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Found 61 hits Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive cation channel 3' AND taxid = 9606   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348097
PNG
(CHEMBL1800440)
Show SMILES CN(C)C1CCc2c1cccc2C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C22H21ClN2S/c1-25(2)19-11-10-16-15(4-3-5-17(16)19)8-6-14-7-9-18-20(12-14)26-21(13-24)22(18)23/h3-5,7,9,12,19H,10-11,13,24H2,1-2H3
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n/an/a 190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348098
PNG
(CHEMBL1800430)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCNCc2c1
Show InChI InChI=1S/C20H17ClN2S/c21-20-17-6-4-14(10-18(17)24-19(20)11-22)2-1-13-3-5-15-7-8-23-12-16(15)9-13/h3-6,9-10,23H,7-8,11-12,22H2
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n/an/a 220n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348107
PNG
(CHEMBL1800432)
Show SMILES CCN1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C22H21ClN2S/c1-2-25-10-9-17-7-5-15(11-18(17)14-25)3-4-16-6-8-19-20(12-16)26-21(13-24)22(19)23/h5-8,11-12H,2,9-10,13-14,24H2,1H3
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348111
PNG
(CHEMBL1800436)
Show SMILES CN(C)C1CCCc2c(cccc12)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C23H23ClN2S/c1-26(2)20-8-4-6-17-16(5-3-7-18(17)20)11-9-15-10-12-19-21(13-15)27-22(14-25)23(19)24/h3,5,7,10,12-13,20H,4,6,8,14,25H2,1-2H3
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n/an/a 230n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348104
PNG
(CHEMBL1800428)
Show SMILES CC1N(C)CCc2ccc(cc12)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C22H21ClN2S/c1-14-19-11-15(5-7-17(19)9-10-25(14)2)3-4-16-6-8-18-20(12-16)26-21(13-24)22(18)23/h5-8,11-12,14H,9-10,13,24H2,1-2H3
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n/an/a 270n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348113
PNG
(CHEMBL1800433)
Show SMILES CC(C)N1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C23H23ClN2S/c1-15(2)26-10-9-18-7-5-16(11-19(18)14-26)3-4-17-6-8-20-21(12-17)27-22(13-25)23(20)24/h5-8,11-12,15H,9-10,13-14,25H2,1-2H3
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n/an/a 310n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348099
PNG
(CHEMBL1800331)
Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C#Cc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C26H27N3/c1-17(2)25-24-15-19(6-8-20(24)12-13-29(25)3)5-4-18-7-9-22-16-23(26(27)28)11-10-21(22)14-18/h6-11,14-17,25H,12-13H2,1-3H3,(H3,27,28)
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n/an/a 460n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50259583
PNG
(3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...)
Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C18H16N6O/c19-16-15(17(25)24-18(20)21)22-10-14(23-16)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,19,23)(H4,20,21,24,25)
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n/an/a 490n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Bioorg Med Chem Lett 19: 2514-8 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348095
PNG
(CHEMBL1800437)
Show SMILES CCN(CC)N1CCCc2c(cccc12)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C24H26ClN3S/c1-3-27(4-2)28-14-6-8-19-18(7-5-9-21(19)28)12-10-17-11-13-20-22(15-17)29-23(16-26)24(20)25/h5,7,9,11,13,15H,3-4,6,8,14,16,26H2,1-2H3
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n/an/a 510n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50259353
PNG
(3-amino-6-chloro-N-(diaminomethylene)-5-(naphthale...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(Nc2ccc3ccccc3c2)nc1N
Show InChI InChI=1S/C16H14ClN7O/c17-12-14(23-13(18)11(22-12)15(25)24-16(19)20)21-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H3,18,21,23)(H4,19,20,24,25)
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n/an/a 510n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Bioorg Med Chem Lett 19: 2514-8 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50259584
PNG
(3-amino-N-(diaminomethylene)-5-(3-(thiophen-3-yl)p...)
Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccsc1
