES CC1SC(Sc2ccc(cc2)[N+]([O-])=O)C(O)[C@H](O)C1O
Show InChI InChI=1S/C12H15NO5S2/c1-6-9(14)10(15)11(16)12(19-6)20-8-4-2-7(3-5-8)13(17)18/h2-6,9-12,14-16H,1H3/t6?,9?,10-,11?,12?/m1/s1
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3.30E+3n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
In vitro inhibition of alpha-L-fucosidase isolated from bovine kidney.


Bioorg Med Chem Lett 11: 2555-9 (2001)

More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104398
PNG
((R)-2-Methyl-6-(4-nitro-phenylsulfanyl)-tetrahydro...)
Show SMILES CC1SC(Sc2ccc(cc2)[N+]([O-])=O)C(O)[C@H](O)C1O
Show InChI InChI=1S/C12H15NO5S2/c1-6-9(14)10(15)11(16)12(19-6)20-8-4-2-7(3-5-8)13(17)18/h2-6,9-12,14-16H,1H3/t6?,9?,10-,11?,12?/m1/s1
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antibodypedia
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Article
3.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was tested for the inhibitory activity against alpha-L-fucosidase from bovine epididymis


Citation and Details
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