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Found 46 hits Enz. Inhib. hit(s) with Target = 'Amine oxidase [flavin-containing]' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monoamine oxidase


(Mus musculus)
BDBM50037429
PNG
(8-(3-chlorostyryl)caffeine | 8-[(E)-2-(3-chlorophe...)
Show SMILES Cn1c(\C=C\c2cccc(Cl)c2)nc2n(C)c(=O)n(C)c(=O)c12
Show InChI InChI=1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-14-13(19)15(22)21(3)16(23)20(14)2/h4-9H,1-3H3/b8-7+
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100n/an/an/an/an/an/an/an/a



North-West University

Curated by ChEMBL


Assay Description
Inhibition of mouse brain MAOB


Citation and Details
More data for this
Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B)


(Mus musculus)
BDBM11018
PNG
(2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-...)
Show SMILES CC1c2nc(\C=C\c3cccc(Cl)c3)n(C)c2C(=O)N(C)C1=O
Show InChI InChI=1S/C17H16ClN3O2/c1-10-14-15(17(23)21(3)16(10)22)20(2)13(19-14)8-7-11-5-4-6-12(18)9-11/h4-10H,1-3H3/b8-7+
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200 -38.2n/an/an/an/an/a7.425



Emory University



Assay Description
MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364455
PNG
(CHEMBL1950682)
Show SMILES Cn1c(nc2n(C)c(=O)n(C)c(=O)c12)-c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H19N5O3/c1-24-16-18(25(2)21(29)26(3)20(16)28)23-17(24)13-9-11-15(12-10-13)22-19(27)14-7-5-4-6-8-14/h4-12H,1-3H3,(H,22,27)
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260n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364455
PNG
(CHEMBL1950682)
Show SMILES Cn1c(nc2n(C)c(=O)n(C)c(=O)c12)-c1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C21H19N5O3/c1-24-16-18(25(2)21(29)26(3)20(16)28)23-17(24)13-9-11-15(12-10-13)22-19(27)14-7-5-4-6-8-14/h4-12H,1-3H3,(H,22,27)
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260n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364457
PNG
(CHEMBL1950684)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O4/c1-25-17-19(26(2)22(30)27(3)21(17)29)24-18(25)13-5-9-15(10-6-13)23-20(28)14-7-11-16(31-4)12-8-14/h5-12H,1-4H3,(H,23,28)
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1.18E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50305644
PNG
((2E,4E)-5-Benzo[1,3]dioxol-5-yl-penta-2,4-dienoic ...)
Show SMILES COC(=O)\C=C\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C13H12O4/c1-15-13(14)5-3-2-4-10-6-7-11-12(8-10)17-9-16-11/h2-8H,9H2,1H3/b4-2+,5-3+
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1.60E+3n/an/an/an/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Inhibition of mouse brain MAOB


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364456
PNG
(CHEMBL1950683)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O3/c1-13-5-7-15(8-6-13)20(28)23-16-11-9-14(10-12-16)18-24-19-17(25(18)2)21(29)27(4)22(30)26(19)3/h5-12H,1-4H3,(H,23,28)
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1.63E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine Oxidase Type B (MAO-B)


(Mus musculus)
BDBM11021
PNG
((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol |...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CO
Show InChI InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+
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PubMed
2.40E+3 -32.1n/an/an/an/an/a7.425



Emory University



Assay Description
MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Monoamine oxidase


