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Found 2 hits Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive cation channel 3' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 3


(Rattus norvegicus)
BDBM50259583
PNG
(3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...)
Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N6O/c19-16-15(17(25)24-18(20)21)22-10-14(23-16)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,19,23)(H4,20,21,24,25)
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UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a 950n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rat ASIC3 assessed as inhibition of peak current by patch clamp electrophisiology


Citation and Details
More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Rattus norvegicus)
BDBM50157090
PNG
(6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...)
Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)
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UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 9.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 in rat DRG neurons


Citation and Details
More data for this
Ligand-Target Pair