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Compile Data Set for Download or QSAR

Found 701 hits Enz. Inhib. hit(s) with Target = 'Alpha-glucosidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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14n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 8.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280031
PNG
((6S,7R,8R)-Octahydro-indolizine-1,6,7,8-tetraol | ...)
Show SMILES OC1CCN2C[C@H](O)[C@@H](O)[C@H](O)C12
Show InChI InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4?,5-,6?,7+,8+/m0/s1
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15n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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160n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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340n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by H...


Bioorg Med Chem Lett 21: 2441-4 (2011)

More data for this
Ligand-Target Pair
alpha-glucosidase (Gaa)


(Mus musculus (Mouse))
BDBM243075
PNG
(α-Gl inhibitor, C3)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)N1c2[nH]c(=O)[nH]c(=O)c2C(C(O)C(O)C(O)C(O)CO)c2c1[nH]c(=O)[nH]c2=O
Show InChI InChI=1S/C26H26N6O11S/c27-10-1-5-12(6-2-10)44(42,43)13-7-3-11(4-8-13)32-21-16(23(38)30-25(40)28-21)15(17-22(32)29-26(41)31-24(17)39)19(36)20(37)18(35)14(34)9-33/h1-8,14-15,18-20,33-37H,9,27H2,(H2,28,30,38,40)(H2,29,31,39,41)
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2.50E+3n/an/an/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25C with minor changes, according to the meth...


J Enzyme Inhib Med Chem 28: 1228-35 (2013)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280029
PNG
((2R,3R,4R,5S)-2-(1-Hydroxy-propyl)-piperidine-3,4,...)
Show SMILES CCC(O)[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H17NO4/c1-2-4(10)6-8(13)7(12)5(11)3-9-6/h4-13H,2-3H2,1H3/t4?,5-,6+,7+,8+/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84968
PNG
(Urea derivative, 12)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)cc1O
Show InChI InChI=1S/C21H16F2N2O3/c22-15-6-9-18(17(23)12-15)25-21(28)24-16-7-3-13(4-8-16)1-2-14-5-10-19(26)20(27)11-14/h1-12,26-27H,(H2,24,25,28)/b2-1+
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3.20E+3n/a 8.40E+3n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84969
PNG
(Urea derivative, 13)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(Cl)cc3)cc2)cc1O
Show InChI InChI=1S/C21H17ClN2O3/c22-16-6-10-18(11-7-16)24-21(27)23-17-8-3-14(4-9-17)1-2-15-5-12-19(25)20(26)13-15/h1-13,25-26H,(H2,23,24,27)/b2-1+
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4.60E+3n/a 1.43E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50341204
PNG
((Z)-3-butylidenephthalide | CHEMBL1765390)
Show SMILES CCC\C=C1\OC(=O)c2ccccc12
Show InChI InChI=1S/C12H12O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-8H,2-3H2,1H3/b11-8+
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4.86E+3n/an/an/an/an/an/an/an/a



Universidad Nacional Aut£noma de M£xico

Curated by ChEMBL


Assay Description
Mixed type inhibition of baker's yeast alpha-glucosidase by Dixon plot analysis