(Mus musculus)
BDBM50364453
PNG
(CHEMBL1950680)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O3/c1-12-4-6-14(7-5-12)19(27)22-15-10-8-13(9-11-15)17-23-16-18(24-17)25(2)21(29)26(3)20(16)28/h4-11H,1-3H3,(H,22,27)(H,23,24)
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2.77E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364453
PNG
(CHEMBL1950680)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O3/c1-12-4-6-14(7-5-12)19(27)22-15-10-8-13(9-11-15)17-23-16-18(24-17)25(2)21(29)26(3)20(16)28/h4-11H,1-3H3,(H,22,27)(H,23,24)
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2.77E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364459
PNG
(CHEMBL1950686)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O3/c1-12-7-9-13(10-8-12)19(27)22-15-6-4-5-14(11-15)17-23-16-18(24-17)25(2)21(29)26(3)20(16)28/h4-11H,1-3H3,(H,22,27)(H,23,24)
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2.87E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364461
PNG
(CHEMBL1950688)
Show SMILES Cn1c(nc2n(C)c(=O)n(C)c(=O)c12)-c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H19N5O3/c1-24-16-18(25(2)21(29)26(3)20(16)28)23-17(24)14-10-7-11-15(12-14)22-19(27)13-8-5-4-6-9-13/h4-12H,1-3H3,(H,22,27)
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2.95E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50148573
PNG
((E,E)-1-piperoylpiperidine | 1-[(2E,4E)-5-(1,3-ben...)
Show SMILES O=C(\C=C\C=C\c1ccc2OCOc2c1)N1CCCCC1
Show InChI InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
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3.19E+3n/an/an/an/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Inhibition of mouse brain MAOB


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364460
PNG
(CHEMBL1950687)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O4/c1-25-18-16(20(28)26(2)21(25)29)23-17(24-18)13-5-4-6-14(11-13)22-19(27)12-7-9-15(30-3)10-8-12/h4-11H,1-3H3,(H,22,27)(H,23,24)
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3.49E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364460
PNG
(CHEMBL1950687)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O4/c1-25-18-16(20(28)26(2)21(25)29)23-17(24-18)13-5-4-6-14(11-13)22-19(27)12-7-9-15(30-3)10-8-12/h4-11H,1-3H3,(H,22,27)(H,23,24)
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3.49E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364462
PNG
(CHEMBL1950689)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O3/c1-13-8-10-14(11-9-13)20(28)23-16-7-5-6-15(12-16)18-24-19-17(25(18)2)21(29)27(4)22(30)26(19)3/h5-12H,1-4H3,(H,23,28)
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3.56E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364463
PNG
(CHEMBL1950690)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O4/c1-25-17-19(26(2)22(30)27(3)21(17)29)24-18(25)14-6-5-7-15(12-14)23-20(28)13-8-10-16(31-4)11-9-13/h5-12H,1-4H3,(H,23,28)
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3.92E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364463
PNG
(CHEMBL1950690)
Show SMILES COc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O4/c1-25-17-19(26(2)22(30)27(3)21(17)29)24-18(25)14-6-5-7-15(12-14)23-20(28)13-8-10-16(31-4)11-9-13/h5-12H,1-4H3,(H,23,28)
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3.92E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364454
PNG
(CHEMBL1950681)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O4/c1-25-18-16(20(28)26(2)21(25)29)23-17(24-18)12-4-8-14(9-5-12)22-19(27)13-6-10-15(30-3)11-7-13/h4-11H,1-3H3,(H,22,27)(H,23,24)
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3.97E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364458
PNG
(CHEMBL1950685)
Show SMILES Cn1c2nc([nH]c2c(=O)n(C)c1=O)-c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H17N5O3/c1-24-17-15(19(27)25(2)20(24)28)22-16(23-17)13-9-6-10-14(11-13)21-18(26)12-7-4-3-5-8-12/h3-11H,1-2H3,(H,21,26)(H,22,23)
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4.21E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364458
PNG
(CHEMBL1950685)
Show SMILES Cn1c2nc([nH]c2c(=O)n(C)c1=O)-c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H17N5O3/c1-24-17-15(19(27)25(2)20(24)28)22-16(23-17)13-9-6-10-14(11-13)21-18(26)12-7-4-3-5-8-12/h3-11H,1-2H3,(H,21,26)(H,22,23)
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4.21E+3n/an/an/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50148573
PNG
((E,E)-1-piperoylpiperidine | 1-[(2E,4E)-5-(1,3-ben...)
Show SMILES O=C(\C=C\C=C\c1ccc2OCOc2c1)N1CCCCC1
Show InChI InChI=1S/C17H19NO3/c19-17(18-10-4-1-5-11-18)7-3-2-6-14-8-9-15-16(12-14)21-13-20-15/h2-3,6-9,12H,1,4-5,10-11,13H2/b6-2+,7-3+
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1.90E+4n/an/an/an/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Inhibition of mouse brain MAOA


