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Compile Data Set for Download or QSAR

Found 23 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase B' AND taxid = 10090   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase B


(Mus musculus)
BDBM50078122
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)CP(O)(=O)[C@@H]([NH3+])Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C28H33N2O5P/c1-28(27(32)33,19-23-15-9-4-10-16-23)30-26(31)24(17-21-11-5-2-6-12-21)20-36(34,35)25(29)18-22-13-7-3-8-14-22/h2-16,24-25H,17-20,29H2,1H3,(H,30,31)(H,32,33)(H,34,35)/p+1/t24-,25-,28+/m1/s1
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>0.0000100n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrate


Bioorg Med Chem Lett 9: 1511-6 (1999)

More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50078120
PNG
((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Show SMILES C[C@H]([NH3+])P(O)(=O)C[C@@H](Cc1ccccc1)C(=O)N[C@@](C)(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C22H29N2O5P/c1-16(23)30(28,29)15-19(13-17-9-5-3-6-10-17)20(25)24-22(2,21(26)27)14-18-11-7-4-8-12-18/h3-12,16,19H,13-15,23H2,1-2H3,(H,24,25)(H,26,27)(H,28,29)/p+1/t16-,19-,22+/m1/s1
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>0.0000100n/an/an/an/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrate


Bioorg Med Chem Lett 9: 1511-6 (1999)

More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282715
PNG
(1-[(S)-2-((1R,2S)-2-Amino-1-cyano-3-phenyl-propyla...)
Show SMILES COC(=O)C1CCCN1C(=O)[C@H](CC(C)C)N[C@H](C#N)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C22H32N4O3/c1-15(2)12-18(21(27)26-11-7-10-20(26)22(28)29-3)25-19(14-23)17(24)13-16-8-5-4-6-9-16/h4-6,8-9,15,17-20,25H,7,10-13,24H2,1-3H3/t17-,18-,19+,20?/m0/s1
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n/an/a 1.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282726
PNG
((S)-1-[(S)-2-((1R,2S)-2-Amino-1-cyano-3-phenyl-pro...)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)N[C@@H](C#N)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C22H32N4O3/c1-15(2)12-18(21(27)26-11-7-10-20(26)22(28)29-3)25-19(14-23)17(24)13-16-8-5-4-6-9-16/h4-6,8-9,15,17-20,25H,7,10-13,24H2,1-3H3/t17-,18-,19-,20-/m0/s1
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n/an/a 2.80E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282725
PNG
(CHEMBL35627 | methyl (2S)-2-{[(2S)-2-amino-1-cyano...)
Show SMILES COC(=O)[C@@H](NC(C#N)[C@@H](N)Cc1ccccc1)C(C)C
Show InChI InChI=1S/C16H23N3O2/c1-11(2)15(16(20)21-3)19-14(10-17)13(18)9-12-7-5-4-6-8-12/h4-8,11,13-15,19H,9,18H2,1-3H3/t13-,14?,15-/m0/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282728
PNG
(CHEMBL36081 | methyl (2S)-6-amino-2-{[(2S)-2-amino...)
Show SMILES COC(=O)[C@H](CCCCN)NC(C#N)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C17H26N4O2/c1-23-17(22)15(9-5-6-10-18)21-16(12-19)14(20)11-13-7-3-2-4-8-13/h2-4,7-8,14-16,21H,5-6,9-11,18,20H2,1H3/t14-,15-,16?/m0/s1
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n/an/a 4.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282720
PNG
(CHEMBL288458 | methyl (2S)-2-{[(2S)-2-amino-1-cyan...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(C#N)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C17H25N3O2/c1-12(2)9-15(17(21)22-3)20-16(11-18)14(19)10-13-7-5-4-6-8-13/h4-8,12,14-16,20H,9-10,19H2,1-3H3/t14-,15-,16?/m0/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 1.60E+5n/an/an/an/an/an/a



University of Wisconsin





Biochemistry 27: 7301-10 (1988)