Show InChI InChI=1S/C16H14N6OS/c17-14-13(15(23)22-16(18)19)20-7-12(21-14)10-3-1-2-9(6-10)11-4-5-24-8-11/h1-8H,(H2,17,21)(H4,18,19,22,23)
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n/an/a 640n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Bioorg Med Chem Lett 19: 2514-8 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348106
PNG
(CHEMBL1800431)
Show SMILES CN1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C21H19ClN2S/c1-24-9-8-16-6-4-14(10-17(16)13-24)2-3-15-5-7-18-19(11-15)25-20(12-23)21(18)22/h4-7,10-11H,8-9,12-13,23H2,1H3
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n/an/a 680n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342661
PNG
(2-(3-(phenylethynyl)phenyl)pyridin-4-amine | CHEMB...)
Show SMILES Nc1ccnc(c1)-c1cccc(c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H14N2/c20-18-11-12-21-19(14-18)17-8-4-7-16(13-17)10-9-15-5-2-1-3-6-15/h1-8,11-14H,(H2,20,21)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342642
PNG
(6-(6-(2-methylpiperidin-1-yl)pyridin-2-yl)-1,2,3,4...)
Show SMILES CC1CCCCN1c1cccc(n1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C20H25N3/c1-15-5-2-3-12-23(15)20-7-4-6-19(22-20)17-8-9-18-14-21-11-10-16(18)13-17/h4,6-9,13,15,21H,2-3,5,10-12,14H2,1H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348112
PNG
(CHEMBL1800438)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1cccc2C(CCCc12)N1CCCC1
Show InChI InChI=1S/C25H25ClN2S/c26-25-21-12-10-17(15-23(21)29-24(25)16-27)9-11-18-5-3-7-20-19(18)6-4-8-22(20)28-13-1-2-14-28/h3,5,7,10,12,15,22H,1-2,4,6,8,13-14,16,27H2
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n/an/a 2.50E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342660
PNG
(4-(3-(4-aminopyridin-2-yl)phenyl)but-3-yn-1-ol | C...)
Show SMILES Nc1ccnc(c1)-c1cccc(c1)C#CCCO
Show InChI InChI=1S/C15H14N2O/c16-14-7-8-17-15(11-14)13-6-3-5-12(10-13)4-1-2-9-18/h3,5-8,10-11,18H,2,9H2,(H2,16,17)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348103
PNG
(CHEMBL1800427)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C17H12ClNS/c18-17-14-9-8-13(10-15(14)20-16(17)11-19)7-6-12-4-2-1-3-5-12/h1-5,8-10H,11,19H2
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n/an/a 2.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342647
PNG
(6-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)p...)
Show SMILES CN1CCN(CC1)c1ccc(cc1C(F)(F)F)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C21H24F3N3/c1-26-8-10-27(11-9-26)20-5-4-16(13-19(20)21(22,23)24)15-2-3-18-14-25-7-6-17(18)12-15/h2-5,12-13,25H,6-11,14H2,1H3
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n/an/a 3.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342641
PNG
(6-(3,5-dichlorophenyl)-1,2,3,4-tetrahydroisoquinol...)
Show SMILES Clc1cc(Cl)cc(c1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C15H13Cl2N/c16-14-6-13(7-15(17)8-14)10-1-2-12-9-18-4-3-11(12)5-10/h1-2,5-8,18H,3-4,9H2
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n/an/a 3.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348102
PNG
(CHEMBL1800334)
Show SMILES NC(=N)c1sc2cc(ccc2c1Cl)C#Cc1ccccc1
Show InChI InChI=1S/C17H11ClN2S/c18-15-13-9-8-12(7-6-11-4-2-1-3-5-11)10-14(13)21-16(15)17(19)20/h1-5,8-10H,(H3,19,20)
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n/an/a 3.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342649
PNG
(6-methyl-N-(4-(6-(piperazin-1-yl)pyridin-3-yl)phen...)
Show SMILES Cc1cccc(Nc2ccc(cc2)-c2ccc(nc2)N2CCNCC2)n1
Show InChI InChI=1S/C21H23N5/c1-16-3-2-4-20(24-16)25-19-8-5-17(6-9-19)18-7-10-21(23-15-18)26-13-11-22-12-14-26/h2-10,15,22H,11-14H2,1H3,(H,24,25)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348096
PNG
(CHEMBL1800439)
Show SMILES CC(N(C)C)c1cccc(c1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C21H21ClN2S/c1-14(24(2)3)17-6-4-5-15(11-17)7-8-16-9-10-18-19(12-16)25-20(13-23)21(18)22/h4-6,9-12,14H,13,23H2,1-3H3
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n/an/a 4.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM16173
PNG
(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Show SMILES NC(=N)NC(=O)c1nc(Cl)c(N)nc1N
Show InChI InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 (unknown origin) assessed as inhibition of peak current by patch clamp electrophisiology