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50305644
PNG
((2E,4E)-5-Benzo[1,3]dioxol-5-yl-penta-2,4-dienoic ...)
Show SMILES COC(=O)\C=C\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C13H12O4/c1-15-13(14)5-3-2-4-10-6-7-11-12(8-10)17-9-16-11/h2-8H,9H2,1H3/b4-2+,5-3+
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2.71E+4n/an/an/an/an/an/an/an/a



University of Cambridge

Curated by ChEMBL


Assay Description
Inhibition of mouse brain MAOA


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50121457
PNG
(1-[3-(2,4-Dihydroxy-phenyl)-5-m-tolyl-4,5-dihydro-...)
Show SMILES CC(=O)N1N=C(CC1c1cccc(C)c1)c1ccc(O)cc1O
Show InChI InChI=1S/C18H18N2O3/c1-11-4-3-5-13(8-11)17-10-16(19-20(17)12(2)21)15-7-6-14(22)9-18(15)23/h3-9,17,22-23H,10H2,1-2H3
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n/an/a 40n/an/an/an/an/an/a



Università di Roma La Sapienza

Curated by ChEMBL


Assay Description
Inhibitory activity against Monoamine oxidase at the selectivity factor of 4000


Bioorg Med Chem Lett 12: 3629-33 (2002)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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n/an/a 8.00E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro antagonistic activity against Monoamine oxidase


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364457
PNG
(CHEMBL1950684)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O4/c1-25-17-19(26(2)22(30)27(3)21(17)29)24-18(25)13-5-9-15(10-6-13)23-20(28)14-7-11-16(31-4)12-8-14/h5-12H,1-4H3,(H,23,28)
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n/an/a 1.07E+4n/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364456
PNG
(CHEMBL1950683)
Show SMILES Cc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O3/c1-13-5-7-15(8-6-13)20(28)23-16-11-9-14(10-12-16)18-24-19-17(25(18)2)21(29)27(4)22(30)26(19)3/h5-12H,1-4H3,(H,23,28)
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n/an/a 1.13E+4n/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364459
PNG
(CHEMBL1950686)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O3/c1-12-7-9-13(10-8-12)19(27)22-15-6-4-5-14(11-15)17-23-16-18(24-17)25(2)21(29)26(3)20(16)28/h4-11H,1-3H3,(H,22,27)(H,23,24)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364461
PNG
(CHEMBL1950688)
Show SMILES Cn1c(nc2n(C)c(=O)n(C)c(=O)c12)-c1cccc(NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H19N5O3/c1-24-16-18(25(2)21(29)26(3)20(16)28)23-17(24)14-10-7-11-15(12-14)22-19(27)13-8-5-4-6-9-13/h4-12H,1-3H3,(H,22,27)
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n/an/a 1.45E+4n/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364462
PNG
(CHEMBL1950689)
Show SMILES Cc1ccc(cc1)C(=O)Nc1cccc(c1)-c1nc2n(C)c(=O)n(C)c(=O)c2n1C
Show InChI InChI=1S/C22H21N5O3/c1-13-8-10-14(11-9-13)20(28)23-16-7-5-6-15(12-16)18-24-19-17(25(18)2)21(29)27(4)22(30)26(19)3/h5-12H,1-4H3,(H,23,28)
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n/an/a 1.67E+4n/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50364454
PNG
(CHEMBL1950681)
Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2n(C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C21H19N5O4/c1-25-18-16(20(28)26(2)21(25)29)23-17(24-18)12-4-8-14(9-5-12)22-19(27)13-6-10-15(30-3)11-7-13/h4-11H,1-3H3,(H,22,27)(H,23,24)
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n/an/a 1.72E+4n/an/an/an/an/an/a



Wenzhou Medical College

Curated by ChEMBL


Assay Description
Inhibition of MAO-B in mouse cerebral homogenate using kynuramine as substrate after 30 mins by fluorimetry in the presence of MOA-A inhibitor clorgy...