J Nat Prod 76: 468-83 (2013)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84967
PNG
(Urea derivative, 11)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3)cc2)cc1O
Show InChI InChI=1S/C21H17FN2O3/c22-16-6-10-18(11-7-16)24-21(27)23-17-8-3-14(4-9-17)1-2-15-5-12-19(25)20(26)13-15/h1-13,25-26H,(H2,23,24,27)/b2-1+
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7.20E+3n/a 1.98E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280030
PNG
((2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-trio...)
Show SMILES O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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8.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84972
PNG
(Urea derivative, 16)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(F)cc3F)cc2)cc1
Show InChI InChI=1S/C21H16F2N2O2/c22-16-7-12-20(19(23)13-16)25-21(27)24-17-8-3-14(4-9-17)1-2-15-5-10-18(26)11-6-15/h1-13,26H,(H2,24,25,27)/b2-1+
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9.40E+3n/a 1.85E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84963
PNG
(Urea derivative, 7)
Show SMILES COc1ccc(NC(=O)Nc2ccc(\C=C\c3ccc(O)c(O)c3)cc2)cc1
Show InChI InChI=1S/C22H20N2O4/c1-28-19-11-9-18(10-12-19)24-22(27)23-17-7-4-15(5-8-17)2-3-16-6-13-20(25)21(26)14-16/h2-14,25-26H,1H3,(H2,23,24,27)/b3-2+
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1.05E+4n/a 1.95E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84962
PNG
(Urea derivative, 6)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccccc3)cc2)cc1O
Show InChI InChI=1S/C21H18N2O3/c24-19-13-10-16(14-20(19)25)7-6-15-8-11-18(12-9-15)23-21(26)22-17-4-2-1-3-5-17/h1-14,24-25H,(H2,22,23,26)/b7-6+
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1.06E+4n/a 4.21E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84966
PNG
(Urea derivative, 10)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccc(cc3)C(F)(F)F)cc2)cc1O
Show InChI InChI=1S/C22H17F3N2O3/c23-22(24,25)16-6-10-18(11-7-16)27-21(30)26-17-8-3-14(4-9-17)1-2-15-5-12-19(28)20(29)13-15/h1-13,28-29H,(H2,26,27,30)/b2-1+
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1.21E+4n/a 2.88E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM243075
PNG
(α-Gl inhibitor, C3)
Show SMILES Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)N1c2[nH]c(=O)[nH]c(=O)c2C(C(O)C(O)C(O)C(O)CO)c2c1[nH]c(=O)[nH]c2=O
Show InChI InChI=1S/C26H26N6O11S/c27-10-1-5-12(6-2-10)44(42,43)13-7-3-11(4-8-13)32-21-16(23(38)30-25(40)28-21)15(17-22(32)29-26(41)31-24(17)39)19(36)20(37)18(35)14(34)9-33/h1-8,14-15,18-20,33-37H,9,27H2,(H2,28,30,38,40)(H2,29,31,39,41)
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1.40E+4n/an/an/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25C with minor changes, according to the meth...


J Enzyme Inhib Med Chem 28: 1228-35 (2013)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50203367
PNG
(CHEMBL3891396)
Show SMILES CCOc1ccccc1NC(=O)Cn1cc(Cn2c(nc(c2-c2ccccc2)-c2ccccc2)-c2cccc(Br)c2)nn1
Show InChI InChI=1S/C34H29BrN6O2/c1-2-43-30-19-10-9-18-29(30)36-31(42)23-40-21-28(38-39-40)22-41-33(25-14-7-4-8-15-25)32(24-12-5-3-6-13-24)37-34(41)26-16-11-17-27(35)20-26/h3-21H,2,22-23H2,1H3,(H,36,42)
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1.48E+4n/an/an/an/an/an/an/an/a



Jishou University

Curated by ChEMBL


Assay Description
Non-competitive inhibition of bakers yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by Lineweaver-Burk plot analysi...


Citation and Details
More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280030
PNG
((2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-trio...)
Show SMILES O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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1.50E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84970
PNG
(Urea derivative, 14)
Show SMILES Oc1ccc(\C=C\c2ccc(NC(=O)Nc3ccccc3)cc2)cc1
Show InChI InChI=1S/C21H18N2O2/c24-20-14-10-17(11-15-20)7-6-16-8-12-19(13-9-16)23-21(25)22-18-4-2-1-3-5-18/h1-15,24H,(H2,22,23,25)/b7-6+
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1.70E+4n/a 2.91E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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1.80E+4n/a 3.95E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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2.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM23926
PNG
((E)-resveratrol | 5-[(E)-2-(4-hydroxyphenyl)etheny...)
Show SMILES Oc1ccc(\C=C\c2cc(O)cc(O)c2)cc1
Show InChI InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
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2.15E+4n/a 2.64E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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2.30E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 6.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50018905
PNG
(2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridi...)
Show SMILES CCOC([O-])=C1C(C(C(=[OH+])OCC)=C(C)N=C1C)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C19H22N2O6/c1-5-26-18(22)15-11(3)20-12(4)16(19(23)27-6-2)17(15)13-8-7-9-14(10-13)21(24)25/h7-10,17,22H,5-6H2,1-4H3
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2.50E+4n/an/an/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Non-competitive inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl alpha-D-glucopyranoside as substrate preincubated for 15...


Eur J Med Chem 95: 199-209 (2015)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280030
PNG
((2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-trio...)
Show SMILES O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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2.90E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM243074
PNG
(α-Gl inhibitor, C2)
Show SMILES OCC(O)C(O)C(O)C(O)C1c2c([nH]c(=O)[nH]c2=O)N(c2ccc(Br)cc2)c2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C20H20BrN5O9/c21-6-1-3-7(4-2-6)26-15-10(17(32)24-19(34)22-15)9(11-16(26)23-20(35)25-18(11)33)13(30)14(31)12(29)8(28)5-27/h1-4,8-9,12-14,27-31H,5H2,(H2,22,24,32,34)(H2,23,25,33,35)
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3.00E+4n/an/an/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25C with minor changes, according to the meth...