Bioorg Med Chem Lett 19: 2514-8 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348101
PNG
(CHEMBL1800333)
Show SMILES NCc1ccc2cc(ccc2c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H15N/c20-14-17-9-11-18-12-16(8-10-19(18)13-17)7-6-15-4-2-1-3-5-15/h1-5,8-13H,14,20H2
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n/an/a 4.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342662
PNG
(2-phenyl-6-(pyridin-2-ylmethyl)pyridin-4-amine | C...)
Show SMILES Nc1cc(Cc2ccccn2)nc(c1)-c1ccccc1
Show InChI InChI=1S/C17H15N3/c18-14-10-16(12-15-8-4-5-9-19-15)20-17(11-14)13-6-2-1-3-7-13/h1-11H,12H2,(H2,18,20)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348100
PNG
(CHEMBL1800332)
Show SMILES NC(=N)c1ccc2cc(ccc2c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H14N2/c20-19(21)18-11-10-16-12-15(8-9-17(16)13-18)7-6-14-4-2-1-3-5-14/h1-5,8-13H,(H3,20,21)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342659
PNG
(2-phenylpyridin-4-amine | CHEMBL1770738)
Show SMILES Nc1ccnc(c1)-c1ccccc1
Show InChI InChI=1S/C11H10N2/c12-10-6-7-13-11(8-10)9-4-2-1-3-5-9/h1-8H,(H2,12,13)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342643
PNG
(6-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydrois...)
Show SMILES FC(F)(F)c1cccc(c1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C16H14F3N/c17-16(18,19)15-3-1-2-11(9-15)12-4-5-14-10-20-7-6-13(14)8-12/h1-5,8-9,20H,6-7,10H2
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n/an/a 7.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342651
PNG
(CHEMBL1770730 | N-(6-methylpyridin-2-yl)furo[2,3-c...)
Show SMILES Cc1cccc(Nc2nccc3ccoc23)n1
Show InChI InChI=1S/C13H11N3O/c1-9-3-2-4-11(15-9)16-13-12-10(5-7-14-13)6-8-17-12/h2-8H,1H3,(H,14,15,16)
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n/an/a 9.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342650
PNG
(4-amino-N-(4-chlorophenethyl)-2-propylquinoline-6-...)
Show SMILES CCCc1cc(N)c2cc(ccc2n1)C(=O)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C21H22ClN3O/c1-2-3-17-13-19(23)18-12-15(6-9-20(18)25-17)21(26)24-11-10-14-4-7-16(22)8-5-14/h4-9,12-13H,2-3,10-11H2,1H3,(H2,23,25)(H,24,26)
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n/an/a 9.60E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348108
PNG
(CHEMBL1800434)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(CC(F)F)Cc2c1
Show InChI InChI=1S/C22H19ClF2N2S/c23-22-18-6-4-15(10-19(18)28-20(22)11-26)2-1-14-3-5-16-7-8-27(13-21(24)25)12-17(16)9-14/h3-6,9-10,21H,7-8,11-13,26H2
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n/an/a 1.02E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342640
PNG
(6-bromo-2-((5-methoxy-1H-indol-3-yl)methyl)-1,2,3,...)