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50122758
PNG
(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)
Show SMILES Cc1nc(cs1)C#Cc1cccnc1
Show InChI InChI=1S/C11H8N2S/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10/h2-3,6-8H,1H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Tested for in vitro antagonistic activity against Monoamine oxidase A


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50017845
PNG
(3-(3,4-Dihydroxy-5-nitro-phenyl)-1-(3,4,5-trimetho...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)\C=C\c1cc(O)c(O)c(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H17NO8/c1-25-15-8-11(9-16(26-2)18(15)27-3)13(20)5-4-10-6-12(19(23)24)17(22)14(21)7-10/h4-9,21-22H,1-3H3/b5-4+
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n/an/a 5.00E+4n/an/an/an/an/an/a



Orion Corporation Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against the Monoamine oxidase A


J Med Chem 32: 841-6 (1989)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50017857
PNG
(3-(3,4-Dihydroxy-5-nitro-phenyl)-1-phenyl-propenon...)
Show SMILES Oc1cc(\C=C\C(=O)c2ccccc2)cc(c1O)[N+]([O-])=O
Show InChI InChI=1S/C15H11NO5/c17-13(11-4-2-1-3-5-11)7-6-10-8-12(16(20)21)15(19)14(18)9-10/h1-9,18-19H/b7-6+
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n/an/a 5.00E+4n/an/an/an/an/an/a



Orion Corporation Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against the Monoamine oxidase A


J Med Chem 32: 841-6 (1989)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50017850
PNG
(1-(3,4-Dihydroxy-phenyl)-2-methyl-propan-1-one | C...)
Show SMILES CC(C)C(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C10H12O3/c1-6(2)10(13)7-3-4-8(11)9(12)5-7/h3-6,11-12H,1-2H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



Orion Corporation Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against the Monoamine oxidase A