J Enzyme Inhib Med Chem 28: 1228-35 (2013)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM84959
PNG
(Stilbene derivative, 2)
Show SMILES Nc1ccc(\C=C\c2ccc(O)c(O)c2)cc1
Show InChI InChI=1S/C14H13NO2/c15-12-6-3-10(4-7-12)1-2-11-5-8-13(16)14(17)9-11/h1-9,16-17H,15H2/b2-1+
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3.51E+4n/a 4.64E+4n/an/an/an/an/an/a



Gyeongsang National University



Assay Description
All enzymatic activities were determined by using the appropriate substrate (p-nitrophenyl-alpha-D-glucopyranoside, p-nitrophenyl-beta-D-gulcopyranos...


Chembiochem 11: 2125-31 (2010)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280030
PNG
((2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-trio...)
Show SMILES O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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4.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on Asp. Wentii beta Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280029
PNG
((2R,3R,4R,5S)-2-(1-Hydroxy-propyl)-piperidine-3,4,...)
Show SMILES CCC(O)[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H17NO4/c1-2-4(10)6-8(13)7(12)5(11)3-9-6/h4-13H,2-3H2,1H3/t4?,5-,6+,7+,8+/m0/s1
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6.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on almonds beta Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50074020
PNG
(CHEMBL1099206)
Show SMILES CCOC(=O)C1=C(C)NC(C)=C(C1c1ccc(cc1)[N+]([O-])=O)C(=O)OCC
Show InChI InChI=1S/C19H22N2O6/c1-5-26-18(22)15-11(3)20-12(4)16(19(23)27-6-2)17(15)13-7-9-14(10-8-13)21(24)25/h7-10,17,20H,5-6H2,1-4H3
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6.80E+4n/an/an/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Competitive inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl alpha-D-glucopyranoside as substrate preincubated for 15 min...


Eur J Med Chem 95: 199-209 (2015)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM243073
PNG
(α-Gl inhibitor, C1)
Show SMILES OCC(O)C(O)C(O)C(O)C1c2c([nH]c(=O)[nH]c2=O)N(c2ccc(O)cc2)c2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C20H21N5O10/c26-5-8(28)12(29)14(31)13(30)9-10-15(21-19(34)23-17(10)32)25(6-1-3-7(27)4-2-6)16-11(9)18(33)24-20(35)22-16/h1-4,8-9,12-14,26-31H,5H2,(H2,21,23,32,34)(H2,22,24,33,35)
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7.00E+4n/an/an/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25C with minor changes, according to the meth...


J Enzyme Inhib Med Chem 28: 1228-35 (2013)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50339930
PNG
(CHEMBL1761668 | N1-((S)-1-((S)-1-amino-3-(4-hydrox...)
Show SMILES NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)Nc1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C36H41N5O11/c37-34(49)26(15-19-5-9-22(43)10-6-19)41-35(50)27(16-20-17-38-25-4-2-1-3-24(20)25)40-30(45)14-13-29(44)39-21-7-11-23(12-8-21)51-36-33(48)32(47)31(46)28(18-42)52-36/h1-12,17,26-28,31-33,36,38,42-43,46-48H,13-16,18H2,(H2,37,49)(H,39,44)(H,40,45)(H,41,50)/t26-,27-,28+,31+,32-,33+,36+/m0/s1
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1.10E+5n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by H...


Bioorg Med Chem Lett 21: 2441-4 (2011)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM243074
PNG
(α-Gl inhibitor, C2)
Show SMILES OCC(O)C(O)C(O)C(O)C1c2c([nH]c(=O)[nH]c2=O)N(c2ccc(Br)cc2)c2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C20H20BrN5O9/c21-6-1-3-7(4-2-6)26-15-10(17(32)24-19(34)22-15)9(11-16(26)23-20(35)25-18(11)33)13(30)14(31)12(29)8(28)5-27/h1-4,8-9,12-14,27-31H,5H2,(H2,22,24,32,34)(H2,23,25,33,35)
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1.30E+5n/an/an/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25C with minor changes, according to the meth...