Show SMILES COc1ccc2[nH]cc(CN3CCc4cc(Br)ccc4C3)c2c1
Show InChI InChI=1S/C19H19BrN2O/c1-23-17-4-5-19-18(9-17)15(10-21-19)12-22-7-6-13-8-16(20)3-2-14(13)11-22/h2-5,8-10,21H,6-7,11-12H2,1H3
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n/an/a 1.09E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342646
PNG
(6-(4-(4-methylpiperazin-1-yl)phenyl)-1,2,3,4-tetra...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C20H25N3/c1-22-10-12-23(13-11-22)20-6-4-16(5-7-20)17-2-3-19-15-21-9-8-18(19)14-17/h2-7,14,21H,8-13,15H2,1H3
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n/an/a 1.44E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342648
PNG
(2-methyl-4-(4-(6-methylpyridin-2-ylamino)phenyl)bu...)
Show SMILES Cc1cccc(Nc2ccc(cc2)C#CC(C)(C)O)n1
Show InChI InChI=1S/C17H18N2O/c1-13-5-4-6-16(18-13)19-15-9-7-14(8-10-15)11-12-17(2,3)20/h4-10,20H,1-3H3,(H,18,19)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348110
PNG
(CHEMBL1800079)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(Cc3ccccc3)Cc2c1
Show InChI InChI=1S/C27H23ClN2S/c28-27-24-11-9-20(15-25(24)31-26(27)16-29)7-6-19-8-10-22-12-13-30(18-23(22)14-19)17-21-4-2-1-3-5-21/h1-5,8-11,14-15H,12-13,16-18,29H2
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n/an/a 1.71E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342645
PNG
(6-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,...)
Show SMILES C1Cc2cc(cnc2N1)-c1ccc2CNCCc2c1
Show InChI InChI=1S/C16H17N3/c1-2-14-9-17-5-3-12(14)7-11(1)15-8-13-4-6-18-16(13)19-10-15/h1-2,7-8,10,17H,3-6,9H2,(H,18,19)
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n/an/a 1.94E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342663
PNG
(4-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-meth...)
Show SMILES Cc1cc(N2CCc3cc(Br)ccc3C2)c2ccccc2n1
Show InChI InChI=1S/C19H17BrN2/c1-13-10-19(17-4-2-3-5-18(17)21-13)22-9-8-14-11-16(20)7-6-15(14)12-22/h2-7,10-11H,8-9,12H2,1H3
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n/an/a 2.76E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348109
PNG
(CHEMBL1800435)
Show SMILES NCc1sc2cc(ccc2c1Cl)C#Cc1ccc2CCN(CC(F)(F)F)Cc2c1
Show InChI InChI=1S/C22H18ClF3N2S/c23-21-18-6-4-15(10-19(18)29-20(21)11-27)2-1-14-3-5-16-7-8-28(12-17(16)9-14)13-22(24,25)26/h3-6,9-10H,7-8,11-13,27H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50348105
PNG
(CHEMBL1800429)
Show SMILES CC(C)(C)OC(=O)N1CCc2ccc(cc2C1)C#Cc1ccc2c(Cl)c(CN)sc2c1
Show InChI InChI=1S/C25H25ClN2O2S/c1-25(2,3)30-24(29)28-11-10-18-8-6-16(12-19(18)15-28)4-5-17-7-9-20-21(13-17)31-22(14-27)23(20)26/h6-9,12-13H,10-11,14-15,27H2,1-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 assessed as inhibition of peak current by electrophysiology method