J Med Chem 32: 841-6 (1989)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50193718
PNG
(2-(2,4-dihydroxy-phenyl)-5-hydroxy-8,8-dimethyl-3-...)
Show SMILES CC(C)=CCc1c(oc2cc3OC(C)(C)C=Cc3c(O)c2c1=O)-c1ccc(O)cc1O
Show InChI InChI=1S/C25H24O6/c1-13(2)5-7-17-23(29)21-20(30-24(17)15-8-6-14(26)11-18(15)27)12-19-16(22(21)28)9-10-25(3,4)31-19/h5-6,8-12,26-28H,7H2,1-4H3
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n/an/a 8.00E+4n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50175016
PNG
(1,3,6,7-tetrahydroxy-4-(1,1-dimethyl-2-propenyl)-8...)
Show SMILES CC(C)=CCc1c(O)c(O)cc2oc3c(c(O)cc(O)c3c(=O)c12)C(C)(C)C=C
Show InChI InChI=1S/C23H24O6/c1-6-23(4,5)19-14(25)9-13(24)18-21(28)17-12(8-7-11(2)3)20(27)15(26)10-16(17)29-22(18)19/h6-7,9-10,24-27H,1,8H2,2-5H3
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n/an/a 8.83E+4n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50193719
PNG
((S)-5,7,7'-trihydroxy-2',2'-dimethyl-6-(3-methylbu...)
Show SMILES CC(C)=CCc1c(O)cc2O[C@@H](CC(=O)c2c1O)c1cc2C=CC(C)(C)Oc2cc1O
Show InChI InChI=1S/C25H26O6/c1-13(2)5-6-15-17(26)11-22-23(24(15)29)19(28)12-21(30-22)16-9-14-7-8-25(3,4)31-20(14)10-18(16)27/h5,7-11,21,26-27,29H,6,12H2,1-4H3/t21-/m0/s1
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n/an/a 8.97E+4n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50217273
PNG
(CHEMBL390040 | isocudraxanthone K)
Show SMILES CC(C)(C=C)c1c(O)cc2oc3c4C=CC(C)(C)Oc4c(O)cc3c(=O)c2c1O
Show InChI InChI=1S/C23H22O6/c1-6-22(2,3)17-13(24)10-15-16(19(17)27)18(26)12-9-14(25)21-11(20(12)28-15)7-8-23(4,5)29-21/h6-10,24-25,27H,1H2,2-5H3
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n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50217268
PNG
(1,6,7-trihydroxy-3-methoxy-2,4-(3-methylbut-2-enyl...)
Show SMILES COc1c(CC=C(C)C)c(O)c2c(oc3cc(O)c(O)cc3c2=O)c1CC=C(C)C
Show InChI InChI=1S/C24H26O6/c1-12(2)6-8-14-21(27)20-22(28)16-10-17(25)18(26)11-19(16)30-24(20)15(23(14)29-5)9-7-13(3)4/h6-7,10-11,25-27H,8-9H2,1-5H3
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n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50217269
PNG
(1,3,6,7-tetrahydroxy-4-(1,1-dimethylallyl)-8-(3-hy...)
Show SMILES CC(C)(O)CCc1c(O)c(O)cc2oc3c(c(O)cc(O)c3c(=O)c12)C(C)(C)C=C
Show InChI InChI=1S/C23H26O7/c1-6-22(2,3)18-13(25)9-12(24)17-20(28)16-11(7-8-23(4,5)29)19(27)14(26)10-15(16)30-21(17)18/h6,9-10,24-27,29H,1,7-8H2,2-5H3
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n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50217270
PNG
(1,3,6,7-tetrahydroxy-4-(1,1-dimethylallyl)xanthone...)
Show SMILES CC(C)(C=C)c1c(O)cc(O)c2c1oc1cc(O)c(O)cc1c2=O
Show InChI InChI=1S/C18H16O6/c1-4-18(2,3)15-12(22)6-11(21)14-16(23)8-5-9(19)10(20)7-13(8)24-17(14)15/h4-7,19-22H,1H2,2-3H3
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n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50175017
PNG
(3,6,8-trihydroxy-2-methoxy-1-(3-methylbut-2-enyl)-...)
Show SMILES COc1c(O)cc2oc3c(c(O)cc(O)c3c(=O)c2c1CC=C(C)C)C(C)(C)C=C
Show InChI InChI=1S/C24H26O6/c1-7-24(4,5)20-15(26)10-14(25)19-21(28)18-13(9-8-12(2)3)22(29-6)16(27)11-17(18)30-23(19)20/h7-8,10-11,25-27H,1,9H2,2-6H3
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n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50217272
PNG
(1,6,7-trihydroxy-8-(3-methylbut-2-enyl)-4',5'-dihy...)
Show SMILES CC1Oc2cc(O)c3c(oc4cc(O)c(O)c(CC=C(C)C)c4c3=O)c2C1(C)C
Show InChI InChI=1S/C23H24O6/c1-10(2)6-7-12-17-15(9-14(25)20(12)26)29-22-18(21(17)27)13(24)8-16-19(22)23(4,5)11(3)28-16/h6,8-9,11,24-26H,7H2,1-5H3
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n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50217274
PNG
((-)-Cudraflavone A | 3,8-Dihydroxy-11,11-dimethyl-...)
Show SMILES CC(C)=CC1Oc2cc(O)ccc2-c2oc3cc4OC(C)(C)C=Cc4c(O)c3c(=O)c12
Show InChI InChI=1S/C25H22O6/c1-12(2)9-18-21-23(28)20-19(11-17-14(22(20)27)7-8-25(3,4)31-17)30-24(21)15-6-5-13(26)10-16(15)29-18/h5-11,18,26-27H,1-4H3
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PubMed
n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair
Monoamine oxidase


(Mus musculus)
BDBM50175013
PNG
(1,3,6,7-tetrahydroxy-5-(3-methylbut-2-enyl)-2-(2-m...)
Show SMILES CC(C)=CCc1c(O)c(O)cc2c1oc1cc(O)c(c(O)c1c2=O)C(C)(C)C=C
Show InChI InChI=1S/C23H24O6/c1-6-23(4,5)18-14(24)10-16-17(21(18)28)20(27)13-9-15(25)19(26)12(22(13)29-16)8-7-11(2)3/h6-7,9-10,24-26,28H,1,8H2,2-5H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a>1.50E+5n/an/an/an/an/an/a



Chungbuk National University

Curated by ChEMBL


Assay Description
Inhibition at monoamine oxidase in mouse brain


Citation and Details
More data for this
Ligand-Target Pair