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Found 17 hits Enz. Inhib. hit(s) with Target = 'Alpha-carbonic anhydrase' AND taxid = 6239   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25910
PNG
(3-(4-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccc(F)cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H13FN4O3S/c16-9-3-1-8(2-4-9)13-11-7-10(24(18,22)23)5-6-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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6 -46.9n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25913
PNG
(3-(4-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccc(Cl)cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H13ClN4O3S/c16-9-3-1-8(2-4-9)13-11-7-10(24(18,22)23)5-6-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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6.5 -46.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25909
PNG
(3-(3-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(F)c1)S(N)(=O)=O
Show InChI InChI=1S/C15H13FN4O3S/c16-9-3-1-2-8(6-9)13-11-7-10(24(18,22)23)4-5-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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9.90 -45.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25912
PNG
(3-(3-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(Cl)c1)S(N)(=O)=O
Show InChI InChI=1S/C15H13ClN4O3S/c16-9-3-1-2-8(6-9)13-11-7-10(24(18,22)23)4-5-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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10.1 -45.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25916
PNG
(3-(4-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccc(Br)cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H13BrN4O3S/c16-9-3-1-8(2-4-9)13-11-7-10(24(18,22)23)5-6-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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11.5 -45.3n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25907
PNG
(2-(hydrazinecarbonyl)-3-(4-methylphenyl)-1H-indole...)
Show SMILES Cc1ccc(cc1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN
Show InChI InChI=1S/C16H16N4O3S/c1-9-2-4-10(5-3-9)14-12-8-11(24(18,22)23)6-7-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23)
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12.2 -45.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25908
PNG
(3-(2-fluorophenyl)-2-(hydrazinecarbonyl)-1H-indole...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1F)S(N)(=O)=O
Show InChI InChI=1S/C15H13FN4O3S/c16-11-4-2-1-3-9(11)13-10-7-8(24(18,22)23)5-6-12(10)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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12.5 -45.1n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25906
PNG
(2-(hydrazinecarbonyl)-3-(3-methylphenyl)-1H-indole...)
Show SMILES Cc1cccc(c1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN
Show InChI InChI=1S/C16H16N4O3S/c1-9-3-2-4-10(7-9)14-12-8-11(24(18,22)23)5-6-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23)
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13.3 -45.0n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25915
PNG
(3-(3-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1cccc(Br)c1)S(N)(=O)=O
Show InChI InChI=1S/C15H13BrN4O3S/c16-9-3-1-2-8(6-9)13-11-7-10(24(18,22)23)4-5-12(11)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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13.4 -44.9n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM10880
PNG
(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
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PubMed
35 -42.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM10882
PNG
(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Show SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O
Show InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
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40 -42.2n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25914
PNG
(3-(2-bromophenyl)-2-(hydrazinecarbonyl)-1H-indole-...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Br)S(N)(=O)=O
Show InChI InChI=1S/C15H13BrN4O3S/c16-11-4-2-1-3-9(11)13-10-7-8(24(18,22)23)5-6-12(10)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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260 -37.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25918
PNG
(2-(hydrazinecarbonyl)-3-(2,3,4,5,6-pentafluorophen...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1c(F)c(F)c(F)c(F)c1F)S(N)(=O)=O
Show InChI InChI=1S/C15H9F5N4O3S/c16-9-8(10(17)12(19)13(20)11(9)18)7-5-3-4(28(22,26)27)1-2-6(5)23-14(7)15(25)24-21/h1-3,23H,21H2,(H,24,25)(H2,22,26,27)
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260 -37.6n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25905
PNG
(2-(hydrazinecarbonyl)-3-(2-methylphenyl)-1H-indole...)
Show SMILES Cc1ccccc1-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN
Show InChI InChI=1S/C16H16N4O3S/c1-9-4-2-3-5-11(9)14-12-8-10(24(18,22)23)6-7-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23)
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326 -37.0n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25917
PNG
(2-(hydrazinecarbonyl)-3-(3-methoxyphenyl)-1H-indol...)
Show SMILES COc1cccc(c1)-c1c([nH]c2ccc(cc12)S(N)(=O)=O)C(=O)NN
Show InChI InChI=1S/C16H16N4O4S/c1-24-10-4-2-3-9(7-10)14-12-8-11(25(18,22)23)5-6-13(12)19-15(14)16(21)20-17/h2-8,19H,17H2,1H3,(H,20,21)(H2,18,22,23)
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330 -37.0n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25904
PNG
(2-(hydrazinecarbonyl)-3-phenyl-1H-indole-5-sulfona...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1)S(N)(=O)=O
Show InChI InChI=1S/C15H14N4O3S/c16-19-15(20)14-13(9-4-2-1-3-5-9)11-8-10(23(17,21)22)6-7-12(11)18-14/h1-8,18H,16H2,(H,19,20)(H2,17,21,22)
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PubMed
339 -36.9n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair
alpha-Carbonic Anhydrase


(Caenorhabditis elegans)
BDBM25911
PNG
(3-(2-chlorophenyl)-2-(hydrazinecarbonyl)-1H-indole...)
Show SMILES NNC(=O)c1[nH]c2ccc(cc2c1-c1ccccc1Cl)S(N)(=O)=O
Show InChI InChI=1S/C15H13ClN4O3S/c16-11-4-2-1-3-9(11)13-10-7-8(24(18,22)23)5-6-12(10)19-14(13)15(21)20-17/h1-7,19H,17H2,(H,20,21)(H2,18,22,23)
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372 -36.7n/an/an/an/an/a7.425



Istanbul University



Assay Description
An SX.18MV-R Applied Photophysics (Oxford, UK) stopped-flow instrument has been used to assay the catalytic/inhibition of various CA isozymes. Phenol...


Bioorg Med Chem 17: 3212-5 (2009)

More data for this
Ligand-Target Pair