Bioorg Med Chem Lett 21: 4255-8 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296576
PNG
(2-(3-chloro-5-methylphenyl)-1H-indole-5-carboximid...)
Show SMILES Cc1cc(Cl)cc(c1)-c1cc2cc(ccc2[nH]1)C(N)=N
Show InChI InChI=1S/C16H14ClN3/c1-9-4-11(7-13(17)5-9)15-8-12-6-10(16(18)19)2-3-14(12)20-15/h2-8,20H,1H3,(H3,18,19)
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n/an/a 5.10E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296571
PNG
(2-(3,5-dibromophenyl)-1H-indole-5-carboximidamide ...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Br)cc(Br)c1
Show InChI InChI=1S/C15H11Br2N3/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,(H3,18,19)
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n/an/a 5.90E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296570
PNG
(2-(3-bromo-5-fluorophenyl)-1H-indole-5-carboximida...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(F)cc(Br)c1
Show InChI InChI=1S/C15H11BrFN3/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,(H3,18,19)
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n/an/a 5.90E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296575
PNG
(2-(3-(benzylamino)-5-chlorophenyl)-1H-indole-5-car...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(NCc2ccccc2)c1
Show InChI InChI=1S/C22H19ClN4/c23-18-9-17(10-19(12-18)26-13-14-4-2-1-3-5-14)21-11-16-8-15(22(24)25)6-7-20(16)27-21/h1-12,26-27H,13H2,(H3,24,25)
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n/an/a 7.70E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296573
PNG
(2-(3-amino-5-chlorophenyl)-1H-indole-5-carboximida...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(N)cc(Cl)c1
Show InChI InChI=1S/C15H13ClN4/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,17H2,(H3,18,19)
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n/an/a 9.50E+4n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342656
PNG
(CHEMBL1770735 | benzo[b]thiophen-2-ylmethanamine)
Show SMILES NCc1cc2ccccc2s1
Show InChI InChI=1S/C9H9NS/c10-6-8-5-7-3-1-2-4-9(7)11-8/h1-5H,6,10H2
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n/an/a 9.70E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342644
PNG
(2-((5-methoxy-1H-indol-3-yl)methyl)-6-(3-(trifluor...)
Show SMILES COc1ccc2[nH]cc(CN3CCc4cc(ccc4C3)-c3cccc(c3)C(F)(F)F)c2c1
Show InChI InChI=1S/C26H23F3N2O/c1-32-23-7-8-25-24(13-23)21(14-30-25)16-31-10-9-19-11-18(5-6-20(19)15-31)17-3-2-4-22(12-17)26(27,28)29/h2-8,11-14,30H,9-10,15-16H2,1H3
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n/an/a 1.03E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296574
PNG
(2-(3-chloro-5-((phenylamino)methyl)phenyl)-1H-indo...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(CNc2ccccc2)c1
Show InChI InChI=1S/C22H19ClN4/c23-18-9-14(13-26-19-4-2-1-3-5-19)8-16(11-18)21-12-17-10-15(22(24)25)6-7-20(17)27-21/h1-12,26-27H,13H2,(H3,24,25)
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n/an/a 1.14E+5n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50342654
PNG
(6-phenylpyrimidin-4-amine | CHEMBL1770733)
Show SMILES Nc1cc(ncn1)-c1ccccc1
Show InChI InChI=1S/C10H9N3/c11-10-6-9(12-7-13-10)8-4-2-1-3-5-8/h1-7H,(H2,11,12,13)
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n/an/a 1.30E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assay


Bioorg Med Chem Lett 21: 2646-9 (2011)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296565
PNG
(2-(3,5-dichlorophenyl)-1H-indole-5-carboximidamide...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C15H11Cl2N3/c16-11-4-10(5-12(17)7-11)14-6-9-3-8(15(18)19)1-2-13(9)20-14/h1-7,20H,(H3,18,19)
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n/an/a 1.33E+5n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
Amiloride-sensitive cation channel 3


(Homo sapiens)
BDBM50296566
PNG
(2-(2,3,5-trichlorophenyl)-1H-indole-5-carboximidam...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(Cl)cc(Cl)c1Cl
Show InChI InChI=1S/C15H10Cl3N3/c16-9-5-10(14(18)11(17)6-9)13-4-8-3-7(15(19)20)1-2-12(8)21-13/h1-6,21H,(H3,19,20)
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n/an/a 1.35E+5n/an/an/an/an/an/a



Merck.

Curated by ChEMBL


Assay Description
Inhibition of ASIC3 by patch-clamp electrophysiology assay


Bioorg Med Chem Lett 19: 4059-63 (2009)

More data for this
Ligand-Target Pair
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