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Found 6 hits Enz. Inhib. hit(s) with Target = 'Amiloride-sensitive sodium channel subunit alpha' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112167
PNG
(CHEMBL3608428)
Show SMILES Cl.[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCc3ccccn3)cc2)(CCCc2ccc(OCC(=O)NCCc3ccccn3)cc2)C1
Show InChI InChI=1/C46H55ClN10O5.2ClH/c47-43-45(49)56-44(48)42(55-43)46(60)54-37-12-7-29-57(30-37,27-5-8-33-13-17-38(18-14-33)61-31-40(58)52-25-21-35-10-1-3-23-50-35)28-6-9-34-15-19-39(20-16-34)62-32-41(59)53-26-22-36-11-2-4-24-51-36;;/h1-4,10-11,13-20,23-24,37H,5-9,12,21-22,25-32H2,(H6-,48,49,52,53,54,56,58,59,60);2*1H/t37-;;/s2
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n/an/a 6n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


ACS Med Chem Lett 6: 729-31 (2015)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112170
PNG
(CHEMBL3608425)
Show SMILES [O-]C(=O)C(F)(F)F.COc1ccc(CCC[N+]2(CCCc3ccccc3)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1/C29H37ClN6O2.C2HF3O2/c1-38-24-15-13-22(14-16-24)11-6-18-36(17-5-10-21-8-3-2-4-9-21)19-7-12-23(20-36)33-29(37)25-27(31)35-28(32)26(30)34-25;3-2(4,5)1(6)7/h2-4,8-9,13-16,23H,5-7,10-12,17-20H2,1H3,(H4-,31,32,33,35,37);(H,6,7)
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n/an/a 6n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


ACS Med Chem Lett 6: 729-31 (2015)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112171
PNG
(CHEMBL3608426)
Show SMILES Cl.[Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCn3ccnc3)cc2)(CCCc2ccc(OCC(=O)NCCn3ccnc3)cc2)C1
Show InChI InChI=1/C42H53ClN12O5.2ClH/c43-39-41(45)52-40(44)38(51-39)42(58)50-33-6-3-25-55(26-33,23-1-4-31-7-11-34(12-8-31)59-27-36(56)48-17-21-53-19-15-46-29-53)24-2-5-32-9-13-35(14-10-32)60-28-37(57)49-18-22-54-20-16-47-30-54;;/h7-16,19-20,29-30,33H,1-6,17-18,21-28H2,(H6-,44,45,48,49,50,52,56,57,58);2*1H/t33-;;/s2
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n/an/a 9n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


ACS Med Chem Lett 6: 729-31 (2015)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112172
PNG
(CHEMBL3608427)
Show SMILES [Cl-].Nc1nc(N)c(nc1Cl)C(=O)N[C@H]1CCC[N+](CCCc2ccc(OCC(=O)NCCCO)cc2)(CCCc2ccc(OCC(=O)NCCCO)cc2)C1
Show InChI InChI=1/C38H53ClN8O7.ClH/c39-35-37(41)46-36(40)34(45-35)38(52)44-29-8-3-21-47(24-29,19-1-6-27-9-13-30(14-10-27)53-25-32(50)42-17-4-22-48)20-2-7-28-11-15-31(16-12-28)54-26-33(51)43-18-5-23-49;/h9-16,29,48-49H,1-8,17-26H2,(H6-,40,41,42,43,44,46,50,51,52);1H/t29-;/s2
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n/an/a 13n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


ACS Med Chem Lett 6: 729-31 (2015)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112169
PNG
(CHEMBL3608424)
Show SMILES [Cl-].COc1ccc(CCC[N+]2(CCCc3ccc(cc3)C(=O)NCCCN(C)C)CCCC(C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1/C35H49ClN8O3.ClH/c1-43(2)20-7-19-39-34(45)27-15-11-25(12-16-27)8-4-21-44(22-5-9-26-13-17-29(47-3)18-14-26)23-6-10-28(24-44)40-35(46)30-32(37)42-33(38)31(36)41-30;/h11-18,28H,4-10,19-24H2,1-3H3,(H5-,37,38,39,40,42,45,46);1H
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n/an/a 20n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


ACS Med Chem Lett 6: 729-31 (2015)

More data for this
Ligand-Target Pair
Amiloride-sensitive sodium channel subunit alpha


(Mus musculus)
BDBM50112168
PNG
(CHEMBL3608423)
Show SMILES [Cl-].COc1ccc(CCC[N@@+]2(C)CCC[C@@H](C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1
Show InChI InChI=1/C21H29ClN6O2.ClH/c1-28(11-3-5-14-7-9-16(30-2)10-8-14)12-4-6-15(13-28)25-21(29)17-19(23)27-20(24)18(22)26-17;/h7-10,15H,3-6,11-13H2,1-2H3,(H4-,23,24,25,27,29);1H/t15-,28-;/s2
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PubMed
n/an/a 70n/an/an/an/an/an/a



Temple University School of Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of ENaC in mouse M1 assessed as effect on trans epithelial electrical resistance by measuring short circuit currents by voltage-clamp base...


ACS Med Chem Lett 6: 729-31 (2015)

More data for this
Ligand-Target Pair