J Enzyme Inhib Med Chem 28: 1228-35 (2013)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL12


(Saccharomyces cerevisiae)
BDBM243073
PNG
(α-Gl inhibitor, C1)
Show SMILES OCC(O)C(O)C(O)C(O)C1c2c([nH]c(=O)[nH]c2=O)N(c2ccc(O)cc2)c2[nH]c(=O)[nH]c(=O)c12
Show InChI InChI=1S/C20H21N5O10/c26-5-8(28)12(29)14(31)13(30)9-10-15(21-19(34)23-17(10)32)25(6-1-3-7(27)4-2-6)16-11(9)18(33)24-20(35)22-16/h1-4,8-9,12-14,26-31H,5H2,(H2,21,23,32,34)(H2,22,24,33,35)
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1.70E+5n/an/an/an/an/an/an/an/a



Shiraz University



Assay Description
In this study, the inhibition assay of yeast enzyme was performed in 100 mM phosphate buffer pH 7.0 at 25C with minor changes, according to the meth...


J Enzyme Inhib Med Chem 28: 1228-35 (2013)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50329783
PNG
(5-N,6-S-[N'-(4-Dansylamino)butyliminomethylidene]-...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCC\N=C1/SC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)N12
Show InChI InChI=1S/C23H32N4O6S2/c1-26(2)16-9-5-8-15-14(16)7-6-10-18(15)35(32,33)25-12-4-3-11-24-23-27-17(13-34-23)19(28)20(29)21(30)22(27)31/h5-10,17,19-22,25,28-31H,3-4,11-13H2,1-2H3/b24-23-/t17-,19-,20+,21-,22-/m1/s1
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2.46E+5n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase after 10 to 30 mins


Bioorg Med Chem 18: 7439-45 (2010)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50329781
PNG
(5-N,6-S-[N'-[4-(7'-Diethylaminocoumarin-30-ylcarbo...)
Show SMILES CCN(CC)c1ccc2cc(c(=O)oc2c1)S(=O)(=O)NCCCC\N=C1/SC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)N12
Show InChI InChI=1S/C24H34N4O8S2/c1-3-27(4-2)15-8-7-14-11-18(23(33)36-17(14)12-15)38(34,35)26-10-6-5-9-25-24-28-16(13-37-24)19(29)20(30)21(31)22(28)32/h7-8,11-12,16,19-22,26,29-32H,3-6,9-10,13H2,1-2H3/b25-24-/t16-,19-,20+,21-,22-/m1/s1
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3.13E+5n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase after 10 to 30 mins


Bioorg Med Chem 18: 7439-45 (2010)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280030
PNG
((2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-trio...)
Show SMILES O[C@H]1CN[C@H](CF)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H12FNO3/c7-1-3-5(10)6(11)4(9)2-8-3/h3-6,8-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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3.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 7.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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4.10E+5n/an/an/an/an/an/an/an/a



Hokuriku University

Curated by ChEMBL


Assay Description
Tested for competitive inhibition of golgi alpha mannosidase II


Citation and Details
More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50329780
PNG
(5-N,6-S-[N'-[4-(6-Dansylaminohexanamido)butyl]imin...)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCS(=O)(=O)NCCCC\N=C1/SC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)N12
Show InChI InChI=1S/C28H43N5O8S3/c1-32(2)21-12-8-11-20-19(21)10-9-13-23(20)44(40,41)31-16-4-3-7-17-43(38,39)30-15-6-5-14-29-28-33-22(18-42-28)24(34)25(35)26(36)27(33)37/h8-13,22,24-27,30-31,34-37H,3-7,14-18H2,1-2H3/b29-28-/t22-,24-,25+,26-,27-/m1/s1
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4.51E+5n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase after 10 to 30 mins


Bioorg Med Chem 18: 7439-45 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL62


(Saccharomyces cerevisiae)
BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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4.60E+5n/an/an/an/an/an/an/an/a



Universidad Nacional Auto£?noma de Me£?xico

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase assessed as inhibition of p-nitrophenyl-alpha-D-glucopyranoside substrate hydrolysis after 35 mins by spectrosc...