More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282722
PNG
((S)-2-((1R,2S)-2-Amino-1-cyano-3-phenyl-propylamin...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)N[C@@H](C#N)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C20H23N3O2/c1-25-20(24)18(13-16-10-6-3-7-11-16)23-19(14-21)17(22)12-15-8-4-2-5-9-15/h2-11,17-19,23H,12-13,22H2,1H3/t17-,18-,19-/m0/s1
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n/an/a 2.21E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282729
PNG
((S)-2-((1S,2S)-2-Amino-1-cyano-3-phenyl-propylamin...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)N[C@H](C#N)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C20H23N3O2/c1-25-20(24)18(13-16-10-6-3-7-11-16)23-19(14-21)17(22)12-15-8-4-2-5-9-15/h2-11,17-19,23H,12-13,22H2,1H3/t17-,18-,19+/m0/s1
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n/an/a 2.93E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282717
PNG
(1-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-4-m...)
Show SMILES COC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1ccccc1
Show InChI InChI=1S/C21H31N3O4/c1-14(2)12-17(20(26)24-11-7-10-18(24)21(27)28-3)23-19(25)16(22)13-15-8-5-4-6-9-15/h4-6,8-9,14,16-18H,7,10-13,22H2,1-3H3,(H,23,25)/t16-,17-,18-/m0/s1
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n/an/a 8.24E+5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282713
PNG
((S)-2-((S)-2-tert-Butoxycarbonylamino-1-cyano-3-ph...)
Show SMILES COC(=O)[C@@H](NC(C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C
Show InChI InChI=1S/C21H31N3O4/c1-14(2)18(19(25)27-6)23-17(13-22)16(12-15-10-8-7-9-11-15)24-20(26)28-21(3,4)5/h7-11,14,16-18,23H,12H2,1-6H3,(H,24,26)/t16-,17?,18-/m0/s1
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n/an/a 1.00E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282711
PNG
(1-[(S)-2-((1R,2S)-2-tert-Butoxycarbonylamino-1-cya...)
Show SMILES COC(=O)C1CCCN1C(=O)[C@H](CC(C)C)N[C@H](C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C27H40N4O5/c1-18(2)15-21(24(32)31-14-10-13-23(31)25(33)35-6)29-22(17-28)20(16-19-11-8-7-9-12-19)30-26(34)36-27(3,4)5/h7-9,11-12,18,20-23,29H,10,13-16H2,1-6H3,(H,30,34)/t20-,21-,22+,23?/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282716
PNG
((S)-2-((1R,2S)-2-tert-Butoxycarbonylamino-1-cyano-...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)N[C@H](C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C25H31N3O4/c1-25(2,3)32-24(30)28-20(15-18-11-7-5-8-12-18)22(17-26)27-21(23(29)31-4)16-19-13-9-6-10-14-19/h5-14,20-22,27H,15-16H2,1-4H3,(H,28,30)/t20-,21-,22+/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282724
PNG
((S)-2-((1R,2S)-2-Amino-1-carbamoyl-3-phenyl-propyl...)
Show SMILES COC(=O)[C@H](CC(C)C)N[C@@H]([C@@H](N)Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C17H27N3O3/c1-11(2)9-14(17(22)23-3)20-15(16(19)21)13(18)10-12-7-5-4-6-8-12/h4-8,11,13-15,20H,9-10,18H2,1-3H3,(H2,19,21)/t13-,14-,15-/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282723
PNG
((S)-2-((1S,2S)-2-tert-Butoxycarbonylamino-1-cyano-...)
Show SMILES COC(=O)[C@H](Cc1ccccc1)N[C@@H](C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C25H31N3O4/c1-25(2,3)32-24(30)28-20(15-18-11-7-5-8-12-18)22(17-26)27-21(23(29)31-4)16-19-13-9-6-10-14-19/h5-14,20-22,27H,15-16H2,1-4H3,(H,28,30)/t20-,21-,22-/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50027516
PNG
(2-(2-Amino-3-phenyl-propionylamino)-4-methyl-penta...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C15H22N2O3/c1-10(2)8-13(15(19)20)17-14(18)12(16)9-11-6-4-3-5-7-11/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20)/t12-,13-/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282712
PNG
((S)-6-Amino-2-((S)-2-tert-butoxycarbonylamino-1-cy...)
Show SMILES COC(=O)[C@H](CCCCN)NC(C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C22H34N4O4/c1-22(2,3)30-21(28)26-18(14-16-10-6-5-7-11-16)19(15-24)25-17(20(27)29-4)12-8-9-13-23/h5-7,10-11,17-19,25H,8-9,12-14,23H2,1-4H3,(H,26,28)/t17-,18-,19?/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282721
PNG
(1-[(S)-2-((1S,2S)-2-tert-Butoxycarbonylamino-1-cya...)
Show SMILES COC(=O)C1CCCN1C(=O)[C@H](CC(C)C)N[C@@H](C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C27H40N4O5/c1-18(2)15-21(24(32)31-14-10-13-23(31)25(33)35-6)29-22(17-28)20(16-19-11-8-7-9-12-19)30-26(34)36-27(3,4)5/h7-9,11-12,18,20-23,29H,10,13-16H2,1-6H3,(H,30,34)/t20-,21-,22-,23?/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282714
PNG
(1-[(S)-2-((1R,2S)-2-Amino-1-carbamoyl-3-phenyl-pro...)
Show SMILES COC(=O)C1CCCN1C(=O)[C@H](CC(C)C)N[C@@H]([C@@H](N)Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C22H34N4O4/c1-14(2)12-17(21(28)26-11-7-10-18(26)22(29)30-3)25-19(20(24)27)16(23)13-15-8-5-4-6-9-15/h4-6,8-9,14,16-19,25H,7,10-13,23H2,1-3H3,(H2,24,27)/t16-,17-,18?,19-/m0/s1
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TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


Citation and Details
More data for this
Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282719
PNG
((S)-2-((S)-2-tert-Butoxycarbonylamino-1-cyano-3-ph...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(C#N)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C22H33N3O4/c1-15(2)12-18(20(26)28-6)24-19(14-23)17(13-16-10-8-7-9-11-16)25-21(27)29-22(3,4)5/h7-11,15,17-19,24H,12-13H2,1-6H3,(H,25,27)/t17-,18-,19?/m0/s1
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UniChem

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Article
n/an/a 1.00E+6n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Aminopeptidase B in murine L-cells by Aoyagi method.


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Ligand-Target Pair
Aminopeptidase B


(Mus musculus)
BDBM50282718
PNG
(1-[(S)-2-((1S,2S)-2-Amino-1-carbamoyl-3-phenyl-pro...)
Show SMILES COC(=O)C1CCCN1C(=O)[C@H](CC(C)C)N[C@H]([C@@H](N)Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C22H34N4O4/c1-14(2)12-17(21(28)26-11-7-10-18(26)22(29)30-3)25-19(20(24)27)16(23)13-15-8-5-4-6-9-15/h4-6,8-9,14,16-19,25H,7,10-13,23H2,1-3H3,(H2,24,27)/t16-,17-,18?,19+/m0/s1
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GoogleScholar
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PC cid
PC sid
UniChem

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AffyNet 
Article
n/an/a 1.00E+6n/an/an/an/an/an/a


TBA

Assay Description
Concentration required for inhibitory potency against Aminopeptidase B in murine L-cells by aoyagi method using L-lysine-2-naphthylamide hydrochlorid...


Citation and Details
More data for this
Ligand-Target Pair