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Compile Data Set for Download or QSAR

Found 15 hits Enz. Inhib. hit(s) with Target = 'Aminopeptidase N' AND taxid = 10116   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase N


(Rattus norvegicus)
BDBM50001950
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50368571
PNG
(CHEMBL1203858)
Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C19H28N4O4/c1-27-19(26)16(10-12-11-22-15-8-3-2-6-13(12)15)23-18(25)17(24)14(21)7-4-5-9-20/h2-3,6,8,11,14,16-17,22,24H,4-5,7,9-10,20-21H2,1H3,(H,23,25)/t14-,16+,17+/m1/s1
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n/an/a 1.02E+4n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM23971
PNG
((2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanami...)
Show SMILES CC(C)C[C@H](NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
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n/an/a 1.94E+4n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001947
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)C(O)[C@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19-,22?/m1/s1
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n/an/a 9.12E+4n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001941
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-4-methyl-...)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C14H29N3O4/c1-9(2)8-11(14(20)21-3)17-13(19)12(18)10(16)6-4-5-7-15/h9-12,18H,4-8,15-16H2,1-3H3,(H,17,19)/t10-,11+,12+/m1/s1
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n/an/a 2.01E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001951
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19+,22+/m0/s1
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n/an/a 2.25E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001949
PNG
(2-(2,6-Diamino-hexanoylamino)-3-[2-(2-nitro-phenyl...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C24H29N5O5S/c1-34-24(31)19(27-22(30)17(26)9-6-7-13-25)14-16-15-8-2-3-10-18(15)28-23(16)35-21-12-5-4-11-20(21)29(32)33/h2-5,8,10-12,17,19,28H,6-7,9,13-14,25-26H2,1H3,(H,27,30)/t17-,19-/m0/s1
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n/an/a 2.61E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50368568
PNG
(CHEMBL1203859)
Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C19H28N4O4/c1-27-19(26)16(10-12-11-22-15-8-3-2-6-13(12)15)23-18(25)17(24)14(21)7-4-5-9-20/h2-3,6,8,11,14,16-17,22,24H,4-5,7,9-10,20-21H2,1H3,(H,23,25)/t14-,16+,17-/m1/s1
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n/an/a 5.02E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50368570
PNG
(CHEMBL1794908)
Show SMILES COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](O)[C@H](N)CCCCN
Show InChI InChI=1S/C19H28N4O4/c1-27-19(26)16(10-12-11-22-15-8-3-2-6-13(12)15)23-18(25)17(24)14(21)7-4-5-9-20/h2-3,6,8,11,14,16-17,22,24H,4-5,7,9-10,20-21H2,1H3,(H,23,25)/t14-,16-,17-/m1/s1
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n/an/a 8.26E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001944
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-[2-(2-n...)
Show SMILES COC(=O)[C@H](Cc1c(Sc2ccccc2[N+]([O-])=O)[nH]c2ccccc12)NC(=O)C(O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H31N5O6S/c1-36-25(33)19(28-23(32)22(31)17(27)9-6-7-13-26)14-16-15-8-2-3-10-18(15)29-24(16)37-21-12-5-4-11-20(21)30(34)35/h2-5,8,10-12,17,19,22,29,31H,6-7,9,13-14,26-27H2,1H3,(H,28,32)/t17-,19-,22?/m0/s1
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n/an/a 8.52E+5n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001945
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-(1H-ind...)
Show SMILES COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C19H28N4O4/c1-27-19(26)16(10-12-11-22-15-8-3-2-6-13(12)15)23-18(25)17(24)14(21)7-4-5-9-20/h2-3,6,8,11,14,16-17,22,24H,4-5,7,9-10,20-21H2,1H3,(H,23,25)/t14-,16+,17-/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001948
PNG
(2-(3,7-Diamino-2-hydroxy-heptanoylamino)-3-(1H-ind...)
Show SMILES COC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C19H28N4O4/c1-27-19(26)16(10-12-11-22-15-8-3-2-6-13(12)15)23-18(25)17(24)14(21)7-4-5-9-20/h2-3,6,8,11,14,16-17,22,24H,4-5,7,9-10,20-21H2,1H3,(H,23,25)/t14-,16+,17+/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50368567
PNG
(CHEMBL1794905)
Show SMILES COC(=O)[C@H](CC(C)C)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C14H29N3O4/c1-9(2)8-11(14(20)21-3)17-13(19)12(18)10(16)6-4-5-7-15/h9-12,18H,4-8,15-16H2,1-3H3,(H,17,19)/t10-,11-,12+/m0/s1
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Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50001946
PNG
(2-(6-Amino-2-aminomethyl-hexanoylamino)-3-(1H-indo...)
Show SMILES NCCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C17H24N4O3/c18-8-4-3-6-13(19)16(22)21-15(17(23)24)9-11-10-20-14-7-2-1-5-12(11)14/h1-2,5,7,10,13,15,20H,3-4,6,8-9,18-19H2,(H,21,22)(H,23,24)/t13-,15-/m0/s1
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Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M (AP-M) using [3H]Leu-enkephalin as subst...


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair
Aminopeptidase N


(Rattus norvegicus)
BDBM50368569
PNG
(CHEMBL1794904)
Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](O)[C@@H](N)CCCCN
Show InChI InChI=1S/C19H28N4O4/c1-27-19(26)16(10-12-11-22-15-8-3-2-6-13(12)15)23-18(25)17(24)14(21)7-4-5-9-20/h2-3,6,8,11,14,16-17,22,24H,4-5,7,9-10,20-21H2,1H3,(H,23,25)/t14-,16-,17+/m0/s1
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n/an/a>1.00E+6n/an/an/an/an/an/a



Instituto de Qu£mica M£dica

Curated by ChEMBL


Assay Description
Compound was evaluated for its inhibitory potency against purified membrane bound rat brain Aminopeptidase M using [3H]Leu-enkephalin as substrate


J Med Chem 35: 889-95 (1992)

More data for this
Ligand-Target Pair