J Nat Prod 74: 314-20 (2011)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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4.60E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM50329779
PNG
(5-N,6-S-[N'-(4-Dapoxylsulfonylamino)butyliminometh...)
Show SMILES CN(C)c1ccc(cc1)-c1cnc(o1)-c1cccc(c1)S(=O)(=O)NCCCC\N=C1/SC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)N12
Show InChI InChI=1S/C28H35N5O7S2/c1-32(2)19-10-8-17(9-11-19)22-15-30-26(40-22)18-6-5-7-20(14-18)42(38,39)31-13-4-3-12-29-28-33-21(16-41-28)23(34)24(35)25(36)27(33)37/h5-11,14-15,21,23-25,27,31,34-37H,3-4,12-13,16H2,1-2H3/b29-28-/t21-,23-,24+,25-,27-/m1/s1
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7.14E+5n/an/an/an/an/an/an/an/a



Universidad de Sevilla

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase after 10 to 30 mins


Bioorg Med Chem 18: 7439-45 (2010)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50339929
PNG
(CHEMBL1761667 | N1-((S)-1-((S)-1-amino-3-(4-hydrox...)
Show SMILES NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C30H31N5O6/c31-29(40)25(15-18-5-9-21(36)10-6-18)35-30(41)26(16-19-17-32-24-4-2-1-3-23(19)24)34-28(39)14-13-27(38)33-20-7-11-22(37)12-8-20/h1-12,17,25-26,32,36-37H,13-16H2,(H2,31,40)(H,33,38)(H,34,39)(H,35,41)/t25-,26-/m0/s1
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1.40E+6n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by H...


Bioorg Med Chem Lett 21: 2441-4 (2011)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280031
PNG
((6S,7R,8R)-Octahydro-indolizine-1,6,7,8-tetraol | ...)
Show SMILES OC1CCN2C[C@H](O)[C@@H](O)[C@H](O)C12
Show InChI InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4?,5-,6?,7+,8+/m0/s1
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>1.50E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on rice alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280032
PNG
((2R,3R,4R,5S)-2-Methyl-piperidine-3,4,5-triol | 1,...)
Show SMILES C[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO3/c1-3-5(9)6(10)4(8)2-7-3/h3-10H,2H2,1H3/t3-,4+,5-,6-/m1/s1
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1.56E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Neutral alpha-glucosidase AB


(Homo sapiens)
BDBM50280029
PNG
((2R,3R,4R,5S)-2-(1-Hydroxy-propyl)-piperidine-3,4,...)
Show SMILES CCC(O)[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C8H17NO4/c1-2-4(10)6-8(13)7(12)5(11)3-9-6/h4-13H,2-3H2,1H3/t4?,5-,6+,7+,8+/m0/s1
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2.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive Inhibition constant of the compound was determined on yeast alpha Glucosidase at pH 5.0


Bioorg Med Chem Lett 2: 27-32 (1992)

More data for this
Ligand-Target Pair
Alpha-glucosidase MAL62


(Saccharomyces cerevisiae)
BDBM50341204
PNG
((Z)-3-butylidenephthalide | CHEMBL1765390)
Show SMILES CCC\C=C1\OC(=O)c2ccccc12
Show InChI InChI=1S/C12H12O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-8H,2-3H2,1H3/b11-8+
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4.86E+6n/an/an/an/an/an/an/an/a



Universidad Nacional Auto£?noma de Me£?xico

Curated by ChEMBL


Assay Description
Inhibition of yeast alpha-glucosidase assessed as inhibition of p-nitrophenyl-alpha-D-glucopyranoside substrate hydrolysis after 35 mins by spectrosc...


J Nat Prod 74: 314-20 (2011)

More data for this
Ligand-Target Pair
α-glucosidase


(Saccharomyces cerevisiae S288c (Baker's yeast))
BDBM108221
PNG
(5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H...)
Show SMILES OCC1C(O)C(O)C(O)c2nc(CCCc3ccc(cc3)-c3ccccc3)cn12
Show InChI InChI=1S/C23H26N2O4/c26-14-19-20(27)21(28)22(29)23-24-18(13-25(19)23)8-4-5-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-3,6-7,9-13,19-22,26-29H,4-5,8,14H2
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n/an/a 6n/an/an/an/an/an/a



Nankai University



Assay Description
In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....


Chembiochem 14: 1239-47 (2013)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Oryza sativa subsp. japonica)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



Toyama Medical and Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibitory concentration against rice alpha-glucosidase


J Med Chem 48: 2036-44 (2005)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Oryza sativa subsp. japonica)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Universit£ d'Orl£ans

Curated by ChEMBL


Assay Description
Inhibitory activity against alpha-Glucosidase from rice


Bioorg Med Chem Lett 14: 5991-5 (2004)

More data for this
Ligand-Target Pair
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