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Found 7 hits Enz. Inhib. hit(s) with Target = 'Alpha-glucosidase' AND taxid = 1422   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50333465
PNG
((2R,3R,4R,5R,6R)-5-((2R,3R,4R,5S,6R)-5-((2R,3R,4S,...)
Show SMILES C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1
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340n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by H...


Bioorg Med Chem Lett 21: 2441-4 (2011)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50339930
PNG
(CHEMBL1761668 | N1-((S)-1-((S)-1-amino-3-(4-hydrox...)
Show SMILES NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)Nc1ccc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1
Show InChI InChI=1S/C36H41N5O11/c37-34(49)26(15-19-5-9-22(43)10-6-19)41-35(50)27(16-20-17-38-25-4-2-1-3-24(20)25)40-30(45)14-13-29(44)39-21-7-11-23(12-8-21)51-36-33(48)32(47)31(46)28(18-42)52-36/h1-12,17,26-28,31-33,36,38,42-43,46-48H,13-16,18H2,(H2,37,49)(H,39,44)(H,40,45)(H,41,50)/t26-,27-,28+,31+,32-,33+,36+/m0/s1
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1.10E+5n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by H...


Bioorg Med Chem Lett 21: 2441-4 (2011)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50339929
PNG
(CHEMBL1761667 | N1-((S)-1-((S)-1-amino-3-(4-hydrox...)
Show SMILES NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCC(=O)Nc1ccc(O)cc1
Show InChI InChI=1S/C30H31N5O6/c31-29(40)25(15-18-5-9-21(36)10-6-18)35-30(41)26(16-19-17-32-24-4-2-1-3-23(19)24)34-28(39)14-13-27(38)33-20-7-11-22(37)12-8-20/h1-12,17,25-26,32,36-37H,13-16H2,(H2,31,40)(H,33,38)(H,34,39)(H,35,41)/t25-,26-/m0/s1
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1.40E+6n/an/an/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Competitive inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as production of chromogenic p-Nitrphenol measured after 3 mins by H...


Bioorg Med Chem Lett 21: 2441-4 (2011)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50231670
PNG
((2R,3R,4R,5S)-1-(8-(3-(3H-1,2,3-triazol-4-yl)pheno...)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCCCOc1cccc(c1)-c1c[nH]nn1
Show InChI InChI=1S/C22H34N4O5/c27-15-19-21(29)22(30)20(28)14-26(19)10-5-3-1-2-4-6-11-31-17-9-7-8-16(12-17)18-13-23-25-24-18/h7-9,12-13,19-22,27-30H,1-6,10-11,14-15H2,(H,23,24,25)/t19-,20+,21-,22-/m1/s1
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n/an/a 1.15E+3n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Inhibition of alpha glucosidase from bacillus sterothermophilus


Bioorg Med Chem Lett 18: 954-8 (2008)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM18351
PNG
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1
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n/an/a 1.67E+3n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Inhibition of alpha glucosidase from bacillus sterothermophilus


Bioorg Med Chem Lett 18: 954-8 (2008)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50231671
PNG
((2R,3R,4R,5S)-1-(6-(3-(3H-1,2,3-triazol-4-yl)pheno...)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCOc1cccc(c1)-c1c[nH]nn1
Show InChI InChI=1S/C20H30N4O5/c25-13-17-19(27)20(28)18(26)12-24(17)8-3-1-2-4-9-29-15-7-5-6-14(10-15)16-11-21-23-22-16/h5-7,10-11,17-20,25-28H,1-4,8-9,12-13H2,(H,21,22,23)/t17-,18+,19-,20-/m1/s1
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n/an/a 2.41E+3n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Inhibition of alpha glucosidase from bacillus sterothermophilus


Bioorg Med Chem Lett 18: 954-8 (2008)

More data for this
Ligand-Target Pair
Alpha-glucosidase


(Bacillus stearothermophilus)
BDBM50231672
PNG
((2R,3R,4R,5S)-1-(4-(3-(1H-1,2,3-triazol-4-yl)pheno...)
Show SMILES OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCOc1cccc(c1)-c1c[nH]nn1
Show InChI InChI=1S/C18H26N4O5/c23-11-15-17(25)18(26)16(24)10-22(15)6-1-2-7-27-13-5-3-4-12(8-13)14-9-19-21-20-14/h3-5,8-9,15-18,23-26H,1-2,6-7,10-11H2,(H,19,20,21)/t15-,16+,17-,18-/m1/s1
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n/an/a 6.07E+3n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
Inhibition of alpha glucosidase from bacillus sterothermophilus


Bioorg Med Chem Lett 18: 954-8 (2008)

More data for this
Ligand-Target Pair